目的 面向采血人群的“智慧服务”是智慧医院构建的重要内容,引进智能采血管理系统有助于采血“智慧服务”的实现。文章介绍了广州市属大型三甲医院应用智能采血管理系统的实践,并对于系统出现的问题进行整理及分析,以找出有效解决对策。方法 将采血系统出现故障后的解决对策改良前后分为对照组和观察组,记录采血过程中出现故障的原因及次数,采血故障解决对策改良后的数据为观察组。结果 观察组相较于对照组各项故障的发生率显著降低。结论 在智慧医院构建背景下引进智能采血系统可有助于实现采血“智慧服务”,但在实施过程中应做好新旧采血方式的衔接并落实问题收集和对策制定。
Objective Intelligent Service for blood collection crowd is an important content of intelligent hospital,the introduction of intelligent blood collection management system is conducive to the implementation of “Intelligent Service” blood collection.This paper introduces the application of Intelligent Blood Collection Management System in Guangzhou first-class Hospital,collectis and analyses common systematic problems,to effectively find out the solutions.Materials and methods The patients were divided into control group and observation group before and after the improvement of the countermeasures after the failure of the blood collection system,the reasons and times of the failure were recorded,and the data after the improvement of the countermeasures were taken as the observation group.Results The incidence of various faults in the observation group was significantly lower than that in the control group.Conclusions The introduction of intelligent blood collection system under the background of the construction of smart hospital can help realize the “intelligent service” of blood collection,but in the implementation process,it is necessary to do a good job in the connection of old and new blood collection methods and implement the problem collection and countermeasures.
目的 探讨CT增强延迟扫描技术在非小细胞肺癌术前诊断中的应用价值。方法 对2021年5月—2024年5月商丘市第一人民医院收治的82例非小细胞肺癌手术治疗患者进行回顾性分析,将其分为观察组,另选取82例肺部良性肿瘤患者作为对照组,收集其术前CT增强延迟扫描结果,以术后病理诊断结果为金标准,分析CT增强延迟扫描技术在非小细胞肺癌术前诊断中的应用价值。并对比不同临床病理特征非小细胞肺癌患者CT增强延迟扫描的CT增强值,采用Spearman相关性分析法分析CT增强值与非小细胞肺癌病理特征的关系。结果 CT增强延迟扫描显示观察组患者分叶征(12.50% vs 53.57%)、内部空泡征数量(6.25% vs 39.29%)低于对照组(χ 2 =26.560、24.680,P<0.05),观察组患者边缘毛刺(56.25% vs 17.86%)、胸部凹陷征(59.38% vs 14.29%)、高于对照组(χ 2 =43.330、64.600,P<0.05);82例非小细胞肺癌通过CT增强延迟扫描共确诊79例,CT增强延迟扫描诊断对非小细胞肺癌的准确率为96.34%(79/82),与病理诊断结果100.00%对比差异无统计学意义(χ 2 =3.060,P=0.080);82例非小细胞肺癌平均CT增强值为(39.14±7.31),不同性别、年龄、肿瘤最大直径、淋巴结浸润情况患者CT增强值对比差异无统计学意义(P>0.05),不同病理类型[腺癌(43.75±7.15)vs 鳞癌(34.74±6.12)]、细胞分化程度[中、低分化(45.71±7.21)vs 高分化(32.81±5.11)]、临床分期[Ⅰ期(31.03±2.12)vs Ⅱ期(36.61±3.13)vs Ⅲa期(46.32±6.83)]患者、淋巴结转移[是(42.75±4.21)vs 否(35.77±8.13)]CT增强值对比差异有统计学意义(t/F=5.243、8.804、84.828、4.378,P<0.05);Spearman相关分析结果显示:病理类型、细胞分化程度、临床分期、淋巴结转移与非小细胞肺癌患者CT增强值呈正相关(r=0.431,P=0.021;r=0.511,P=0.009;r=0.586,P=0.005;r=0.579,P=0.008,P<0.05)。结论 CT增强延迟扫描技术对非小细胞肺癌术前确诊具有重要价值,其诊断准确率与病理诊断并无显著差异,且可通过CT增强延迟扫描技术确定患者CT增强值,从而为非小细胞肺癌患者术后病理特征判断提供参考。
Objective To explore the application value of CT enhanced delayed scanning in preoperative diagnosis of non-small cell lung cancer(NSCLC).Methods A retrospective analysis was conducted on 82 patients with NSCLCwho underwent surgical treatment in a hospital from May 2021 to May 2024.They were included into an observation group and another 82 patients with benign lung tumors were included in the control group.The preoperative CT enhanced delayed scanning results were collected,and the postoperative pathological diagnosis was used as the “gold standard” to analyze the application value of CT enhanced delayed scanning in the preoperative diagnosis of NSCLC.And the CT enhancement values of delayed CT scans in NSCLC patients with different clinical and pathological features were compared,and Spearman correlation analysis was used to analyze the relationship between CT enhancement values and pathological features of NSCLC.Results CT enhanced delayed scanning showed that