目的 研究慢性非特异性腰痛患者腰椎正侧位X线中腰椎侧弯、L1-5棘突偏歪和椎体滑脱情况,总结规律,为慢性非特异性腰痛患者治疗提供依据。方法 选取164例慢性非特异性腰痛患者,观察并记录每例患者腰椎正侧位X线中腰椎侧弯、L1~L5棘突偏歪和椎体滑脱情况。用统计学软件分析腰椎侧弯、棘突偏歪和椎体滑脱情况。结果 共有59例发生腰椎侧弯,占35.98%,其中Cobb角5°~10 °有47例,占28.66%;Cobb角>10°有12例,占7.32%。腰椎侧弯发病以L4为下端椎为主。以L3为下端椎有12例患者,占20.34%;以L4为下端椎有37例患者,占62.71%;以L5为发椎有10例患者,占16.95%。共119例发生棘突偏歪,占总例数的72.56%。L5棘突偏歪最常见,发生率为57.93%;L4次之,发生率为48.17%。L5棘突偏歪率与L1~L3棘突偏歪率比较差异均有统计学意义(χ 2 分别为14.580,11.771,7.484,P分别为<0.001,0.001,0.006),但与L4棘突偏歪率比较差异无统计学意义(χ 2 =3.124,P=0.077)。共30例患者存在椎体滑脱,占18.29%。L5最常发生滑脱,发生率为8.54%;L4次之,发生率为7.93%。L4与L5椎体滑脱率比较差异无统计学意义(χ 2 =0.040,P=0.841);L4分别与L1,L2,L3以及L5分别与L1,L2,L3椎体滑脱率差异均有统计学意义(L5与L1、L2、L3:χ 2 分别为14.580、11.771、7.484,P分别为<0.001、0.001、0.006;L4与L1、L2、L3:χ 2 分别为13.495、10.712、6.550,P分别为<0.001、0.001、0.010)。结论 慢性非特异性腰痛患者较常发生腰椎侧弯,侧弯以L4为下端椎为主;慢性非特异性腰痛患者较常发生棘突偏歪,L5棘突偏歪最常见,L4次之;L5和L4是慢性非特异性腰痛患者最常发生滑脱的椎体。在治疗慢性非特异性腰痛患者时,与L5和L4相关的肌肉、筋膜等软组织损伤以及关节退行性变或紊乱应引起重点关注。
Objective To study the lumbar scoliosis,L1-5 spinous process deviation and spondylolisthesis in spine X-ray of patients with chronic non-specific low back pain(CNLBP),and summarizing the existing rules,so as to provide imaging theoretical support for the treatment of CNLBP.Methods A total of 164 patients with CNLBP were selected.The lumbar scoliosis,L1-5 spinous process deviation and spondylolisthesis were observed and recorded in the anteroposterior and lateral X-ray films of each patient.The lumbar scoliosis,spinous process deviation and spondylolisthesis were statistically analyzed by statistical software.Results A total of 59 people had lumbar scoliosis,accounting for 35.98%.There were 47 patients with 5°-10° Cobb angle,accounting for 28.66%.There were 12 patients with Cobb angle >10°,accounting for 7.32%.L4 was the main lower apical vertebra of lumbar scoliosis.There were 12 patients with L3 as the lower apical vertebra,accounting for 20.34%;37 patients with L4 as the lower apical vertebra,accounting for 62.71%;10 patients with L5 as the lower apical vertebra,accounting for 16.95%.A total of 119 people appeared spinous process deviation,accounting for 72.56%.L5 spinous process deviation was the most common,with proportion of 57.93%,and L4 was the second,with proportion of was 48.17%.The results of chi-square test showed that there were significant differences between L5 and L1-L3 spinous process deviation(χ 2 was 14.580,11.771,7.484,and P values were <0.001,0.001,0.006 respectively),but no significant difference between L5 and L4 spinous process(χ 2 =3.124,P=0.077).A total of 30 patients had spondylolisthesis,accounting for 18.29%.L5 was the most common of spondylolisthesis,with an occurrence rate of 8.54%.L4 was the second,with an occurrence rate of 7.93%.There was no significant difference in spondylolisthesis rate between L4 and L5(χ 2 =0.040,P=0.841).The spondylolisthesis rates of L4 and L5 were significantly different from those of L1,L2 and L3(L5 and L1,L2,L3:χ 2 was 14.580,11.771,7.484,and P values was <0.001,0.001,0.006 respectively;L4 and L1,L2,L3:χ 2 was 13.495,10.712,6.550,P values were <0.001,0.001,0.010 respectively).Conclusions Lumbar scoliosis is more common in patients with CNLBP,and L4 is the main lower apical vertebra of lumbar scoliosis.Patients with CNLBP often have spinous process deviation,and the most common is L5 spinous process deviation,followed by L4.L5 and L4 are the most common vertebrae with spondylolisthesis in patients with CNLBP.The soft injury and joint degeneration or disorder related to L5 and L4 should be paid more attention in the treatment of patients with CNLBP.
