论著

基于网络药理学与分子对接技术研究白头翁汤治疗细菌性痢疾的潜在活性成分及作用机制

Research on potential active ingredients and mechanisms of Baitouweng Decoction in the treatment of bacterial dysentery through network pharmacology and molecular docking

:216-227
 
       目的  采用网络药理学方法与分子对接技术分析白头翁汤治疗细菌性痢疾(BD)的潜在活性成分与作用机制。方法  借助中药系统药理学数据库与分析平台(TCMSP)及PubChem数据库检索筛选白头翁汤方的化学成分和作用靶点,通过Uniprot数据库校正基因名,同时通过比较毒物基因组学数据库(CTD)、药物靶标数据库(TTD)、GeneCards数据库和药物和药物靶标数据库(DRUGBANK)获得BD相关疾病靶点。经在线绘图平台微生信分析“活性成分-疾病”交集靶点,使用Cyoscape 3.7.2软件构建可视化的中药-活性成分-靶点网络、蛋白质互作网络,筛选潜在的关键活性成分与核心靶点;通过Metascape数据库对进行靶点的基因本体(GO)功能分析和京都百科全书基因和基因组通路数据库(KEGG)通路富集分析,同时使用Cyoscape 3.7.2软件构建基因-通路网络,筛选潜在的通路及其作用机制。同时采用分子对接技术对白头翁汤中关键活性成分和BD核心靶点进行分析。结果  白头翁汤共筛选出266个潜在活性成分,其中,槲皮素、β-谷甾醇、异鼠李素、异延胡索单酚碱、小檗红碱、豆甾醇等66个关键活性成分可通过肿瘤坏死因子(TNF)、白细胞介素-6(IL-6)、前列腺素内过氧化物合酶2(PTGS2)、丝氨酸/苏氨酸蛋白激酶1(AKT1)、血管内皮生长因子A(VEGFA)、V-rel网状内皮细胞病毒癌基因同源物A(RELA)、半胱氨酸天冬氨酸蛋白酶3(CASP3)、白细胞介素-8(CXCL8)、白细胞介素-1B(IL-1B)、丝裂原活化蛋白激酶1(MAPK1)、白细胞介素-10(IL-10)等33个潜在交集靶点作用于BD。GO基因功能分析共得到生物过程(BP)条目20个、细胞组成(CC)条目6个、分子功能(MF)条目9个(P<0.01),主要涉及外部凋亡过程、细胞迁移正向调控、细胞因子受体结合、蛋白同源二聚活性、TNF受体超家族结合等生物进程。KEGG通路富集分析确定13条信号通路(P<0.01),主要涉及癌症信号通路、白细胞介素-17(IL-17)信号通路等关键通路。分子对接结果显示槲皮素、β-谷甾醇、异鼠李素、异延胡索单酚碱等核心活性成分与TNF、IL-6、PTGS2核心靶点具有良好的结合效应(结合能<-5 kJ/mol)。结论  白头翁汤主要通过槲皮素、β-谷甾醇等潜在的多种活性成分作用于TNF、IL-6、IL-1B、PTGS2、AKT1、VEGFA等潜在的关键靶点调控IL-17等信号通路,从而发挥治疗细菌性痢疾的作用,符合中药复方多成分、多靶标、多途径起效的显著特征。
      Objective To analyze the potential active ingredients and mechanism of Baitouweng Decoction in the treatment of bacillary dysentery(BD)by means of network pharmacology and molecular docking technology.Methods With the help of the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(Traditional Chinese Medicine Systems Pharmacology Database,TCMSP)and PubChem database to search and screen the chemical composition and target of Baitouweng Decoction,the gene name was corrected through the Uniprot database,and the CTD database,TTD database,GeneCards database and DRUGBANK database obtain BD-related disease targets.The intersection target was obtained through the online  drawing platform,and Cytoscape 3.7.2 was used to construct a network of Pulsatilla active ingredient-component disease intersection target.The protein-protein interaction analysis of the intersection target was performed through the String database,and the Cytoscape 3.7.2 software was used for visualization.The Metascape database platform performed GO function analysis and KEGG pathway enrichment analysis on the target to predict its mechanism of action.The  key active ingredient compounds in Baitouweng Decoction were molecularly docked with the core protein in the intersection target.Results A total of 266 potential active ingredients in Baitouweng Decoction were screened,of which 66 key active ingredients such as quercetin,β-sitosterol,isorhamnetin,Isocorypalmine,berberine,stigmasterol,etc.It acts on BD through 33 potential intersection targets such as TNF,IL-6,PTGS2,AKT1,VEGFA,RELA,CASP3,CXCL8,IL-1B,MAPK1,IL-10.GO gene function analysis yielded a total of 20 biological process(BP)entries,6 cell composition(CC)entries,and 9 molecular function(MF)entries(P<0.01),which mainly involve external apoptosis process and positive regulation of cell migration,Cytokine receptor binding,protein homodimerization activity,tumor necrosis factor receptor superfamily binding and other biological processes.KEGG pathway enrichment analysis identified 13 signal pathways(P<0.01),mainly related to key pathways such as cancer signal pathway and IL-17 signal pathway.The results of molecular docking showed that the core active ingredients such as quercetin,β-sitosterol,isorhamnetin,Isocorypalmine and TNF,IL-6,PTGS2 core targets have good binding effects(binding energy <-5 KJ /mol).Conclusions Baitouweng Decoction modulated signaling pathways involving IL-17 through its active constituents like quercetin and β-sitosterol,targeting key molecules such as TNF,IL-6,IL-1β,PTGS2,AKT1,and VEGFA,reflecting the multi-target therapeutic approach of traditional Chinese medicine.
论著