the number of lobular(12.50% vs 53.57%)and internal vacuolar signs(6.25% vs39.29%)in the observation group was significantly lower than that in the control group(χ 2 =26.560,24.680,P<0.05),while the edge spicules(56.25% vs 17.86%)and chest depression signs(59.38% vs 14.29%)in the observation group were significantly higher than that in the control group(χ 2 =43.330,64.600,P<0.05).A total of 79 cases of 82 NSCLC were diagnosed by CT-enhanced delayed scan,and the accuracy of CT-enhanced delayed scan diagnosis for NSCLC was 96.34%(79/82),with no significant difference from the pathological diagnosis result of 100.00%(χ 2 =3.060,P=0.080).The average CT enhancement value of 82 NSCLC cases was(39.14±7.31).There was no significant difference in CT enhancement values among patients of different genders,ages,maximum tumor diameter,and lymph node infiltration(P>0.05).Patients with different pathological types [adenocarcinoma(43.75±7.15)vs squamous cell carcinoma(34.74±6.12)],degree of cell differentiation [moderate,and low differentiation(45.7±7.21)vs high differentiation(32.81±5.11)],clinical stage [I(31.03±2.12)vs II(36.61±3.13)vs IIIa(46.32±6.83)] and lymph node metastasis [yes(42.75±4.21),vs no(35.77±8.13)] CT enhancement had significant difference(t/F=5.243,8.804,84.828,4.378,P<0.05).The Spearman correlation analysis results showed that pathological type,degree of cell differentiation,clinical stage,lymph node metastasis were positively correlated with CT enhancement values in NSCLC patients(r=0.431,P=0.021;r=0.511,P=0.009;r=0.586,P=0.005;r=0.579,P=0.008).Conclusions CT enhanced delayed scanning has important value in preoperative diagnosis of NSCLC.Its diagnostic accuracy is not significantly different from pathological diagnosis,and the CT enhanced value of patients can be determined through CT enhanced delayed scanning,providing reference for postoperative pathological feature judgment of NSCLC patients.
目的 探讨内镜下黏膜切除术患者肠道准备教育程序的优化方法及改善效果。方法 选择2022年12月—2023年12月广州市中西医结合医院接收的内镜下黏膜切除术患者180例进行研究,电脑随机编号按奇偶数分为两组各90例,对照组采取常规肠道准备教育工作,观察组实施基于优化的教育程序展开教育工作,比较两组依从性、肠道准备质量、满意度、不适症状发生情况。结果 观察组饮食依从率96.88%、服药依从率98.44%、运动依从率93.75%,均高于对照组的78.13%、79.69%、71.88%(χ 2 分别为6.172、7.745、7.120,P分别为0.012、0.005、0.007)。观察组左侧、横结肠、右侧等评分及肠道准备质量总分高于对照组(t分别为7.175、6.442、5.971、8.234,均P<0.001)。观察组肠道准备满意度为98.89%,高于对照组的88.89%(χ 2 =7.842,P=0.005)。观察组恶心11.11%、呕吐4.44%、腹胀5.56%、腹痛0.00%,低于对照组的22.22%、13.33%、14.44%、6.67%(χ 2 分别为4.000、4.390、3.950、4.310,P分别为0.045、0.036、0.046、0.037)。结论 对内镜下黏膜切除术患者实施基于优化的教育程序展开肠道准备教育工作可提高患者肠道准备依从性,保证良好的肠道准备质量和肠道清洁度,提高患者的满意度,有助减少肠道不适症状。
Objective To explore the optimization method and improvement effect of bowel preparation education program in patients undergoing endoscopic mucosal resection.Methods A total of 180 patients with endoscopic mucosal resection admitted to the hospital from December 2022 to December 2023 were selected for the study.They were randomly divided into two groups with 90 cases in each group.The control group was given routine bowel preparation education,and the observation group was given education based on optimized education procedures.The compliance,quality of bowel preparation,satisfaction and discomfort symptoms were compared between the two groups.Results The diet compliance rate 96.88%,medication compliance rate 98.44%,exercise compliance rate 93.75% in the observation group were significantly higher than 78.13%,79.69%,71.88% in the control group(χ 2 =6.172,7.745,7.120,P=0.012,0.005,0.007).The scores of left colon,transverse colon and right colon and the total score of bowel preparation quality in the observation group were significantly higher