近几十年来，全球近视患病率不断上升，已成为全世界主要的公共卫生问题之一。众多研究表明户外活动能有效控制近视的发生和发展。本文综述了户外活动对近视防控作用的研究进展及其作用机制，以期为近视防控提供新的思路。

     In recent decades, the prevalence of myopia has been increasing globally, becoming one of the major public health issues worldwide. Numerous studies indicate that outdoor activities can effectively control the onset and progression of myopia. This article reviews the research progress on prevention and control effect and mechanism of outdoor activities on myopia, hoping to provide new insights for myopia prevention and control. 

      近视是一种常见的屈光不正状态，也是全球范围内普遍存在的视觉健康问题，其特征是在眼部调节放松的状态下，平行光线经眼的屈光系统折射后聚焦在视网膜前，导致视远模糊。近视通常在儿童期发生和发展，但在成年期仍可继续发生和发展。本综述对已发表的关于成年人近视发生和进展的文献进行总结，描述成年人近视的流行病学特征，包括近视率、近视发病率、近视进展率及其近视特征（屈光度及眼轴），总结成年人近视发病和进展的危险因素。了解成年人近视的发展特点和管理方式对于近视防控实践具有重要意义。

   Myopia is a common refractive error and a universal visual health problem in the world. It is characterized by the fact that parallel light rays refract through the refractive system of the eye and focus in front of the retina when the eye accommodatior is relaxed, resulting in distant blurred vision. Myopia usually occurs and develops in childhood, but can continue to occur and develop in adulthood. This review summarizes the published literature on the occurrence and progression of myopia in adults, describes the epidemiological characteristics of myopia in adults, including myopia rate, myopia incidence rate, myopia progression rate, and myopia characteristics（diopter and ocular axis） ; and summarizes the  risk factors for the occurrence and progression of myopia in adults. Understanding the developmental characteristics and management methods of adult myopia is of great significance for myopia prevention and control practice. 

       目的   探讨眼底豹纹斑密度（FTD）及视盘旁萎缩弧（PPA）与眼轴长（AL）的相关性，为眼底定量化在儿童近视防控的应用提供科学依据。方法   本研究随机抽取广州市荔湾区两所小学三年级学生作为研究对象，在校园视力筛查的过程中同时采集AL、CR和眼底彩照。使用AI软件对眼底彩照进行量化分析，量化指标包括不同区域和范围的FTD及PPA面积大小，根据眼轴长度分为三组：A组（AL＜23 mm）；B组（23 mm≤AL＜24 mm）；C组（24 mm≤AL）。结果   共有398例右眼被纳入统计分析，年龄范围8~11岁，中位数是9岁，男性人数占55.1％。三组组间AL、AL/CR和SE比较均有统计学差异（P＜0.05）。A组与B组相比，FTD在后极部整体范围、黄斑中心3 mm区域、黄斑中心3 mm区域上方区域具有统计学差异（P＜0.05），C组与B组相比，PPA面积及FTD在后极部整体范围、视盘为中心4.5 mm范围、黄斑为中心直径3 mm和6 mm范围均具有统计学差异（P＜0.05），Spearman相关性分析表明，AL与PPA（r=0.443）和FTD（r=0.322）呈正相关（P＜0.001）。亚组相关性分析表明，A组仅黄斑为中心直径3 mm上方范围FTD与AL呈正相关（P=0.028），B组PPA、黄斑中心直径3 mm及其上方范围FTD与AL呈正相关（P＜0.05），C组仅PPA与AL呈正相关（P=0.005）。结论 眼底定量对于儿童近视防控具有潜在价值，PPA和FTD与AL呈正相关性，不同区域和范围FTD与AL相关性具有一定差异性，黄斑中心直径3 mm范围及其上方范围与眼轴相关性最强。FTD在短眼轴阶段就可以作为生物标记物预测近视严重程度，而PPA主要在长眼轴阶段体现生物标记物的作用。

       Objective  To investigate the correlation between fundus tessellated density（FTD）and peripapillary atrophy（PPA）with axial length（AL）, providing a scientific basis for the application of fundus quantification in the prevention and control of myopia in children. Methods  This study randomly selected third-grade students from two primary schools in Liwan District, Guangzhou City, as research subjects. Axial length（AL）, corneal radius（CR）, and fundus color photographs were collected simultaneously during the school vision screening process. AI software was utilized to perform quantitative analysis on the fundus color photographs, with quantification indicators including the area size of PPA and FTD in different regions and ranges. Subjects were divided into three groups based on axial length：Group A（AL＜23 mm）; Group B（23 mm≤AL＜24 mm）; Group C（AL≥24 mm）. Results  A total of 398 right eyes were included in the statistical analysis, with an age range of 8 to 11, a median age of 9, and 55.1% were male. There were significant statistical differences in AL, AL/CR, and spherical equivalent（SE）among the three groups（P＜0.05）. Compared with Group B, Group A showed significant statistical differences in FTD in the overall posterior pole, the 3 mm diameter area centered on the fovea, and the superior area of the 3 mm foveal center（P＜0.05）. Compared with Group B, Group C showed significant differences in PPA area and FTD in the overall posterior pole, the 4.5 mm diameter area centered on the optic disc, and the 3 mm and 6 mm diameter areas centered on the fovea（P＜0.05）. Spearman correlation analysis indicated that AL was significantly positively correlated with PPA（r=0.443）and FTD（r=0.322）（P＜0.001）. Subgroup correlation analysis showed that in Group A, only the FTD in the superior area of the 3 mm diameter centered on the fovea was significantly positively correlated with AL（P=0.028）. In Group B, PPA and FTD in the 3 mm diameter and superior area centered on the fovea were significantly positively correlated with AL（P＜0.05）. In Group C, only PPA was significantly positively correlated with AL（P=0.005）. Conclusions  Fundus quantification holds potential value for the prevention and control of myopia in children. PPA and FTD show significant positive correlations with AL, with varying degrees of correlation in different regions and ranges of FTD with AL. The 3 mm diameter area centered on the fovea and its superior area have the strongest correlation with the eye axis. FTD can serve as a biomarker to predict the severity of myopia in the early stages of eye axis elongation, while PPA primarily manifests as a biomarker in the later stages of elongation. 

    目的   研究羽毛球颠球运动对低年级小学生近视的改善效果，为制定儿童青少年近视干预方案提供依据。方法   采用方便抽样方法，抽取广州市1个城区1所小学三年级4个班共182名学生作为研究对象。基线调查完成后，以班为单位，采用随机数字表法将4个班分为干预组（2个班，91例）和对照组（2个班，91例），干预组安排羽毛球颠球项目体育活动，对照组按原教学计划安排非球类常规体育活动。比较两组干预前后筛查性近视率、视力不良率和近视进展程度。结果  干预前两组的年龄、性别、筛查性近视率、视力不良率及近视分级比较，差异均无统计学意义（P＞0.05）。两组干预后的等效球镜度数（SE）比较，差异无统计学意义（P＞0.05）；对照组干预后的裸眼远视力（UDVA）低于干预组，△UDVA、△SE均高于干预组，差异均有统计学意义（P＜0.05）。对照组新发筛查性近视率29.13%、累积筛查性近视率49.45%、累积视力不良率68.13%及近视进展程度，均高于干预组新发筛查性近视率7.69%、累积筛查性近视率34.07%、累积视力不良率52.74%及近视进展程度，差异均有统计学意义（P＜0.05）。结论   羽毛球颠球运动能降低低年级小学生视力不良进展速度，减少近视的发生率及近视程度，学校可结合引起近视的因素进行灵活应用，以预防近视的发生发展。

      Objective  To study the impact of badminton juggling on the myopia of lower-grade primary school students and to provide a basis for developing myopia intervention strategies for children and adolescents．Methods  By using the convenience sampling method，182 third-grade students from four classes in a primary school in a district of Guangzhou were selected as subjects．After completing the baseline survey，the four classes were divided into an intervention group（2 classes，91 students）and a control group（2 classes，91 students）using a random number table．The intervention group was arranged to participate in badminton juggling sports activities，while the control group followed the original teaching plan without ball games．The study compared the screening rate of myopia，the rate of poor vision，and the degree of myopia progression before and after the study in both groups．Results  On baseline，there were no statistically significant differences between the two groups in terms of age，gender，rate of screening myopia，poor vision，and myopia grading（P＞0.05）．After 12 months，there was no statistically significant difference in the spherical equivalent（SE） comparison between the two groups（P＞0.05）．However，the uncorrected distance visual acuity（UDVA） of the control group after 12 months was significantly lower than that of the intervention group，and both △UDVA and △SE were significantly higher than those of the intervention group，with all differences being statistically significant（P＜0.05）．Incidence of screening myopia in the control group （29.13%），the cumulative rate of screening myopia（49.45%），the cumulative rate of poor vision （68.13%），and the degree of myopia progression was significantly higher than those in the intervention group，which had incidence of screening myopia at 7.69%，the cumulative rate of screening myopia at 34.07%，cumulative rate of poor vision at 52.74%．All these differences were statistically significant（P＜0.05）．Conclusions  Badminton juggling can slow down vision deterioration，reduce the incidence and severity of myopia in lower grade primary school students．Schools can flexibly apply these findings in conjunction with factors that contribute to myopia to prevent its occurrence and development．