目的 评价血塞通联合右美托咪定对脑缺血再灌注损伤大鼠的脑保护效果。方法 选择老龄雄性Wistar大鼠50只,随机分为假手术(C)组、脑缺血再灌注(R)组、血塞通(P)组、右美托咪定(D)组,血塞通联合右美托咪定(PD)组,每组各10只。根据组别给予不同药物,行神经行为学测试;于第3、7天,测量脑梗死面积、脑水含量,以及超氧化物歧化酶(Superoxide dismutase,SOD)、谷胱甘肽过氧化酶(Glutathione peroxidase,GSH-PX)活性测定。结果 给药后第3、5、7天,与P、D组相比,PD组神经行为学评分改善更加显著(P<0.001);给药后第3、7天,与P组相比,PD组脑梗死面积、脑水含量均降低(P=0.01,P=0.002),SOD、GSH-PX活性升高显著(P=0.03,P=0.001);与D组相比,PD组脑梗死面积、脑水含量也显著降低(P<0.01,P=0.008);SOD、GSH-PX活性升高显著(P=0.009,P<0.001)。结论 血塞通联合右美托咪定较单独应用药物,能显著减轻缺血再灌注损伤造成的脑损害,具有脑保护作用。
Objective To explore the effects of Xuesaitong combined with dexmedetomidine on cerebral ischemia-reperfusion in elderly rats.Methods Fifty elderly male Wistar rats were randomly divided into 5 groups:sham operation(C)group,cerebral ischemia-reperfusion(R)group,Xuesaitong(P)group,dexmedetomidine(D)group,Xuesaitong combined with dexmedetomidine(PD)group.Xuesaitong was given in group P,dexmedetomidine was given in group D,and normal saline was given in group C and group R,continuously for 7 days.After 3- and 7-day treatment,the brain of rats was dissected out to assay the area of cerebral infarction,degree of cerebral edema,superoxide dismutase(SOD) and glutathione peroxidase(GSH-PX) activity.Results When compared PD group with P and D group,neurobehavioral score was lower at 3,5,7 day(P<0.001);area of cerebral infarction,degree of cerebral edema were less(P=0.01,P=0.002),activity of SOD and GSH-PX were higher at 3,7 days(P=0.03,P=0.001)respectively.When compared PD group with D group,area of cerebral infarction,degree of cerebral edema were less(P<0.01,P=0.008),activity of SOD and GSH-PX were higher at 3,7 days(P=0.009,P<0.001)respectively.Conclusions The combination of Xuesaitong and dexmedetomidine can obviously reduce the damage by cerebral ischemia-reperfusion in elderly rats and has brain protective effects.