阴道分娩后尿失禁患者疾病应对方式及其相关影响因素分析

Analysis of disease coping strategies and related influencing factors in patients with urinary incontinence after vaginal delivery

:211-215
 
       目的   探讨阴道分娩后尿失禁患者疾病应对方式的影响因素。方法   选取2022年1月—2023年1月医院收治的阴道分娩后尿失禁患者78例,评估所有患者的应对方式,根据结果分为积极应对组与消极应对组,设计基线资料调查表,详细统计两组患者的基线资料并比较,重点分析阴道分娩后尿失禁患者疾病应对方式的影响因素。结果   经评估,78例阴道分娩后尿失禁患者疾病消极应对有40例,占比51.28%;积极应对组与消极应对组患者的产次(χ 2 =4.110,P=0.043)、文化水平(Z=2.094,P=0.036)、家庭关怀度(Z=2.069,P=0.040)与自我效能(Z=2.249,P=0.025)比较差异有统计学意义,组间年龄(t=0.096,P=0.924)、孕次(t=1.257,P=0.212)、体质指数(BMI)(t=0.125,P=0.901)、工作(χ 2 =0.778,P=0.378)、家庭月人均收入(χ 2 =0.044,P=0.834)、漏尿(χ 2 =0.040,P=0.842)比较差异无统计学意义;经回归分析发现,家庭关怀度低(OR=1.799,P=0.041)、自我效能低(OR=1.942,P=0.026)、经产妇(OR=2.554,P=0.045)及文化水平低(OR=1.837,P=0.038)均是阴道分娩后尿失禁患者疾病应对方式的影响因素。结论   阴道分娩后尿失禁患者疾病消极应对风险高,可能与产次、文化水平、家庭关怀度及自我效能有关。
       Objective To explore the influencing factors of disease coping strategies in patients with urinary incontinence after vaginal delivery.Methods A total of 78 patients with urinary incontinence after vaginal delivery admitted to the hospital from January 2022 to January 2023 were selected.The coping strategies of all patients were evaluated,and they were divided into a positive coping group and a negative coping group based on the results.A baseline data questionnaire was designed,and the baseline data of the two groups of patients were compared in detail.The focus was on analyzing the factors influencing the disease coping strategies of patients with urinary incontinence after vaginal delivery.Results After evaluation,40 out of 78 patients with urinary incontinence after vaginal delivery had negative coping strategies,accounting for 51.28%.The parity of patients in the positive and negative coping groups(χ 2 =4.110,P=0.043),educational level(Z=2.094,P=0.036),family care(Z=2.069,P=0.040),and self-efficacy(Z=2.249,P=0.025)among the groups were different.Age between groups(t=0.096,P=0.924),gestational age(t=1.257,P=0.212),body mass index(t=0.125,P=0.901),and work experience(χ 2 =0.778,P=0.378),monthly per capita income of households(χ 2 =0.044,P=0.834),urinary leakage(χ 2 =0.040,P=0.842)had no statistically significant difference in comparison.Through regression analysis,it was found that low family care(OR=1.799,P=0.041),low self-efficacy(OR=1.942,P=0.026),postpartum women(OR=2.554,P=0.045),and low educational level(OR=1.837,P=0.038)were all influencing factors on the disease coping strategies of patients with urinary incontinence after vaginal delivery.Conclusions  Patients with urinary incontinence after vaginal delivery have a higher risk of negative coping with the disease,which may be related to parity,educational level,family care and self-efficacy.
论著

