目的 探讨分析超声引导下胸膜活检(USPB)联合胸腔积液检验对于临床确诊结核性胸膜炎的应用价值。方法 选取2021年6月—2023年6月广州市胸科医院收治的96例临床诊断为结核性胸膜炎(渗出性胸膜炎)的患者为研究对象,分别使用胸腔积液检验(包含胸腔积液腺苷脱氨酶及细菌培养)、USPB、两者联合三种方法诊断,计算其准确率、特异度及灵敏度并进行分析。结果 胸腔积液诊断准确率73.96%、灵敏度72.84%,USPB诊断准确率为85.42%、灵敏度82.71%,两者联合诊断准确率为88.54%,灵敏度90.12%,较胸腔积液检验单独诊断准确率及灵敏度明显升高(P<0.05),胸腔积液、USPB、两者联合诊断特异度差异(P>0.05)无统计学意义。结论 USPB联合胸腔积液检验对结核性胸膜炎的确诊具有较高临床价值。
Objective To investigate the value of ultrasound-guided pleural biopsy(USPB)combined with pleural effusion test in the diagnosis of tuberculous pleurisy.Methods A total of 96 patients with tuberculous pleurisy(exudative pleurisy)admitted to the Guangzhou Chest Hospital from June 2021 to June 2023 were selected.The accuracy,specificity,and sensitivity of pleural effusion test(including adenosine deaminase and bacterial culture),USPB,and their combination were calculated and analyzed.Results The diagnostic accuracy of pleural effusion was 73.96% and the sensitivity was 72.84%.The diagnostic accuracy of USPB was 85.42% and the sensitivity was 82.71%.The diagnostic accuracy 88.54% and sensitivity 90.12% of USPB combined with pleural effusion test were significantly higher than that of pleural effusion alone(P<0.05),but there was no significant difference in the diagnostic specificity of pleural effusion,USPB and combination of them(P>0.05).Conclusions USPB combined with pleural effusion test has high clinical value in the diagnosis of tuberculous pleurisy.
目的 比较宫腔镜病灶切除术与超声监测下吸宫术治疗剖宫产瘢痕部位妊娠(CSP)的有效性。方法 回顾性分析2021年7月—2023年10月在南宁市妇幼保健院确诊为I、Ⅱ型CSP并接受治疗的129例患者,停经时间在38~83 d,中位停经时间48 d。其中42例患者接受了宫腔镜病灶切除术治疗(A组),87例患者接受超声监测下吸宫术治疗(B组),比较两组患者术后1、3、7、14 d的人绒毛膜促性腺激素水平以及手术出血量、手术时间、住院时间、住院花费。结果 两组患者在术后1 d,血清HCG水平下降,下降幅度均超过50%,且A组患者术后1 d血清HCG的下降幅度及下降速率大于B组患者(P<0.05);术后3、7、14 d,两组血清HCG水平仍持续下降。另外,A组患者手术出血量、手术时间、住院时间、住院花费分别为(15.35±14.53)mL、(60.73±53.05)min、(4.33±1.90)d、(6 689.23±2 216.19)元;B组患者手术出血量、手术时间、住院时间、住院费用分别为(26.09±29.24)mL、(51.59±54.46)min、(4.82±1.83)d、(6 270.34±2 547.85)元。A组患者术中出血量低于B组、住院时间短于B组(P<0.05),手术时间及住院费用与B组比较差异无统计学意义(P均>0.05)。结论 宫腔镜病灶切除术与超声监测下吸宫术均能有效治疗CSP,但宫腔镜病灶切除术在术后血清HCG的下降幅度及下降速率、术中出血量、住院时间等方面优于超声监测下吸宫术,而且手术时间和住院费用并没有显著增加。
Objective To compare the efficacy between hysteroscopic resection surgery and ultrasound-guided uterine aspiration in the treatment of cesarean scar pregnancy(CSP).Methods A retrospective analysis was performed in 129 patients diagnosed with CSP(type I or Ⅱ)and treated in Nanning Maternal and Child Health Hospital from July 2021 to October 2023.Their duration of amenorrhea was between 38~83 d,with a median of 48 days.Among them,42 patients were treated with hysteroscopic resection surgery therapy(group A),87 patients were treated with ultrasound-guided uterine aspiration therapy and(group B).Then,the levels of human chorionic gonadotropin(HCG),the amount of the intraoperative bleeding volume,surgical time,hospitalization time,and hospitalization expenses were compared