目的 对入住重症监护病房(ICU)重症孕产妇患者的病种特征和住院费用进行分析。方法 从医院信息管理系统中搜索2009—2019年广州市某省级重症孕产妇救治中心ICU的重症孕产妇住院病例,对病例资料进行描述性流行病学分析。结果 2009—2019年该救治中心ICU共收治重症孕产妇1 616例,病种排名前五位依次为心血管疾病430例(26.61%)、血液及造血器官疾病310例(19.18%)、妊娠期特定并发疾病287例(17.76%)、消化系统疾病218例(13.49%)、呼吸系统疾病110例(6.81%)。患者经济负担中位数排名前五位依次为肌肉骨骼系统和结缔组织疾病(62 252.60元)、消化系统疾病(61 684.41元)、感染性疾病(42 945.70元)、血液及造血器官疾病(40 403.52元)、神经系统疾病(40 055.93元)。结论 入住ICU内的重症孕产妇以心血管疾病、血液及造血器官疾病为主,经济学分析表明肌肉骨骼系统和结缔组织疾病造成的经济损失较大。
Objective To analyze the disease characteristics and hospitalization expenses of severe maternal patients in intensive care unit(ICU).Methods Hospitalized cases of severe maternal disease in ICU of a provincial critical care center in Guangzhou from 2009 to 2019 were searched from the hospital information management system,and case data was analyzed by descriptive epidemiology.Results From 2009 to 2019,a total of 1616 critically ill maternal patients received intensive care treatment at this center.The predominant diseases observed were cardiovascular disorders(26.61%),blood and hematopoietic organ diseases(19.18%),specific pregnancy-related complications(17.76%),gastrointestinal ailments(13.49%),and respiratory disorders(6.81%).Among the top five patient groups,the median economic burden was the highest in musculoskeletal system and connective tissue diseases(62 252.600 yuan),followed by digestive system diseases(61 684.410 yuan),infectious diseases(42 945.700 yuan),blood and hematopoietic organ diseases(40 403.515 yuan),and nervous system disorders(40 055.930 yuan)Furthermore,a discernible correlation between hospitalization cost and length of stay was identified.Conclusions Cardiovascular diseases and disorders of blood and hematopoietic organs are the primary causes for maternal admissions to ICU.Economic analysis shows that musculoskeletal system and connective tissues diseases cause bigger economic loss .
目的 探讨出生胎龄<37周早产儿发生败血症时的临床特征及其不良结局的危险因素。方法 收集2020年1月—2023年12月安徽医科大学第一附属医院本部新生儿科收治出生胎龄<37周且发生败血症早产儿的临床资料;根据败血症发生时间分为早发型败血症(EOS)49例,晚发型败血症(LOS)150例;根据是否出现不良结局,分为结局不良组90例,结局良好组109例。分析EOS和LOS败血症的临床特征,并采用多因素Logistic回归分析早产儿败血症出现不良结局的危险因素。结果 早产儿败血症中EOS患儿出生胎龄更小,生后1 min Apgar评分更低,孕母羊水污染、胎膜早破≥18 h发生率较LOS更高(P<0.05);早产儿败血症临床表现无特异性,但LOS患儿休克发生率更高(P<0.05);早产儿易发生革兰阴性菌感染,合并先天性心脏病(OR=2.490,P<0.05)、出生胎龄<30周(OR=4.851,P<0.05)、出生体质量小于1 500 g(OR=4.169,P<0.05)是早产儿败血症发生不良结局的危险因素。结论 早产儿败血症临床表现无特异性,更易发生革兰阴性菌感染,出生胎龄越小、体质量越低发生不良结局的风险更高。
Objective To analyze the clinical characteristics and risk factors of adverse outcomes of sepsis in premature infants with gestational age < 37 weeks.Methods Clinical data of preterm infants < 37 weeksof gestational age admitted to the Department of Neonatology of the First Affiliated Hospital of Anhui Medical University from January 2020 to December 2023 were collected.According to the timing of sepsis,49 cases with early-onset sepsis(EOS)and 150 cases with late-onset sepsis(LOS)were diagnosed.According to the outcome,90 cases were divided into the adverse outcome group and 109 cases were good outcome group.The clinical characteristics of EOS and LOS were analyzed,and the risk factors of adverse outcomes were analyzed by