人工晶状体集中带量采购效果分析

Effect of centralized volume-based procurement policy of intraocular lens

:203-210
 
       目的 评价人工晶状体(IOL)集中带量采购政策对于白内障摘除术中人工晶状体选择的影响。 回顾性分析2020年6月—2022年5月在广州市第一人民医院眼科完成白内障超声乳化摘除联合IOL植入术的患者,根据医院开始集采的时间(2021年5月)将患者分为集采前组与集采后组。比较两组患者的一般资料、IOL类别、IOL价格、手术费用、国产IOL占比等。结果 集采前组(2020年6月—2021年5月)与集采后组(2021年6月—2022年5月)的白内障手术量分别为1 188例及1 099例(双眼手术者仅纳入一眼),两组患者的年龄及性别比例比较差异均无统计学意义(P0.05)。集采前IOL价格为3 770(3 162~7 950)元,高于集采后的1 613(1 079~4 994)元(P<0.001)。两组患者中非球面单焦点IOL所占比例均为最高,集采后多焦点及散光IOL的数量较集采前增加(集采前vs.集采后:多焦IOL:1.9% vs15.0%;散光IOL:0.2% vs 1.3%,均P<0.05),球面IOL的数量减少(集采前后:7.7% vs 0.6%,P<0.05)。集采后国产IOL的使用率由0.5%增加至3.5%(P<0.001)。并且集采后选择多焦点IOL的患者年龄更大[集采前(62.3±12.4)岁,集采后(66.1±10.5)岁,P=0.02]。结论  IOL集中带量采购政策减轻了白内障患者的经济负担,增加了高端IOL的使用量,同时减少了国家医疗保险的支出,并且促进国产医用耗材的使用。
     Objective  To evaluate the influence of intraocular lens(IOLs)purchasing policy in  a  centralized volume-based manner on patients’ selection of cataract extraction surgery.Methods The  patients who  completed  cataract phacoemulsification combined with IOLs implantation in the ophthalmology department of Guangzhou First People’s Hospital from June 2020 to May 2022 were retrospectively analyzed.According to the time of centralized  IOLs procurement policy implemented in our hospital(May 2021),the patients were divided into before centralized purchase group(from June 2020 to May 2021)and centralized purchase group(from June 2021 to May 2022).The demographics of study population,IOLs category,IOLs cost,operation cost and the proportion of Chinese-made IOLs were compared between the two groups.Results The total numbers of operations in the before centralized purchase group and centralized purchase group  were 1 188 and 1 099 eyes(only one eye was included in the binocular surgery),respectively.There was no significant difference in the age and sex between the two groups(P>0.05).The median cost of IOLs in the before centralized purchase group was 3 770(3 162,7 950),which was higher than that of centralized purchase group [1 613(1 079,4 994),P<0.001].The proportion of aspherical  IOLs was the highest in both groups.The number of multifocal and astigmatic  IOLs in the centralized purchase group increased significantly compared with those of before centralized purchase group(multifocal IOLs:1.9% and 15.0%;astigmatic IOLs:0.2% and 1.3%,all P<0.05).The number of spherical IOLs decreased significantly(7.7% and 0.6%,P<0.05).The utilization rate of domestic IOLs increased from 0.5% to 3.5%(P<0.001).The patients who chose multifocal IOLs in centralized purchase group were older than patients in before centralized purchase group [(62.3±12.4)vs(66.1±10.5),P=0.02].Conclusions The centralized volume-based procurement policy of IOLs reduces the economic burden of patients and increase the use of high-end IOLs.At the same time,it reduces the expenditure of national medical insurance and promotes the use of domestic medical consumables.
论著

重症烧伤患者血培养念珠菌阳性的病原学特征

Pathogenic characteristics of Candida positive blood culture in severe burn patients