than those in the control group(t=7.175,6.442,5.971,8.234,all P<0.001).The satisfaction of bowel preparation in the observation group(98.89%)was significantly higher than that in the control group(88.89%)(χ 2 =7.842,P=0.005).Nausea 11.11%,vomiting 4.44%,abdominal distension 5.56%,abdominal pain 0.00% in the observation group were significantly lower than 22.22%,13.33%,14.44%,6.67% in the control group(χ 2 =4.000,4.390,3.950,4.310,P=0.045,0.036,0.046,0.037).Conclusions The implementation of bowel preparation education based on optimized education program in patients undergoing endoscopic mucosal resection can improve the compliance of bowel preparation,ensure good quality of bowel preparation and bowel cleanliness,improve patient satisfaction,and reduce the occurrence of intestinal discomfort symptoms,which is worthy of promotion.
目的 探讨便携式超声仪超声重点评估(e-FAST)技术在批量伤员军地联合院前救治中的应用效果。方法 抽取2021年5月—2023年10月中国人民解放军联勤保障部队第九八八医院中心急诊科收治的80例批量伤员,均开展军地联合院前救治,按照治疗方案不同分为观察组和对照组,每组患者40例,其中对照组在救治现场行基于创伤严重程度(CRAMS)评分,进行常规急救处置,救护车返院后行CT检查并进行相应伤情治疗,观察组救治现场行CRAMS评分,进行常规急救处置,院前接诊医师在现场或救护车上使用便携式超声仪按照e-FAST流程检查相应部位,初步诊断后进行相应伤情治疗,对比两组患者治疗效果,两组患者诊断时间、初次医疗接触—进入手术室时间及入院诊断与出院时确定性诊断的符合率、两组患者治疗前后CRAMS评分及CRAMS≤8分抢救成功率。结果 观察组治疗有效率为95.0%,对照组为85.0%,对比差异无统计学意义(χ 2 =2.222,P=0.136);观察组患者的诊断时间(13.56±2.36)min、初次医疗接触—进入手术室时间(30.42±8.99)min均短于对照组[(23.64±5.69)、(52.27±12.60)min],差异有统计学意义(t=10.349、8.928,P<0.05);观察组患者入院诊断与出院时确定性诊断的符合为97.5%,对照组患者入院诊断与出院时确定性诊断的符合为95.0%,差异无统计学意义(χ 2 =0.346,P=0.556);治疗后两组患者的CRAMS评分均升高,且观察组(9.87±2.62)分高于对照组(8.60±2.98)分,差异有统计学意义(t=2.024,P=0.046);观察组患者CRAMS≤8分的抢救成功率为97.50%,对照组CRAMS≤8抢救成功率为85.00%,观察组患者CRAMS≤8分的抢救成功率高于对照组(χ 2 =3.914,P=0.048)。结论 本研究从军地联合救治批量伤员切入,瞄准部队医院军民融合战略发展路线,本文针对便携式超声仪e-FAST应用范围前移,明显地提高急救人员院前救治能力,提高抢救成功率,值得临床参考。
Objective To explore the application effect of portable ultrasound e-FAST technology in the pre hospital treatment of batch wounded soldiers in military civilian joint hospitals.Methods Eighty batch wounded patients admitted to the emergency department of 988 Hospital from May 2021 to October 2023 were selected,all of whom underwent military civilian joint pre hospital treatment.They were divided into an observation group and a control group according to different treatment plans,with 40 patients in each group.The control group received CRAMS scores at the treatment site for routine first aid treatment,CT scans after ambulance return to the hospital for corresponding injury treatment,the observation group received CRAMS scores at the treatment site for routine first aid treatment,and the pre-hospital attending physician used a portable ultrasound instrument to examine the corresponding parts on site or in the ambulance according to the e-FAST process.After preliminary diagnosis,corresponding injury treatment was carried out.The treatment effects of the two groups of patients were compared,and the diagnosis time and initial diagnosis of the two groups of patients were compared.The time from medical contact to entering the operation room,the compliance rate of discharge and admission diagnoses,the CRAMS score before and after treatment,and the success rate of rescue with CRAMS ≤ 8 for both groups of patients were compared.Results The effective rate of treatment in the observation group was 95.0%,while in the control group it was 85.0%,which difference was not statistically significant(χ 2 =2.222,P=0.136).The time to diagnosis(13.56±2.36)min,time to the operating room(30.42±8.99)min were shorter than that in the control group[(23.64±5.69),(52.27±12.60)min],with significant difference(t=10.349,8.928,P<0.05).The consistency between the admission