multivariate logistic regression.Results The gestational age of EOS infants was smaller at birth,the 1 minute Apgar score was lower ,and the incidence of amniotic fluid contamination and premature rupture of membranes ≥18h were higher than those in LOS infants(P<0.05).The clinical manifestations of sepsis in premature infants were not specific,but the incidence of shock was higher in LOS children(P<0.05).Preterm infants were more likely to develop gram-negative bacterial infection,congenital heart disease(OR=2.490,P<0.05),gestational age <30 weeks(OR=4.851,P<0.05),and birth weight < 1 500 g(OR=4.169,P<0.05)were identified as significant risk factors for adverse sepsis outcomes in preterm infants.Conclusions The clinical manifestations of septicemia in preterm infants are non-specific,and they are more likely to suffer from gram-negative bacterial infection.The younger the gestational age and lower the birth weight of preterm infants,the higher the risk of adverse outcomes after sepsis.
无创正压通气的使用是患者发生鼻面部压力性损伤的重要原因之一,随着我国防控政策的放开,新增老年新冠感染患者急剧增加。文章对使用无创正压通气发生相关压力性损伤现状进行综述,介绍老年患者使用无创正压通气发生鼻面部压力性损伤的主要影响因素、评估方法以及预防措施现状,旨在为临床医务人员预防其相关压力性损伤提供参考。
The use of non-invasive positive pressure ventilation is one of the important reasons for nasal and facial pressure injuries in patients.With the release of China's epidemic prevention policy,the number of new elderly patients with COVID-19 has increased dramatically.This paper summarizes the current situation of stress injuries caused by noninvasive positive pressure ventilation,introduces the main influencing factors,evaluation methods and prevention measures of nasal and facial stress injuries in elderly patients with noninvasive positive pressure ventilation,aiming to provide a reference for clinical medical personnel to prevent their related stress injuries.
运动可以调节机体代谢,预防和治疗由糖脂代谢紊乱所引发的心血管疾病。运动因子是在运动过程中,由肌肉、脂肪以及肝脏等多个组织合成和分泌的一系列生物活性物质,包括蛋白质和多肽类分子、小分子代谢物以及核酸等。诸多研究证实,运动因子是运动调节机体代谢的重要因素之一,也是机体从运动中获益的关键分子机制。近年来,随着蛋白质组学、代谢组学以及高通量测序等相关技术的飞速发展,越来越多的运动因子被陆续发现和证实。这不仅拓宽了人们对机体从运动中获益相关机制的认知,还激发了人们对运动因子在健康领域应用前景的浓厚兴趣。文章系统地阐述了运动因子对机体心血管系统的影响,旨在揭示运动因子在促进心血管健康以及治疗心血管疾病等方面的积极效用。
Exercise can prevent and treat cardiovascular diseases resulting from the metabolic disorders of glucose and lipid.Exerkines are defined as a series of bioactive substances in response to exercise including proteins,peptides,small molecular metabolites and nucleic acids.Multiple tissues can produce exerkines,such as skeletal muscle,adipose tissue,and liver.Many studies indicate that exerkines play essential roles in improving glucose and lipid metabolism,which are crucial to harness the health-related benefits mediated by exercise.In recent years,with the progression of proteomics,metabolomics and high-throughput sequencings,an increasing number of exerkines are discovered.These findings expand the research on beneficial effects of exercise and draw attention to the clinical implications of exerkines.This review aims to explore the influence of exerkines on cardiovascular system and reveal their potential roles in the prevention and treatment of cardiovascular disease.
