目的 探讨老年慢性阻塞性肺疾病急性加重期（AECOPD）患者应用十味龙胆花颗粒联合硫酸特布他林治疗的临床效果。方法 回顾性选取我院收治的116例老年AECOPD患者（选例时间：2024年1月~2026年2月）为研究对象，根据治疗方案将其分为参照组（58例，接受硫酸特布他林治疗）、联合组（58例，接受十味龙胆花颗粒联合硫酸特布他林治疗）。对比两组临床疗效、不良反应及治疗前后中医证候积分、慢性阻塞性肺疾病评估测试（CAT）评分、血气指标［动脉血二氧化碳分压（PaCO2）、血氧饱和度（SpO2）、动脉血氧分压（PaO2）］、免疫功能、炎症相关细胞因子［白细胞介素-8（IL-8）、分泌卷曲相关蛋白1（SFRP1）、肿瘤坏死因子-α（TNF-α）、趋化因子配体9（CXCL9）］水平。结果 联合组总有效率（94.83%）高于参照组（79.31%）（P＜0.05）；联合组治疗后各中医证候积分均较参照组低（P＜0.05）；与参照组相比，治疗后联合组CAT评分较低（P＜0.05）；联合组治疗后PaCO2水平较参照组低，SpO2、PaO2水平较参照组高（P＜0.05）；联合组治疗后CD3+、CD4+、CD4+/CD8+水平较参照组高，CD8+水平较参照组低（P＜0.05）；治疗后联合组血清IL-8、SFRP1、TNF-α、CXCL9水平均较参照组低（P＜0.05）；不良反应发生情况组间比较，无明显差异（P＞0.05）。结论 十味龙胆花颗粒联合硫酸特布他林可提高老年AECOPD患者治疗效果，减轻临床症状，改善肺功能、免疫功能及血气指标，降低机体炎症反应程度。

对比微创拔牙与传统拔牙在下颌阻生智齿治疗中的效果及并发症概率。方法：自2023年1月至2025年9月，选取110名下颌阻生智齿患者，采用随机数字列表法，将对象均衡地分为实验组（55人）与对照组（55人）。观察组行微创拔牙术（高速涡轮手机分牙+微创牙挺），对照组行传统拔牙术（骨凿劈冠+锤击增隙）。对比两组手术时间、术后疼痛程度、张口度及术中及术后并发症发生率。结果： 观察组施行手术的时间明显短于对照组[（25.38±5.47）min vs （31.65±6.83）min，P<0.001]；术后24h及7d的VAS评分均低于对照组[（3.52±1.21）分 vs （5.87±1.56）分，（0.89±0.65）分 vs （1.95±0.91）分，均P<0.001]，张口度大于对照组（均P<0.001）。观察组术中并发症总发生率（1.82%）显著低于对照组（14.55%）（P=0.009），术后并发症总发生率（3.64%）亦显著低于对照组（20.00%）（P=0.022）。结论：相较于常规拔牙方式，下颌阻生智齿的微创手术能显著减少治疗时间，减轻术后疼痛与张口受限，并显著降低术中及术后并发症风险，疗效与安全性俱佳，具备临床推广价值。