between the two groups at one,three,seven and 14 days postoperativey.Results After one day of surgery,the serum HCG levels of two groups significantly decreased,with a decrease of more than 50%,and the magnitude and rate of decrease in serum HCG levels of group A were significantly larger than those of group B(P<0.05);After three,seven,and 14 day of surgery,serum HCG levels continued to decrease.Furthermore,the intraoperative bleeding volume,surgical time,hospitalization time,hospitalization expenses in group A were(15.35±14.53)mL,(60.73±53.05)min,(4.33±1.90)d,(6 689.23±2 216.19)yuan,respectively.That in group B were(26.09±29.24)mL,(51.59±54.46)min,(4.82±1.83)d,(6 270.34±2 547.85)yuan,respectively.Compared to group B,the intraoperative bleeding volume of group A was significantly lower(P<0.05),and the hospitalization time is shorter,while there was no significant difference in surgical time and hospitalization expenses.Conclusions Both of hysteroscopic resection surgery and ultrasound-guided uterine aspiration can treat cesarean scar pregnancy effectively,but the former is superior to the latter in terms of the magnitude and rate of decrease in serum HCG levels after surgery,intraoperative bleeding volume,and hospitalization time,with no significant increase in surgical time and hospitalization expenses.
目的 探讨预防性风险管理在肌层浸润性膀胱癌根治术后的应用效果及对术后生活质量影响。方法 选取2020年6月—2023年10月安阳市肿瘤医院收治的66例肌层浸润性膀胱癌患者,应用抽签法分为观察组(n=33)与对照组(n=33)。所有患者均采取根治性全膀胱切除术与淋巴清扫术治疗,对照组患者术后实施常规护理,观察组在对照组基础上增加预防性风险管理。对比两组术后尿量、胃肠功能恢复时间、术后住院时间,干预前后病耻感及负面情绪、术后并发症发生率,最后对比两组干预前后生活质量变化。结果 两组患者术后尿量对比差异无统计学意义(P>0.05),观察组术后胃肠功能恢复时间为(5.27±0.82)d,术后住院时间为(18.31±3.27)d,短于对照组的(7.25±1.12)(23.27±4.18)d,对比差异有统计学意义(t分别为8.194、5.369,P<0.05);干预后两组患者病耻感量表(SSCI)、抑郁自评量表(SDS)和焦虑自评量表(SAS)评分均降低,观察组分别为(35.67±7.45)(40.02±2.43)(45.36±4.17)分,低于对照组的(48.27±10.69)(54.54±3.54)(51.37±4.38)分,对比差异有统计学意义(t分别为5.555、19.426、5.709,P<0.05);观察组术后并发症发生率为9.09%,低于对照组的30.30%(χ 2 =4.690,P=0.030);干预后两组膀胱癌特异性模块、功能状况、精神状况、家庭/社会状况及躯体状况相关维度膀胱癌患者生活质量量表(FACT-BL)评分均升高,观察组分别为(34.27±3.26)(25.11±4.23)(21.51±4.23)(25.02±4.43)(20.56±3.11)分,高于对照组的(27.00±4.34)(21.11±3.24)(16.12±2.12)(21.54±5.54)(15.87±4.13)分,对比差异有统计学意义(t分别为7.694、4.313、6.544、2.818、5.211,P<0.05)。结论 预防性风险管理在肌层浸润性膀胱癌根治术后的应用效果显著,可缩短患者术后胃肠功能恢复时间及住院时间,改善患者负面情绪,有助减少术后并发症,提升患者生活质量。
Objective To explore the effect of preventive risk management on postoperative application and quality of life of myometrial invasive bladder cancer patients after radical surgery.Methods A total of 66 patients with myometrial invasive bladder cancer admitted to Anyang Cancer Hospital from June 2020 to October 2023 were selected as research objects,and were divided into observation group(n=33)and control group(n=33)by lot drawing.All patients were treated with radical total cystectomy and lymph node dissection.The control group received routine nursing care after surgery,while the observation group received