论著

支气管镜灌洗对儿童重症肺部感染合并肺实变的应用效果及对 CT 特征、肺功能影响

Application effects of bronchoalveolar lavage in children with severe pulmonary infection complicated by lung consolidation and its impact on CT features and pulmonary function

:951-956
 
       目的   探讨支气管镜灌洗用于儿童重症肺部感染合并肺实变的治疗效果及对CT特征、肺功能的影响。法   选取2022年5月—2024年5月铜仁市人民医院收治的100例重症肺部感染合并肺实变患儿开展前瞻性研究,应用随机数表法分为对照组和观察组,每组各50例。对照组患儿采取常规治疗,观察组则采取常规治疗加支气管镜灌洗治疗。对比其临床疗效,治疗前后炎症因子、CT特征及肺功能变化。结果   观察组治疗总有效率高于对照组(P<0.05);治疗后观察组患儿白细胞计数(10.36±2.52)×109 /L、白细胞介素-6(20.57±5.05)ng/L、C反应蛋白(13.12±2.64)mg/L、降钙素原(101.62±12.16)pg/L均低于对照组白细胞计数(13.25±3.32)×109 /L、白细胞介素-6(31.69±4.11)ng/L、C反应蛋白(16.16±4.44)mg/L、降钙素原(113.46±18.11)pg/L(P<0.05);治疗后两组患儿胸腔积液、支气管壁增厚、空气支气管征、肺部实变、磨玻璃影等相关CT影像特征占比下降,且观察组低于对照组(P<0.05);治疗后两组患儿呼气流量峰值水平均升高,观察组(90.67±18.45)L/s高于对照组(81.27±17.69)L/s,用力肺活量水平均更高,观察组(3.33±0.68)L高于对照组(2.68±0.25)L(P<0.05)。结论   针对儿童重症肺部感染合并肺实变,在常规治疗基础上增加支气管镜灌洗可提升临床疗效,减轻机体炎症反应,改善胸部CT各种表现及肺功能。
        Objective  To explore the therapeutic effects of bronchoalveolar lavage in children with  severe pulmonary infection complicated by lung consolidation and its impact on CT features and pulmonary function.Methods A prospective study was conducted on 100 children with severe pulmonary infection complicated with pulmonary consolidation in a hospital from May 2022 to May 2024.They were randomly divided into observation group and control group using a random number table method,50 cases in each group.The control group of children received routine treatment,and the observation group received conventional treatment plus bronchoalvelar lavage.Clinical efficacy,inflammatory factors,CT features,and alterations in pulmonary function before and after therapy were compared.Results  The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the white blood cell count(10.36±2.52)×109 /L,interleukin-6(20.57±5.05)ng/L,C-reactive protein(13.12±2.64)mg/L,and procalcitonin(101.62±12.16)pg/L in the observation group were all lower than those in the control group(13.25±3.32)×109 /L,interleukin-6(31.69±4.11)ng/L,C-reactive protein(16.16±4.44)mg/L,and procalcitonin(113.46±18.11)pg/L(P<0.05).After treatment,the proportion of CT imaging features such as pleural effusion,bronchial wall thickening,air bronchogram sign,lung consolidation,ground glass opacities,decreased in both groups of children,and the observation group was lower than the control group(P<0.05).After treatment,the peak levels of expiratory flow in both groups of children increased,with the observation group(90.67±18.45)L/s higher than the control group(81.27±17.69)L/s.The forced vital capacity levels were also higher,with the observation group(3.33±0.68)L higher than the control group(2.68±0.25)L(P<0.05).Conclusions  Adding bronchoalvelar lavage to routine treatment for children with severe pulmonary infection complicated with pulmonary consolidation can improve their clinical efficacy,alleviate inflammatory reactions,and improve various chest CT manifestations and lung function.
论著

血塞通联合右美托咪定对老龄大鼠脑缺血再灌注损伤的保护效果研究

Effects of Xuesaitong combined with dexmedetomidine on cerebral ischemia-reperfusion injury in elderly rats