      目的   分析高原地区3～6年级学生屈光状态及屈光参数之间的关系。方法  2023年9月，采用随机抽样方法选取林芝市波密县某两所小学3～6年级535名学生进行校园筛查。计算并记录裸眼远视力（UCVA），非睫状肌麻痹电脑验光下散光及其轴位、等效球镜（SE）、眼轴（AL）、角膜曲率半径（CR）和眼轴/角膜曲率半径轴率比（AL/CR）。采用SPSS 22.00统计软件分析数据。结果  3～6年级学生AL和AL/CR大体趋势为随年级升高而增长，SE随年级升高而降低。3～6年级学生总体筛查性近视患病率为29.91%，且3～6年级筛查性近视患病率分别为20.35%、25.53%、30.53%和51.38%。总体散光患病率为51.59%，其中顺规散光、逆规散光及斜轴散光分别占90.22%、7.61%及2.17%。视力不良者约40.37%。以非睫状肌麻痹验光SE≤-0.50 D同时UCVA＜5.0作为筛查性近视的诊断，AL/CR诊断筛查性近视的灵敏度为0.656、特异度为0.887和Youden指数为0.534，曲线下面积（AUC）为0.802，优于AL评估（AUC=0.764）。结论   高原地区3～6年级学生的筛查性近视患病率随年级升高而快速增长，且散光患病率较高，视力不良者较多。AL／CR值对筛查性近视监测具有一定的临床意义。

      Objective  To analyze the  relationship  between  refractive  status and  refractive  parameters of  students in grades three-six in plateau area．Methods  In September，2023，a random sampling method was used to select 535 students from grades three-six of two primary schools in Bomi County，Nyingchi City，for school screening．Distance uncorrected visual acuity（UCVA），astigmatism and its axis position，equivalent spherical（SE），axial length（AL），corneal radius（CR），and axial length/corneal radius ratio（AL/CR）were calculated and recorded．The data was analyzed using the statistical software SPSS 22.00．Results  The general trend of AL and AL/CR for grade three-six students was increased with grade increasing，while SE decreased with grade increasing．The overall prevalence of screening myopia was 29.91%，and the prevalence of screening myopia in grades three to six was 20.35%，25.53%，30.53% and 51.38%，respectively．The overall prevalence rate of astigmatism was 51.59%，including 90.22%，7.61% and 2.17% for astigmatism with the rule，astigmatism against the rule and oblique astigmatism，respectively．About 40.37% of the students had poor vision．Screening myopia was diagnosed using non-cycloplegic optometry with SE ≤-0.50 D combined with UCVA＜5.0．The sensitivity and specificity of AL/CR for screening myopia were 0.656 and 0.887，respectively，with a Youden index of 0.534 and an area under the curve（AUC）of 0.802．This was superior to the AL evaluation，which had an AUC of 0.764．Conclusions  The prevalence of screening myopia increased rapidly with the increase of grade in grade 3 to 6 in plateau area．And there were high prevalence of astigmatism and more poor vision．AL/CR value has a certain clinical significance in the monitoring of screening myopia．

目的 探讨眼底豹纹斑密度（FTD）及视盘旁萎缩弧（PPA）与眼轴长（AL）的相关性,为眼底定量化在儿童近视防控的应用提供科学依据。方法 本研究随机抽取广州市荔湾区两所小学三年级学生作为研究对象,在校园视力筛查的过程中同时采集AL、CR和眼底彩照。使用AI软件对眼底彩照进行量化分析,量化指标包括不同区域和范围的FTD及PPA面积大小,根据眼轴长度分为三组：A组（AL<23 mm）;B组（23 mm≤AL<24 mm）;C组（24 mm≤AL）。结果 共有398例右眼被纳入统计分析,年龄范围8~11岁,中位数是9岁,男性人数占55.1％。三组组间AL、AL/CR和SE比较均有统计学差异（P<0.05）。A组与B组相比,FTD在后极部整体范围、黄斑中心3 mm区域、黄斑中心3 mm区域上方区域具有统计学差异（P<0.05）,C组与B组相比,PPA面积及FTD在后极部整体范围、视盘为中心4.5 mm范围、黄斑为中心直径3 mm和6 mm范围均具有统计学差异（P<0.05）,Spearman相关性分析表明,AL与PPA（r=0.443）和FTD（r=0.322）呈正相关（P<0.001）。亚组相关性分析表明,A组仅黄斑为中心直径3 mm上方范围FTD与AL呈正相关（P=0.028）,B组PPA、黄斑中心直径3 mm及其上方范围FTD与AL呈正相关（P<0.05）,C组仅PPA与AL呈正相关（P=0.005）。结论 眼底定量对于儿童近视防控具有潜在价值,PPA和FTD与AL呈正相关性,不同区域和范围FTD与AL相关性具有一定差异性,黄斑中心直径3 mm范围及其上方范围与眼轴相关性最强。FTD在短眼轴阶段就可以作为生物标记物预测近视严重程度,而PPA主要在长眼轴阶段体现生物标记物的作用。

Objective To investigate the correlation between fundus tessellated density（FTD）and peripapillary atrophy（PPA）with axial length（AL）,providing a scientific basis for the application of fundus quantification in the prevention and control of myopia in children．Methods This study randomly selected third-grade students from two primary schools in Liwan District,Guangzhou City,as research subjects．Axial length（AL）,corneal radius（CR）,and fundus color photographs were collected simultaneously during the school vision screening process．AI software was utilized to perform quantitative analysis on the fundus color photographs,with quantification indicators including the area size of PPA and FTD in different regions and ranges．Subjects were divided into three groups based on axial length：Group A（AL<23 mm）;Group B（23 mm≤AL<24 mm）;Group C（AL≥24 mm）．Results A total of 398 right eyes were included in the statistical analysis,with an age range of 8 to 11,a median age of 9,and 55.1% were male．There were significant statistical differences in AL,AL/CR,and spherical equivalent（SE）among the three groups（P<0.05）．Compared with Group B,Group A showed significant statistical differences in FTD in the overall posterior pole,the 3 mm diameter area centered on the fovea,and the superior area of the 3 mm foveal center（P<0.05）．Compared with Group B,Group C showed significant differences in PPA area and FTD in the overall posterior pole,the 4.5 mm diameter area centered on the optic disc,and the 3 mm and 6 mm diameter areas centered on the fovea（P<0.05）．Spearman correlation analysis indicated that AL was significantly positively correlated with PPA（r=0.443）and FTD（r=0.322）（P<0.001）．Subgroup correlation analysis showed that in Group A,only the FTD in the superior area of the 3 mm diameter centered on the fovea was significantly positively correlated with AL（P=0.028）．In Group B,PPA and FTD in the 3 mm diameter and superior area centered on the fovea were significantly positively correlated with AL（P<0.05）．In Group C,only PPA was significantly positively correlated with AL（P=0.005）．Conclusions Fundus quantification holds potential value for the prevention and control of myopia in children．PPA and FTD show significant positive correlations with AL,with varying degrees of correlation in different regions and ranges of FTD with AL．The 3 mm diameter area centered on the fovea and its superior area have the strongest correlation with the eye axis．FTD can serve as a biomarker to predict the severity of myopia in the early stages of eye axis elongation,while PPA primarily manifests as a biomarker in the later stages of elongation．