preventive risk management in addition to the control group.The postoperative urine output,recovery time of gastrointestinal function,and hospitalization time between two groups were compared,as well as the shame and negative emotions before and after intervention,the incidence of postoperative complications,and the changes in quality of life between the two groups before and after intervention.Results There was no significant difference in postoperative urine volume between the two groups of patients(P>0.05),and the postoperative gastrointestinal function recovery time(5.27±0.82)d,postoperative hospitalization time(18.31±3.27)d were shorter than the control group[(7.25±1.12)d,(23.27±4.18)d],with statistical significantce(t=8.194,5.369,P<0.05).After intervention,the Stigma Scale of Chronic Illness(SSCI),Self Rating Depression Scale(SDS),and Self-Rating Anxiety Scale(SAS)in both groups of patients decreased,and the observation group[(35.67±7.45),(40.02±2.43),(45.36±4.17)]scored lower than the control group[(48.27±10.69),(54.54±3.54),(51.37±4.38)],statistically significant(t=5.555,19.426,5.709,P<0.05).The incidence of postoperative complications in the observation group was significantly lower at 9.09% compared to the control group at 30.30%(χ 2 =4.690,P=0.030,P<0.05).After intervention,the scores of bladder cancer specific module,functional status,mental status,family/social status and physical status related dimensions of bladder cancer patients’ quality of life scale for bladder cancer patients(FACT-BL)in both groups increased,and the observation group[(34.27±3.26),(25.11±4.23),(21.51±4.23),(25.02±4.43),(20.56±3.11)] scored higher than the control group[(27.00±4.34),(21.11±3.24),(16.12±2.12),(21.54±5.54),(15.87±4.13)],the comparison was statistically significant(t=7.694,4.313,6.544,2.818,5.211,P<0.05).Conclusions Preventive risk management has a significant effect on the application of myometrial invasive bladder cancer after radical surgery,which can shorten the recovery time of gastrointestinal function and hospital stay,improve patients’ negative emotions,assist in preventing postoperative complications,and improve patients’ quality of life.
目的 基于SEER数据库分析三阴性乳腺癌(TNBC)的预后,并建立Cox回归临床预测模型且进行内部验证。方法 使用SEER*Stat软件(8.4.2版)筛选2010—2015年诊断为TNBC的病例,进行单因素和Cox多因素回归以及向后逐步回归分析,明确与生存相关的独立危险因素,构建预测TNBC患者3年和5年癌症特异生存(CSS)率的Nomogram图,并用受试者工作特征曲线,Harrell’s一致性指数,临床预测模型校准曲线以及决策曲线对该模型进行评估及内部验证,以评估该模型的临床预测效能。结果 共筛选出符合纳入标准的TNBC患者5 564例,按照7∶3的比例随机拆分为训练集(n=3 894)和验证集(n=1 670)。通过单因素,多因素分析显示TNM分期、放射治疗、化学治疗以及手术和其他治疗的先后顺序是与TNBC患者CSS显著相关的独立危险因素(P<0.05)。利用上述预后相关因素建立Nomogram图模型。训练集的C-index为0.731(95%CI:0.712~0.749),验证集的C-index为0.719(95%CI:0.688~0.749),训练集和验证集3年和5年生存ROC曲线的曲线下面积均>0.7,区分度较好,且校准曲线拟合良好。结论 TNM分期、放射治疗、化学治疗以及手术和其他治疗的先后顺序是TNBC的独立预后因素,基于此建立的Nomogram图临床预测模型区分度、准确度以及临床适用性较好,能较好地预测TNBC患者的生存预后。
