放射治疗(放疗)可以提高妇科恶性肿瘤患者的总体生存率,降低复发率,增加手术机会。但肿瘤周围的健康组织不可避免地会进入电离辐射区域从而导致阴道狭窄、缩短和失去弹性,文章结合近年来国内外的放疗后阴道损伤治疗方式进行综述,总结分析治疗的优缺点,旨在为放疗后阴道损伤的临床治疗提供帮助。
Radiotherapy can improve the overall survival rate,reduce the recurrence rate and increase the chance of surgery in patients with gynecological malignant tumors.However,the healthy tissue around the tumor can inevitably be included the ionizing radiation area,resulting in vaginal stenosis,shortening and loss of elasticity.This paper reviews the treatment methods of post-radiotherapy vaginal injury at home and abroad in recent years,to summarize and analyze theadvantages and disadvantages of treatment,aiming to provide help for the clinical treatment of post-radiotherapy vaginal injury.
戊型肝炎病毒(HEV)是导致急性肝炎的重要病原体,部分HEV感染者可进展为肝衰竭,此外,慢性感染和肝外表现可也在HEV感染者中发生。全球每年感染HEV的患者数达2000万,其中330万例患者有肝炎相关的临床症状,年死亡例数约为4.4万(2015年数据)。在我国,HEV以散发流行为主。近年来由于对其研究的重视,HEV病原学、流行病学、临床诊疗和预防取得较大的进展,文章拟对目前HEV防治热点以及新进展进行总结和分析。
Hepatitis E virus(HEV)is an important pathogen that causes acute hepatitis.Some HEV-infected individualsmay progress to liver failure.In addition,chronic infection(including liver fibrosis and cirrhosis)and extrahepatic manifestations can also occur in HEV infection.Worldwide,there are 20 million cases of HEV infection each year,with 3.3 million cases presenting clinical symptoms related to hepatitis,and an annual death toll of approximately 44,000(data from 2015).In China,HEV mainly present as sporadic outbreaks.In recent years,there has been significant progress in the pathogenesis,epidemiology,clinical diagnosis and treatment,and prevention of HEV.This review aims to summarize and analyze the current hotspots and new developments in the prevention and treatment of HEV.
目的 探讨免疫及靶向药物联合肝动脉灌注化学治疗(化疗)治疗晚期肝癌的临床疗效。方法 选取甘肃省武威市人民医院2021年1月—2024年1月收治的78例晚期肝癌患者进行回顾性分析,其中20例患者采取单纯肝动脉灌注化疗(HAIC)治疗为单化疗组,30例患者采取HAIC联合程序性细胞死亡受体-1(PD-1)抗体治疗为免疫组,28例患者采取HAIC联合PD-1抗体免疫治疗与甲磺酸仑伐替尼胶囊靶向治疗为联合组。对比三组临床疗效、治疗前后胚抗原(CEA)、糖类抗原125(CA125)、甲胎蛋白(AFP)表达水平,不良反应发生率,并采用Piper疲乏修正量表(PFS-R)、世界卫生组织生存质量量表简表(WHOQOL-BREF)对两组癌因性疲乏程度及生存质量进行评价。结果 单纯化疗组、免疫组、联合组客观缓解率分别为15.00%、40.00%、64.29%,疾病控制率为30.00%、66.67%、82.14%,联合组高于单纯化疗组与免疫组(χ 2 =11.720,P=0.003;χ 2 =13.890,P<0.001);治疗后三组患者CEA、CA125、AFP水平均降低,且联合组[CEA:(13.62±4.24)ng/mL、CA125:(31.62±13.66)U/mL、AFP:(35.21±5.93)ng/mL]低于免疫组[(17.85±3.32)ng/mL、(59.26±9.35)U/mL、(42.12±4.12)ng/mL]及单纯化疗组[(23.73±4.79)ng/mL、(64.57±5.23)U/mL、(47.46±5.32)ng/mL],对比差异有统计学意义(F=7.698,P<0.001;F=11.480,P<0.001;F=14.952,P<0.001;P<0.05);所有患者均无5级不良反应及严重肝功能损害出现,且三组血小板减少、白细胞减少、腹痛、呕吐、消化道出血、厌食等不良反应发生率对比差异无统计学意义(P>0.05);治疗后三组患者PFS-R评分均降低,联合组(3.85±1.13)分低于免疫组(5.39±1.25)分及单纯化疗组(6.33±1.26)分,WHOQOL-BREF评分均升高,联合组(348.58±66.12)分高于免疫组(297.24±72.21)分及单纯化疗组(256.35±41.67)分,对比差异有统计学意义(F=2.526,P=0.014;F=2.167,P=0.033)。结论 免疫及靶向药物联合肝动脉灌注化疗治疗晚期肝癌疗效显著,可有效控制疾病进展的同时,降低机体肿瘤标志物水平,安全性可控,同时可改善患者生存质量,减轻癌因性疲乏程度。
Objective To explore the clinical efficacy of immune and targeted drugs combined with hepatic artery infusion chemotherapy(HAIC)in the treatment of advanced liver cancer.Methods A retrospective analysis was conducted on 78 patients with advanced liver cancer admitted to our hospital from January 2021 to January 2024.Among them,20 patients were treated with simple HAIC and divided into a single chemotherapy group.Thirty patients were treated with HAIC combined with PD-1 antibody,and divided into an immune group.Twenty-eight patients were treated with HAIC combined with PD-1 antibody immunotherapy and lenvatinib