:197-202
 
       目的   分析重症烧伤患者血培养标本中检测出念珠菌的临床分布,探究重症烧伤患者血流念珠菌感染的病原学特征。方法   选取2012—2023年在广州市红十字会医院住院治疗的重症烧伤患者血培养标本1 148份,分析分离出念珠菌的非重复患者病死率、菌种分布、同时送检的其他类型标本念珠菌培养结果及患者念珠菌血流感染的检出时间与季节分布、抗菌药物使用情况及对常用抗真菌药物的耐药情况。结果  1 148份血培养标本中77份检出真菌,阳性率为6.71%。检出念珠菌感染的非重复患者27例,其中近平滑念珠菌13例,构成比为48.15%、白念珠菌8株,构成比为29.63%。血与静脉导管培养均检出念珠菌的有22例(81.48%);血与伤口分泌物培养圴检出念珠菌的有10例(37.04%);血、静脉导管、伤口分泌物培养圴检出念珠菌的有4例(14.81%)。静脉导管检出念珠菌高于其他类型标本。27例重症烧伤患者血流感染检出念珠菌的时间主要分布在入院后第2~3周、季节主要分布在春夏季。近平滑念珠菌、白念珠菌、热带念珠菌对氟康唑敏感率分别为83.33%、87.50%和75.00%。结论   重症烧伤患者血流近平滑念珠菌检出率最高,发生血流感染时间主要在春夏季及烧伤入院后第2~3周,静脉导管留置是增加重症烧伤患者念珠菌血流感染的因素。我院念珠菌对抗真菌药物具有较高敏感性。
      Objective  To retrospective analyze the clinical distribution of Candida species detected in blood cultures of patients with severe burns and to investigate the etiological characteristics of Candida bloodstream infections in these patients.Methods  A total of 1 148 blood culture specimens were collected from patients with severe burns hospitalized at an institution between 2012 and 2023.Patients data with Candida bloodstream infections isolated from 1 148 blood culture specimens were analyzed,including mortality rates,species distribution,Candida culture results from other simultaneously collected specimen types,and the timing and seasonal distribution of Candida bloodstream infections,the use of antibiotics and  resistance to commonly-used antifungal drugs.Results  A total of 1 148 blood culture samples,77 fungi were separated,resulting in a positive rate of 6.71%.Among the 27 patients with Candida infections,13 cases(48.15%)were caused by Candida parapsilosis and 8 cases(29.63%)by Candida albicans.Candida was isolated from both blood and intravenous catheter cultures in 22 cases,with a positivity  rate of 81.48%.Candida was isolated from both blood and wound secretion cultures in 10 cases(positivity rate of 37.04%),and 4 cases from blood,intravenous catheter and wound secretion cultures(positivity rate of 14.81%).The detection rate of Candidafrom intravenous catheters was higher than that from other specimen types.Candida bloodstream infections were most commonly observed during the 2nd and 3rd week after admission,with a seasonal peak in spring and summer.The  susceptibility  rates of Candida parapsilosis、Candida albicans and Candida tropicalis to fluconazole were 83.33%、87.50% and 75.00%,respectively.Conclusions  The detection rate of Candida parapsilosis in bloodstream infections among patients with severe burns was the highest.These infections predominantly occur during the spring and summer and in the 2nd and 3rd week post-admission.The presence of intravenous catheters significantly contributes to Candida infections.The Candida in the hospital has high sensitivity to antifungal drugs.
论著

膝骨关节炎患者术前衰弱列线图预测模型的建立

Establishment of a preoperative frailty nomogram prediction model in patients with knee osteoarthritis