diagnosis and the definitive diagnosis at discharge of the observation group patients was 97.5%,while the consistency of the control group patients was 95.0%.There was no significant difference between the groups(χ 2 =0.346,P=0.556).After treatment,the CRAMS scores of both groups of patients increased,the observation group(9.87±2.62)was higher than that of the control group(8.60±2.98)(t=2.024,P=0.046).The success rate of CRAMS ≤ 8 rescue in the observation group was 97.50%,while the success rate in the control group was 85.00%.The success rate of CRAMS ≤ 8 rescue in the observation group was higher than that in the control group(χ 2 =3.914,P=0.048).Conclusions This study focuses on the joint treatment of batch wounded soldiers by military and civilian forces,aiming at the development path of military civilian integration strategy in military hospitals.The application scope of portable ultrasound e-FAST has been moved forward,which significantly improves the pre hospital treatment ability of emergency personnel and improves the success rate of rescue.It is worth clinical reference.
目的 探讨自行设计教育路径在非内分泌科糖尿病患者同质化管理中的应用效果。方法 采用时间分段法将200例非内分泌科住院糖尿病患者分为对照组和研究组各100例,对照组所在非内分泌科各科室责任护士在糖尿病联络护士指导下进行糖尿病常规健康教育,研究组自行设计非内分泌科糖尿病健康教育路径并实施同质化管理,观察比较两组患者糖尿病知识知晓程度、血糖水平、自我管理能力、护理满意度。结果 出院时研究组患者密西歇根糖尿病知识测试问卷(DKT)评分(18.37±3.06)分,对照组为(16.01±3.59)分,研究组高于对照组(t=5.004,P<0.05);管理6个月空腹血糖(FBG)、餐后2h血糖(2hPBG)、糖化血红蛋白(HbAlc)分别为[7.00(7.00,8.00)]mmol/L、[8.00(6.00,9.00)]mmol/L、[7.50(6.00,8.00)]%,对照组分别为[8.00(7.00,10.00)]mmol/L、[9.00(8.00,11.00)]mmol/L、[8.00(7.00,9.00)]%,研究组均低于对照组(Z=6.398、5.248、3.034,均P<0.05);研究组糖尿病自我管理能力行为量表(SDSCA-6)评分、纽卡斯尔护理满意度量表(NNSS)评分分别为(35.36±4.75)分、(83.42±6.92)分,对照组分别为(30.90±7.56)分、(72.31±9.26)分,研究组均高于对照组(t=4.998、9.614,均P<0.05)。结论 糖尿病教育路径结合同质化管理能提高非内分泌科住院糖尿病患者糖尿病知识的掌握程度,有效控制血糖水平,提高患者自我管理能力和对护理工作满意度。
Objective To explore the application effect of self-designed education path in homogenization management of non-endocrinology diabetic patients.Methods A total of 200 inpatients with diabetes in non-endocrinology departments were divided into control group and research group with 100 cases in each group.The responsible nurses in the non-endocrinology departments of the control group conducted routine diabetes health education under the guidance of diabetes liaison nurses.The research group designed its own non-endocrinology diabetes health education path and implemented homogenized management.The knowledge level of diabetes mellitus,blood sugar level,self-management ability and nursing satisfaction of the two groups were observed and compared.Results At discharge,the DKT score of the study group was(18.37±3.06) and that of the control group was(16.01±3.59),which was higher than that of the control group(t=5.004,P<0.05).After 6 months management,FBG,2 HPBG and HbAlc of study group were[7.00(7.00,8.00)] mmol/L,[8.00(6.00,9.00)] mmol/L,[7.50(6.00,8.00)]%,respectively,while those in the control group was[8.00(7.00,10.00)]mmol/L,[9.00(8.00,11.00)]mmol/L and[8.00(7.00,9.00)]%,respectively.The study group was lower than the control group(Z=6.398,5.248,3.034,all P<0.05).SDSCA-6 scores and NNSS scores in the study group were(35.36±4.75)scores and(83.42±6.92)scores,respectively,while those in the control group were(30.90±7.56)scores and(72.31±9.26)scores,which were higher in the study group than in the control group(t=4.998,9.614,all P<0.05).Conclusions The combination of diabetes education pathway and homogenized management can improve the mastery of diabetes knowledge,effectively control blood sugar level,improve patients’ self-management ability and satisfaction with nursing work.