mesylate capsule targeted therapy,and divided into a combination group.The clinical efficacy of three groups,the expressionlevels of CEA,CA125,AFP,and incidence of adverse reactions before and after treatment were compared.Piper Fatigue Correction Scale(PFS-R)and the WHO QOL-BREF were used to assess cancer-related fatigue in both groups.The degree of fatigue and quality of life were assessed.Results The objective response rates of the simple chemotherapy group,the immune group,and the combination group were 15.00%,40.00% and 64.29%,respectively.The disease control rates were 30.00%,66.67% and 82.14%,respectively.The indicators above of the combination group was significantly higher than those in the simple chemotherapy group and the immune group(χ 2 =11.720,P=0.003;χ 2 =13.890,P<0.001;P<0.05).After treatment,the levels of CEA,CA125 and AFP were all decreased in the three groups,and those in the combined group (CEA[13.62±4.24]ng/mL,CA125[31.62±13.66]U/mL,AFP:Ng/mL[35.21±5.93])were lower than those in the immune group(17.85±3.32 ng/mL,59.26±9.35 U/mL,/ 42.12±4.12 ng/mL)and single chemotherapy group(23.73±4.79 ng/mL,64.57±5.23 U/mL47.46±5.32]ng/mL),the differences were statistically significant(F=7.698,P<0.001;F=11.480,P<0.001;F=14.952,P<0.001;P<0.05).All patients had no grade 5 adverse reactions or severe liver function damage,and there was no statistically significant difference in the incidence adverse reactions such as thrombocytopenia,leukopenia,abdominal pain,vomiting,gastrointestinal bleeding,and anorexia among the three groups(P>0.05).After treatment,the PFS-R score of the three groups was decreased,and the combined group(3.85±1.13)score was lower than that of the immune group(5.39±1.25)and the chemotherapy group(6.33±1.26).While the WHOQOL-BREF score was increased,the score of combination group(348.58±66.12)was higher than that of immune group(297.24±72.21)and chemotherapy group(256.35±41.67),and the difference was statistically significant(F=2.526,P=0.014;F=2.167,P=0.033;P<0.05).Conclusions The combination of immune and targeted drugs with hepatic artery infusion chemotherapy has a significant therapeutic effect on advanced liver cancer.It can effectively control disease progression,reduce tumor marker levels in the body,improve patient quality of life,and alleviate cancer-related fatigue,with controllable safety
目的 探究腕踝针联合揿针治疗带状疱疹后遗痛的临床疗效观察。方法 选取上海市黄浦区中西医结合医院2021年10月—2024年4月收治的80例带状疱疹后遗神经痛患者为研究对象,按随机数表法分为研究组、对照组,各40例。对照组采用口服甲钴胺治疗;研究组采用腕踝针联合揿针治疗。比较两组治疗疗效;治疗前后采用视觉模拟评分(VAS)与阿森斯失眠量表评分(AIS)、皮肤病生活质量指数(DLQI)、汉密尔顿抑郁量表评分(HAMD)、汉密尔顿焦虑量表评分(HAMA)。结果 研究组治疗总有效率为92.5%,对照组治疗总有效率为75%。比较差异有统计学意义(P<0.05)。两组患者治疗后VAS、AIS均比治疗前改善,研究组VAS评分为(1.00±0.45)、AIS评分为(7.15±0.89),优于对照组VAS(2.15±0.36)和AIS(5.65±0.70),比较差异有统计学意义(P<0.05)。相较于治疗前,两组患者DLQI评分均有改善,研究组[休闲活动评分(1.73±0.45)、人际交往评分(1.13±0.34)、工作学习评分(0.94±0.25)、自觉症状评分(1.83±0.38)、日常活动评分(0.98±0.28)]优于对照组[休闲活动评分(2.06±0.40)、人际交往评分(1.81±0.39)、工作学习评分(1.08±0.38)、自觉症状评分(2.01±0.34)、日常活动评分(1.10±0.30)],差异有统计学意义(P<0.05)。两组患者HAMD评分、HAMA评分,相较于治疗前均有改善,研究组HAMD评分为(34.63±2.61)、HAMA评分为(35.75±2.48),优于对照组HAMD评分(47.68±3.21)和HAMA评分(46.90±3.31),差异有统计学意义(P<0.05)。结论 腕踝针联合揿针治疗带状疱疹后遗神经痛的临床疗效显著,可有效改善患者生活质量、疼痛程度、焦虑及抑郁程度,提升患者睡眠质量。