To compare the efficacy and complication rates of minimally invasive tooth extraction versus traditional extraction in treating impacted lower wisdom teeth. Methods: From January 2023 to September 2025,110 patients with impacted lower wisdom teeth were randomly assigned to an experimental group (55 cases) and a control group (55 cases) using a random number table. The experimental group underwent minimally invasive extraction (high-speed rotary mobile phone tooth splitting + minimally invasive tooth elevator), while the control group received traditional extraction (bone chisel splitting + hammer gap widening). The study compared operative time, postoperative pain (VAS score), mouth opening degree, and intraoperative/operative complications between the two groups. Results: The experimental group showed significantly shorter operative time [(25.38±5.47) min vs (31.65±6.83) min, P<0.001]. Postoperative VAS scores at 24h and 7d were significantly lower in the experimental group [(3.52±1.21) vs (5.87±1.56) points, (0.89±0.65) vs (1.95±0.91) points, both P<0.001], with greater mouth opening degree (P<0.001). The total intraoperative complication rate (1.82%) in the experimental group was significantly lower than the control group (14.55%) (P=0.009), and the postoperative complication rate (3.64%) was also significantly lower than the control group (20.00%) (P=0.022). Conclusion: Compared with traditional tooth extraction, minimally invasive tooth extraction can effectively shorten the operation time, reduce postoperative pain and limited mouth opening, and significantly reduce the risk of intraoperative and postoperative complications. The efficacy and safety are excellent, and it has the value of clinical promotion.

目的：评估血细胞分离机单采制备自体富血小板血浆（PRP）治疗雄激素性脱发（AGA）的疗效及安全性。方法：纳入31例AGA患者，采用单采技术制备血小板浓度803~1669×10?/L的自体PRP，激活后行头皮注射治疗3次（间隔1个月）。于基线（T1）及每次治疗后1、2、3个月（T2~T4）评估毛发密度与不良反应。结果：患者均为男性。毛发密度由T1的（111.77±12.00）根/cm2升至T4的（133.74±16.34）根/cm2（均P＜0.001）。医师评估有效率80.6%，患者满意率74.2%。主要不良反应为注射部位出血、肿痛及灼热感，均自行缓解；1例出现额部及眼睑明显水肿，5 d后消退。结论：单采自体PRP治疗AGA疗效确切且安全。规范控制PRP制备质量及血小板浓度有助于优化疗效。

Objective: To evaluate the clinical efficacy and safety of autologous platelet-rich plasma (PRP) prepared via apheresis using a blood cell separator for the treatment of androgenetic alopecia (AGA). Methods: A total of 31 patients with AGA who completed the study were enrolled. Autologous PRP with a platelet concentration of 803-1669×10?/L was prepared using apheresis technology. After activation, the PRP was administered via intralesional scalp injections for a total of 3 sessions at 1-month intervals. Hair density changes and adverse reactions were evaluated at baseline (T1) and at 1, 2, and 3 months after the initial treatment (T2-T4). Results: All included patients were male. Hair density significantly increased from (111.77±12.00) hairs/cm2 at baseline to (133.74±16.34) hairs/cm2 at T4 (all P<0.001). The clinician-evaluated effective rate was 80.6%, and the patient satisfaction rate was 74.2%. The primary adverse reactions included hemorrhage, swelling, burning sensation, and transient pain at the injection site, all of which resolved spontaneously. Notably, 1 patient developed marked edema in the forehead and eyelids, which subsided spontaneously after approximately 5 days. Conclusion: Autologous PRP prepared via apheresis is effective and safe for the treatment of AGA. Standardized quality control of PRP preparation and platelet concentration may contribute to further optimizing the therapeutic outcomes.

肛周脓肿术后防瘘是临床的关注点，本文基于“治未病”思想，提出覆盖肛周脓肿术后防瘘全周期的防治策略，包括未病调体质、调摄饮食、优化手术、加强创面管理降低风险，既发截断病势、辨证防治并发症及局部干预防蔓延，康复期整体调养与随访促愈防复，为中医药在肛周脓肿术后防瘘的临床实践应用方面提供参考。

Prevention of fistula formation after perianal abscess surgery is a clinical concern. Based on the concept of "treating disease before it arises," this paper proposes a comprehensive prevention and treatment strategy covering the entire cycle of fistula prevention after perianal abscess surgery, including regulating constitution before disease onset, adjusting diet, optimizing surgery, strengthening wound management to reduce risk, interrupting disease progression after onset, treating complications based on syndrome differentiation, and local intervention to prevent spread. During the rehabilitation period, holistic recuperation and follow-up are emphasized to promote healing and prevent recurrence, providing a reference for the clinical application of traditional Chinese medicine in preventing fistula after perianal abscess surgery.