目的 探讨盐酸达泊西汀联合达克罗宁胶浆治疗早泄的临床疗效。方法 选取男科门诊146例早泄患者,随机分组,对照组服用达泊西汀片,研究组为达泊西汀片和达克罗宁胶浆联合治疗,再将研究组分为阴茎头敏感度高组和敏感度正常组,记录各组治疗前、治疗8周后早泄相关指标。结果 治疗后对照组阴道内射精潜伏期(IELT)、早泄诊断量表(PEDT)和早泄指数量表(IPE)中Q6+Q7分别为(4.68±2.79)、(9.52±2.14)、(6.48±1.30),研究组IELT、PEDT和Q6+Q7分别为(6.09±3.09)、(7.52±1.92)、(7.85±1.36),各组相关指标均较治疗前改善(P<0.05),研究组各指标改善程度优于对照组(P<0.05);治疗后敏感度高组IELT、PEDT和Q6+Q7分别为(6.76±2.99)、(6.84±1.53)、(8.16±1.10),敏感度正常组IELT、PEDT和Q6+Q7分别为(5.13±3.02)、(8.50±2.03)、(7.40±1.59),敏感度高组各指标改善程度优于敏感度正常组(P<0.05);对照组、研究组总有效率分别为69.86%(51/73)、84.93%(62/73),研究组治疗效果优于对照组(P<0.05);敏感度高组、敏感度正常组总有效率分别为93.02%(40/43)、73.33(22/30),敏感度高组治疗效果优于敏感度正常组(P<0.05)。结论 达泊西汀联合达克罗宁胶浆治疗早泄效果显著,阴茎头敏感患者联合达克罗宁胶浆治疗受益更大。
Objective To investigate the clinical efficacy of dapoxetine hydrochloride combined with dclonine mucilage in the treatment of premature ejaculation.Methods A total of 146 patients from andrology department with premature ejaculation were selected and randomly divided into control group and research group.The control group was treated with dapoxetine alone,while the research group was treated with dapoxetine combined with dacronine mucilage.The research group was divided into high sensitivity group and normal sensitivity group.The indexes related to premature ejaculation were recorded before treatment and 8 weeks after treatment.Results After treatment,intravaginal ejaculatory latency time(IELT),Premature Ejaculation Diagnosis Tool(PEDT)and Q6+Q7 of the index of premature ejaculation(IPE)in control group were(4.68±2.79),(9.52±2.14)and (6.48±1.30),respectively,while IELT,PEDT and Q6+Q7 in research group were(6.09±3.09),(7.52±1.92) and (7.85±1.36),respectively.The relevant indexes in all groups were significantly improved compared with those before treatment(P<0.05),and the improvement of all indexes in research group was better than that in control group(P<0.05).After treatment,IELT,PEDT and Q6+Q7 in the highly sensitivity group were(6.76±2.99),(6.84±1.53)and(8.16±1.10),respectively,while IELT,PEDT and Q6+Q7 in the normal sensitivity group were(5.13±3.02),(8.50±2.03)and(7.40±1.59),respectively.The improvement of all indexes in the high sensitivity group was better than that in the normal sensitivity group(P<0.05).The total effective rate of the control group and the research group was 69.86%(51/73)and 84.93%(62/73),respectively.The therapeutic effect of the research group was significantly better than that of the control group(P<0.05).The total effective rate of the high sensitivity group and the normal sensitivity group was 93.02%(40/43)and 73.33%(22/30),respectively.The therapeutic effect of the high sensitivity group was significantly better than that of the normal sensitivity group(P<0.05).Conclusions Dapoxetine combined with dacronine mucilage has significant effect in the treatment of premature ejaculation,and the patients with high sensitivity of penile head will benefit more from combined dacronine mucilage therapy.