Objective To investigate the clinical efficacy of wrist and ankle acupuncture combined with thumbtack needle in the treatment of postherpetic herpes zoster pain.Methods Eighty patients with postherpetic neuralgia admitted to Shanghai Huangpu District Hospital of Integrative Medicine from October 2021 to April 2024 were selected for the study,and were divided into a study group and a control group of 40 cases each according to the random number table method.The control group was treated with oral mecoblamin tables;the study group was treated with wrist and ankle acupuncture combined with thumbtack needle.The efficacy of treatment between the two groups was compared;before and after treatment,the visual analogue score(VAS)and Asens Insomnia Scale(AIS),Dermatological Quality of Life Index(DLQI),Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA)were compared.Results The treatment efficiency was 92.5% in the study group and 75% in the control group.The difference was statistically significant(P<0.05).VAS scores and AIS scores of patients in both groups improved after treatment,and VAS score(1.00±0.45),AIS score(7.15±0.89)of the study group were better than VAS score(2.15±0.36),AIS score(5.65±0.70)of the control group.The differences were statistically significant(P<0.05).The DLQI scores of both groups improved after treatment,and the score of study group(leisure activity score[1.73±0.45],interpersonal interaction score[1.13±0.34],work-study score[0.94±0.25],self-perceived symptom score[1.83±0.38],daily activities score[0.98±0.28])were higher than those of the control group(leisure activity score[2.06±0.40],interpersonal score[1.81±0.39],work-study score[1.08±0.38],conscious symptom score[2.01±0.34],daily activity score[1.10±0.30]).The differences were statistically significant(P<0.05).HAMD scores and HAMA scores of patients in both groups,showed significant improvement after treatment,and HAMD scores(34.63±2.61)and HAMA scores(35.75±2.48)of the study group were better than HAMD scores(47.68±3.21)and HAMA scores(46.90±3.31)of the control group.The difference was statistically significant(P<0.05).Conclusions The clinical efficacy of wrist and ankle acupuncture combined with thumbtack needle in the treatment of postherpetic pain is remarkable,effectively improving the quality of life,pain,anxiety and depression,and enhancing the quality of sleep of patients.
目的 初步探讨可注射型载阿霉素水凝胶对胶质瘤的治疗作用。方法 使用透析法检测载阿霉素水凝胶在体外释放药物的情况。构建大鼠皮下C6胶质瘤模型,按不同给药途径分为空白对照组、经静脉注射组、水凝胶组。给药15 h后,经免疫荧光检测阿霉素在肿瘤内部的分布情况。给药7 d后,计算出各组的抑瘤率;并对肿瘤组织进行苏木精-伊红染色。结果 在体外,载阿霉素水凝胶具有缓释药物的性能。在体内,与经静脉给药相比,局部注射载阿霉素水凝胶使瘤内分布更多阿霉素,抑瘤率更高(42% vs 64%),肿瘤细胞坏死更明显。结论 载阿霉素水凝胶可为胶质瘤局部化学治提供新的载体。
Objective To investigate the therapeutic effect of injectable doxorubicin-containing hydrogel on glioma.Methods The release of doxorubicin hydrogel in vitro was detected by dialysis.The subcutaneous C6 glioma model of rats was constructed and divided into blank control group,intravenous injection group and hydrogel group according to different administration methods.The distribution of doxorubicin in the tumor was detected by immunofluorescence 15 hours after administration.After 7 days of administration,the tumor inhibition rate of each group was calculated.The tumor tissue was stained with hematoxylin eosin.Results In vitro,doxorubicin-containing hydrogels had sustained drug release properties.In vivo,compared with intravenous administration,local injection of doxorubicin-containing hydrogel resulted in more doxorubicin distribution,higher tumor inhibition rate(42% vs 64%)and more obvious tumor cell necrosis.Conclusions Doxorubicin-containing hydrogel can provide a new carrierfor local chemotherapy of glioma.