目的 分析高原地区3~6年级学生屈光状态及屈光参数之间的关系。方法 2023年9月,采用随机抽样方法选取林芝市波密县某两所小学3~6年级535名学生进行校园筛查。计算并记录裸眼远视力（UCVA）,非睫状肌麻痹电脑验光下散光及其轴位、等效球镜（SE）、眼轴（AL）、角膜曲率半径（CR）和眼轴/角膜曲率半径轴率比（AL/CR）。采用SPSS 22.00统计软件分析数据。结果 3~6年级学生AL和AL/CR大体趋势为随年级升高而增长,SE随年级升高而降低。3~6年级学生总体筛查性近视患病率为29.91%,且3~6年级筛查性近视患病率分别为20.35%、25.53%、30.53%和51.38%。总体散光患病率为51.59%,其中顺规散光、逆规散光及斜轴散光分别占90.22%、7.61%及2.17%。视力不良者约40.37%。以非睫状肌麻痹验光SE≤-0.50 D同时UCVA<5.0作为筛查性近视的诊断,AL/CR诊断筛查性近视的灵敏度为0.656、特异度为0.887和Youden指数为0.534,曲线下面积（AUC）为0.802,优于AL评估（AUC=0.764）。结论 高原地区3~6年级学生的筛查性近视患病率随年级升高而快速增长,且散光患病率较高,视力不良者较多。AL／CR值对筛查性近视监测具有一定的临床意义。

Objective To analyze the relationship between refractive status and refractive parameters of students in grades three-six in plateau area．Methods In September,2023,a random sampling method was used to select 535 students from grades three-six of two primary schools in Bomi County,Nyingchi City,for school screening．Distance uncorrected visual acuity（UCVA）,astigmatism and its axis position,equivalent spherical（SE）,axial length（AL）,corneal radius（CR）,and axial length/corneal radius ratio（AL/CR）were calculated and recorded．The data was analyzed using the statistical software SPSS 22.00. Results The general trend of AL and AL/CR for grade three-six students was increased with grade increasing,while SE decreased with grade increasing．The overall prevalence of screening myopia was 29.91%,and the prevalence of screening myopia in grades three to six was 20.35%,25.53%,30.53% and 51.38%,respectively．The overall prevalence rate of astigmatism was 51.59%,including 90.22%,7.61% and 2.17% for astigmatism with the rule,astigmatism against the rule and oblique astigmatism,respectively．About 40.37% of the students had poor vision．Screening myopia was diagnosed using non-cycloplegic optometry with SE ≤-0.50 D combined with UCVA<5.0．The sensitivity and specificity of AL/CR for screening myopia were 0.656 and 0.887,respectively,with a Youden index of 0.534 and an area under the curve（AUC）of 0.802．This was superior to the AL evaluation,which had an AUC of 0.764．Conclusions The prevalence of screening myopia increased rapidly with the increase of grade in grade 3 to 6 in plateau area．And there were high prevalence of astigmatism and more poor vision．AL/CR value has a certain clinical significance in the monitoring of screening myopia．

      近年来，人工智能技术（AI）的发展正在逐渐改变传统的医疗行业，机器学习作为人工智能技术中的主流被越来越多地应用于分析复杂的医学数据，为疾病的诊断、预后风险评估、诊疗决策的制定等方面提供了便利。文章对国内外机器学习算法在术后谵妄中的应用进行综述，以期为术后谵妄预测模型的构建提供新的思路，为临床早期评估术后谵妄提供新的依据。

    In recent years，the development of artificial intelligence（AI）is gradually changing the traditional medical industry．Machine learning，as the mainstream of artificial intelligence technology，is increasingly applied to analyze complex data in medical research．It provides convenience for disease diagnosis，risk assessment and diagnosis and treatment decision making．This paper reviews the application of machine learning algorithms in postoperative delirium at home and abroad，in order to provide a new idea for the construction of postoperative delirium prediction model and a new basis for early clinical evaluation of postoperative delirium．

       药源性心脏毒性是临床常见的药物不良反应，是药物研发和临床治疗需面临的严峻考验。对药源性心脏毒性的评价是目前研究的重点，基于其机制复杂多样、临床表现不一、影响因素多，早期评价具有困难。生物标志物是评价心脏毒性的重要指标之一，文章总结了目前已经报道的多种心脏毒性标志物及其潜在的生物标志物，希望能从中找到特异性强、敏感性高的标志物，以贡献于药物心脏安全性评价工作。

    As a common clinical adverse reaction，pharmacogenic cardiotoxicity is a severe challenge for drug development and clinical treatment．The evaluation of pharmacogenic cardiotoxicity is the focus of current research，and early evaluation is difficult with its complex and diverse mechanisms，varying clinical manifestations，and numerous influencing factors．Biomarker is an important index to evaluate cardiotoxicity．This article summarizes a variety of cardiotoxicity biomarkers and other potential biomarkers that have been reported so far，hoping to find  biomarkers with strong specificity and high sensitivity，so as tocontribute to the evaluation on cardiac safety of drugs．

       近年来浆细胞性乳腺炎的发病率逐渐升高，已占乳腺疾病的4%~5%，该病易反复发作，经久不愈，抗生素、糖皮质激素、抗结核药、他莫昔芬等治疗效果不明显，单纯手术切除如切除范围小极易复发，而切除范围大则乳腺外形变化较大，严重者甚至需要切除乳腺。乳腺外形的缺损改变对患者身心健康造成伤害。随着研究不断深入，采用中西医结合治疗浆细胞性乳腺炎，可取得较好的治疗效果，降低复发率，而且对乳腺外观无影响。该文通过对文献的整理，对中西医结合治疗浆细胞性乳腺炎进行论述。

       In recent years，the incidence of plasma cell mastitis has gradually increased，accounting for 4 % ~ 5 % of breast diseases．The disease is prone to repeated attacks and unhealed for a long time．The treatment effect of antibiotics，glucocorticoids，anti-tuberculosis drugs and tamoxifen is not obvious．Simple surgical  resection is easy to  relapse if the  resection range is small，while the shape of the breast changes greatly，if the resection range is large．And even the breast needs to be removed in severe cases．The defect change of breast shape is harmful to the physical and mental health of patients．With the deepening of research，the combination of traditional Chinese and Western medicine in the treatment of plasma cell mastitis can achieve better therapeutic effect，reduce the recurrence rate，and has no effect on the appearance of breast．This article discusses the treatment of plasma cell mastitis with integrated traditional Chinese and Western medicine by sorting out the literature．

       患有发育障碍类疾病的儿童数量庞大，给社会造成了严重的影响。这类疾病难以预防和治愈，同时缺乏特效药物，因此治疗主要依赖于行为和教育干预，药物治疗只是辅助手段。然而，目前临床相关治疗均有一定的不足，如存在不良反应、治疗周期相对较长、专业性要求相对较高等缺点。与之相比，音乐疗法具有操作简便、不良反应少等优势，因此可应用于儿科多种慢性疾病的治疗。文章旨在通过研究现代音乐治疗，探讨结合古代五音疗法、现代知识以及中医理论，为儿童临床治疗提供一定的方法指导。

      The number of children suffering from developmental disorders is substantial，causing significant impact on society．These diseases are difficult to prevent and cure，with a lack of specific medications，thus treatment primarily  relies on behavioral and educational interventions，with medication being only an auxiliary measure．However，current clinical treatments have certain drawbacks，such as potential toxic side effects，relatively long treatment periods，and high demands for specialization．In contrast，music therapy offers significant advantages such as easy operation and minimal side effects，making it suitable for the treatment of various chronic pediatric disease．This paper aims to explore the integration of ancient pentatonic therapy，modern knowledge，and traditional Chinese medicine theory through the study of modern music therapy，providing guidance for clinical treatment of children．

       目的   探讨多梳蛋白SUZ12对肝细胞肝癌（HCC）细胞增殖、血管生成拟态形成和人脐静脉内皮细胞（HUVECs）血管生成的影响。方法 分别利用MTT比色法及体外血管生成实验检测SUZ12表达水平改变对HCC细胞SMMC-7721、Hep3B增殖、血管生成拟态形成和HUVECs血管生成的影响。结果  MTT结果显示，在HCC细胞中分别敲低或过表达SUZ12均对HCC细胞的增殖能力无明显影响。将SUZ12低表达HCC细胞与HUVECs共培养后，HCC细胞的血管生成拟态管样结构形成增多。此外，将SUZ12敲低组HCC细胞的培养上清用于培养HUVECs后，HUVECs的血管生成拟态管样结构形成也明显增多。结论  SUZ12对HCC细胞的增殖无影响，其在HCC中可抑制HCC细胞和HUVECs的血管生成拟态管样结构形成。上述结果提示SUZ12可能通过调控HCC细胞及HUVECs的血管生成发挥抑癌作用。