:918-923
 
       目的   评价血塞通联合右美托咪定对脑缺血再灌注损伤大鼠的脑保护效果。方法   选择老龄雄性Wistar大鼠50只,随机分为假手术(C)组、脑缺血再灌注(R)组、血塞通(P)组、右美托咪定(D)组,血塞通联合右美托咪定(PD)组,每组各10只。根据组别给予不同药物,行神经行为学测试;于第3、7天,测量脑梗死面积、脑水含量,以及超氧化物歧化酶(Superoxide dismutase,SOD)、谷胱甘肽过氧化酶(Glutathione peroxidase,GSH-PX)活性测定。结果   给药后第3、5、7天,与P、D组相比,PD组神经行为学评分改善更加显著(P<0.001);给药后第3、7天,与P组相比,PD组脑梗死面积、脑水含量均降低(P=0.01,P=0.002),SOD、GSH-PX活性升高显著(P=0.03,P=0.001);与D组相比,PD组脑梗死面积、脑水含量也显著降低(P<0.01,P=0.008);SOD、GSH-PX活性升高显著(P=0.009,P<0.001)。结论   血塞通联合右美托咪定较单独应用药物,能显著减轻缺血再灌注损伤造成的脑损害,具有脑保护作用。
       Objective  To explore the effects of Xuesaitong combined with dexmedetomidine on cerebral ischemia-reperfusion in elderly rats.Methods  Fifty elderly male Wistar rats were randomly divided into 5 groups:sham operation(C)group,cerebral ischemia-reperfusion(R)group,Xuesaitong(P)group,dexmedetomidine(D)group,Xuesaitong combined with dexmedetomidine(PD)group.Xuesaitong was given in group P,dexmedetomidine was given in group D,and normal saline was given in group C and group R,continuously for 7 days.After 3- and 7-day treatment,the brain of rats was dissected out to assay the area of cerebral infarction,degree of cerebral edema,superoxide dismutaseSOD) and glutathione peroxidaseGSH-PX) activity.Results When compared PD group with P and D group,neurobehavioral score was lower at 3,5,7 day(P<0.001);area of cerebral infarction,degree of cerebral edema were less(P=0.01,P=0.002),activity of SOD and GSH-PX were higher at 3,7 days(P=0.03,P=0.001)respectively.When compared PD group with D group,area of cerebral infarction,degree of cerebral edema were less(P<0.01,P=0.008),activity of SOD and GSH-PX were higher at 3,7 days(P=0.009,P<0.001)respectively.Conclusions  The combination of Xuesaitong and dexmedetomidine can obviously reduce the damage by cerebral ischemia-reperfusion in elderly rats and has brain protective effects.
医院管理

广州中医优势病种分值付费政策实施效果探析

Analysis on the effect of dominant diseases of traditional Chinese medicine under the DIP payment mode in Guangzhou

:849-854
 
       目的   分析广州市中医优势病种按病种分值付费政策实施效果,以期为完善广州市中医病种付费方式改革提供参考思路。方法   以广州市某三甲中医医院住院患者在政策实施前(n=6 057)及实施后(n=7 208)住院病历为研究样本,对医院次均住院医疗费用、中医综合治疗费占比、平均住院日进行两独立样本非参数检验等描述性统计分析。  政策实施后,住院人次增长19%,患者次均住院医疗费用下降7.02%(P<0.001),中医综合治疗费用占比提升0.8%P>0.05),医疗机构平均住院日缩短0.63 d(P<0.001),入组中医优势病种患者自费率较非入组的低,医疗机构总体病例组合指数下降,中医优势病种结算有盈余。结论  中医优势病种按病种分值付费政策有利于医保-患者-医院三方共赢;但中医优势病种入组率有待提高,建议加大对中医医疗机构的支持与助力;中医综合治疗费用占比提升不显著,建议完善中医治疗项目医疗服务价格动态调整机制;中医优势病种仅局限在住院,建议实现诊疗单元全覆盖。
       Objective  To discuss the correlation analysis of the hospitalization expenses of TCM dominant diseases under the DIP payment mode,and provide a reference for further promoting the reform of the payment mode of TCM dominant diseases in Guangzhou.Methods  The nonparametric test was used to analyze the number of inpatients,the average hospitalization cost,and the proportion of TCM comprehensive treatment on the data of inpatient records before and after the implementation of the TCM dominant diseases policy,the sample sizes were 6 057 and 7 028 respectively.Results  After the implementation of the TCM dominant diseases policy,there was a slight fluctuation in the number of inpatients from 6 057 to 7 208,the average hospitalization cost was decreased by 7.02%(P<0.001),the proportion of TCM comprehensive treatment costs had an increase of 0.8%(P0.05),the average length of hospital stay was shorten by 0.63 days(P<0.001),the self-expense  rate of the patients with the TCM dominant diseases of in the group was lower than that of the patients without the group,the total case mix index value of the hospital decreased,but there was a surplus on the group of TCM dominant diseases settlement.Conclusios  The policy is conducive to the tripartite win-win of medical insurance,patients and hospitals.However,the enrollment rate of TCM dominant diseases need to be improved,which is suggested to increase the support for TCM hospitals.The proportion of TCM comprehensive treatment has not increased significantly,so it is suggested to improve the dynamic adjustment mechanism of medical service price of TCM treatment items.The TCM dominant diseases are only limited to hospitalization,and it is recommended to achieve full coverage of diagnosis and treatment units.
论著