作为中医药文化瑰宝,针灸在疾病治疗中展现出独特价值,但其标准化操作、疗效量化评价及安全风险控制仍是制约现代化转型的关键问题。随着人工智能技术的突破性发展,机器学习在医疗领域引发的技术革命为针灸创新提供了新机遇。超声医学凭借可视化、定量化及动态监测优势,与机器学习算法形成技术协同,推动传统针灸向精准化、智能化方向迈进。通过超声成像实时定位穴位层次结构与针体轨迹,结合机器学习对多维数据的深度分析,显著提升了针刺治疗的精准性与安全性,同时为建立客观疗效评价体系提供了技术支撑。文章旨在全面回顾超声引导下机器学习技术在针灸研究领域的应用状况,深入剖析现有研究中存在的挑战与局限,并前瞻性地探讨未来的研究方向与趋势,旨在为针灸实践与应用研究的深化与发展提供理论指导与实践启示。
As an invaluable component of traditional Chinese medicine,acupuncture boasts a distinctive value in thetreatment of diseases.However,the standardization of its practice,the quantitative assessment of its therapeutic efficacy,and the implementation of safety risk control measures remain pivotal challenges hindering its modernization and transformation.The advent of artificial intelligence technology has precipitated a technological revolution in the medical field,thereby generating novel opportunities for innovation in acupuncture.The integration of ultrasound medicine and machine learning algorithms,leveraging their respective strengths in visualization,quantification and dynamic monitoring,has emerged as a technological synergy.This synergy is poised to propel traditional acupuncture towards precision and intelligence.The integration of ultrasound imaging with machine learning algorithms enables real-time localization of acupoints and needle trajectory,enhancing the precision and safety of acupuncture treatment.Additionally,it facilitates the development of objective efficacy evaluation systems.The present article aims to comprehensively review the application of ultrasound-guided machine learning technology in the field of acupuncture and moxibustion research.It does so by first analyzing the challenges and limitations of existing research and then prospectively exploring future research directions and trends.The article’s ultimate aim is to provide theoretical guidance and practical inspiration for the deepening and development of acupuncture and moxibustion practice.
目的 探讨便携式超声仪超声重点评估(e-FAST)技术在批量伤员军地联合院前救治中的应用效果。方法 抽取2021年5月—2023年10月中国人民解放军联勤保障部队第九八八医院中心急诊科收治的80例批量伤员,均开展军地联合院前救治,按照治疗方案不同分为观察组和对照组,每组患者40例,其中对照组在救治现场行基于创伤严重程度(CRAMS)评分,进行常规急救处置,救护车返院后行CT检查并进行相应伤情治疗,观察组救治现场行CRAMS评分,进行常规急救处置,院前接诊医师在现场或救护车上使用便携式超声仪按照e-FAST流程检查相应部位,初步诊断后进行相应伤情治疗,对比两组患者治疗效果,两组患者诊断时间、初次医疗接触—进入手术室时间及入院诊断与出院时确定性诊断的符合率、两组患者治疗前后CRAMS评分及CRAMS≤8分抢救成功率。结果 观察组治疗有效率为95.0%,对照组为85.0%,对比差异无统计学意义(χ 2 =2.222,P=0.136);观察组患者的诊断时间(13.56±2.36)min、初次医疗接触—进入手术室时间(30.42±8.99)min均短于对照组[(23.64±5.69)、(52.27±12.60)min],差异有统计学意义(t=10.349、8.928,P<0.05);观察组患者入院诊断与出院时确定性诊断的符合为97.5%,对照组患者入院诊断与出院时确定性诊断的符合为95.0%,差异无统计学意义(χ 2 =0.346,P=0.556);治疗后两组患者的CRAMS评分均升高,且观察组(9.87±2.62)分高于对照组(8.60±2.98)分,差异有统计学意义(t=2.024,P=0.046);观察组患者CRAMS≤8分的抢救成功率为97.50%,对照组CRAMS≤8抢救成功率为85.00%,观察组患者CRAMS≤8分的抢救成功率高于对照组(χ 2 =3.914,P=0.048)。结论 本研究从军地联合救治批量伤员切入,瞄准部队医院军民融合战略发展路线,本文针对便携式超声仪e-FAST应用范围前移,明显地提高急救人员院前救治能力,提高抢救成功率,值得临床参考。