:179-186
 
       目的   基于Nomogram初步构建膝骨关节炎(KOA)患者术前衰弱的风险预测模型。方法   便利选取172例于2021年12月—2022年8月在广州市某三甲医院关节外科接受择期膝关节置换术的KOA患者为研究对象,依据衰弱的发生与否分为衰弱组(n=111)和非衰弱组(n=61),通过单因素分析筛选变量,纳入Logistic回归分析,并构建列线图模型。结果   单因素分析结果显示年龄、BMI、膝关节疼痛年限、合并症、抑郁、焦虑、疼痛、睡眠障碍、营养状况等在不同组间比较差异存在统计学的意义(P<0.05)。多因素Logistic回归分析表明,BMI异常(OR=3.360)、膝关节疼痛年限>5年(OR=14.188)、抑郁(OR=5.608)、睡眠障碍(OR=25.480)是KOA患者术前衰弱的独立危险因素(P<0.05)。基于此,建立了预测膝骨关节炎患者术前衰弱风险的列线图预测模型。结果显示C-index为0.915,校正曲线接近理想曲线,ROC曲线下面积(AUC)为0.919(95%CI:0.878~0.961),可见该预测模型具有较好的区分度和准确度。结论   根据BMI、膝关节疼痛年限、抑郁以及睡眠障碍这四个独立危险因素,可以准确地预测膝骨关节炎患者术前衰弱的风险。
    Objective  To develop a nomogram for predicting the risk of preoperative frailty in knee osteoarthritis patients.Methods  A convenience sample of 172 patients who underwent elective knee arthroplasty at a Grade-A hospital in Guangzhou from December 2021 to August 2022 was selected.The patients were divided into two groups based on the presence of preoperative frailty:frailty group(n=111)and non-frailty group(n=61).The variables with statistical differences were screened by univariate analysis for multivariate logistic regression analysis,and the nomogram prediction model was established.Results  Univariate analysis identified significant differences between the groups in age,BMI,years of knee pain,complications,depression,anxiety,pain,sleep disturbance,and nutrition(P<0.05).Multivariate logistic regression showed that abnormal BMI(OR=3.360),years of knee pain > 5(OR=14.188),depression(OR=5.608),and sleep disorders(OR=25.480)were independent  risk factors for preoperative frailty in knee osteoarthritis patients(P<0.05).Based on these findings,a nomogram prediction model was established.Model verification results demonstrated that the nomogram had good differentiation and accuracy in predicting the risk of preoperative frailty,with a C-index of 0.915,an area under the ROC curve of 0.919(95% CI:0.878~0.961),and a calibration curve slope close to 1.Conclusions  The nomogram,based on four independent risk factors(BMI,years of knee pain,depression,and sleep disturbance),effectively predicts the risk of preoperative frailty in knee osteoarthritis patients.
论著

安罗替尼联合不同 ALK 抑制剂治疗非小细胞肺癌的疗效比较

Comparion of the therapeutic effect of anlotinib combined with ALK inhibitors in treating non-small cell lung cancer

:171-178
 
       目的 评价不同间变性淋巴瘤激酶(ALK)抑制剂联合安罗替尼治疗非小细胞肺癌(NSCLC)的疗效。方法 收集ALK突变阳性NSCLC患者的临床资料,筛选服用ALK抑制剂疗效不佳再加用安罗替尼的病例。根据不同的用药方案分为阿来替尼+安罗替尼,塞瑞替尼+安罗替尼和克唑替尼+安罗替尼三个组别。记录患者联合用药前最近一次的影像学检查结果,并以此为基线按Recist1.1评价疗效,以病情进展、患者死亡、停药、改变治疗方案为终点计算各组患者的无事件生存期(EFS),收集肿瘤标志物、血常规和肝功、心功能、肾功能生化检测等指标数据,统计分析患者联合用药前后各项指标的变化。结果 经筛选,共纳入49例患者的临床数据。阿来替尼+安罗替尼组有23例,疾病控制率(DCR)为86.96%;平均EFS为(10.8±3.6)个月,中位EFS为8.3个月;塞瑞替尼+安罗替尼组有14例,DCR为71.43%;平均EFS为(6.5±2.9)个月,中位EFS为5.6个月;克唑替尼+安罗替尼组有12列,DCR为66.67%;平均EFS为(7.7±3.2)个月,中位EFS为7.2个月。阿来替尼+安罗替尼组的平均EFS长于另外两组(P<0.05)。各研究组肿瘤标志物仅有CyFra21-1在克唑替尼+安罗替尼组在联合用药后升高(P<0.05),生化检测和血常规指标在用药前后差异无统计学意义(P>0.05)。  ALK抑制剂与安罗替尼联用,疗效最好为阿来替尼,其次为塞瑞替尼,最后为克唑替尼。三种ALK抑制剂与安罗替尼联用后,均未导致心、肝、肾功能和血细胞损害。
      Objective  To evaluate the efficacy of different anaplastic lymphoma kinase(ALK)inhibitors combined with anlotinib in the treatment of non-small cell lung cancer(NSCLC).Methods  Clinical data of drug resistant NSCLC patients with ALK positive mutation was collected who were treated with ALK inhibitors and anlotinib synchronously.According to different regimens,three groups were set,alectinib+anlotinib,ceritinib+anlotinib,and crizotinib+anlotinib.The latest imageological examination  results of the patient before the synchronous therapy was set as the baseline to evaluate the therapeutic effect according to Recist1.1.The event free survival(EFS)of each group was calculated with disease progression,patient death,treatment discontinuation and changing regimen as endpoints.Data of tumor markers,hematology test,liver function,cardiac function,renal function biochemical examination was collected and analyzed statistically before and after the combination therapy,with P<0.05 as the statistically significant difference.Results  After screening,clinical data of 49 patients were collected.Twenty-three patients in the alectinib+anlotinib group,with a disease control rate(DCR) of 86.96%;mean EFS was(10.8±3.6)months,median EFS of 8.3 months;14 patients in the ceritinib+anlotinib group,with a DCR of 71.43%,mean EFS was(6.5±2.9)months,median EFS was 5.6 months;12 patients in the crizotinib+anlotinib group,with a DCR of 66.67%,mean EFS was(7.7±3.2)months,median EFS was 7.2 months.EFS of alectinib+anlotinib group was longer significantly than the other two groups(P<0.05).Only CyFra21-1,increased significantly after the combination of crizotinib and anlotinib(P<0.05).No statistically significant difference in biochemical test and hematology test before and after the treatment(P>0.05).Conclusions  The therapeutic effect of ALK inhibitors with anlotinib was ordered,alectinib being the most effective,followed by ceritinib and finally crizotinib.The combination of ALK inhibitors with anlotinib did not cause any abnormal results in the examination of heart,liver,kidney and blood cells.
论著