      Objective  To investigate the effects of SUZ12 on cell proliferation of hepatocellular carcinoma（HCC），vasculogenic mimicry formation and human umbilical vein endothelial cells（HUVECs）angiogenesis．Methods  MTT assay was performed to detect the proliferation of SMMC-7721 and Hep3B cells．The effects of SUZ12 on the angiogenesis of HCC cells and HUVECs cells were studied by in vitro angiogenesis experiment．Results  The result of MTT assay showed that SUZ12 knockdown or overexpression in HCC cells had no significant effect on the proliferation of HCC cells．We found that when HCC cells with low SUZ12 expression were co-cultured with HUVECs cells，the formation of vasculogenic mimicry tubular structures in HCC cells increased．In addition，we also found that after the culture supernatant of HCC cells in the SUZ12 knockdown group was used to culture HUVECs cells，the formation of vasculogenic mimicry tubular structures in HUVECs cells also increased significantly．Conclusions  SUZ12 has no effect on the proliferation of HCC cells，but it can inhibit the formation of vasculogenic mimicry tubular structures in HCC cells and HUVECs cells．These results suggest that SUZ12 plays a role in cancer inhibition by regulating the angiogenesis of HCCcells and HUVECs cells．

       目的   开发适合中国肾癌患者的生命质量测定量表的特异模块。方法   采用议题小组和核心小组的程序化决策方式，提出条目池，形成初步量表，采用医生及患者重要性评分法、相关系数法、变异度法、因子分析法和克朗巴赫系数α对20例肾癌患者和20名医护人员进行的数据进行统计分析。结果   经过上述方法进行筛检，结合专家小组的建议，最终得到含有11个条目的肾癌生命质量测定量表的特异模块。结论 肾癌的生命质量测定量表特异模块严格按照程序执行，具有较好的内容效度。

      Objective  To develop the specific module of the quality of life instruments for patients with renal cancer（QLICP-RE）．Methods  With the structured group（nominal group and focus group）methods，the item pool was put forward and a preliminary instrument was formed．The data from 20 renal cancer patients and 20 doctors/nurses were analyzed by statistical procedures．Doctors and patients’ importance rating procedure，correlation analysis，method of coefficient of variation，factor analysis，and Cronbach’s α．Results  By above statistical procedures and advises of expert panel，11-items of the specific module were formed finally．Conclusions  The specific module of QLICP-RE developed on the strict procedures has good content validity and representativeness．

       目的   探讨Ki-67、微小染色体维持蛋白2（MCM2）、p16在宫颈鳞状上皮内病变中的表达及其临床意义。方法   采用免疫组化检测Ki-67、MCM2、p16在宫颈炎症组14例、低级别鳞状上皮内病变（LSIL）组47例、高级别鳞状上皮内病变（HSIL）组49例中的表达情况，以病理结果作为金标准，对结果进行统计分析。结果  HSIL组中Ki-67、MCM2、p16阳性率均高于炎症组和LSIL组（均P＜0.017）。HSIL组中Ki-67、MCM2过表达率均显著高于炎症组和LSIL组（均P＜0.017）。随着宫颈病变级别增加，Ki-67及MCM2阳性范围从基底层至表层逐渐扩大。MCM2及Ki-67在LSIL组中表达模式多为基底层的非过表达模式，HSIL组多为中层及以上的过表达模式。Spearman相关性分析显示，MCM2和Ki-67在宫颈鳞状上皮内病变中的表达强度之间呈正相关（r=0.801，P＜0.05）；p16与MCM2在宫颈鳞状上皮内病变中的表达呈正相关（r=0.559，P＜0.05）；p16与Ki-67在宫颈鳞状上皮内病变中的表达呈正相关（r=0.478，P＜0.05）。结论  p16阳性提示宫颈高级别鳞状上皮内病变。MCM2与Ki-67在宫颈鳞状上皮内病变中的表达具有较高一致性，MCM2可作为宫颈鳞状上皮内病变新的增殖标志物。

       Objective  To investigate the expression and significance of Ki-67，MCM2 and p16 in cervical intraepithelial lesions．Methods  The expressions of Ki-67，MCM2 and p16 in cervicitis group（14 cases），low-grade squamous intraepithelial lesion（LSIL） group（47 cases）and high-grade squamous intraepithelial lesion（HSIL） group（49 cases）were detected by immunohistochemistry．The pathological results were used as the gold standard for statistical analysis．Results  The positive  rates of Ki-67，MCM2 and p16 in HSIL group were significantly higher than those in cervicitis group and LSIL group（P＜0.017）．The over-expression rates of Ki-67，MCM2 in HSIL group were significantly higher than those in cervicitis group and LSIL grou（P＜0.017）．With the increase of cervical lesion grade，the positive range of Ki-67 and MCM2 gradually expanded from basallayer to surface layer．The expression patterns of MCM2 and Ki-67 in LSIL group were mostly non-overexpressed in the basal layers，while those in HSIL group were mostly overexpressed in the middle layer and above．Spearman correlation analysis showed that the expression intensity of MCM2 and Ki-67 in cervical squamous intraepithelial lesions was positively correlated（r=0.801，P＜0.05）．There was a positive correlation between the expression of p16 and MCM2 in cervical squamous intraepithelial lesions（r=0.559，P＜0.05）．There was a positive correlation between the expression of p16 and Ki-67 in cervical squamous intraepithelial lesions（r=0.478，P＜0.05）．Conclusions  Positive p16 indicates high-grade squamous intraepithelial lesion．The expression of MCM2 and Ki-67 in cervical intraepithelial lesions is highly consistent．MCM2 can be used as a new proliferative marker for cervical intraepithelial lesions．

       目的   评估多种气道湿化方法对喉癌患者术后气道湿化的效果。方法   检索PubMed、Cochrane、Embase、Web of Science、Ovid、中国知网、万方、CBM、Google Scholar等数据库和网站，检索时限为建库至2023年2月。搜集关于喉癌患者术后不同气道湿化方法的随机对照试验，采用JBI2016年随机对照试验RCT评价标准评价文献质量。使用ADDIS1.16.5软件进行网状Meta分析。结果   纳入18篇研究，共1 596例患者。结果显示，镇痛泵持续泵入与注射器间断滴入、喷雾瓶间断喷雾在痰痂形成方面比较差异有统计学意义［OR（95%CI）=537.70（4.18，124 511.88）、0（0，0.52），P＜0.05］；湿化满意度方面，注射器间断滴入与喷雾瓶间断喷雾比较差异有统计学意义［OR（95%CI）=8.55（1.40，73.35），P＜0.05］；其余比较差异无统计学意义（P＞0.05）。概率排序显示，降低肺部感染、黏膜出血和痰痂形成、痰液黏稠度、咳嗽和湿化不满意的发生，最优方法分别为湿化泵持续泵入、镇痛泵持续泵入、MR400湿化器和输液器持续泵入。结论   综合网状Meta分析及概率排序结果，考虑到喉癌患者术后早期下床活动，推荐便携式持续湿化方法。

       Objective  To access the effects of multiple airway humidification methods for postoperative patients with laryngeal cancer．Methods  PubMed，Cochrane Library，EMbase，Web of Science，Ovid，China National Knowledge Infrastructure，Wanfang database，CBM and Google Scholar were searched systematically from establishment to February 2023，respectively．Related  randomized controlled trials on airway humidification for postoperative patients with laryngeal cancer was analyzed and the quality of the literature was assessed using the JBI 2016 RCT evaluation．The network Meta analysis was performed using ADDIS 1.16.5 softwares．Results  A total of 18 articles and 1596 patients were inciuded．The results showed that the analgesia pump continued to pump into the airway compared with the syringe intermittently drip and the spray bottle intermittent spray was statistically different in the formation of sputum［OR（95%CI）=537.70（4.18，124 511.88），0（0，0.52），P＜0.05］．In terms of satisfaction of wetness，the difference between the intermittent drop of the syringe and the intermittent spray of the spray bottle was statistically different［OR（95%CI）=8.55（1.40，73.35），P＜0.05］，the others were not statistically different（P＞0.05）．Probability ranking table shows that the optimal methods were the humidification pump continues to pump into the airway，the analgesia pump continued to pump into the airway，the MR400 humidifier and the infusion set continuously pumped into the airway，which were beneficial to the reduction in pulmonary infection，tracheal mucosal hemorrhage and formation of phlegm callus，the degree of sputum viscosity，cough and unsatisfactory wetness．Conclusions  Based on the comprehensive mesh meta-analysis and probability ranking results，a portable continuous humidification method is  recommended considering the early post-operative activities of laryngeal cancer patients．