Objective To explore the application effect of portable ultrasound e-FAST technology in the pre hospital treatment of batch wounded soldiers in military civilian joint hospitals.Methods Eighty batch wounded patients admitted to the emergency department of 988 Hospital from May 2021 to October 2023 were selected,all of whom underwent military civilian joint pre hospital treatment.They were divided into an observation group and a control group according to different treatment plans,with 40 patients in each group.The control group received CRAMS scores at the treatment site for routine first aid treatment,CT scans after ambulance return to the hospital for corresponding injury treatment,the observation group received CRAMS scores at the treatment site for routine first aid treatment,and the pre-hospital attending physician used a portable ultrasound instrument to examine the corresponding parts on site or in the ambulance according to the e-FAST process.After preliminary diagnosis,corresponding injury treatment was carried out.The treatment effects of the two groups of patients were compared,and the diagnosis time and initial diagnosis of the two groups of patients were compared.The time from medical contact to entering the operation room,the compliance rate of discharge and admission diagnoses,the CRAMS score before and after treatment,and the success rate of rescue with CRAMS ≤ 8 for both groups of patients were compared.Results The effective rate of treatment in the observation group was 95.0%,while in the control group it was 85.0%,which difference was not statistically significant(χ 2 =2.222,P=0.136).The time to diagnosis(13.56±2.36)min,time to the operating room(30.42±8.99)min were shorter than that in the control group[(23.64±5.69),(52.27±12.60)min],with significant difference(t=10.349,8.928,P<0.05).The consistency between the admission diagnosis and the definitive diagnosis at discharge of the observation group patients was 97.5%,while the consistency of the control group patients was 95.0%.There was no significant difference between the groups(χ 2 =0.346,P=0.556).After treatment,the CRAMS scores of both groups of patients increased,the observation group(9.87±2.62)was higher than that of the control group(8.60±2.98)(t=2.024,P=0.046).The success rate of CRAMS ≤ 8 rescue in the observation group was 97.50%,while the success rate in the control group was 85.00%.The success rate of CRAMS ≤ 8 rescue in the observation group was higher than that in the control group(χ 2 =3.914,P=0.048).Conclusions This study focuses on the joint treatment of batch wounded soldiers by military and civilian forces,aiming at the development path of military civilian integration strategy in military hospitals.The application scope of portable ultrasound e-FAST has been moved forward,which significantly improves the pre hospital treatment ability of emergency personnel and improves the success rate of rescue.It is worth clinical reference.