心房颤动患者射频消融术中清醒状态下电复律疗效观察

Efficacy of awake electrical cardioversion during radiofrequency ablation of atrial fibrillation

:166-170
 
       目的 探讨术中未恢复窦性心律需要行电复律的心房颤动(房颤)患者在清醒和镇静两种状态下的安全性及有效性。方法 选择2022年1月—2023年12月100例接受射频消融术中行同步直流电复律的持续性房颤患者进行研究,采用随机数字表法将患者分为观察组(清醒状态)和对照组(镇静状态),其中观察组和对照组各为50例。观察两组患者接受电复律的成功率、复发率和不良事件发生率(呼吸抑制、低血压、谵妄、肺水肿、心律失常)等指标。结果 观察组和对照组首次电复律成功分别有48、49例,成功率分别为96%、98%,组间比较差异无统计学意义(P=0.558)。观察组术后30 min内有2例复发,对照组术后30 min内无复发,组间比较差异无统计学意义(P=0.153)。在不良反应方面,观察组共发生1例心律失常事件,1例低血压事件,不良反应的总发生率为4%。对照组共发生3例呼吸抑制事件、2例谵妄事件、1例心律失常事件、2例低血压事件,不良反应的总发生率为16%,组间比较差异有统计学意义(P=0.046)。结论 对持续性房颤患者在射频消融术中,处于清醒状态下行电复律也具有良好的临床疗效,可以减少不良事件的发生,安全性更高。
  Objective  To compare the safety and efficacy of awake state and sedation state in patients with atrial fibrillation(AF)who did not recover sinus rhythm and needed electrical cardioversion during operation.Methods  A total of 100 patients with persistent atrial fibrillation who underwent synchronous direct current cardioversion during radiofrequency ablation from January 2022 to December 2023 were selected and divided into the observation group(awake state)and the control group(sedation state)according to the random number table method,with 50 cases in each group.The success rate of electrical cardioversion,recurrence rate and incidence of adverse events(respiratory depression,hypotension,delirium,pulmonary edema,arrhythmia)were observed.Results  The first electrical cardioversion was successful in 48 and 49 patients in the observation group and the control group,and the success rates were 96% and 98%,respectively.There was no significant difference between the two groupsP=0.558).There were 2 cases of  recurrence in the observation group and no  recurrence in the control group within 30 minutes after operation,and there was no significant difference between the two groups(P=0.153).In terms of adverse reactions,there were 1 case of arrhythmia event and 1 case of hypotension event in the observation group,and the total incidence of adverse reactions was 4%.There were 3 cases of respiratory depression events,2 cases of delirium events,1 case of arrhythmia events,and 2 cases of hypotension events in the control group.The total incidence of adverse reactions was 16%,and the difference between the two groups was statistically significant(P=0.046).Conclusions  Electrical cardioversion in awake state during  radiofrequency ablation of persistent atrial fibrillation has a good clinical efficacy and safety,which can reduce the occurrence of adverse events.
医院管理