口服铁剂对改善男性机采血小板固定献血者铁缺乏的效果

The effect of oral iron supplements on improving iron deficiency in male regular plateletpheresis donors

:815-818
 
       目的   探讨口服铁剂方法用于改善铁缺乏的男性机采血小板固定献血者铁营养状况效果,为采供血机构完善无偿献血者关爱策略提供数据支持。方法   选择2022年9月—2023年8月珠海市中心血站男性血小板固定献血者进行铁蛋白(FER)检测。以FER<30 ng/mL为铁缺乏的判定标准。将49名铁缺乏的男性机采血小板固定献血者随机分成干预组、对照组,分别进行口服铁剂干预,比较两组干预前后血红蛋白(Hb)、血清铁(SI)、FER的浓度变化情况。结果   共检测205名男性机采固定献血者,其中49名FER<30 ng/mL(铁缺乏组),占23.90%,其Hb、SI、FER均值低于FER≥30 ng/mL男性机采固定献血者(正常组)。49名铁缺乏的机采固定献血者口服铁剂干预后:干预组SI、FER浓度分别为(15.97±5.14)μmol/L、(30.55±14.42)ng/mL,高于对照组[(11.49±4.02)μmol/L、(12.77±5.86)ng/mL)],其差异有统计学意义(t=3.466,P<0.001;t=5.493,P<0.001)。干预组Hb为(143.42±10.85)g/L,高于对照组的(140.88±12.97)g/L,但差异无统计学意义(t=-0.726,P=0.471)。结论   针对铁蛋白低值的机采男性固定献血者,采取口服铁剂方法可以有效改善其铁缺乏状况。
       Objective  To explore the effect of oral iron  supplements on improving iron  deficiency in male  regular plateletpheresis donors.Methods  Male regular plateletpheresis donors from Zhuhai Blood Central Station were selected for ferritin(FER)detection.Using FER<30 ng/mL as the criterion for determining iron deficiency,49 donors were selected as the study subjects and divided into intervention group and control group,and the changes in hemoglobin(Hb),serum iron(SI),andFER concentrations were compared.Results  A total of 205 male regular plateletpheresis donors underwent FER detection,of which 49 donors had FER under 30 ng/mL(iron deficiency group),accounting for 23.90%.The mean Hb,SI,and FER levels in the iron deficiency group were significantly lower than those with FER≥30 ng/mL.After oral iron intervention,the SI and FER levels in the intervention group([15.97±5.14] μmol/L,[30.55±14.42] ng/mL)were significantly higher than those in the control group([11.49±4.02] μmol/L,[12.77±5.86] ng/mL),and the difference were statistically significant(t=3.466,P<0.001;t=5.493,P=0.000).The Hb values of the intervention group and the control group were(143.42±10.85)g/L and(140.88±12.97)g/L,respectively,with no statistically significant difference between the groups(t=-0.726,P=0.471).Conclusions  Oral iron supplementation can effectively improve iron deficiency in male regular plateletpheresis donors.
论著

钝性分离扩皮法与常规扩皮法在乳腺癌术后患者 PICC 置管中的应用效果

Application effect of blunt separating skin expansion and conventional skin expansion in PICC catheterization for patients with breast cancer after operation