目的：探讨沙库巴曲缬沙坦钠对慢性心力衰竭（CHF）患者心电稳定性及心脏负荷的改善作用。方法：病例纳入2023年10月~2025年5月收治的102例CHF患者为研究对象，依据就诊时间段及治疗方案不同，将2023年3月~2024年6月沿用缬沙坦+螺内酯+比索洛尔治疗的51例患者列为常规组，将2024年7月~2025年9月采用沙库巴曲缬沙坦+螺内酯+比索洛尔治疗的51例患者列为试验组，比较两组患者的心肌纤维化，心电稳定性，心脏负荷及治疗安全性。所有患者均接受为期半年随访，比较两组患者的预后情况。结果：治疗后，试验组的基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-9（MMP-9）、半乳糖凝集素-3（Gal-3）、可溶性生长刺激表达基因2蛋白（sST2）均低于常规组（t=5.045，2.889，4.115，4.582；P＜0.05）。试验组的校正QT间期（QTc）、QT离散度（QTd）、T波峰-末间期（Tp-e）、室性早搏次数分别为（405.39±40.26）ms、（45.25±5.33）ms、（90.33±5.28）ms、（80.36±5.39）次/24h，均低于常规组[（450.22±42.19）ms、（50.37±6.15）ms、（95.29±6.44）ms、（85.27±6.18）次/24h]（t=5.490，4.493，4.253，4.276；P＜0.05）。试验组的收缩期肺动脉压（sPAP）、三尖瓣反流峰值速度（TRVmax）、左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）分别为（20.48±5.26）mmHg、（2.13±0.25）m/s、（45.29±5.62）mm、（30.61±5.33）mm，均低于常规组[（25.35±6.29）mmHg、（3.22±0.47）m/s、（50.45±6.15）mm、（35.49±6.27）mm]（t=4.242，14.622，4.423，4.235；P＜0.05）。试验组的药物相关副反应发生率与常规组比较，差异无统计学意义（P＞0.05）。截至随访结束时，试验组的不良预后发生率9.80%（5/51）低于常规组27.45%（14/51）（x2=5.239；P＜0.05）。结论：沙库巴曲缬沙坦钠能延缓CHF患者的心肌纤维化进程并改善心电稳定性，在有效改善心电稳定性并降低不良预后发生风险同时未显著增加治疗风险。

Objective:To explore the improvement effect of sacubitril valsartan sodium on electrocardiogram stability and cardiac load in patients with CHF.Methods:A total of 102 CHF patients admitted from October 2023 to May 2025 were included in the study. Based on the treatment period and regimen, 51 patients treated with valsartan, spironolactone, and bisoprolol from March 2023 to June 2024 were classified as the conventional group, while 51 patients treated with sacubitril/valsartan, spironolactone, and bisoprolol from July 2024 to September 2025 were designated as the experimental group. The myocardial fibrosis, electrocardiographic stability, cardiac workload, and treatment safety were compared between the two groups. All patients underwent a six-month follow-up to assess their prognosis.Results:After treatment, the levels of MMP-2, MMP-9, Gal-3, and sST2 in the experimental group were lower than the control group (t=5.045，2.889，4.115，4.582; P<0.05). The QTc, QTd, Tp-e, and number of ventricular premature beats in the experimental group were (405.39 ± 40.26) ms, (45.25 ± 5.33) ms, (90.33 ± 5.28) ms, and (80.36 ± 5.39) beats per 24 hours, lower than the control group [(450.22 ± 42.19) ms, (50.37 ± 6.15) ms, (95.29 ± 6.44) ms, and (85.27 ± 6.18) beats per 24 hours] (t=5.490，4.493，4.253，4.276; P<0.05). The sPAP, TRVmax, LVEDD, and LVESD of the experimental group were (20.48 ± 5.26) mmHg, (2.13 ± 0.25) m/s, (45.29 ± 5.62) mm, and (30.61 ± 5.33) mm, lower than the conventional group [(25.35 ± 6.29) mmHg, (3.22 ± 0.47) m/s, (50.45 ± 6.15) mm, and (35.49 ± 6.27) mm] (t=4.242，14.622，4.423，4.235; P<0.05). The incidence of drug-related side effects in the experimental group was not significantly different from that in the control group (P>0.05). As of the end of follow-up, the incidence of poor prognosis in the experimental group was 9.80% (5/51) lower than that in the conventional group 27.45% (14/51) (x2=5.239; P<0.05).Conclusion:Sacubitril valsartan sodium can delay the progression of myocardial fibrosis and improve electrocardiogram stability in CHF patients, effectively improving electrocardiogram stability and reducing the risk of adverse prognosis without significantly increasing treatment risk.