      目的   应用 Python语言对《圣济总录》中腰痛病篇中的中药进行用药规律分析，提取腰痛病治疗方法及用药特色指导临床腰痛病治疗思路。方法   运用 Python语言中的语言提取对《圣济总录》中腰痛篇章中的所有中药方剂识别，提取方剂组成，统计并分析方剂中中药的规律并将其结果可视化呈现。结果   最终共纳入62首方剂，包含药物86味。其中使用频次≥7次、频率≥1.6%的药物共20味，频次频率最高的为桂枝；所用中药四气以温性为主，占56.74%；五味以辛、甘、苦为主，共约占90%，归经以肝肾经为主；药物功效以补虚类为主，占27.13%；关联规则分析显示提升度最高的组合为麻黄-独活，置信度最高的组合为巴戟天-牛膝、牵牛子-牛膝，支持度最高的组合为川芎-当归、川芎-杜仲；通过聚类分析得到3个聚类结果。结论   《圣济总录》治疗腰痛病方面善用通法和补法，强调活血通络，补益肝肾，尤擅长治疗肝肾亏虚或风寒所客等腰痛病证。

       Objective Python language was used to analyze the rules of traditional Chinese medicine in the chapter of low back pain in Shengji Zonglu，and to extract the treatment methods and medication characteristics of low back pain to guide the clinical treatment of low back pain．Methods The language extraction in Python language was used to identify all the Chinese medicine prescriptions in the chapter of low back pain in Shengji Zonglu，extract the composition of the prescription，and analyze the rules of Chinese medicine in the prescription to visually present the results．Results A total of 62 prescriptions were included，including 86 drugs．Among them，with there were 20 kinds of drugs，the frequency of use ≥7 times，the frequency ≥1.6%，and cmnamomi Mmulus highest frequency．Four gas used in traditional Chinese medicine is given priority to with warm，accounted for 56.74%．The five flavors were mainly pungent，sweet and bitter，accounting for about 90%，and the liver and kidney meridians were the main meridians．The drug efficacy was mainly deficiency tonic，accounting for 27.13%．The association  rule analysis showed that the combination with the highest improvement was Ephedrae Herba- Angelicae Pubescentis Radix，the combination with the highest confidence was Morindae Officinalis Radix- Achyranthis Bidentatae Radix，Pharbitidis Semen- Achyranthis Bidentatae Radix．and the combination with the highest support was Chuanxiong Rhizoma- Angelicae Sinensis Radix，Chuanxiong Rhizoma- Eucommiae Cortex．Three clustering result is obtained by cluster analysis．Conclusions In the treatment of low back pain，Shengji Zonglu is good at using both blocking methods and reinforcing methods，emphasizing circulating blood and unblocking meridians supplementing liver and kidney，especially in the treatment of low back pain syndrome caused by liver and kidney deficiency or wind and cold．

       目的   挖掘使用美托洛尔后的药物不良事件（ADE），为临床合理用药提供参考意见。方法   对美国食品药品管理局（FDA）FDA药物ADE报告系统（FAERS）数据库进行信号挖掘，采用报告比值比法和比例报告比值法，分析FAERS数据库中2004年第1季度至2023年第2季度关于美托洛尔的ADE报告。结果   在FAERS数据库中收集到美托洛尔相关ADE共24 184例、667个阳性信号，共涉及27个系统器官分类。ADE严重报告共16 766（占69.33%），ADE报告频次排名前3的分别是头晕、心动过缓、呼吸困难。结论   美托洛尔的不良反应主要集中在全身性疾病及给药部位各种反应、心脏器官疾病和各类损伤。在使用美托洛尔过程中发生ADE时，应该及时采取相应的干预措施。

       Objective  To explore the adverse drug events（ADEs）after the use of metoprolol and provide  reference opinions for clinical rational drug use．Methods  Signal mining was conducted on the FDA Adverse Event Reporting System（FAERS）database in the United States．The  reporting  ratio method and proportional  reporting  ratio method were used to analyze ADEs reports related to metoprolol in the FAERS database from the first quarter of 2019 to the second quarter of 2023．Results  A total of 24 184 cases of metoprolol related ADEs were collected in the FAERS database，with 667 positive signals and a total of 27 system organ class involved．Conclusions  The adverse reactions of metoprolol mainly focus on systemic diseases，various reactions at the administration site，heart organ diseases，and various injuries．It is recommended that timely intervention measures should be taken when ADE occurs during the use of metoprolol．

     目的   分析谷草转氨酶（AST）、胆碱酯酶（CHE）、糖类抗原125（CA125）以及甲胎蛋白（AFP）对肝硬化患者的诊断效能。方法   选择70例肝硬化患者为观察组研究对象，另取70例同期健康体检者为对照组。两组研究对象均接受生化检验、肿瘤标志物检验。对比两组研究对象的AST、CHE、CA125、AFP检测结果，分析上述指标对肝硬化患者的诊断效能。结果   观察组肝硬化患者的CHE低于对照组，AST、CA125与AFP高于对照组（P＜0.05）；AST与CHE在肝硬化诊断中具有良好的灵敏度、特异度；CA125联合AFP的灵敏度、特异度、符合率均高于CA125或AFP单独检验（P＜0.05）。结论  AST、CHE、CA125、AFP在肝硬化患者临床诊断中具有良好的应用表现，是反映患者肝硬化病情进展的重要参考指标。

     Objective  To analyze the diagnostic efficacy of aspartate aminotransferase（AST），cholinesterase（CHE），carbohydrate antigen 125（CA125），and alpha fetoprotein（AFP）in patients with liver cirrhosis．Methods  A total of 70 patients with liver cirrhosis were included in the observation group as the study subjects，and 70 healthy individuals who underwent physical examinations during the same period were selected as the control group．Both groups of  research subjects underwent biochemical testing and tumor marker testing．The AST，CHE，CA125，and AFP detection  results of two groups of research subjects were compared，and the diagnostic effect of the above indicators on patients with liver cirrhosis were analyzed．Results  The CHE test  results of patients with liver cirrhosis in the observation group were significantly lower than those of healthy individuals undergoing physical examination，and the AST，CA125，and AFP test results were higher（P＜0.05）．AST and CHE had good sensitivity and specificity in the diagnosis of liver cirrhosis．The sensitivity，specificity and coincidence  rate of CA125 combined with AFP were higher than those of CA125 or AFP alone．Conclusions  AST，CHE，CA125，and AFP have good clinical application performance in the diagnosis of liver cirrhosis patients，and are important reference indicators reflecting the progression of liver cirrhosis in patients．

目的 探讨多梳蛋白SUZ12对肝细胞肝癌（HCC）细胞增殖、血管生成拟态形成和人脐静脉内皮细胞（HUVECs）血管生成的影响。方法 分别利用MTT比色法及体外血管生成实验检测SUZ12表达水平改变对HCC细胞SMMC-7721、Hep3B增殖、血管生成拟态形成和HUVECs血管生成的影响。结果 MTT结果显示,在HCC细胞中分别敲低或过表达SUZ12均对HCC细胞的增殖能力无明显影响。将SUZ12低表达HCC细胞与HUVECs共培养后,HCC细胞的血管生成拟态管样结构形成增多。此外,将SUZ12敲低组HCC细胞的培养上清用于培养HUVECs后,HUVECs的血管生成拟态管样结构形成也明显增多。结论 SUZ12对HCC细胞的增殖无影响,其在HCC中可抑制HCC细胞和HUVECs的血管生成拟态管样结构形成。上述结果提示SUZ12可能通过调控HCC细胞及HUVECs的血管生成发挥抑癌作用。

Objective To investigate the effects of SUZ12 on cell proliferation of hepatocellular carcinoma（HCC）,vasculogenic mimicry formation and human umbilical vein endothelial cells（HUVECs）angiogenesis．Methods MTT assay was performed to detect the proliferation of SMMC-7721 and Hep3B cells．The effects of SUZ12 on the angiogenesis of HCC cells and HUVECs cells were studied by in vitro angiogenesis experiment．Results The result of MTT assay showed that SUZ12 knockdown or overexpression in HCC cells had no significant effect on the proliferation of HCC cells．We found that when HCC cells with low SUZ12 expression were co-cultured with HUVECs cells,the formation of vasculogenic mimicry tubular structures in HCC cells increased．In addition,we also found that after the culture supernatant of HCC cells in the SUZ12 knockdown group was used to culture HUVECs cells,the formation of vasculogenic mimicry tubular structures in HUVECs cells also increased significantly．Conclusions SUZ12 has no effect on the proliferation of HCC cells,but it can inhibit the formation of vasculogenic mimicry tubular structures in HCC cells and HUVECs cells．These results suggest that SUZ12 plays a role in cancer inhibition by regulating the angiogenesis of HCC cells and HUVECs cells．