广州市越秀区 3 所综合医院 93 例医疗损害责任纠纷案件法院审理浅析

Analysis of the court trial of 93 cases of medical damage liability disputes in three general hospitals in Yuexiu District,Guangzhou

:131-138
 
       目的   对医疗损害责任纠纷案的法庭审理进行分析,探究医疗损害责任纠纷案件的处理现状,对此过程中医疗机构应当关注的问题进行分析总结,以期为医院应对医疗损害鉴定工作和法官审理医疗损害责任纠纷案提供参考。方法   对广州市三所综合医院2015—2021年共93例医疗损害责任纠纷案的判决书进行描述性分析。结果  93例案例中79例进行了医疗损害鉴定。79例进行医疗损害鉴定的案例中,71例鉴定结论被法院采信,采信率达90%。有29例案件鉴定人出庭(占比36.7%),其中有25例鉴定意见被法院采信,采信率为86.2%,仅有7例案例当事人申请了专家辅助证人出庭。医方大多数最终承担次要及以下责任占比为73.4%。鉴定结论为责任范围的,法院最后判决偏向于取最高值和中间值(43例出具责任范围的案例中,14例为最高值,13例为中间值)。结论   医疗机构要充分加强对医疗事故技术鉴定和医疗损害鉴定的认识,高度重视医疗损害鉴定工作,尤其加强尸体解剖告知及病历书写管理,充分利用好鉴定人和专家辅助证人出庭两种手段。
      Objective  To analyze the court trial of medical damage liability disputes,to explore the current situation of medical damage liability disputes,to analyze and summarize the problems encountered in dealing with medical damage disputes,so as to provide some references for hospitals to deal with medical damage disputes.Methods  Descriptive statistical analysis performed on the written judgment of 93 cases of medical damage liability disputes in three large comprehensive hospitals in Yuexiu District,Guangzhou from 2015 to 2021.Results  In 93 cases,79 cases had expertise of medical malpractice.In 79 expertise,71 of them were adopted,and the acceptance rate was 90%.Among the 29 cases in which the appraisers appeared in court,25 expert opinions were accepted by the court,the acceptance rate was 86.2%.In only 7 cases,the parties applied for expert witnesses to appear in court.In most cases,hospitals ultimately took secondary and lower responsibilities,accounting for 73.4%.If the appraisal conclusion falls within the scope of responsibility,the court’s final judgment tends to take the highest and middle values.Conclusions  Medical institutions should fully strengthen their understanding of technical identification of medical accidents and medical malpractice identification.Attach great importance to the identification of medical malpractice,especially strengthen the management of autopsy notification and medical record writing,make full use of two methods:appraisers and experts witnesses appearing in court.
护理研究

基于微视频的护理干预对急性胰腺炎患者疾病知晓、自我管理和遵医行为的影响

The impact of micro video based nursing interventions on disease awareness,self-management and compliance behavior in patients with acute pancreatitis