目的 分析护生死亡态度的潜在类别及其影响因素,为开设符合我国国情的死亡教育课程提供参考。方法 采用便利抽样法,选取唐山市高校护生为调查对象。采用一般资料调查表、死亡态度描绘量表进行调查,基于潜在剖面分析护生死亡态度的类别及不同类别的影响因素。结果 共发放问卷520份,回收问卷516份,回收率为99.23%,剔除无效问卷11份,有效回收率为97.87%。护生死亡态度描绘量表得分为(96.91±13.20)分,经过剖面分析可划分为死亡态度积极-自然接受型(63.60%)和死亡态度消极-恐惧死亡型(36.40%)2个潜在类别。Logistic回归分析结果显示,陪伴临终亲友、未接触过死亡相关场所、半年内有亲友离世的护生属于死亡态度消极-恐惧死亡型的概率较大,自身性格偏外向、研究生学历的护生属于死亡态度积极-自然接受型的概率较大(均P<0.05)。结论 护生死亡态度存在明显的分类特征,可分为死亡态度积极-自然接受型和死亡态度消极-恐惧死亡型2个潜在类别;相关院校可针对不同类别特征的护生开设死亡教育相关课程,以期帮助护生更深刻地认识死亡,树立科学死亡观。
Objective To analyze the potential categories and influencing factors of nursing students’ death attitude,to provide reference for setting up death education courses in line with China’s situation.Methods Convenient sampling method was used to select nursing students in Tangshan.General data questionnaire and death attitude description scale were used to investigate the categories of nursing students’ death attitude and their influencing factors based on latent profiles.Results A total of 520 questionnaires were sent out and 516 were collected with a rate of 99.23%.Eleven invalid questionnaires were excluded with an effective rate of 97.87%.The score of the death attitude description scale of nursing students was(96.91±13.20),which could be divided into two potential categories:positive death attitude - natural acceptance type(51.49%)and negative death attitude - fear type(48.51%)after profile analysis.Logistic regression analysis showed that nursing students who accompanied their dying relatives and friends,had no visit to death-related places,and had relatives and friends who died within six months had a higher probability of negative death attitude - fear of death,while nursing students with extrovert personality and graduate degree had a higher probability of positive death attitude - natural acceptance(all P<0.05).Conclusions There were obvious classification characteristics of nursing students’ attitude towards death,which can be divided into two latent categories:positive attitude towards death - natural acceptance type and negative attitude towards death - fear type.Relevant colleges and universities can set up death education courses for nursing students with different characteristics,in order to help nursing students have a deeper understanding of death and establish a scientific view of death.
目的 探讨电子计算机断层扫描(CT)增强碘对比剂急性不良反应发生及影响因素分析。方法 选取天津市肿瘤医院空港医院2020年10月—2023年10月收治的100例行CT增强出现碘对比剂急性不良反应的患者进行回顾性分析,将其分为观察组,另选取同期在我院行CT增强检查未发生不良反应的100例患者作为对照组。分析观察组患者碘对比剂急性不良反应情况,对比两组患者临床资料及碘对比剂注射情况,以急性不良反应作为因变量(发生急性不良反应=1,未发生急性不良反应=0)纳入Logistic回归模型,分析CT增强碘对比剂急性不良反应发生的独立影响因素。结果 100例发生碘对比剂急性不良反应的患者中轻度65例(65.00%),中度34例(34.00%),重度1例(1.00%);观察组与对照组性别、年龄、体质指数(BMI)、高血压史、糖尿病史、心功能不全史、甲状腺功能亢进史、冠状动脉粥样硬化性心脏病史、碘对比剂使用史、食物过敏史对比差异无统计学意义(P>0.05),观察组与对照组哮喘史(9.00% vs 2.00%)、肾功能不全史(13.00% vs 3.00%)、碘对比剂不良反应发生史(21.00% vs 2.00%)、花粉过敏史(12.00% vs 4.00%)、药物过敏史(26.00% vs 7.00%)及其他过敏史(10.00% vs 2.00%),对比差异有统计学意义(χ 2 =4.710,P=0.030;χ 2 =6.790,P=0.009;χ 2 =17.740,P<0.001;χ 2 =4.350,P=0.037;χ 2 =13.100,P<0.001;χ 2 =5.670,P=0.017);观察组与对照组碘对比剂剂量对比差异无统计学意义(P>0.05),观察组与对照组碘对比剂注射速度(<3 mL/min为55.00% vs 69.00%;≥3 mL/min为45.00% vs 31.00%)、碘对比剂类型(碘克沙醇为34.00% vs 34.00%,碘佛醇为47.00% vs 30.00%,碘海醇为19.00% vs 36.00%)对比差异有统计学意义(χ 2 =4.160,P=0.041;χ 2 =9.010,P=0.011);肾功能不全史、碘对比剂不良反应发生史、药物过敏史、其他过敏史、碘对比剂注射速度为发生碘对比剂急性不良反应的影响因素(P<0.05)。结论 CT增强碘对比剂急性不良反应多以轻度为主,且以往合并肾功能不全、碘对比剂不良反应发生史、药物过敏史、其他过敏史、碘对比剂注射速度过高可能为碘对比剂不良反应发生的影响因素。