目的 开发适合中国肾癌患者的生命质量测定量表的特异模块。方法 采用议题小组和核心小组的程序化决策方式,提出条目池,形成初步量表,采用医生及患者重要性评分法、相关系数法、变异度法、因子分析法和克朗巴赫系数α对20例肾癌患者和20名医护人员进行的数据进行统计分析。结果 经过上述方法进行筛检,结合专家小组的建议,最终得到含有11个条目的肾癌生命质量测定量表的特异模块。结论 肾癌的生命质量测定量表特异模块严格按照程序执行,具有较好的内容效度。

Objective To develop the specific module of the quality of life instruments for patients with renal cancer（QLICP-RE）．Methods With the structured group（nominal group and focus group）methods,the item pool was put forward and a preliminary instrument was formed．The data from 20 renal cancer patients and 20 doctors/nurses were analyzed by statistical procedures．Doctors and patients' importance rating procedure,correlation analysis,method of coefficient of variation,factor analysis,and Cronbach's α．Results By above statistical procedures and advises of expert panel,11-items of the specific module were formed finally．Conclusions The specific module of QLICP-RE developed on the strict procedures has good content validity and representativeness．

目的 探讨Ki-67、微小染色体维持蛋白2（MCM2）、p16在宫颈鳞状上皮内病变中的表达及其临床意义。方法 采用免疫组化检测Ki-67、MCM2、p16在宫颈炎症组14例、低级别鳞状上皮内病变（LSIL）组47例、高级别鳞状上皮内病变（HSIL）组49例中的表达情况,以病理结果作为金标准,对结果进行统计分析。结果 HSIL组中Ki-67、MCM2、p16阳性率均高于炎症组和LSIL组（均P<0.017）。HSIL组中Ki-67、MCM2过表达率均显著高于炎症组和LSIL组（均P<0.017）。随着宫颈病变级别增加,Ki-67及MCM2阳性范围从基底层至表层逐渐扩大。MCM2及Ki-67在LSIL组中表达模式多为基底层的非过表达模式,HSIL组多为中层及以上的过表达模式。Spearman相关性分析显示,MCM2和Ki-67在宫颈鳞状上皮内病变中的表达强度之间呈正相关（r=0.801,P<0.05）;p16与MCM2在宫颈鳞状上皮内病变中的表达呈正相关（r=0.559,P<0.05）;p16与Ki-67在宫颈鳞状上皮内病变中的表达呈正相关（r=0.478,P<0.05）。结论 p16阳性提示宫颈高级别鳞状上皮内病变。MCM2与Ki-67在宫颈鳞状上皮内病变中的表达具有较高一致性,MCM2可作为宫颈鳞状上皮内病变新的增殖标志物。

Objective To investigate the expression and significance of Ki-67,MCM2 and p16 in cervical intraepithelial lesions．Methods The expressions of Ki-67,MCM2 and p16 in cervicitis group（14 cases）,low-grade squamous intraepithelial lesion（LSIL） group（47 cases）and high-grade squamous intraepithelial lesion（HSIL） group（49 cases）were detected by immunohistochemistry．The pathological results were used as the gold standard for statistical analysis．Results The positive rates of Ki-67,MCM2 and p16 in HSIL group were significantly higher than those in cervicitis group and LSIL group（P<0.017）．The over-expression rates of Ki-67,MCM2 in HSIL group were significantly higher than those in cervicitis group and LSIL group（P<0.017）．With the increase of cervical lesion grade,the positive range of Ki-67 and MCM2 gradually expanded from basal layer to surface layer．The expression patterns of MCM2 and Ki-67 in LSIL group were mostly non-overexpressed in the basal layers,while those in HSIL group were mostly overexpressed in the middle layer and above．Spearman correlation analysis showed that the expression intensity of MCM2 and Ki-67 in cervical squamous intraepithelial lesions was positively correlated（r=0.801,P<0.05）．There was a positive correlation between the expression of p16 and MCM2 in cervical squamous intraepithelial lesions（r=0.559,P<0.05）．There was a positive correlation between the expression of p16 and Ki-67 in cervical squamous intraepithelial lesions（r=0.478,P<0.05）．Conclusions Positive p16 indicates high-grade squamous intraepithelial lesion．The expression of MCM2 and Ki-67 in cervical intraepithelial lesions is highly consistent．MCM2 can be used as a new proliferative marker for cervical intraepithelial lesions．

目的 评估多种气道湿化方法对喉癌患者术后气道湿化的效果。方法 检索PubMed、Cochrane、Embase、Web of Science、Ovid、中国知网、万方、CBM、Google Scholar等数据库和网站,检索时限为建库至2023年2月。搜集关于喉癌患者术后不同气道湿化方法的随机对照试验,采用JBI2016年随机对照试验RCT评价标准评价文献质量。使用ADDIS1.16.5软件进行网状Meta分析。结果 纳入18篇研究,共1 596例患者。结果显示,镇痛泵持续泵入与注射器间断滴入、喷雾瓶间断喷雾在痰痂形成方面比较差异有统计学意义[OR（95%CI）=537.70（4.18,124 511.88）、0（0,0.52）,P<0.05];湿化满意度方面,注射器间断滴入与喷雾瓶间断喷雾比较差异有统计学意义[OR（95%CI）=8.55（1.40,73.35）,P<0.05];其余比较差异无统计学意义（P>0.05）。概率排序显示,降低肺部感染、黏膜出血和痰痂形成、痰液黏稠度、咳嗽和湿化不满意的发生,最优方法分别为湿化泵持续泵入、镇痛泵持续泵入、MR400湿化器和输液器持续泵入。结论 综合网状Meta分析及概率排序结果,考虑到喉癌患者术后早期下床活动,推荐便携式持续湿化方法。

Objective To access the effects of multiple airway humidification methods for postoperative patients with laryngeal cancer．Methods PubMed,Cochrane Library,EMbase,Web of Science,Ovid,China National Knowledge Infrastructure,Wanfang database,CBM and Google Scholar were searched systematically from establishment to February 2023,respectively．Related randomized controlled trials on airway humidification for postoperative patients with laryngeal cancer was analyzed and the quality of the literature was assessed using the JBI 2016 RCT evaluation．The network Meta analysis was performed using ADDIS 1.16.5 softwares．Results A total of 18 articles and 1596 patients were inciuded．The results showed that the analgesia pump continued to pump into the airway compared with the syringe intermittently drip and the spray bottle intermittent spray was statistically different in the formation of sputum[OR（95%CI）=537.70（4.18,124 511.88）,0（0,0.52）,P<0.05]．In terms of satisfaction of wetness,the difference between the intermittent drop of the syringe and the intermittent spray of the spray bottle was statistically different[OR（95%CI）=8.55（1.40,73.35）,P<0.05],the others were not statistically different（P>0.05）．Probability ranking table shows that the optimal methods were the humidification pump continues to pump into the airway,the analgesia pump continued to pump into the airway,the MR400 humidifier and the infusion set continuously pumped into the airway,which were beneficial to the reduction in pulmonary infection,tracheal mucosal hemorrhage and formation of phlegm callus,the degree of sputum viscosity,cough and unsatisfactory wetness．Conclusions Based on the comprehensive mesh meta-analysis and probability ranking results,a portable continuous humidification method is recommended considering the early post-operative activities of laryngeal cancer patients．

目的 应用 Python语言对《圣济总录》中腰痛病篇中的中药进行用药规律分析,提取腰痛病治疗方法及用药特色指导临床腰痛病治疗思路。方法 运用 Python语言中的语言提取对《圣济总录》中腰痛篇章中的所有中药方剂识别,提取方剂组成,统计并分析方剂中中药的规律并将其结果可视化呈现。结果 最终共纳入62首方剂,包含药物86味。其中使用频次≥7次、频率≥1.6%的药物共20味,频次频率最高的为桂枝;所用中药四气以温性为主,占56.74%;五味以辛、甘、苦为主,共约占90%,归经以肝肾经为主;药物功效以补虚类为主,占27.13%;关联规则分析显示提升度最高的组合为麻黄-独活,置信度最高的组合为巴戟天-牛膝、牵牛子-牛膝,支持度最高的组合为川芎-当归、川芎-杜仲;通过聚类分析得到3个聚类结果。结论 《圣济总录》治疗腰痛病方面善用通法和补法,强调活血通络,补益肝肾,尤擅长治疗肝肾亏虚或风寒所客等腰痛病证。