目的：分析冠状动脉CT血管成像（CTA）联合动态心电图（DCG）与冠心病患者冠脉狭窄程度及预后情况的关联。方法：研究对象选择我院2024年1月~2025年3月收治的210例冠心病患者及同期接受检查的210例非冠心病患者，分别列为病例组和对照组，比较两组CTA参数、DCG参数间差异。依据入院测得（Gensini）评分不同，将入组患者分别列为轻度组（60例，Gensini评分≤30分）、中度组（75例，Gensini评分＞30分、≤60分）和重度组（75例，Gensini评分＞60分），比较三组CTA参数、DCG参数间差异，分析CTA参数、DCG参数与Gensini评分的相关性。统计入组患者不良预后发生情况，比较不同预后患者CTA参数、DCG参数间差异，归纳冠心病患者预后影响因素，检验CTA参数、DCG参数对患者不良预后的预测效能。结果：病例组的最小管腔直径（MLD）、最小管腔面积（MLA）、血流储备分数（FFR）、正常窦性间期的标准差（SDNN）、每5min平均RR间期的标准差（SDANN）、相邻RR间期差值的均方根（RMSSD）均低于对照组，斑块总体积（TPV）、低频/高频比值（LF/HF）均高于对照组（t=24.128，25.811，15.613，37.636，26.858，9.195，59.862，29.389；P＜0.05）。重度组的MLD、MLA、FFR、SDNN、SDANN、RMSSD均低于中度组，轻度组，TPV、LF-HF均高于中度组，轻度组（F=190.291，51.562，186.482，42.084，44.413，22.541，56.503，109.983；P＜0.05）。MLD、MLA、FFR、SDNN、SDANN、RMSSD均与Gensini评分负相关，TPV、LF-HF均与Gensini评分正相关（r=-0.352，-0.377，-0.445，-0.472，-0.332，-0.356，0.401，0.355；P＜0.05）。经统计，210例冠心病患者的不良预后发生率为38.10%（80/210）。预后不良组的MLD、MLA、FFR、SDNN、SDANN、RMSSD均低于预后良好组，TPV、LF-HF均高于预后良好组（t=6.827，12.219，19.313，6.097，7.097，5.027，7.088，12.465；P＜0.05）。MLA、FFR、SDNN升高为冠心病不良预后的保护因素，LF/HF升高为冠心病不良预后的危险因素。FFR、SDNN联合检测预测不良预后的 AUC 值优于两项指标单独检测（Delong检验，P＜0.05）。结论：CTA、DCG能客观评估冠心病患者冠脉狭窄程度，联合检测FFR、SDNN可作为预测冠心病不良预后的重要辅助手段。