目的 探究经鼻间歇正压通气(NIPPV)和经鼻持续正压通气(NCPAP)作为早产儿呼吸窘迫综合征气管插管机械通气拔管后无创呼吸支持过渡的临床效果的差异。方法 纳入2021年1月—2023年6月在广东省吴川市妇幼保健计划生育服务中心治疗的新生儿呼吸窘迫综合征早产儿66例,用随机数字表法将患儿分为NIPPV组(33例)和NCPAP组(33例)。NIPPV组患儿予经鼻间歇正压通气作为过渡期无创呼吸支持,NCPAP组患儿则予以经鼻持续正压通气作为过渡期无创呼吸支持。对比两组患儿治疗前后血气分析结果、脱机失败率、无创呼吸支持时间、无创后吸氧时间、总给氧时间等指标。结果 接受无创呼吸支持12 h后,NIPPV组患儿的PaO2升至(76.46±1.10)mmHg,高于NCPAP组患儿的(75.51±2.15)mmHg(t=2.249,P=0.028)。此外,NIPPV组患儿的SaO2升至(96.36±0.52)%,也高于NCPAP组患儿的(96.07±0.59)%(t=2.138,P=0.034)。而NIPPV组患儿的PaCO2则降至(41.39±0.74)mmHg,较NCPAP组患儿的(41.87±0.95 )mmHg低(t=-2.230,P=0.025)。NIPPV组无创呼吸支持时间为(3.09±0.52)d,短于NCPAP组的(3.45±0.62)d,且该差异有统计学意义(t=2.584,P=0.012)。同样的,NIPPV组总给氧时间(9.52±0.76)天较NCPAP组的(10.00±0.79)天短,且该差异有统计学意义(t=-2.548,P=0.013)。而两组在脱机失败率、无创呼吸支持后吸氧时间、不良反应发生率等方面比较差异无统计学意义(均P>0.05)。结论 与NCPAP模式相比,早产儿拔管后应用NIPPV模式进行无创呼吸支持取得的临床效果更优。
Objective To explore the difference of clinical effect of nasal intermittent positive pressure ventilation(NIPPV)and nasal continuous positive pressure ventilation(NCPAP)as non-invasive respiratory support mode after extubation in preterm infants with endotracheal intubation.Methods Sixty-six cases of preterm infants with neonatal respiratory distress syndrome treated in our hospital from January 2021 to June 2023 were included.All the subjects were randomly divided into NIPPV group(n=33)and NCPAP group(n=33).The blood gas analysis results,weaning failure rate,non-invasive respiratory support time,oxygen inhalation time after noninvasive ventilation,total oxygen administration time.were compared between the two groups.Results After 12 hours of noninvasive respiratory support,PaO2 in the NIPPV group increased to(76.46±1.10)mmHg,which was significantly higher than that(75.51±2.15)mmHg in the NCPAP group(t=2.249,P=0.028).In addition,SaO2 in the NIPPV group increased to (96.36±0.52)%,which was also significantly higher than that(96.07±0.59)% in the NCPAP group(t=2.138,P=0.034).The PaCO2 in the NIPPV group decreased to (41.39±0.74)mmHg,which was lower than that(41.87±0.95)mmHg in the NCPAP group(t=-2.230,P=0.025).The duration of non-invasive respiratory support in the NIPPV group(3.09±0.52) days was shorter than that(3.45±0.62)days in the NCPAP group,and the difference was statistically significant(t=2.584,P=0.012).Similarly,the total duration of oxygen administration in the NIPPV group(9.52±0.76)days was shorter than that(10.00±0.79)days in the NCPAP group,and the difference was statistically significant(t=-2.548,P=0.013).There were no significant differences in weaning failure rate,oxygen inhalation time after noninvasive respiratory support,and incidence of adverse reactions between the two groups(P>0.05).Conclusions Compared with NCPAP mode,NIPPV mode for non-invasive respiratory support in preterm infants after extubating has better clinical effect,and it is worthy of clinical application.