Objective Python language was used to analyze the rules of traditional Chinese medicine in the chapter of low back pain in Shengji Zonglu,and to extract the treatment methods and medication characteristics of low back pain to guide the clinical treatment of low back pain．Methods The language extraction in Python language was used to identify all the Chinese medicine prescriptions in the chapter of low back pain in Shengji Zonglu,extract the composition of the prescription,and analyze the rules of Chinese medicine in the prescription to visually present the results．Results A total of 62 prescriptions were included,including 86 drugs．Among them,with there were 20 kinds of drugs,the frequency of use ≥7 times,the frequency ≥1.6%,and cmnamomi Mmulus highest frequency．Four gas used in traditional Chinese medicine is given priority to with warm,accounted for 56.74%．The five flavors were mainly pungent,sweet and bitter,accounting for about 90%,and the liver and kidney meridians were the main meridians．The drug efficacy was mainly deficiency tonic,accounting for 27.13%．The association rule analysis showed that the combination with the highest improvement was Ephedrae Herba- Angelicae Pubescentis Radix,the combination with the highest confidence was Morindae Officinalis Radix- Achyranthis Bidentatae Radix,Pharbitidis Semen- Achyranthis Bidentatae Radix．and the combination with the highest support was Chuanxiong Rhizoma- Angelicae Sinensis Radix,Chuanxiong Rhizoma- Eucommiae Cortex．Three clustering result is obtained by cluster analysis．Conclusions In the treatment of low back pain,Shengji Zonglu is good at using both blocking methods and reinforcing methods,emphasizing circulating blood and unblocking meridians supplementing liver and kidney,especially in the treatment of low back pain syndrome caused by liver and kidney deficiency or wind and cold．

目的 挖掘使用美托洛尔后的药物不良事件（ADE）,为临床合理用药提供参考意见。方法 对美国食品药品管理局（FDA）FDA药物ADE报告系统（FAERS）数据库进行信号挖掘,采用报告比值比法和比例报告比值法,分析FAERS数据库中2004年第1季度至2023年第2季度关于美托洛尔的ADE报告。结果 在FAERS数据库中收集到美托洛尔相关ADE共24 184例、667个阳性信号,共涉及27个系统器官分类。ADE严重报告共16 766（占69.33%）,ADE报告频次排名前3的分别是头晕、心动过缓、呼吸困难。结论 美托洛尔的不良反应主要集中在全身性疾病及给药部位各种反应、心脏器官疾病和各类损伤。在使用美托洛尔过程中发生ADE时,应该及时采取相应的干预措施。

Objective To explore the adverse drug events（ADEs）after the use of metoprolol and provide reference opinions for clinical rational drug use．Methods Signal mining was conducted on the FDA Adverse Event Reporting System（FAERS）database in the United States．The reporting ratio method and proportional reporting ratio method were used to analyze ADEs reports related to metoprolol in the FAERS database from the first quarter of 2019 to the second quarter of 2023．Results A total of 24 184 cases of metoprolol related ADEs were collected in the FAERS database,with 667 positive signals and a total of 27 system organ class involved．Conclusions The adverse reactions of metoprolol mainly focus on systemic diseases,various reactions at the administration site,heart organ diseases,and various injuries．It is recommended that timely intervention measures should be taken when ADE occurs during the use of metoprolol．

目的 分析谷草转氨酶（AST）、胆碱酯酶（CHE）、糖类抗原125（CA125）以及甲胎蛋白（AFP）对肝硬化患者的诊断效能。方法 选择70例肝硬化患者为观察组研究对象,另取70例同期健康体检者为对照组。两组研究对象均接受生化检验、肿瘤标志物检验。对比两组研究对象的AST、CHE、CA125、AFP检测结果,分析上述指标对肝硬化患者的诊断效能。结果 观察组肝硬化患者的CHE低于对照组,AST、CA125与AFP高于对照组（P<0.05）;AST与CHE在肝硬化诊断中具有良好的灵敏度、特异度;CA125联合AFP的灵敏度、特异度、符合率均高于CA125或AFP单独检验（P<0.05）。结论 AST、CHE、CA125、AFP在肝硬化患者临床诊断中具有良好的应用表现,是反映患者肝硬化病情进展的重要参考指标。

Objective To analyze the diagnostic efficacy of aspartate aminotransferase（AST）,cholinesterase（CHE）,carbohydrate antigen 125（CA125）,and alpha fetoprotein（AFP）in patients with liver cirrhosis．Methods A total of 70 patients with liver cirrhosis were included in the observation group as the study subjects,and 70 healthy individuals who underwent physical examinations during the same period were selected as the control group．Both groups of research subjects underwent biochemical testing and tumor marker testing．The AST,CHE,CA125,and AFP detection results of two groups of research subjects were compared,and the diagnostic effect of the above indicators on patients with liver cirrhosis were analyzed．Results The CHE test results of patients with liver cirrhosis in the observation group were significantly lower than those of healthy individuals undergoing physical examination,and the AST,CA125,and AFP test results were higher（P<0.05）．AST and CHE had good sensitivity and specificity in the diagnosis of liver cirrhosis．The sensitivity,specificity and coincidence rate of CA125 combined with AFP were higher than those of CA125 or AFP alone．Conclusions AST,CHE,CA125,and AFP have good clinical application performance in the diagnosis of liver cirrhosis patients,and are important reference indicators reflecting the progression of liver cirrhosis in patients．

       目的   分析共同照护模式联合回授法健康教育在2型糖尿病患者中的应用效果。方法   将2023年1月—2023年12月广州市第一人民医院收治 的114例2型糖尿病患者作为此次研究对象，分为研究组（n=57）和对照组（n=57），对照组患者给予常规护理结合健康教育，研究组患者给予共同照护模式联合回授法健康教育，评估两组在培训前及培训后1、3个月的血糖控制情况及糖尿病患者自我管理行为量表（SDSCA）等指标。结果   培训1、3个月后，两组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白均低于培训前，且研究组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组（P＜0.05）。培训1、3个月后，两组患者的糖尿病患者SDSCA评分高于培训前，且研究组各项评分高于对照组（P＜0.05）。重复测量方差分析表明随着时间的推移，患者的血糖控制状况随着不同护理培训策略而得到改善。结论   使用共同照护模式联合回授法健康教育对2型糖尿病患者可以更显著改善血糖控制水平、提高自我管理效能。

       Objective  To analyze the effect of co-care mode and feedback  health education on  patients with type  2 diabetes．Methods  From January 2023 to December 2023，114 patients with type 2 diabetes admitted to Guangzhou First People’s Hospital were divided into two groups：experimental group（n=57）and control group（n=57）．Patients in control group were given routine nursing combined with health education．Patients in study group were given co-care and feedback health education．Before intervention and 1，3 months after intervention，patients’ blood glucose control and diabetic self-management behavior scale（SDSCA）were evaluated．Results  After 1 and 3 months of intervention，the fasting blood glucose，2-hour blood glucose and HbA1c of the two groups were significantly lower than those before intervention，and the fasting blood glucose，2-hour blood glucose and HbA1c of the experimental group were significantly lower than those of the control group（P＜0.05）．After 1 month and 3 months of intervention，the SDSCA scores of diabetic patients in both groups were higher than those before intervention，and the scores of study group were higher than those of control group（P＜0.05）．Repeated measures analysis of variance indicating that glycemic control improved significantly over time with different nursing training strategies．Conclusions  Co-care mode and feedback health education can significantly improve blood glucose control and self-management efficiency in patients with type 2 diabetes．

       目的   探讨基于微视频的护理干预对急性胰腺炎患者疾病知晓、自我管理和遵医行为的影响。方法   根据中心随机法将郑州大学第二附属医院2021年1月—2023年1月收治的88例急性胰腺炎患者作为研究对象，其中传统组44例给予常规干预，微视频组44例在传统组的基础上结合微视频的护理干预，比较两组患者疾病知晓情况、自我管理能力和遵医行为情况。结果   干预2个月后，微视频组病例脱落3例，传统组病例脱落4例，两组疾病知晓各维度高于干预前，且微视频组高于传统组，其中疾病病因（t=3.151，P=0.003）、临床症状（t=7.165，P＜0.001）、并发症（t=5.497，P＜0.001）、如何预防疾病复发（t=8.195，P＜0.001）；两组自我护理能力量表（ESCA）各维度评分高于干预前，且微视频组高于传统组，其中各维度评分结果为自我护理技能（t=2.787，P=0.007）、自我概念（t=2.272，P=0.026）、自护责任感（t=2.644，P=0.011）、健康知识水平（t=3.321，P=0.001）；两组遵医行为各维度评分高于干预前，且微视频组高于传统组，其中各维度评分结果为饮食依从性（t=6.271，P＜0.001）、用药依从性（t=3.539，P=0.001）、锻炼依从性（t=4.469，P＜0.001）、定期复查（t=2.764，P=0.007）。结论   通过运用微视频的护理干预能够提高急性胰腺炎患者疾病知识的掌握，促进机体自我管理水平的恢复，进而提高遵医行为。