:125-130
 
       目的   探讨基于微视频的护理干预对急性胰腺炎患者疾病知晓、自我管理和遵医行为的影响。方法   根据中心随机法将郑州大学第二附属医院2021年1月—2023年1月收治的88例急性胰腺炎患者作为研究对象,其中传统组44例给予常规干预,微视频组44例在传统组的基础上结合微视频的护理干预,比较两组患者疾病知晓情况、自我管理能力和遵医行为情况。结果   干预2个月后,微视频组病例脱落3例,传统组病例脱落4例,两组疾病知晓各维度高于干预前,且微视频组高于传统组,其中疾病病因(t=3.151,P=0.003)、临床症状(t=7.165,P<0.001)、并发症(t=5.497,P<0.001)、如何预防疾病复发(t=8.195,P<0.001);两组自我护理能力量表(ESCA)各维度评分高于干预前,且微视频组高于传统组,其中各维度评分结果为自我护理技能(t=2.787,P=0.007)、自我概念(t=2.272,P=0.026)、自护责任感(t=2.644,P=0.011)、健康知识水平(t=3.321,P=0.001);两组遵医行为各维度评分高于干预前,且微视频组高于传统组,其中各维度评分结果为饮食依从性(t=6.271,P<0.001)、用药依从性(t=3.539,P=0.001)、锻炼依从性(t=4.469,P<0.001)、定期复查(t=2.764,P=0.007)。结论   通过运用微视频的护理干预能够提高急性胰腺炎患者疾病知识的掌握,促进机体自我管理水平的恢复,进而提高遵医行为。
       Objective  To explore the impact of micro video based nursing interventions on disease awareness,self-management and compliance behavior in patients with acute pancreatitis.Methods  According to the central randomization method,88 patients with acute pancreatitis admitted to the Second Affiliated Hospital of Zhengzhou University from January 2021 to January 2023 were selected as the research subjects.Among them,44 patients in the traditional group received routine intervention,and 44 patients in the micro video group received nursing intervention combined with micro video on the basis of the traditional group.The disease awareness,self-management ability and compliance behavior of the two groups of patients were compared.Results  After two months of intervention,three cases were dropped out in the micro video group and four cases were dropped out in the traditional group.The disease awareness in both groups was higher than that before intervention,and the micro video group was higher than the traditional group,including disease etiology(t=3.151,P=0.003),clinical symptoms(t=7.165,P<0.001),complicationst=5.497,P<0.001) and how to prevent disease recurrence(t=8.195,P<0.001).The scores of ESCA in both groups were significantly higher than those before intervention,and the micro video group was higher than the traditional group in terms of self-care skills(t=2.787,P=0.007),self-concept(t=2.272,P=0.026),self-care responsibility(t=2.644,P=0.011) and health knowledge level(t=3.321,P=0.001).The scores of all dimensions of compliance behavior in both groups were significantly higher than those before intervention,and the micro video group had higher scores than the traditional group in terms of dietary compliancet=6.271,P<0.001),medication compliance(t=3.539,P=0.001),exercise compliance(t=4.469,P<0.001) and  regular follow-up(t=2.764,P=0.001).Conclusions  The use of micro video nursing interventions can improve the mastery of disease knowledge in patients with acute pancreatitis,promote the recovery of the body’s self-management level,and thereby improvemedical compliance behavior.
护理研究

共同照护模式联合回授法健康教育对 2 型糖尿病患者病情控制的影响

Research on the impact of co-care model combined with feedback health education on disease control in patients with type 2 diabetes

:117-124
 
       目的   分析共同照护模式联合回授法健康教育在2型糖尿病患者中的应用效果。方法   将2023年1月—2023年12月广州市第一人民医院收治 的114例2型糖尿病患者作为此次研究对象,分为研究组(n=57)和对照组(n=57),对照组患者给予常规护理结合健康教育,研究组患者给予共同照护模式联合回授法健康教育,评估两组在培训前及培训后1、3个月的血糖控制情况及糖尿病患者自我管理行为量表(SDSCA)等指标。结果   培训1、3个月后,两组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白均低于培训前,且研究组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组(P<0.05)。培训1、3个月后,两组患者的糖尿病患者SDSCA评分高于培训前,且研究组各项评分高于对照组(P<0.05)。重复测量方差分析表明随着时间的推移,患者的血糖控制状况随着不同护理培训策略而得到改善。结论   使用共同照护模式联合回授法健康教育对2型糖尿病患者可以更显著改善血糖控制水平、提高自我管理效能。
       Objective  To analyze the effect of co-care mode and feedback  health education on  patients with type  2 diabetes.Methods  From January 2023 to December 2023,114 patients with type 2 diabetes admitted to Guangzhou First People’s Hospital were divided into two groups:experimental group(n=57)and control group(n=57).Patients in control group were given routine nursing combined with health education.Patients in study group were given co-care and feedback health education.Before intervention and 1,3 months after intervention,patients’ blood glucose control and diabetic self-management behavior scale(SDSCA)were evaluated.Results  After 1 and 3 months of intervention,the fasting blood glucose,2-hour blood glucose and HbA1c of the two groups were significantly lower than those before intervention,and the fasting blood glucose,2-hour blood glucose and HbA1c of the experimental group were significantly lower than those of the control group(P<0.05).After 1 month and 3 months of intervention,the SDSCA scores of diabetic patients in both groups were higher than those before intervention,and the scores of study group were higher than those of control group(P<0.05).Repeated measures analysis of variance indicating that glycemic control improved significantly over time with different nursing training strategies.Conclusions  Co-care mode and feedback health education can significantly improve blood glucose control and self-management efficiency in patients with type 2 diabetes.
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