目的 探讨复方黄芪颗粒(CHG)的抗疲劳作用及其机制。方法 48只雄性BALB/C小鼠随机分为空白对照组、低剂量(9.1 g/kg)、中剂量(18.2 g/kg)、高剂量(27.3 g/kg)CHG 3个试验组,每组12只。试验组给予不同剂量的复方黄芪颗粒溶液灌胃,空白对照组小鼠给予等体积生理盐水。给药30 d后,检测小鼠体内相关指标变化,观察其抗疲劳作用并分析相关机制。结果 与空白对照组相比,试验组小鼠体质量差异无统计学意义(P>0.05),小鼠力竭游泳时间及转棒耐力时间均明显延长(P<0.01),血尿素氮(BUN)、乳酸脱氢酶(LDH)、丙二醛(MDA)水平明显降低(P<0.01),肝糖原和肌糖原水平升高(P<0.05),超氧化物歧化酶(SOD)活性升高(P<0.01)。体外抗氧化试验表明CHG以剂量依赖性方式清除2,2-联氮-二(3-乙基-苯并噻唑-6-磺酸)二铵盐(ABTS)和1,1-二苯基-2-三硝基苯肼(DPPH)自由基。当CHG质量浓度为100.000 0 mg/mL时,CHG对DPPH自由基清除能力可达85.030 3%。当CHG质量浓度为25.000 0 mg/mL时,CHG对ABTS自由基清除能力可达96.357 2%。结论 CHG具有抗疲劳的作用,其作用机制可能与抗氧化作用相关。
Objective To investigate the anti-fatigue effects of compound Huangqi granules(CHG)and its mechanism.Methods Forty-eight male BALB/C mice were randomly divided into blank control group,9.1,18.2,27.3 g/kg CHG group(test groups).The test groups received different concentrations of CHG solution by gavage,and the blank control group mice were given equal volume saline.After 30 days of administration,the mice were tested,meanwhile the anti-fatigue effect and mechanism were investigated.Results Compared with blank control group,there was no significant difference in body weight(P>0.05).The exhaustive swimming time and rod turning endurance time of mice were significantly prolonged(P<0.01).The serum levels of blood urea nitrogen,lactate dehydrogenase and malondialdehyde were significantly decreased(P<0.01),while the liver and muscle glycogen levels(P<0.05)and superoxide dismutase activity were increased(P<0.01).In vitro antioxidant tests showed that CHG can remove (1,1-Diphenyl-2-picrylhydrazyl,ABTS) and (2,2’-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid,DPPH) free radicals in a dose-dependent manner.When the CHG concentration is 100 mg/mL,the DPPH free radical scavenging ability of CHG can reach 85.030 3%.When the CHG concentration was 25 mg/mL,the scavenging ability of CHG to ABTS free radicals reached 96.357 2%.Conclusions CHG has anti-fatigue effect,and its mechanism may be related to anti-oxidation effect.
目的 探讨分析超声引导下胸膜活检(USPB)联合胸腔积液检验对于临床确诊结核性胸膜炎的应用价值。方法 选取2021年6月—2023年6月广州市胸科医院收治的96例临床诊断为结核性胸膜炎(渗出性胸膜炎)的患者为研究对象,分别使用胸腔积液检验(包含胸腔积液腺苷脱氨酶及细菌培养)、USPB、两者联合三种方法诊断,计算其准确率、特异度及灵敏度并进行分析。结果 胸腔积液诊断准确率73.96%、灵敏度72.84%,USPB诊断准确率为85.42%、灵敏度82.71%,两者联合诊断准确率为88.54%,灵敏度90.12%,较胸腔积液检验单独诊断准确率及灵敏度明显升高(P<0.05),胸腔积液、USPB、两者联合诊断特异度差异(P>0.05)无统计学意义。结论 USPB联合胸腔积液检验对结核性胸膜炎的确诊具有较高临床价值。
Objective To investigate the value of ultrasound-guided pleural biopsy(USPB)combined with pleural effusion test in the diagnosis of tuberculous pleurisy.Methods A total of 96 patients with tuberculous pleurisy(exudative pleurisy)admitted to the Guangzhou Chest Hospital from June 2021 to June 2023 were selected.The accuracy,specificity,and sensitivity of pleural effusion test(including adenosine deaminase and bacterial culture),USPB,and their combination were calculated and analyzed.Results The diagnostic accuracy of pleural effusion was 73.96% and the sensitivity was 72.84%.The diagnostic accuracy of USPB was 85.42% and the sensitivity was 82.71%.The diagnostic accuracy 88.54% and sensitivity 90.12% of USPB combined with pleural effusion test were significantly higher than that of pleural effusion alone(P<0.05),but there was no significant difference in the diagnostic specificity of pleural effusion,USPB and combination of them(P>0.05).Conclusions USPB combined with pleural effusion test has high clinical value in the diagnosis of tuberculous pleurisy.