       Objective  To explore the impact of micro video based nursing interventions on disease awareness，self-management and compliance behavior in patients with acute pancreatitis．Methods  According to the central randomization method，88 patients with acute pancreatitis admitted to the Second Affiliated Hospital of Zhengzhou University from January 2021 to January 2023 were selected as the research subjects．Among them，44 patients in the traditional group received routine intervention，and 44 patients in the micro video group received nursing intervention combined with micro video on the basis of the traditional group．The disease awareness，self-management ability and compliance behavior of the two groups of patients were compared．Results  After two months of intervention，three cases were dropped out in the micro video group and four cases were dropped out in the traditional group．The disease awareness in both groups was higher than that before intervention，and the micro video group was higher than the traditional group，including disease etiology（t=3.151，P=0.003），clinical symptoms（t=7.165，P＜0.001），complications（t=5.497，P＜0.001） and how to prevent disease recurrence（t=8.195，P＜0.001）．The scores of ESCA in both groups were significantly higher than those before intervention，and the micro video group was higher than the traditional group in terms of self-care skills（t=2.787，P=0.007），self-concept（t=2.272，P=0.026），self-care responsibility（t=2.644，P=0.011） and health knowledge level（t=3.321，P=0.001）．The scores of all dimensions of compliance behavior in both groups were significantly higher than those before intervention，and the micro video group had higher scores than the traditional group in terms of dietary compliance（t=6.271，P＜0.001），medication compliance（t=3.539，P=0.001），exercise compliance（t=4.469，P＜0.001） and  regular follow-up（t=2.764，P=0.001）．Conclusions  The use of micro video nursing interventions can improve the mastery of disease knowledge in patients with acute pancreatitis，promote the recovery of the body’s self-management level，and thereby improvemedical compliance behavior．

目的 分析共同照护模式联合回授法健康教育在2型糖尿病患者中的应用效果。方法 将2023年1月—2023年12月广州市第一人民医院收治 的114例2型糖尿病患者作为此次研究对象,分为研究组（n=57）和对照组（n=57）,对照组患者给予常规护理结合健康教育,研究组患者给予共同照护模式联合回授法健康教育,评估两组在培训前及培训后1、3个月的血糖控制情况及糖尿病患者自我管理行为量表（SDSCA）等指标。结果 培训1、3个月后,两组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白均低于培训前,且研究组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组（P<0.05）。培训1、3个月后,两组患者的糖尿病患者SDSCA评分高于培训前,且研究组各项评分高于对照组（P<0.05）。重复测量方差分析表明随着时间的推移,患者的血糖控制状况随着不同护理培训策略而得到改善。结论 使用共同照护模式联合回授法健康教育对2型糖尿病患者可以更显著改善血糖控制水平、提高自我管理效能。

Objective To analyze the effect of co-care mode and feedback health education on patients with type 2 diabetes．Methods From January 2023 to December 2023,114 patients with type 2 diabetes admitted to Guangzhou First People's Hospital were divided into two groups：experimental group（n=57）and control group（n=57）．Patients in control group were given routine nursing combined with health education．Patients in study group were given co-care and feedback health education． Before intervention and 1,3 months after intervention,patients' blood glucose control and diabetic self-management behavior scale（SDSCA）were evaluated．Results After 1 and 3 months of intervention,the fasting blood glucose,2-hour blood glucose and HbA1c of the two groups were significantly lower than those before intervention,and the fasting blood glucose,2-hour blood glucose and HbA1c of the experimental group were significantly lower than those of the control group（P<0.05）．After 1 month and 3 months of intervention,the SDSCA scores of diabetic patients in both groups were higher than those before intervention,and the scores of study group were higher than those of control group（P<0.05）．Repeated measures analysis of variance indicating that glycemic control improved significantly over time with different nursing training strategies．Conclusions Co-care mode and feedback health education can significantly improve blood glucose control and self-management efficiency in patients with type 2 diabetes．

       目的   对医疗损害责任纠纷案的法庭审理进行分析，探究医疗损害责任纠纷案件的处理现状，对此过程中医疗机构应当关注的问题进行分析总结，以期为医院应对医疗损害鉴定工作和法官审理医疗损害责任纠纷案提供参考。方法   对广州市三所综合医院2015—2021年共93例医疗损害责任纠纷案的判决书进行描述性分析。结果  93例案例中79例进行了医疗损害鉴定。79例进行医疗损害鉴定的案例中，71例鉴定结论被法院采信，采信率达90%。有29例案件鉴定人出庭（占比36.7%），其中有25例鉴定意见被法院采信，采信率为86.2%，仅有7例案例当事人申请了专家辅助证人出庭。医方大多数最终承担次要及以下责任占比为73.4%。鉴定结论为责任范围的，法院最后判决偏向于取最高值和中间值（43例出具责任范围的案例中，14例为最高值，13例为中间值）。结论   医疗机构要充分加强对医疗事故技术鉴定和医疗损害鉴定的认识，高度重视医疗损害鉴定工作，尤其加强尸体解剖告知及病历书写管理，充分利用好鉴定人和专家辅助证人出庭两种手段。

      Objective  To analyze the court trial of medical damage liability disputes，to explore the current situation of medical damage liability disputes，to analyze and summarize the problems encountered in dealing with medical damage disputes，so as to provide some references for hospitals to deal with medical damage disputes．Methods  Descriptive statistical analysis performed on the written judgment of 93 cases of medical damage liability disputes in three large comprehensive hospitals in Yuexiu District，Guangzhou from 2015 to 2021．Results  In 93 cases，79 cases had expertise of medical malpractice．In 79 expertise，71 of them were adopted，and the acceptance rate was 90%．Among the 29 cases in which the appraisers appeared in court，25 expert opinions were accepted by the court，the acceptance rate was 86.2%．In only 7 cases，the parties applied for expert witnesses to appear in court．In most cases，hospitals ultimately took secondary and lower responsibilities，accounting for 73.4%．If the appraisal conclusion falls within the scope of responsibility，the court’s final judgment tends to take the highest and middle values．Conclusions  Medical institutions should fully strengthen their understanding of technical identification of medical accidents and medical malpractice identification．Attach great importance to the identification of medical malpractice，especially strengthen the management of autopsy notification and medical record writing，make full use of two methods：appraisers and experts witnesses appearing in court．

目的 对医疗损害责任纠纷案的法庭审理进行分析,探究医疗损害责任纠纷案件的处理现状,对此过程中医疗机构应当关注的问题进行分析总结,以期为医院应对医疗损害鉴定工作和法官审理医疗损害责任纠纷案提供参考。方法 对广州市三所综合医院2015—2021年共93例医疗损害责任纠纷案的判决书进行描述性分析。结果 93例案例中79例进行了医疗损害鉴定。79例进行医疗损害鉴定的案例中,71例鉴定结论被法院采信,采信率达90%。有29例案件鉴定人出庭（占比36.7%）,其中有25例鉴定意见被法院采信,采信率为86.2%,仅有7例案例当事人申请了专家辅助证人出庭。医方大多数最终承担次要及以下责任,占比为73.4%。鉴定结论为责任范围的,法院最后判决偏向于取最高值和中间值（43例出具责任范围的案例中,14例为最高值,13例为中间值）。结论 医疗机构要充分加强对医疗事故技术鉴定和医疗损害鉴定的认识,高度重视医疗损害鉴定工作,尤其加强尸体解剖告知及病历书写管理,充分利用好鉴定人和专家辅助证人出庭两种手段。

Objective To analyze the court trial of medical damage liability disputes,to explore the current situation of medical damage liability disputes,to analyze and summarize the problems encountered in dealing with medical damage disputes,so as to provide some references for hospitals to deal with medical damage disputes．Methods Descriptive statistical analysis performed on the written judgment of 93 cases of medical damage liability disputes in three large comprehensive hospitals in Yuexiu District,Guangzhou from 2015 to 2021．Results In 93 cases,79 cases had expertise of medical malpractice．In 79 expertise,71 of them were adopted,and the acceptance rate was 90%．Among the 29 cases in which the appraisers appeared in court,25 expert opinions were accepted by the court,the acceptance rate was 86.2%．In only 7 cases,the parties applied for expert witnesses to appear in court．In most cases,hospitals ultimately took secondary and lower responsibilities,accounting for 73.4%．If the appraisal conclusion falls within the scope of responsibility,the court's final judgment tends to take the highest and middle values．Conclusions Medical institutions should fully strengthen their understanding of technical identification of medical accidents and medical malpractice identification．Attach great importance to the identification of medical malpractice,especially strengthen the management of autopsy notification and medical record writing,make full use of two methods：appraisers and experts witnesses appearing in court．