Objective To analyze the prognosis of triple negative breast cancer(TNBC)based on the SEER database,and to establish a Cox regression clinical prediction model with internal validation.Methods Cases diagnosed with TNBC from 2010 to 2015 were screened using SEER*Stat software(version 8.4.2),and univariate and Cox multifactorial regression as well as backward stepwise regression analyses were performed to identify the independent risk factors associated with survival,and to construct a clinical prediction model for predicting the three- and five-year cancer specific survival(CSV)of TNBC patients.Survival(CSS)rates of TNBC patients at 3 and 5 years,and the model was evaluated and internally validated using the ROC curve,Harrell’s consistency index(C-index),clinical prediction model calibration curve,and decision-making curve(DCA curve)to assess the predictive efficacy of the model for clinical prediction.Results A total of 5 564 TNBC patients meeting the inclusion criteria were screened and randomly split into a training set(n=3 894)and a validation set(n=1 670)according to a 7∶3 ratio.By univariate,multivariate analysis showed that T-stage,N-stage,M-stage,radiotherapy,chemotherapy,and the sequence of surgery and other treatments were independent risk factors significantly associated with CSS in TNBC patients.The above prognostic-related factors were utilized to build a Nomogram plot model.The C-index was 0.731(95%CI:0.712-0.749)for the training set and 0.719(95%CI:0.688-0.749)for the validation set,and the areas under the curves of the 3- and 5-year survival ROC curves of both the training and validation sets were >0.7,which was a good differentiation,and the calibration curves were well-fitted.Conclusions T-stage,N-stage,M-stage,radiotherapy,chemotherapy,and the sequence of surgery and other treatments are independent prognostic factors for TNBC,and the Nomogram clinical prediction model based on this has good differentiation,accuracy,and clinical utility,and can better predict the survival prognosis of TNBC patients.
卵巢癌是导致女性死亡的全球第五大原因,其治疗效果受限于早期诊断和治疗方案的有限性。近年来,随着靶向治疗的不断发展,细胞死亡途径作为治疗靶点受到广泛关注,其中双硫死亡作为一种新发现的程序性细胞死亡形式,为癌症治疗提供了新的思路。文章探讨了双硫死亡及其他主要细胞死亡途径包括自噬、细胞焦亡、坏死性凋亡、铁死亡和铜死亡在卵巢癌治疗中的研究进展,有望为卵巢癌患者提供更有效的治疗选择。
Ovarian cancer ranks as the fifth deadliest cancer among women worldwide,with treatment efficacy hamperedby limited early diagnosis and therapeutic options.In recent years,with the continuous development of targeted therapies,cell death pathways have gained widespread attention as therapeutic targets.Among them,disulfideptosis,a newly discovered form of programmed cell death,offers a novel avenue for cancer treatment.This review aims to explore the research progress of disulfideptosis and other major cell death pathways including autophagy,apoptosis,necroptosis,ferroptosis,and cuproptosis in ovarian cancer therapy,with the potential to provide more effective treatment options for ovarian cancer patients.