Objective:To analyze the correlation between CTA combined with DCG and the degree of coronary stenosis and prognosis in patients with coronary heart disease.Methods:The research subjects selected were 210 patients with coronary heart disease admitted to our hospital from January 2024 to March 2025, as well as 210 non coronary heart disease patients who underwent examinations during the same period. They were divided into a case group and a control group. The differences in CTA parameters and DCG parameters between the two groups were compared. According to the different Gensini scores obtained upon admission, the enrolled patients were divided into mild group (60 cases, Gensini score ≤ 30 points), moderate group (75 cases, Gensini score>30 points, ≤ 60 points), and severe group (75 cases, Gensini score>60 points). The differences in CTA parameters and DCG parameters among the three groups were compared, and the correlation between CTA parameters, DCG parameters, and Gensini score was analyzed. Statistically analyze the occurrence of poor prognosis in enrolled patients, compare the differences in CTA and DCG parameters among patients with different prognoses, summarize the factors affecting the prognosis of coronary heart disease patients, and test the predictive power of CTA and DCG parameters for poor prognosis in patients.Results:The MLD, MLA, FFR, SDNN, SDANN, and RMSSD in the case group were all lower than the control group, while the TPV and LF/HF were higher than the control group (t=24.128，25.811，15.613，37.636，26.858，9.195，59.862，29.389; P<0.05). The MLD, MLA, FFR, SDNN, SDANN, and RMSSD of the severe group were lower than the moderate group, mild group, while the TPV and LF-HF of the mild group were higher than the moderate group, mild group (F=190.291，51.562，186.482，42.084，44.413，22.541，56.503，109.983; P<0.05). MLD, MLA, FFR, SDNN, SDANN, and RMSSD are all negatively correlated with Gensini score, while TPV and LF-HF are positively correlated with Gensini score (r=-0.352，-0.377，-0.445，-0.472，-0.332，-0.356，0.401，0.355; P<0.05). According to statistics, the incidence of poor prognosis in 210 patients with coronary heart disease was 38.10% (80/210). The MLD, MLA, FFR, SDNN, SDANN, and RMSSD of the poor prognosis group were lower than the good prognosis group, while TPV and LF-HF were higher than the good prognosis group (t=6.827，12.219，19.313，6.097，7.097，5.027，7.088，12.465; P<0.05). High MLA, FFR, and SDNN are protective factors for poor prognosis of coronary heart disease, while higher values than LF/HF are risk factors for poor prognosis of coronary heart disease. The combined detection of FFR and SDNN has a better AUC value for predicting poor prognosis of coronary heart disease than the detection of FFR and SDNN alone (Delong test, P<0.05）.Conclusion:CTA and DCG can objectively evaluate the degree of coronary stenosis in patients with coronary heart disease, and combined detection of FFR and SDNN can be an important auxiliary tool for predicting poor prognosis of coronary heart disease.

目的：探讨肿瘤PICC置管患者血浆D-二聚体水平与血栓形成风险的相关性，为临床预防及早期诊断提供参考依据。方法：选取2021年6月至2024年6月我院120例肿瘤PICC置管患者为研究对象，收集其临床资料，并根据是否发生血栓形成分为血栓组（n=40）和非血栓组（n=80）。比较两组患者血浆D-二聚体水平、基本资料、PICC置管相关因素的差异，并分析血浆D-二聚体水平与血栓形成风险的相关性。结果：置管后第3天、第7天，血栓组血浆D-二聚体水平分别为（1.77±0.58）mg/L、（2.06±0.76）mg/L，均高于非血栓组的（0.93±0.44）mg/L、（1.34±0.38）mg/L，组间差异有统计学意义（P＜0.05）。多因素Logistic回归分析显示，血浆D-二聚体水平升高、置管时间超过3个月、化疗方案为含铂方案是肿瘤PICC置管患者发生血栓形成的独立危险因素（P<0.05）。ROC分析显示，血浆D-二聚体水平对肿瘤PICC置管患者血栓形成风险的预测价值良好。结论：肿瘤PICC置管患者血浆D-二聚体水平与血栓形成风险密切相关，可作为临床预防及早期诊断的重要指标。