:798-803
 
       目的  对比分析钝性分离扩皮法与常规扩皮法对乳腺癌术后患者经外周静脉置入中心静脉导管(PICC)置管应用效果。方法  选取2022年4月—2024年4月在天津肿瘤医院空港医院接受治疗的120例乳腺癌术后PICC置管患者,依据随机数字表法进行分组处理。对照组60例给予常规扩皮法,观察组60例给予钝性分离扩皮法,对比两组患者扩皮结果。结果  观察组患者满意度为96.67%,对照组患者满意度为86.67%(χ 2 =3.927,P=0.048);观察组患者的穿刺点血液浸湿面积分别为穿刺后即刻(0.87±0.14)cm2 、1 d后(4.89±0.94)cm2 以及3 d后(0.21±0.05)cm2 ,均低于对照组的(2.74±0.63)(9.89±2.04)(0.44±0.12)cm2 ,对比差异有统计学意义(t=22.444、17.243、13.704,P<0.05);观察组患者一次性送鞘成功率为98.33%,对照组患者一次性送鞘成功率为88.33%,观察组高于对照组(χ 2 =4.821,P=0.028);扩皮前两组患者的VAS评分无差异(P>0.05),扩皮后两组患者的VAS评分均降低,且观察组(1.75±0.54)分低于对照组(3.89±1.22)分,对比差异有统计学意义(t=12.425,P<0.001);观察组患者不良事件发生率为5.00%,对照组患者不良事件发生率为16.67%,观察组患者不良事件发生率低于对照组(χ 2 =4.227,P<0.05)。结论  钝性分离扩皮法能够降低穿刺点血液浸湿面积及不良事件发生率,提高一次性送鞘成功率,减轻患者疼痛感,提高患者满意度。
       Objective  To analyze the effect of blunt separating skin expansion and conventional skin expansion in PICC catheterization of patients after breast cancer surgery.Methods  From April 2022 to April 2024,120 patients with postoperative PICC catheterization for breast cancer were selected and grouped according to the random number table method.Sixty patients in the control group received conventional skin expansion,and 60 patients in the observation group  received blunt separation skin expansion,which the results of the two groups were compared.Results  The patient satisfaction was 96.67% in the observation group,86.67% in the control group(χ 2 =3.927,P=0.048,P<0.05).In the observation group,the blood immersion area after catheterization,after 1 d and 3 d were(0.87±0.14),(4.89±0.94),(0.21±0.05)cm2 ,lower than those of the control group [(2.74±0.63)(9.89±2.04)(0.44±0.12)cm2 ],the comparative difference was statistically significant(t=22.444,17.243,13.704,P<0.05).The success rate of disposable sheath delivery in the observation group was 98.33%,which was higher than 88.33% in the control group(χ 2 =4.821,P=0.028<0.05).There was no difference in VAS scores between the two groups before the intervention(P>0.05),VAS scores decreased in both groups after the intervention,the score of the observation group(1.75±0.54)was lower than that of the control group(3.89±1.22),the difference was statistically significant(t=12.425,P<0.001).The incidence of adverse events in the observation group was 5.00%,and in the control group was 16.67%,which difference was significant(χ 2 =4.227,P<0.05).Conclusions  Blunt separating skin expansion can  reduce the area of blood immersion and the incidence of adverse events,improve the success rate of disposable sheath delivery,reduce patient pain,improve patient satisfaction,and have significant clinical application value.
论著

功能性经口摄食分级的吞咽管理对高龄吞咽障碍患者的应用效果

Application effect of Functional Oral Intake Scale swallowing management on elderly patients with swallowing disorders

:775-781
 
       目的  探讨功能性经口摄食分级的吞咽管理对高龄吞咽障碍患者的应用效果。方法  选取2022年5月—2024年5月暨南大学附属广州市红十字会医院收治的80例高龄吞咽障碍患者作为研究对象,应用随机数字表法将其分为观察组与对照组,各40例。对照组患者实施常规干预,观察组实施功能性经口摄食分级的吞咽管理干预,对比两组患者干预效果、干预前后的吞咽功能与营养状况、吞咽障碍相关并发症发生率,以及干预前后两组生活质量变化。结果  观察组总有效率为92.50%,高于对照组的72.50%(χ 2 =5.541,P=0.019);两组干预后综合性营养评估法(SGA)、进食评估问卷调查工具-10(EAT-10)评分均降低,且观察组[(6.62±1.24)(15.26±3.42)分]低于对照组[(10.85±2.32)(23.51±4.37)分],对比差异有统计学意义(t分别为10.170、9.403,P<0.05);观察组吞咽障碍相关并发症发生率17.50%低于对照组42.50%(χ 2 =5.952,P=0.015);两组干预后生活质量综合评定量表(GQOLI-74)相关维度物质评分均升高,且观察组患者GQOLI-74相关维度物质生活(16.62±2.24)、心理功能(18.26±4.42)分、社会功能(21.62±3.66)分、躯体功能(23.26±4.37)分均高于对照组[(13.25±3.32)(13.51±2.37)(15.26±2.35)(16.62±3.73)]分,对比差异有统计学意义(t分别为5.322、5.990、9.248、7.309,P<0.05)。结论  功能性经口摄食分级的吞咽管理对高龄吞咽障碍患者干预效果显著,且可提升其吞咽功能,改善营养状况,同时可辅助降低吞咽障碍相关并发症发生率,提高患者生活质量。
       Objective  To explore the application effect of Functional Oral Intake Scale(FOIS)swallowing management on elderly patients with swallowing disorders.Methods  A total of 80 elderly patients with dysphagia admitted to the Guangzhou Red Cross Hospital Affiliated to Jinan University from May 2022 to May 2024 were selected as research subjects.They were divided into an observation group and a control group,with 40 cases in each group,using a random number table method.The control group received routine intervention,while the observation group received FOIS swallowing management intervention.The intervention effects were compared between the two groups,including pre and post intervention,swallowing function and nutritional status,incidence of swallowing related complications,and changes in quality of life before and after the intervention.Results  The total effective rate of the observation group was 92.50%,which was higher than the 72.50% of control group(χ 2 =5.541,P=0.019).After the intervention,the comprehensive nutrition assessment(SGA)and the feeding assessment instrument-10(EAT-10)were decreased,and the observation group ([6.62±1.24]and[15.26±3.42]) were lower than the control group ([10.85±2.32]and[23.51±4.37]),and the comparative difference was statistically significant(t=10.170,9.403,P<0.05).The incidence of complications related to swallowing disorders in the observation group was 17.50%,lower than that in the control group was 42.50%(χ 2 =5.952,P=0.015).After intervention,the scores of GQOLI-74 related dimensions were increased in both groups.In addition,GQOLI-74 related dimensions of material life(16.62±2.24)scores,psychological function(18.26±4.42)scores,social function(21.62±3.66)scores,physical function(23.26±4.37)scores in observation group were higher than those in control group ([13.25±3.32],[13.51±2.37],[15.26±2.35],[16.62±3.73]),and the difference was statistically significant(t=5.322,5.990,9.248,7.309,P<0.05).Conclusions  The swallowing management of FOIS has a significant intervention effect on elderly patients with swallowing disorders,and can improve their swallowing function,nutritional status,and assist in reducing the incidence of swallowing disorder related complications,thereby improving the quality of life of patients.
论著