嗜酸性粒细胞(EOS)作为过敏反应中关键的先天免疫细胞,在心血管疾病的发生与发展进程中也扮演着至关重要的角色。大量证据显示,血液EOS计数与诸多心血管疾病之间存在紧密联系,但临床研究得出的结论不尽相同。基础研究发现,EOS一方面可通过释放白细胞介素-4(IL-4)、IL-13及阳离子蛋白等细胞因子,对心肌梗死、心肌肥厚、心力衰竭或腹主动脉瘤发挥保护作用;另一方面,EOS表达的阳离子蛋白和血小板活化因子会促进平滑肌细胞增殖和钙化,进而加速动脉粥样硬化的形成。因此,EOS在不同心血管疾病中所发挥的作用存在差异,这与疾病的演变进程、EOS的数量均密切相关。本文对现有的临床和基础研究成果进行汇总,阐述EOS在各类心血管疾病中的不同作用。
Eosinophils(EOS),as key innate immune cells in allergic reactions,play a crucial role in the occurrence and development of cardiovascular diseases.Ample evidence shows that the count of blood EOS is closely related to many cardiovascular diseases.However,the conclusions drawn from clinical studies are inconsistent,and these contradictory observational results still cannot be reasonably explained so far.Basic research has found that,on the one hand,EOS can exert protective effects on myocardial infarction,myocardial hypertrophy,heart failure,or abdominal aortic aneurysm by releasing cytokines such as interleukin-4(IL-4),IL-13,and cationic proteins;on the other hand,the cationic proteins and platelet activating factors expressed by EOS can promote the proliferation and calcification of smooth muscle cells,thereby accelerating the formation of atherosclerosis.Therefore,the roles played by EOS in different cardiovascular diseases vary,which is closely related to the evolution process of the disease and the number of EOS.This article will summarize the existing clinical and basic research results to elaborate the different roles of EOS in various cardiovascular diseases.
目的 对该培训基地师资2021—2023年教学能力进行评价,了解和分析“1+3+n”的院级督导推行前的2021年、“1+3+n”的院级督导推行后的 2022年、2023年师资的教学能力变化。方法 采用问卷调查法收集评价数据,采用SPSS.27.0对教学评价资料进行统计分析,采用净推荐值计算教学口碑,对多年度结果进行纵向比较分析。结果 2021—2023年教学评价次数共5 483次;2021—2023年对师资教学设计能力评价由实施前的8.8提高到9.6、教学实施能力由实施前的9.0提高到9.5、教学热情由实施前的9.0提高到10.0、时间投入由实施前的9.3提高到10.0,不同年份组间比较的差异均有统计学意义(P<0.001);课程净推荐值由实施前的60.5%提高到81.3%,师资课程推荐者占比由实施前的65.5%提高到83.2%,贬损者占比由实施前的5.0%降低到1.9%,差异有统计学意义(χ 2 =175.4,P<0.001)。结论 “1+3+n”院级督导模式的相关举措,对师资教学能力的提高具有促进作用,且该促进作用持续存在,师资教学能力逐年递增。
Objective To evaluate the teaching ability change of teachers from 2021 to 2023,including of teachers’ teaching ability in 2021 before the implementation of "1+3+n" college-level supervision,and in 2022 and 2023 after the implementation of "1+3+n" college-level supervision.Methods Questionnaire survey was used to collect evaluation data,SPSS.27.0 was used to make statistical analysis of teaching evaluation data,and NPS(Net Promoter Score)was used to evaluate teaching quality.Results From 2021 to 2023,there were 5483 teaching evaluations.From 2021 to 2023,teaching design ability evaluation score increased from 8.8 before the implementation to 9.6,teaching implementation ability evaluation score increased from 9.0 before the implementation to 9.5,teaching enthusiasm evaluation score increased from 9.0 before the implementation to 10.0,time investment evaluation score increased from 9.3 before the implementation to 10.0,and the differences between different years were statistically significant(P<0.001).The courses quality increased from 60.5% before the implementation to 81.3%,and the proportion of teachers' course recommenders has increased from 65.5% before the implementation to 83.2%,while the proportion of detractors has decreased from 5.0% before the implementation to 1.9%,with statistical significance(χ 2 =175.4,P<0.001).Conclusions The measures of "1+3+n" college-level supervision mode promote the improvement of teachers’ teaching ability,the promotion effect persists,and the teaching ability increases year by year.
