单采自体PRP对雄激素性脱发的疗效及安全性观察
Observation on the Efficacy and Safety of Apheresis-Derived Autologous Platelet-Rich Plasma for Androgenetic Alopecia
来源期刊：
广州医药
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收稿时间：2026/6/16 2:16:32
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- 关键词：
- 雄激素性脱发；富血小板血浆；血细胞分离机单采；毛发密度；
- Androgenetic alopecia; Platelet-rich plasma; Apheresis; Hair density
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目的：评估血细胞分离机单采制备自体富血小板血浆（PRP）治疗雄激素性脱发（AGA）的疗效及安全性。方法：纳入31例AGA患者，采用单采技术制备血小板浓度803~1669×10?/L的自体PRP，激活后行头皮注射治疗3次（间隔1个月）。于基线（T1）及每次治疗后1、2、3个月（T2~T4）评估毛发密度与不良反应。结果：患者均为男性。毛发密度由T1的（111.77±12.00）根/cm2升至T4的（133.74±16.34）根/cm2（均P＜0.001）。医师评估有效率80.6%，患者满意率74.2%。主要不良反应为注射部位出血、肿痛及灼热感，均自行缓解；1例出现额部及眼睑明显水肿，5 d后消退。结论：单采自体PRP治疗AGA疗效确切且安全。规范控制PRP制备质量及血小板浓度有助于优化疗效。
Objective: To evaluate the clinical efficacy and safety of autologous platelet-rich plasma (PRP) prepared via apheresis using a blood cell separator for the treatment of androgenetic alopecia (AGA).
Methods: A total of 31 patients with AGA who completed the study were enrolled. Autologous PRP with a platelet concentration of 803-1669×10?/L was prepared using apheresis technology. After activation, the PRP was administered via intralesional scalp injections for a total of 3 sessions at 1-month intervals. Hair density changes and adverse reactions were evaluated at baseline (T1) and at 1, 2, and 3 months after the initial treatment (T2-T4).
Results: All included patients were male. Hair density significantly increased from (111.77±12.00) hairs/cm2 at baseline to (133.74±16.34) hairs/cm2 at T4 (all P<0.001). The clinician-evaluated effective rate was 80.6%, and the patient satisfaction rate was 74.2%. The primary adverse reactions included hemorrhage, swelling, burning sensation, and transient pain at the injection site, all of which resolved spontaneously. Notably, 1 patient developed marked edema in the forehead and eyelids, which subsided spontaneously after approximately 5 days.
Conclusion: Autologous PRP prepared via apheresis is effective and safe for the treatment of AGA. Standardized quality control of PRP preparation and platelet concentration may contribute to further optimizing the therapeutic outcomes.
1、广州市卫健委一般引导项目(/upload/407995/20260616/20260616015254_7964.pdf)