不同的复苏方式对感染性休克患者的应用效果

The application effect of different resuscitation methods on patients with septic shock

:675-680
 
       目的   探讨碳酸氢钠林格液联合乳酸靶向复苏对感染性休克患者的应用效果。方法   选取中国人民解放军联勤保障部队第九八八医院2019年1月—2023年12月收治的80例感染性休克患者,应用随机数字表法将其分为观察组与对照组,均为40例。对照组患者采用复方氯化钠溶液进行液体复苏,观察组患者采用碳酸氢钠林格液联合乳酸靶向复苏。对比两组患者复苏前与复苏后24 h的静脉血氧饱和度(SvO2)、平均动脉压(MAP)、心脏指数(CI)、心率(HR)等相关生命体征变化,血乳酸、pH值、血钠(Na+ )、血氯(Cl- )、碳酸氢根离子(HCO3-)水平变化,对比两组患者症状体征消失时间、意识恢复时间、机械通气时间、ICU住院时间、总住院时间及预后不良情况与并发症发生率。结果   复苏后两组SvO2、MAP、CI均升高,且观察组的SvO2为(73.62±6.24)%,MAP为(75.26±11.42)mmHg,CI为(3.62±0.66)min/m2 ,均高于对照组的(66.85±8.32)%、(68.51±8.37)mmHg 和(3.16±0.35)min/m2 ,而HR均降低,其中观察组为(113.26±12.37)次/分,低于对照组的(122.62±12.73)次/分,比较差异有统计学意义(t=4.117,P<0.001;t=3.015,P=0.003;t=3.894,P<0.001;t=3.335,P<0.001)。复苏后两组血乳酸、Cl- 均降低,pH值、Na+ 、HCO3-均升高,观察组血乳酸为(1.46±0.52)mmol/L,低于对照组的(2.25±0.32)mmol/L,比较差异有统计学意义(t=8.183,P<0.001),但两组pH值、Na+ 、Cl- 、HCO3-水平对比差异无统计学意义(P>0.05)。观察组症状体征消失时间为(2.34±0.58)d、意识恢复时间为(1.15±0.27)d、机械通气时间为(5.82±1.08)d、ICU住院时间为(11.85±2.28)d、总住院时间为(23.15±4.26)d,均低于对照组的(3.54±0.72)(2.95±0.34)(10.35±2.12)(15.12±3.23)(27.24±6.37)d,比较差异有统计学意义(t=8.209,P<0.001;t=26.221,P<0.001;t=12.042,P<0.001;t=5.231,P<0.001;t=3.376,P<0.001)。观察组多器官功能障碍综合征、肺水肿、脑水肿、再次休克、死亡等不良预后发生率低于对照组(7.50% vs32.50%;χ 2 =7.810,P=0.005)。结论   碳酸氢钠林格液联合乳酸靶向复苏可稳定感染性休克患者生命体征,降低乳酸水平,改善患者预后,缩短住院时间,且能够辅助降低患者不良预后发生率。
       Objective  To explore the application effect of sodium bicarbonate Ringer’s solution combined with lactate targeted resuscitation on patients with septic shock.Methods  A total of  80  patients with  septic  shock admitted to the  988 Hospital,Joint Logistic Support Force of the Chinese People’s Liberation Army from January 2019 to December 2023 were selected and divided into observation group and control group by random number table method,with 40 cases in both groups.The control group was treated with compound sodium chloride solution for liquid resuscitation,and the observation group was treated with sodium bicarbonate Ringer’s solution combined with lactic acid for targeted resuscitation.The changes in SvO2,MAP,CI,HR,as well as changes in blood lactate,pH,Na+ ,Cl- ,and HCO3- levels were compared between two groups of patients before and 24 hours after resuscitation.The time for symptom disappearance,consciousness recovery,mechanical ventilation,and ICU hospitalization were compared between the two groups of patients,as well as total length of hospital stay,poor prognosis,and incidence of complications.Results  That the SvO2,MAP,and CI were elevated in both groups after resuscitation,and of the observation group (SvO2[73.62±6.24]%,MAP[75.26±11.42]mmHg,CI[3.62±0.66]min/m2 )was  higher than that of the control group ([66.85±8.32]%,[68.51±8.37]mmHg,[3.16±0.35]min/m2 ),the HR was decreased in all cases,the observation group(113.26±12.37)times/min was lower than the control group(122.62±12.73)times/min,the difference was statistically significant(t=4.117,P<0.001;t=3.015,P=0.003;t=3.894,P<0.001;t=3.335,P<0.001).After resuscitation,both groups blood lactate and Cl-  were decased,pH value,Na+ ,and HCO3- increased,and the observation group blood lactate(1.46±0.52)mmol/L was lower than the control group(2.25±0.32)mmol/L,the difference was statistically significant(t=8.183,P<0.001).But the comparison of pH value,Na+ ,Cl- ,and HCO3- levels between the two groups was not different(P>0.05).Time of disappearance(2.34±0.58)d,time of consciousness(1.15±0.27)d,time of mechanical ventilation(5.82±1.08)d,length of ICU stay(11.85±2.28)d and total length of stay([23.15±4.26]d,[3.54±0.72]d,[2.95±0.34]d,[10.35±2.12]d,[15.12±3.23]d,[27.24±6.37]d),the difference was statistically significantt=8.209,P<0.001,t=26.221,P<0.001,t=12.042,P<0.001;t=5.231,P<0.001;t=3.376,P<0.001).The incidence of multiple organ dysfunction syndrome,pulmonary edema,cerebral edema,reshock,and death in the observation group was significantly lower than that in the control group(7.50% vs 32.50%;χ 2 =7.810,P=0.005,P<0.05).Conclusions  The combination of sodium bicarbonate Ringer’s solution and lactate targeted  resuscitation can improve the vital signs of septic shock patients,reduce lactate levels,significantly improve patient prognosis,shorten hospital stay,and assist in reducing the incidence of complications and mortality.
论著