【摘要】目的：探讨器械护士术中分区精细化器械管理对心脏瓣膜置换术（HVR）手术效率及安全性的影响。方法：研究对象包括2024年6月~2026年5月至我院行HVR治疗的110例心脏瓣膜病（VHD）患者，以及同期参与手术的22名器械护士，采用随机数字表法将入组患者及护士分别列为常规组（55例患者、11名护士）、试验组（55例患者、11名护士），常规组内护士术中实施常规器械管理，试验组内护士术中实施分区精细化器械管理。比较两组患者的手术效率、围手术期安全事件，以及两组护士所参与手术的工作效率、术中器械管理情况。结果：在不同器械管理模式下，试验组内患者的主动脉阻断时间、体外循环时间、术中非必要等待时间、手术总耗时均低于常规组（t=8.817，5.730，20.609，9.632；P＜0.05）。试验组内患者的围手术期安全事件发生率9.09%（5/55）低于常规组25.45%（14/55）（x2=5.153；P＜0.05）。试验组内护士的器械摆台时间、器械传递反应时间、手术中断次数、器械整理时间、器械移交时间均低于常规组（t=3.347，6.505，5.971，3.795，5.838；P＜0.05）。试验组内护士的器械管理差错率低于常规组（x2=5.238；P＜0.05）。结论：器械护士术中分区精细化器械管理能提高HVR患者的手术效率并降低围手术期安全事件发生风险，对提高器械护士的器械管理质量、预防器械管理差错有积极影响

[Abstract]Objective:To explore the impact of refined intraoperative instrument management by operating room nurses on the efficiency and safety of HVR surgery.Methods:The study subjects included 110 patients with VHD who underwent HVR treatment at our hospital from June 2024 to May 2026, along with 22 instrument nurses who participated in the surgeries synchronously. Using the random number table method, the enrolled patients and nurses were divided into a control group (55 patients, 11 nurses) and an experimental group (55 patients, 11 nurses). Nurses in the conventional group implemented routine instrument management during surgery, while nurses in the experimental group implemented zoned and refined instrument management during surgery. The surgical efficiency, perioperative safety events of the two groups of patients, as well as the work efficiency and intraoperative instrument management of the surgeries participated by the nurses in the two groups were compared.Results:Under different instrument management modes, the aortic occlusion time, extracorporeal circulation time, intraoperative non-essential waiting time, and total surgical time of patients in the experimental group were all lower than the control group (t=8.817，5.730，20.609，9.632; P<0.05). The incidence of perioperative safety events in the experimental group was 9.09% (5/55) lower than that in the control group 25.45% (14/55) (x2=5.153; P<0.05). The instrument placement time, instrument delivery response time, number of surgical interruptions, instrument sorting time, and instrument handover time of nurses in the experimental group were lower than those in the control group (t=3.347，6.505，5.971，3.795，5.838; P<0.05). The error rate of nurses in the experimental group was lower than the control group (x2=5.238; P < 0.05).Conclusion:Refined intraoperative zone-specific instrument management by instrument nurses enhances surgical efficiency for HVR patients and reduces the risk of perioperative safety incidents, thereby positively impacting the quality of instrument care provided by nurses and preventing instrument-related adverse events.