目的 探讨盐酸达泊西汀联合达克罗宁胶浆治疗早泄的临床疗效。方法 选取男科门诊146例早泄患者,随机分组,对照组服用达泊西汀片,研究组为达泊西汀片和达克罗宁胶浆联合治疗,再将研究组分为阴茎头敏感度高组和敏感度正常组,记录各组治疗前、治疗8周后早泄相关指标。结果 治疗后对照组阴道内射精潜伏期(IELT)、早泄诊断量表(PEDT)和早泄指数量表(IPE)中Q6+Q7分别为(4.68±2.79)、(9.52±2.14)、(6.48±1.30),研究组IELT、PEDT和Q6+Q7分别为(6.09±3.09)、(7.52±1.92)、(7.85±1.36),各组相关指标均较治疗前改善(P<0.05),研究组各指标改善程度优于对照组(P<0.05);治疗后敏感度高组IELT、PEDT和Q6+Q7分别为(6.76±2.99)、(6.84±1.53)、(8.16±1.10),敏感度正常组IELT、PEDT和Q6+Q7分别为(5.13±3.02)、(8.50±2.03)、(7.40±1.59),敏感度高组各指标改善程度优于敏感度正常组(P<0.05);对照组、研究组总有效率分别为69.86%(51/73)、84.93%(62/73),研究组治疗效果优于对照组(P<0.05);敏感度高组、敏感度正常组总有效率分别为93.02%(40/43)、73.33(22/30),敏感度高组治疗效果优于敏感度正常组(P<0.05)。结论 达泊西汀联合达克罗宁胶浆治疗早泄效果显著,阴茎头敏感患者联合达克罗宁胶浆治疗受益更大。
Objective To investigate the clinical efficacy of dapoxetine hydrochloride combined with dclonine mucilage in the treatment of premature ejaculation.Methods A total of 146 patients from andrology department with premature ejaculation were selected and randomly divided into control group and research group.The control group was treated with dapoxetine alone,while the research group was treated with dapoxetine combined with dacronine mucilage.The research group was divided into high sensitivity group and normal sensitivity group.The indexes related to premature ejaculation were recorded before treatment and 8 weeks after treatment.Results After treatment,intravaginal ejaculatory latency time(IELT),Premature Ejaculation Diagnosis Tool(PEDT)and Q6+Q7 of the index of premature ejaculation(IPE)in control group were(4.68±2.79),(9.52±2.14)and (6.48±1.30),respectively,while IELT,PEDT and Q6+Q7 in research group were(6.09±3.09),(7.52±1.92) and (7.85±1.36),respectively.The relevant indexes in all groups were significantly improved compared with those before treatment(P<0.05),and the improvement of all indexes in research group was better than that in control group(P<0.05).After treatment,IELT,PEDT and Q6+Q7 in the highly sensitivity group were(6.76±2.99),(6.84±1.53)and(8.16±1.10),respectively,while IELT,PEDT and Q6+Q7 in the normal sensitivity group were(5.13±3.02),(8.50±2.03)and(7.40±1.59),respectively.The improvement of all indexes in the high sensitivity group was better than that in the normal sensitivity group(P<0.05).The total effective rate of the control group and the research group was 69.86%(51/73)and 84.93%(62/73),respectively.The therapeutic effect of the research group was significantly better than that of the control group(P<0.05).The total effective rate of the high sensitivity group and the normal sensitivity group was 93.02%(40/43)and 73.33%(22/30),respectively.The therapeutic effect of the high sensitivity group was significantly better than that of the normal sensitivity group(P<0.05).Conclusions Dapoxetine combined with dacronine mucilage has significant effect in the treatment of premature ejaculation,and the patients with high sensitivity of penile head will benefit more from combined dacronine mucilage therapy.
目的 比较宫腔镜病灶切除术与超声监测下吸宫术治疗剖宫产瘢痕部位妊娠(CSP)的有效性。方法 回顾性分析2021年7月—2023年10月在南宁市妇幼保健院确诊为I、Ⅱ型CSP并接受治疗的129例患者,停经时间在38~83 d,中位停经时间48 d。其中42例患者接受了宫腔镜病灶切除术治疗(A组),87例患者接受超声监测下吸宫术治疗(B组),比较两组患者术后1、3、7、14 d的人绒毛膜促性腺激素水平以及手术出血量、手术时间、住院时间、住院花费。结果 两组患者在术后1 d,血清HCG水平下降,下降幅度均超过50%,且A组患者术后1 d血清HCG的下降幅度及下降速率大于B组患者(P<0.05);术后3、7、14 d,两组血清HCG水平仍持续下降。另外,A组患者手术出血量、手术时间、住院时间、住院花费分别为(15.35±14.53)mL、(60.73±53.05)min、(4.33±1.90)d、(6 689.23±2 216.19)元;B组患者手术出血量、手术时间、住院时间、住院费用分别为(26.09±29.24)mL、(51.59±54.46)min、(4.82±1.83)d、(6 270.34±2 547.85)元。A组患者术中出血量低于B组、住院时间短于B组(P<0.05),手术时间及住院费用与B组比较差异无统计学意义(P均>0.05)。结论 宫腔镜病灶切除术与超声监测下吸宫术均能有效治疗CSP,但宫腔镜病灶切除术在术后血清HCG的下降幅度及下降速率、术中出血量、住院时间等方面优于超声监测下吸宫术,而且手术时间和住院费用并没有显著增加。