早产儿呼吸窘迫综合征拔管后 NIPPV 和 NCPAP 作为无创呼吸支持过渡的临床效果对比

Comparison of the clinical effects of NIPPV and NCPAP as a noninvasive respiratory support for preterm infants after extubation

:516-522
 
       目的    探究经鼻间歇正压通气(NIPPV)和经鼻持续正压通气(NCPAP)作为早产儿呼吸窘迫综合征气管插管机械通气拔管后无创呼吸支持过渡的临床效果的差异。方法   纳入2021年1月—2023年6月在广东省吴川市妇幼保健计划生育服务中心治疗的新生儿呼吸窘迫综合征早产儿66例,用随机数字表法将患儿分为NIPPV组(33例)和NCPAP组(33例)。NIPPV组患儿予经鼻间歇正压通气作为过渡期无创呼吸支持,NCPAP组患儿则予以经鼻持续正压通气作为过渡期无创呼吸支持。对比两组患儿治疗前后血气分析结果、脱机失败率、无创呼吸支持时间、无创后吸氧时间、总给氧时间等指标。结果  接受无创呼吸支持12 h后,NIPPV组患儿的PaO2升至(76.46±1.10)mmHg,高于NCPAP组患儿的(75.51±2.15)mmHg(t=2.249,P=0.028)。此外,NIPPV组患儿的SaO2升至(96.36±0.52)%,也高于NCPAP组患儿的(96.07±0.59)%(t=2.138,P=0.034)。而NIPPV组患儿的PaCO2则降至(41.39±0.74)mmHg,较NCPAP组患儿的(41.87±0.95 )mmHg低(t=-2.230,P=0.025)。NIPPV组无创呼吸支持时间为(3.09±0.52)d,短于NCPAP组的(3.45±0.62)d,且该差异有统计学意义(t=2.584,P=0.012)。同样的,NIPPV组总给氧时间(9.52±0.76)天较NCPAP组的(10.00±0.79)天短,且该差异有统计学意义(t=-2.548,P=0.013)。而两组在脱机失败率、无创呼吸支持后吸氧时间、不良反应发生率等方面比较差异无统计学意义(均P>0.05)。结论   与NCPAP模式相比,早产儿拔管后应用NIPPV模式进行无创呼吸支持取得的临床效果更优。
      Objective  To explore the difference of clinical effect of nasal intermittent positive pressure ventilation(NIPPV)and nasal continuous positive pressure ventilation(NCPAP)as non-invasive respiratory support mode after extubation in preterm infants with endotracheal intubation.Methods   Sixty-six cases of preterm infants with neonatal respiratory distress syndrome treated in our hospital from January 2021 to June 2023 were included.All the subjects were randomly divided into NIPPV groupn=33)and NCPAP group(n=33).The blood gas analysis results,weaning failure rate,non-invasive respiratory support time,oxygen inhalation time after noninvasive ventilation,total oxygen administration time.were compared between the two groups.Results   After 12 hours of noninvasive respiratory support,PaO2 in the NIPPV group increased to(76.46±1.10)mmHg,which was significantly higher than that(75.51±2.15)mmHg in the NCPAP group(t=2.249,P=0.028).In addition,SaO2 in the NIPPV group increased to (96.36±0.52)%,which was also significantly higher than that(96.07±0.59)% in the NCPAP group(t=2.138,P=0.034).The PaCO2 in the NIPPV group decreased to (41.39±0.74)mmHg,which was lower than that(41.87±0.95)mmHg in the NCPAP group(t=-2.230,P=0.025).The  duration of  non-invasive  respiratory  support in the NIPPV group(3.09±0.52) days was shorter than that(3.45±0.62)days in the NCPAP group,and the difference was statistically significant(t=2.584,P=0.012).Similarly,the total duration of oxygen administration in the NIPPV group(9.52±0.76)days was shorter than that(10.00±0.79)days in the NCPAP group,and the difference was statistically significant(t=-2.548,P=0.013).There were no significant differences in weaning failure rate,oxygen inhalation time after noninvasive respiratory support,and incidence of adverse reactions between the two groups(P>0.05).Conclusions   Compared with NCPAP mode,NIPPV mode for non-invasive respiratory support in preterm infants after extubating has better clinical effect,and it is worthy of clinical application.
论著