Objective To explore the occurrence and influencing factors of acute adverse reactions of iodine contrast agents in enhanced computed tomography(CT).Methods A retrospective analysis was conducted on 100 patients admitted to our hospital from October 2020 to October 2023 who experienced acute adverse reactions to iodine contrast agents during CT enhancement.They were divided into an observation group and another 100 patients who underwent CT enhancement examination in our hospital during the same period without any adverse reactions were selected as the control group.The acute adverse reactions of iodine contrast agent in the observation group of patients were analyzed,the clinical data and injection of iodine contrast agent between the two groups of patients were compared,and include acute adverse reactions as the dependent variable(occurrence of acute adverse reactions=1,absence of acute adverse reactions=0)was used in the Logistic regression model to analyze the independent influencing factors of acute adverse reactions of CT enhanced iodine contrast agent.Results Among the 100 patients who experienced acute adverse reactions to iodine contrast agents,65 were mild reactions,accounting for 65.00%,34 cases had were moderate reactions,accounting for 34.00%,and one cases had severe reactions,accounting for 1.00%.There was no significant difference between the observation group and the control group in gender,age,body mass index(BMI),history of hypertension,diabetes,heart dysfunction,hyperthyroidism,coronary heart disease,use of iodine contrast agent,and food allergy(P>0.05).The history of asthma(9.00% vs 2.00%),renal insufficiency(13.00% vs 3.00%),adverse reactions of iodine contrast(21.00 % vs 2.00%),pollen allergy(12.00% vs 4.00%),drug allerg(26.00% vs 7.00%)and other allergies(10.00 % vs 2.00%)were significantly different(χ 2 =4.710,P=0.030;χ 2 =6.790,P=0.009;χ 2 =17.740,P<0.001;χ 2 =4.350,P=0.037;χ 2 =13.100,P<0.001;χ 2 =5.670,P=0.017).There was no significant difference in the dosage of iodine contrast agent between the observation group and the control group(P>0.05).The injection rate of iodine contrast agent between the observation group and the control group(< 3 mL/min was 55.00% vs 69.00%;≥3 mL/min was 45.00% vs 31.00%),and the types of iodoxanol (iodoxanol[34.00% vs 34.00%],iodoxanol[47.00% vs 30.00%],iodohexanol[19.00% vs 36.00%]) were significantly different(χ 2 =4.160,P=0.041;χ 2 =9.010,P=0.011).History of renal insufficiency,adverse reactions to iodine contrast agents,drug allergies,other allergies,and injection speed of iodine contrast agents were independent risk factors for the occurrence of acute adverse reactions to iodine contrast agents(P<0.05).Conclusions Acute adverse reactions to iodinated contrast agents in CT enhancement are mostly mild.Previous history of renal insufficiency,history of adverse reactions to iodinated contrast agents,history of drug allergies,other allergic histories,and high injection speed of iodinated contrast agents may be influencing factors for the occurrence of adverse reactions to iodinated contrast agents.