目的 探讨慢性阻塞性肺疾病急性加重期（AECOPD）合并呼吸衰竭机械通气患者发生撤机相关性肺水肿（WIPE）的影响因素，以指导临床早期制定个体化干预方案。方法 前瞻性选取2022年5月～2025年5月于本院接受机械通气治疗的AECOPD合并呼吸衰竭患者209例为研究对象，依据自主呼吸试验（SBT）开始后1 h内是否发生WIPE将其分为发生组73例、未发生组136例。统计两组临床资料，通过单因素、多因素Logistic回归分析确定WIPE发生的影响因素，基于回归分析构建预测模型，并验证模型的预测效能。结果 发生组年龄、入院时急性生理与慢性健康评分系统Ⅱ（APACHEⅡ）评分、浅快呼吸指数、入院时肺部超声评分、糖尿病占比、机械通气治疗24 h后动脉血二氧化碳分压（PaCO2）≥80 mmHg占比、机械通气时间≥7 d占比、吸烟史占比、合并多器官功能障碍综合征（MODS）占比、合并左心室舒张功能障碍占比高于未发生组，撤机前6 h血清高迁移率蛋白B1（HMGB1）、C反应蛋白（CRP）、乳酸（Lac）/白蛋白（Alb）高于未发生组（P＜0.05）；入院时APACHEⅡ评分、糖尿病、机械通气治疗24 h后PaCO2、机械通气时间、吸烟史、合并MODS、入院时肺部超声评分及HMGB1、Lac/Alb、CRP为WIPE发生的独立危险因素（P＜0.05）；预测模型预测WIPE发生风险的AUC值为0.880，敏感度、特异度分别为86.30%、72.79%，Hosmer-Lemeshow检验显示该模型与观测值拟合度良好，DCA曲线显示风险阈值在0.05～0.91时该模型具有良好的临床净获益。结论 入院时APACHEⅡ评分、糖尿病、机械通气治疗24 h后PaCO2、机械通气时间、吸烟史、合并MODS、入院时肺部超声评分及HMGB1、Lac/Alb、CRP为AECOPD合并呼吸衰竭机械通气患者发生WIPE的独立危险因素，基于以上危险因素构建的预测模型预测效能良好，临床应制定针对性干预方案，以降低WIPE发生风险。

目的 对比三维中等权重压缩感知并行采集序列（3D IW-CS-SENSE）与常规并行采集序列（3D IW-SENSE）在膝关节磁共振成像中的扫描时间、图像质量及诊断效能。方法 前瞻性采集100例膝关节磁共振影像。对比两组三维序列的定量指标、主观评分以及对损伤分级的准确率。结果 IW-CS-SENSE序列扫描时间显著缩短（122.0 ± 28.0 s vs 221.0 ± 49.0 s，P<0.001）。IW-CS-SENSE序列信噪比、对比噪声比及显示效果评分均低于IW-SENSE序列（P＜0.001），但IW-CS-SENSE序列的SENSE伪影评分更优（5.00 ± 0.00 vs 4.59 ± 0.62，P<0.001）。两序列对半月板、韧带及软骨损伤分级的准确率均无统计学差异（P值分别为0.33，0.58和0.15）。 结论 3D IW-CS-SENSE序列可显著缩短扫描时间和消除SENSE伪影，同时保持与4倍加速3D IW-SENSE序列相当的诊断效能。

Objective To compare the imaging times, image quality, and diagnostic performance of three-dimensional (3D) intermediate-weighted compressed sensing sensitivity encoding (IW-CS-SENSE) sequence with conventional 3D IW-SENSE sequence in knee MR imaging. Methods MR images of one hundred knees were obtained prospectively. The quantitative indices, qualitative scores, and grading accuracies between the two 3D sequences were compared. Results Imaging times of IW-CS-SENSE sequences were significantly reduced (122.0 ± 28.0 s vs 221.0 ± 49.0 s, P < 0.001). The signal-to-noise ratios, contrast-to-noise ratios, and visualization scores of IW-CS-SENSE sequences were significantly lower than IW-SENSE sequences (P < 0.001), while scores of SENSE artefact for IW-CS-SENSE sequences were superior (5.00 ± 0.00 vs 4.59 ± 0.62, P < 0.001). The accuracies in grading meniscal, ACL, and cartilage tears were comparable between the two sequences (P = 0.33, P = 0.58 and P = 0.15, respectively). Conclusion 3D IW-CS-SENSE sequences can reduce scanning time significantly and eliminate SENSE artefacts, while maintaining the same diagnostic performance as the 4-fold accelerated 3D IW-SENSE sequences.