预防性风险管理对肌层浸润性膀胱癌根治术后的应用效果及术后生活质量影响

Effect of preventive risk management after surgery and quality of life of myometrial invasive bladder cancer patients

:494-499
 
       目的   探讨预防性风险管理在肌层浸润性膀胱癌根治术后的应用效果及对术后生活质量影响。方法   选取2020年6月—2023年10月安阳市肿瘤医院收治的66例肌层浸润性膀胱癌患者,应用抽签法分为观察组(n=33)与对照组n=33)。所有患者均采取根治性全膀胱切除术与淋巴清扫术治疗,对照组患者术后实施常规护理,观察组在对照组基础上增加预防性风险管理。对比两组术后尿量、胃肠功能恢复时间、术后住院时间,干预前后病耻感及负面情绪、术后并发症发生率,最后对比两组干预前后生活质量变化。结果   两组患者术后尿量对比差异无统计学意义(P>0.05),观察组术后胃肠功能恢复时间为(5.27±0.82)d,术后住院时间为(18.31±3.27)d,短于对照组的(7.25±1.12)(23.27±4.18)d,对比差异有统计学意义(t分别为8.194、5.369,P<0.05);干预后两组患者病耻感量表(SSCI)、抑郁自评量表(SDS)和焦虑自评量表(SAS)评分均降低,观察组分别为(35.67±7.45)(40.02±2.43)(45.36±4.17)分,低于对照组的(48.27±10.69)(54.54±3.54)(51.37±4.38)分,对比差异有统计学意义(t分别为5.555、19.426、5.709,P<0.05);观察组术后并发症发生率为9.09%,低于对照组的30.30%(χ 2 =4.690,P=0.030);干预后两组膀胱癌特异性模块、功能状况、精神状况、家庭/社会状况及躯体状况相关维度膀胱癌患者生活质量量表(FACT-BL)评分均升高,观察组分别为(34.27±3.26)(25.11±4.23)(21.51±4.23)(25.02±4.43)(20.56±3.11)分,高于对照组的(27.00±4.34)(21.11±3.24)(16.12±2.12)(21.54±5.54)(15.87±4.13)分,对比差异有统计学意义(t分别为7.694、4.313、6.544、2.818、5.211,P<0.05)。结论   预防性风险管理在肌层浸润性膀胱癌根治术后的应用效果显著,可缩短患者术后胃肠功能恢复时间及住院时间,改善患者负面情绪,有助减少术后并发症,提升患者生活质量。
       Objective  To explore the effect of preventive risk management on postoperative application and quality of life of myometrial invasive bladder cancer patients after radical surgery.Methods  A total of 66 patients with myometrial invasive bladder cancer admitted to Anyang Cancer Hospital from June 2020 to October 2023 were selected as research objects,and were divided into observation group(n=33)and control group(n=33)by lot drawing.All patients were treated with  radical total cystectomy and lymph node dissection.The control group received routine nursing care after surgery,while the observation group received preventive risk management in addition to the control group.The postoperative urine output,recovery time of gastrointestinal function,and hospitalization time between two groups were compared,as well as the shame and negative emotions before and after intervention,the incidence of postoperative complications,and the changes in quality of life between the two groups before and after intervention.Results  There was no significant difference in postoperative urine volume between the two groups of patients(P>0.05),and the postoperative gastrointestinal function recovery time(5.27±0.82)d,postoperative hospitalization time(18.31±3.27)d were shorter than the control group[(7.25±1.12)d,(23.27±4.18)d],with statistical significantce(t=8.194,5.369,P<0.05).After intervention,the Stigma Scale of Chronic Illness(SSCI),Self Rating Depression Scale(SDS),and Self-Rating Anxiety Scale(SAS)in both groups of patients decreased,and the observation group[(35.67±7.45),(40.02±2.43),(45.36±4.17)]scored lower than the control group[(48.27±10.69),(54.54±3.54),(51.37±4.38)],statistically significantt=5.555,19.426,5.709,P<0.05).The incidence of postoperative complications in the observation group was significantly lower at 9.09% compared to the control group at 30.30%(χ 2 =4.690,P=0.030,P<0.05).After intervention,the scores of bladder cancer specific module,functional status,mental status,family/social status and physical status  related dimensions of bladder cancer patients’ quality of life scale for bladder cancer patients(FACT-BL)in both groups increased,and the observation group[(34.27±3.26),(25.11±4.23),(21.51±4.23),(25.02±4.43),(20.56±3.11)] scored higher than the control group[(27.00±4.34),(21.11±3.24),(16.12±2.12),(21.54±5.54),(15.87±4.13)],the comparison was statistically significant(t=7.694,4.313,6.544,2.818,5.211,P<0.05).Conclusions  Preventive  risk management has a significant effect on the application of myometrial invasive bladder cancer after radical surgery,which can shorten the recovery time of gastrointestinal function and hospital stay,improve patients’ negative emotions,assist in preventing postoperative complications,and improve patients’ quality of life.
医学教育