目的 探讨剖宫产后再次分娩阴道试产失败的影响因素。方法 选取2021年5月—2024年5月在枣庄市妇幼保健院分娩的138例有剖宫产手术史的足月妊娠产妇进行回顾性分析。所有产妇依照其阴道试产结果将成功阴道分娩的35例产妇分为成功组,将阴道试产失败中转剖宫产的103例产妇分为失败组。对比两组产妇的妊娠结局、孕期情况及围产期情况,最后采用多因素Logistic回归分析法分析剖宫产后再次分娩阴道试产失败的影响因素。结果 两组产妇子宫破裂、胎儿窘迫、产褥感染及产后出血等妊娠不良结局总发生率对比差异无统计学意义(11.43% vs 6.80%,χ 2 =0.760,P=0.382 >0.05);通过对比两组产妇孕期情况发现,失败组与成功组孕妇年龄、孕次、身高、孕前体质量、妊娠期合并症、分娩前体质量指数(BMI)比较差异无统计学意义(P>0.05),失败组与成功组孕妇孕期体质量增长[(4.56±2.56)kg vs(12.45±3.24)kg]、分娩孕周[(39.46±1.25)周 vs(37.95±1.37)周]、阴道分娩史(8.57% vs 26.21%)、妊娠间隔时间[(2.74±0.35)年 vs(3.37±0.57)年]及瘢痕厚度[(4.51±0.56)mm vs(5.42±0.38)mm],对比差异有统计学意义(t=3.497,P<0.001;t=5.755,P<0.001;χ 2 =4.780,P=0.029;t=6.148,P<0.001;t=10.764,P<0.001);通过对比两组产妇围产期情况发现,失败组与成功组新生儿性别、是否镇痛比例比较差异无统计学意义(P>0.05),失败组与成功组孕妇产前新生儿估重[(3352.31±153.67)g vs(3046.25±141.68)g]、是否引产[60.00% vs 52.43%]、胎膜早破[11.43% vs 35.92%]、入院时是否临产[857% vs 27.18%],对比差异有统计学意义(t=10.805,P<0.001;χ 2 =7.330,P=0.007;χ 2 =7.500,P=0.006;χ 2 =5.200,P=0.023);以阴道试产情况作为因变量(失败=1,成功=0)纳入Logistic回归模型,结果显示,分娩孕周过晚、产前新生儿估重过高、引产及入院时未临产为剖宫产后再次分娩阴道试产失败的影响因素(P<0.05)。结论 分娩孕周过高、产前新生儿估重过高、引产及入院时未临产为剖宫产后再次分娩阴道试产失败的独立影响因素,需针对分娩孕周、产前新生儿估重过高的剖宫产后再次分娩阴道试产产妇给予高度关注并采取相应措施进行干预,同时自然临产能够降低阴道试产失败风险,但针对具有引产指征的产妇,依然需要及时引产。
Objective To explore the influencing factors of vaginal trial delivery failure after cesarean section.Methods A retrospective analysis was conducted on 138 full-term pregnant women with a history of cesarean section who gave birth in our hospital from May 2021 to May 2024.All women were divided into two groups according to the results of their vaginal trial delivery.Based on their vaginal trial results,35 parturients who successfully delivered were divided into the successful group,and 103 parturients who failed vaginal trial delivery and transitioned to cesarean section were divided into the failed group.The pregnancy outcomes of postpartum women and the pregnancy and perinatal conditions were compared between the two groups,and multivariate Logistic regression analysis was used to analyze the independent influencing factors of vaginal trial delivery failure after cesarean section.Results There was no significant difference in the total incidence of adverse pregnancy outcomes such as uterine rupture,fetal distress,postpartum infection,and postpartum hemorrhage between the two groups of parturients (P>0.05).By comparing the pregnancy status of two groups of pregnant women,it was found that there was no difference (P>0.05).The average weight gain during pregnancy of failure and successful group,gestational age,cases with vaginal delivery history,intervalbetween pregnancy and scar thickness,the contrast difference was significant (all P<0.05) .By comparing the perinatal situation of the two groups,there was no difference in the sex of fetus and analgesia receiving of parturients between the failed group and the successful group (P>0.05),while there is difference in weight estimation,whether induced labour,premature rupture of fetal membrane,whether admitted to hospital (all P<0.05).Vaginal trial delivery was set as the dependent variable (failure=1,success=0) and it was incorporated into the Logistic regression model.The results showed that high gestational age during delivery,high estimated weight of fetus before delivery,induction of labor,and non-labor upon admission were independent influencing factors for vaginal trial delivery failure after cesarean section (P<0.05).Conclusions Excessive gestational age,high estimated weight of fetus before delivery,induced labor,and non-labor upon admission were independent influencing factors for the failure of vaginal trial delivery after cesarean section.It is necessary to pay high attention and take corresponding measures to intervene in women who have undergone vaginal trial delivery after cesarean section due to excessive gestational age and high estimated weight of fetus before delivery.At the same time,spontaneous labour can reduce the risk of vaginal trial delivery failure.However,for women with indications for induced labor,timely induction is still necessary.