目的 比较宫腔镜病灶切除术与超声监测下吸宫术治疗剖宫产瘢痕部位妊娠(CSP)的有效性。方法 回顾性分析2021年7月—2023年10月在南宁市妇幼保健院确诊为I、Ⅱ型CSP并接受治疗的129例患者,停经时间在38~83 d,中位停经时间48 d。其中42例患者接受了宫腔镜病灶切除术治疗(A组),87例患者接受超声监测下吸宫术治疗(B组),比较两组患者术后1、3、7、14 d的人绒毛膜促性腺激素水平以及手术出血量、手术时间、住院时间、住院花费。结果 两组患者在术后1 d,血清HCG水平下降,下降幅度均超过50%,且A组患者术后1 d血清HCG的下降幅度及下降速率大于B组患者(P<0.05);术后3、7、14 d,两组血清HCG水平仍持续下降。另外,A组患者手术出血量、手术时间、住院时间、住院花费分别为(15.35±14.53)mL、(60.73±53.05)min、(4.33±1.90)d、(6 689.23±2 216.19)元;B组患者手术出血量、手术时间、住院时间、住院费用分别为(26.09±29.24)mL、(51.59±54.46)min、(4.82±1.83)d、(6 270.34±2 547.85)元。A组患者术中出血量低于B组、住院时间短于B组(P<0.05),手术时间及住院费用与B组比较差异无统计学意义(P均>0.05)。结论 宫腔镜病灶切除术与超声监测下吸宫术均能有效治疗CSP,但宫腔镜病灶切除术在术后血清HCG的下降幅度及下降速率、术中出血量、住院时间等方面优于超声监测下吸宫术,而且手术时间和住院费用并没有显著增加。
Objective To compare the efficacy between hysteroscopic resection surgery and ultrasound-guided uterine aspiration in the treatment of cesarean scar pregnancy(CSP).Methods A retrospective analysis was performed in 129 patients diagnosed with CSP(type I or Ⅱ)and treated in Nanning Maternal and Child Health Hospital from July 2021 to October 2023.Their duration of amenorrhea was between 38~83 d,with a median of 48 days.Among them,42 patients were treated with hysteroscopic resection surgery therapy(group A),87 patients were treated with ultrasound-guided uterine aspiration therapy and(group B).Then,the levels of human chorionic gonadotropin(HCG),the amount of the intraoperative bleeding volume,surgical time,hospitalization time,and hospitalization expenses were compared between the two groups at one,three,seven and 14 days postoperativey.Results After one day of surgery,the serum HCG levels of two groups significantly decreased,with a decrease of more than 50%,and the magnitude and rate of decrease in serum HCG levels of group A were significantly larger than those of group B(P<0.05);After three,seven,and 14 day of surgery,serum HCG levels continued to decrease.Furthermore,the intraoperative bleeding volume,surgical time,hospitalization time,hospitalization expenses in group A were(15.35±14.53)mL,(60.73±53.05)min,(4.33±1.90)d,(6 689.23±2 216.19)yuan,respectively.That in group B were(26.09±29.24)mL,(51.59±54.46)min,(4.82±1.83)d,(6 270.34±2 547.85)yuan,respectively.Compared to group B,the intraoperative bleeding volume of group A was significantly lower(P<0.05),and the hospitalization time is shorter,while there was no significant difference in surgical time and hospitalization expenses.Conclusions Both of hysteroscopic resection surgery and ultrasound-guided uterine aspiration can treat cesarean scar pregnancy effectively,but the former is superior to the latter in terms of the magnitude and rate of decrease in serum HCG levels after surgery,intraoperative bleeding volume,and hospitalization time,with no significant increase in surgical time and hospitalization expenses.