住院医师规范化培训师资教学能力提升效果评价

Evaluation on the improvement of resident standardization training teachers’ teaching ability

:416-421
 
       目的   对该培训基地师资2021—2023年教学能力进行评价,了解和分析“1+3+n”的院级督导推行前的2021年、“1+3+n”的院级督导推行后的 2022年、2023年师资的教学能力变化。方法   采用问卷调查法收集评价数据,采用SPSS.27.0对教学评价资料进行统计分析,采用净推荐值计算教学口碑,对多年度结果进行纵向比较分析。结果  2021—2023年教学评价次数共5 483次;2021—2023年对师资教学设计能力评价由实施前的8.8提高到9.6、教学实施能力由实施前的9.0提高到9.5、教学热情由实施前的9.0提高到10.0、时间投入由实施前的9.3提高到10.0,不同年份组间比较的差异均有统计学意义(P<0.001);课程净推荐值由实施前的60.5%提高到81.3%,师资课程推荐者占比由实施前的65.5%提高到83.2%,贬损者占比由实施前的5.0%降低到1.9%,差异有统计学意义(χ 2 =175.4,P<0.001)。结论   “1+3+n院级督导模式的相关举措,对师资教学能力的提高具有促进作用,且该促进作用持续存在,师资教学能力逐年递增。
    Objective  To evaluate the teaching ability change of teachers  from 2021 to 2023,including of teachers’ teaching ability in 2021 before the implementation of "1+3+n" college-level supervision,and in  2022  and  2023  after the implementation of "1+3+n" college-level supervision.Methods  Questionnaire survey was used to collect evaluation data,SPSS.27.0 was used to make statistical analysis of teaching evaluation data,and NPS(Net Promoter Score)was used to evaluate teaching quality.Results  From 2021 to 2023,there were 5483 teaching evaluations.From 2021 to 2023,teaching design ability evaluation score increased from 8.8 before the implementation to 9.6,teaching implementation ability evaluation score increased from 9.0 before the implementation to 9.5,teaching enthusiasm evaluation score increased from 9.0 before the implementation to 10.0,time investment evaluation score increased from 9.3 before the implementation to 10.0,and the differences between different years were statistically significant(P<0.001).The courses quality increased from 60.5% before the implementation to 81.3%,and the proportion of teachers' course recommenders has increased from 65.5% before the implementation to 83.2%,while the proportion of detractors has decreased from 5.0% before the implementation to 1.9%,with statistical significance(χ 2 =175.4,P<0.001).Conclusions  The measures of "1+3+n" college-level supervision mode promote the improvement of teachers’ teaching ability,the promotion effect persists,and the teaching ability increases year by year.
出版者信息








《广州医药》公众号