目的 探讨运动干预联合治疗性聆听对孤独症谱系障碍儿童社会交往功能的影响。方法 选取黄河三门峡医院2020年1月—2023年10月收治的100例孤独症患儿,应用随机数字表法分为两组,各50例。对照组患儿实施常规护理,观察组在对照组基础上增加运动干预联合治疗性聆听。分别在干预前及干预6个月后采用孤独症治疗评价量表(ATEC)、儿童感觉统合发展评定量表、格塞尔发育量表(GDS)及中国韦氏儿童智力量表(WISC-R)评价两组患儿社会交往能力、感觉统合发展水平、神经发育水平及智力水平变化。结果 干预后两组患儿的ATEC各部分评分,包括健康/生理/行为、感知/认知能力、社交能力、语言表达/沟通能力及ATEC总分均降低,观察组低于对照组(P<0.05);干预后两组患儿学习能力发展、本体感觉、触觉防御、前庭功能及儿童感觉统合发展评定量表总分均升高,观察组高于对照组(P<0.05);干预后两组患儿动作能、应物能、言语能、应人能相关神经发育情况评分均升高,观察组高于对照组(P<0.05);干预后两组患儿言语智商、操作智商、总智商相关WISC-R评分均升高,观察组高于对照组(P<0.05)。结论 运动干预联合治疗性聆听对孤独症谱系障碍儿童应用效果显著,可提升其社会交往能力,促进感觉统合发展,进而促进其神经发育及智力水平提升。
Objective To explore the effect of exercise intervention combined with therapeutic listening on social communication function in children with autism spectrum disorder.Methods A total of 100 autistic children who were admitted to our hospital from January 2020 to October 2023 were selected and divided into two groups by random number table method,with 50 children each.The control group received routine care,while the observation group received exercise intervention combined with therapeutic listening in addition to routine care.The Autism Treatment Evaluation Scale (ATEC),Children’s Sensory Integration Development Scale,Gesell Development Scale,and Wechsler Intelligence Scale for Children-Revised by China (WISC-R)were used before and 6 months after the intervention to evaluate the social communication ability,sensory integration development level,neural development level,and intellectual level changes of the two groups of children.Results After intervention,the score of every dimension in ATEC including the health/physiology/behavior,perception/cognitive ability,social ability,language expression/communication ability,and total ATEC score of the two groups of children decreased,and the observation group was lower than the control group (P<0.05).After intervention,the total scores of the learning ability development insufficient,proprioceptive dysfunction,excessive tactile defense,vestibular dysfunction,and children’s sensory integration development assessment scale in both groups of children increased,with the observation group being higher than the control group (P<0.05).After intervention,the neurological development scores related to motor,adapt,language,and social ability in both groups of children increased,and the observation group was higher than the control group (P<0.05).After intervention,the WISC-R scores related to verbal intelligence,operational intelligence,and total intelligence in both groups of children increased,and the observation group was higher than the control group (P<0.05).Conclusions The combination of exercise intervention and therapeutic listening has asignificant effect on children with autism spectrum disorder,which can enhance their social communication ability,promote sensory integration development,and ultimately promote their neural development and intellectual level improvement.