Objective To compare the efficacy between hysteroscopic resection surgery and ultrasound-guided uterine aspiration in the treatment of cesarean scar pregnancy(CSP).Methods A retrospective analysis was performed in 129 patients diagnosed with CSP(type I or Ⅱ)and treated in Nanning Maternal and Child Health Hospital from July 2021 to October 2023.Their duration of amenorrhea was between 38~83 d,with a median of 48 days.Among them,42 patients were treated with hysteroscopic resection surgery therapy(group A),87 patients were treated with ultrasound-guided uterine aspiration therapy and(group B).Then,the levels of human chorionic gonadotropin(HCG),the amount of the intraoperative bleeding volume,surgical time,hospitalization time,and hospitalization expenses were compared between the two groups at one,three,seven and 14 days postoperativey.Results After one day of surgery,the serum HCG levels of two groups significantly decreased,with a decrease of more than 50%,and the magnitude and rate of decrease in serum HCG levels of group A were significantly larger than those of group B(P<0.05);After three,seven,and 14 day of surgery,serum HCG levels continued to decrease.Furthermore,the intraoperative bleeding volume,surgical time,hospitalization time,hospitalization expenses in group A were(15.35±14.53)mL,(60.73±53.05)min,(4.33±1.90)d,(6 689.23±2 216.19)yuan,respectively.That in group B were(26.09±29.24)mL,(51.59±54.46)min,(4.82±1.83)d,(6 270.34±2 547.85)yuan,respectively.Compared to group B,the intraoperative bleeding volume of group A was significantly lower(P<0.05),and the hospitalization time is shorter,while there was no significant difference in surgical time and hospitalization expenses.Conclusions Both of hysteroscopic resection surgery and ultrasound-guided uterine aspiration can treat cesarean scar pregnancy effectively,but the former is superior to the latter in terms of the magnitude and rate of decrease in serum HCG levels after surgery,intraoperative bleeding volume,and hospitalization time,with no significant increase in surgical time and hospitalization expenses.
目的 评价现有关于干预组仅涉及不同针具针刺或联合常规针刺治疗腰椎间盘突出症系统评价的方法学质量,以比较不同针具针刺治疗腰椎间盘突出症的治疗效果。方法 通过CNKI(中国知网)、万方数据库、VIP(维普)、PubMed、Web of Science等数据库以及其他相关电子资源,对诊断、治疗腰椎间盘突出症的多种针灸技术进行全面的研究。使用AMSTAR2软件,对所有参与的系统性评估结果进行地分析,并根据不同的检测结果,确定文献筛选标准。通过Revman5.4和Cochrance风险偏倚工具,以及Stata16.0的网格Meta分析,挑选了3 381个满足纳入排除要求的随机对照试验。结果 以Stata 16.0统计软件制作排序图可知,杵针+电针的临床有效率SUCRA=81.6%排名第一;目测类比评分显示,银质针SUCRA(用于评估疗效的指标)=95%,排名第一。结论 根据现有的研究证据,杵针+电针以及银质针优于其他9种干预措施,但确切的结果仍需要大量的随机对照试验来证明。
Objective To evaluate the methodological quality of the existing systematic evaluation of the intervention group involving only different needle sets of acupuncture or combined with conventional acupuncture in the treatment of lumbar disc herniation,in order to compare the therapeutic effect of different needle sets of acupuncture in the treatment of lumbar disc herniation.Methods Through CNKI,Wanfang database,VIP,PubMed,web of science and other databases as well as other relevant resources,a variety of acupuncture techniques for the diagnosis and treatment of lumbar disc herniation were comprehensively studied.Through the use of AMSTAR2 software,all participating systematic evaluation results were effectively analyzed,and according to different test results,which literature meets the requirements were determined.Through revman5.4,Cochrane risk bias tool,and grid meta-analysis of stata16.0,3 381 RCTs meeting the inclusion and exclusion requirements were selected.Results According to the ranking chart made by stata16.0 statistical software,the clinical effective rate of pestle needle + electroacupuncture ranked first with sucra=81.6%.According to the visual analogy score,the silver needle sucra=95%,ranking first.Conclusions According to the existing research evidence,pestle needle + electroacupuncture and silver needle are better than the other nine interventions,but the exact results still need a large number of randomized controlled trials to prove.