目的 探讨、对比休克指数(SI)与血乳酸水平预测院前创伤性休克患者预后中的应用。方法 于2020年12月—2023年12月收治80例创伤性休克患者,均接受SI、乳酸水平的监测。结合监测的结果进行分组:乳酸正常组:乳酸水平在2 mmol/L以下,升高组:2 mmol/L以上;SI正常组:SI在0.9以下,升高组:SI在0.9以上。观察、记录患者入院7 d后的序贯性器官功能衰竭评分(SOFA),对多器官功能障碍综合征(MODS)情况进行评估。同时观察、记录机械通气、血管活性药物的使用和住院等情况。结果 乳酸水平升高组60例,正常组20组;SI升高组58例,正常组22例,女性乳酸水平、SI,与男性比较差异无统计学意义(P>0.05)。是否发生多器官功能障碍者的年龄、性别、SI指数比较差异无统计学意义(P>0.05);格拉斯哥昏迷评分(GCS)评分[(4.22±1.53)分 vs (9.46±3.82)分,t=7.816,P<0.001]、住院时间[(23.34±5.71)d vs (12.26±2.11)d,t=11.830,P<0.001]、基础乳酸值[(4.75±2.36)mmol/L vs (2.04±1.11)mmol/L,t=6.721,P<0.001]与发生MODS在组间对比差异有统计学意义。SI升高组的容量复苏收缩压>80 mmHg(%)有27例,与乳酸水平升高组比较差异有统计学意义(P<0.05)(46.55% vs 18.18%,χ 2 =12.237,P<0.001)。乳酸水平升高组中,11例患者接受机械通气,乳酸水平均升高(P<0.05);9例患者使用血管活性药物,乳酸水平均升高,比较差异无统计学意义(P>0.05);38例住院患者,24例乳酸水平升高(P<0.05)。13例患者接受机械通气,12例SI升高,比较差异无统计学意义(P>0.05);11例患者接受血管活性物治疗,8例SI升高,比较差异无统计学意义(P>0.05);39例患者住院,SI升高22例,比较差异有统计学意义(P<0.05)。结论 针对重症的创伤性休克患者,当血乳酸水平升高时会大大增加MODS发生的概率,乳酸水平在对重症创伤性休克患者预后进行预测时,应用价值更高。
Objective To explore and compare the application of shock index(SI)and blood lactic acid level in predicting the prognosis of patients with pre-hospital traumatic shock.Methods From December 2020 to December 2023,80 patients with traumatic shock were enrolled,and their SI and levels of lactic acid were monitored.Patients were grouped according to the monitoring results:normal group:lactic acid level below 2 mmol/L,increased group:above 2 mmol/L;normal group:SI below 0.9,and increased group:SI above 0.9.The sequential organ failure score(SOFA)was observed and recorded 7 days after hospitalization,and the situation of multiple organ dysfunction syndrome(MODS)was evaluated.At the same time,mechanical ventilation,the use of vasoactive substances and hospitalization were observed and recorded.Results There were 60 cases in the group with increased lactic acid level and 20 cases in the normal group.There were 58 cases of increased SI and 22 cases of normal.The lactic acid level and SI index in women were higher than those in men,with no difference(P>0.05).There were no differences in age,sex,SI index and the incidence of MODS(P>0.05).GCS score(4.22±1.53 vs 9.46±3.82),hospitalization days(23.34±5.71 vs 12.26±2.11)d,basal lactate value(4.75±2.36 vs 2.04±1.11)mmol L-1 were significantly different from those of MODS(t=11.830,P<0.001;t=6.721,P<0.001,P<0.05).There were 27 cases with volume resuscitation systolic blood pressure > 80 mmhg(%)in the group with increased SI,which was different from that of SI and lactic acid(46.55% vs18.18%,χ 2 =12.237,P<0.001;P<0.05).Lactic acid increased group:11 patients received mechanical ventilation,and the lactic acid levels of all 11 patients increased(P<0.05).Nine patients used vasoactive substances,and their lactic acid levels all increased,with no significant difference(P>0.05).Of the 38 inpatients,24 cases had elevated lactic acid levels(P<0.05).Thirteen patients received mechanical ventilation,and 12 patients had elevated SI,with no statistical significance(P>0.05).Eleven patients were treated with vasoactive agents,and 8 patients had increased SI,with no difference(P>0.05).Among the 39 patients hospitalized,22 cases had increased SI,and the difference was statistically significant(P<0.05).Conclusions For patients with severe traumatic shock,when the blood lactic acid level increases,the probability of MODS will be greatly increased.Compared with SI index,lactic acid level has higher application value in predicting the prognosis of patients with severe traumatic shock.
目的 探讨口服铁剂方法用于改善铁缺乏的男性机采血小板固定献血者铁营养状况效果,为采供血机构完善无偿献血者关爱策略提供数据支持。方法 选择2022年9月—2023年8月珠海市中心血站男性血小板固定献血者进行铁蛋白(FER)检测。以FER<30 ng/mL为铁缺乏的判定标准。将49名铁缺乏的男性机采血小板固定献血者随机分成干预组、对照组,分别进行口服铁剂干预,比较两组干预前后血红蛋白(Hb)、血清铁(SI)、FER的浓度变化情况。结果 共检测205名男性机采固定献血者,其中49名FER<30 ng/mL(铁缺乏组),占23.90%,其Hb、SI、FER均值低于FER≥30 ng/mL男性机采固定献血者(正常组)。49名铁缺乏的机采固定献血者口服铁剂干预后:干预组SI、FER浓度分别为(15.97±5.14)μmol/L、(30.55±14.42)ng/mL,高于对照组[(11.49±4.02)μmol/L、(12.77±5.86)ng/mL)],其差异有统计学意义(t=3.466,P<0.001;t=5.493,P<0.001)。干预组Hb为(143.42±10.85)g/L,高于对照组的(140.88±12.97)g/L,但差异无统计学意义(t=-0.726,P=0.471)。结论 针对铁蛋白低值的机采男性固定献血者,采取口服铁剂方法可以有效改善其铁缺乏状况。
Objective To explore the effect of oral iron supplements on improving iron deficiency in male regular plateletpheresis donors.Methods Male regular plateletpheresis donors from Zhuhai Blood Central Station were selected for ferritin(FER)detection.Using FER<30 ng/mL as the criterion for determining iron deficiency,49 donors were selected as the study subjects and divided into intervention group and control group,and the changes in hemoglobin(Hb),serum iron(SI),andFER concentrations were compared.Results A total of 205 male regular plateletpheresis donors underwent FER detection,of which 49 donors had FER under 30 ng/mL(iron deficiency group),accounting for 23.90%.The mean Hb,SI,and FER levels in the iron deficiency group were significantly lower than those with FER≥30 ng/mL.After oral iron intervention,the SI and FER levels in the intervention group([15.97±5.14] μmol/L,[30.55±14.42] ng/mL)were significantly higher than those in the control group([11.49±4.02] μmol/L,[12.77±5.86] ng/mL),and the difference were statistically significant(t=3.466,P<0.001;t=5.493,P=0.000).The Hb values of the intervention group and the control group were(143.42±10.85)g/L and(140.88±12.97)g/L,respectively,with no statistically significant difference between the groups(t=-0.726,P=0.471).Conclusions Oral iron supplementation can effectively improve iron deficiency in male regular plateletpheresis donors.