目的 对兰索拉唑肠溶片联合氟哌噻吨美利曲辛治疗焦虑糜烂性胃炎患者的治疗效果进行研究。方法 选取2013年1月—2015年1月在我院收治的伴有焦虑情绪的糜烂性胃炎患者106例。随机分为对照组,给予兰索拉唑肠溶片治疗,观察组,给予兰索拉唑肠溶片联合氟哌噻吨美利曲辛治疗,并且对疗效进行比较。结果 治疗前,两组患者在腹痛、腹胀、反酸、嗳气以及黏膜糜烂各指标评分比较,差异无统计学意义(P>0.05);治疗后,2组患者以上指标均有所改善,并且观察组患者同期指标改善均优于对照组(P<0.05);治疗前,两组患者胃黏膜中PGE2和MDA含量无差异(P>0.05);治疗后,两组患者的PGE2均上升,而MDA则下降,并且观察组患者PGE2含量比对照组高,MDA则比对照组低,差异均有统计学意义(P<0.05);治疗前,两组患者HAMA、HAMD评分差异不明显,无统计学意义(P>0.05);治疗后,两组患者焦虑情况均有所改善,并且观察组患者情绪改善程度优于对照组患者,差异均有统计学意义(P<0.05);观察组不良反应发生率为5.6%,对照组不良反应发生率5.6%,差异无统计学意义,P>0.05。结论 兰索拉唑与氟哌噻吨美利曲辛联合应用有助于改善糜烂性胃炎患者的病情,并且可以缓解患者的焦虑情绪,安全性高,值得临床推广。

Objective To observe the clinical efficacy of lansoprazole enteric-coated tablets combined with flupentixol-melitracen in treating anxiety patients with erosive gastritis. Methods 106 patients with erosive gastritis and anxiety in our hospital from January 2013 to January 2015 were divided into an observation group and a control group, with 53 patients in each group. The control group was given lansoprazole enteric-coated tablets alone, and the observation group was treated with lansoprazole enteric-coated tablets and flupentixol-melitracen. Clinical symptoms and mucosal erosion were compared between the two groups of patients before and after treatment. Gastric mucosa malondialdehyde (MDA) and prostration E2 (PGE2) contents, anxiety and depression status were also assessed. Results After treatment, the scores of abdominal pain, bloating, acid reflux, belching, and mucosal erosions were significantly lower in the observation group than in the control group (P< 0.05). PGE2and MDA contents in the gastric mucosa in the observation group were different from those in the control group(P< 0.05). HAMA and HAMD scores were lower in the observation group than in the control group (P< 0.05). There was no difference of adverse reaction rate between the control group and the observation group (P>0.05). Conclusion Lansoprazole enteric-coated tablets combined with flupentixol-melitracen has better clinical efficacy than lansoprazole enteric-coated tablets only in patients with erosive gastritis and anxiety in terms of the improvement of clinical symptoms and mucosal erosion and the relief of negative emotions.

目的 评估CO₂激光治疗宫颈上皮内瘤变Ⅱ级（CIN2）病例的疗效。方法 收集2021年11月至2023年10月在本院行CO2激光治疗的92例CIN2患者的临床资料, 采用液基细胞学检查（LCT）和人乳头状瘤病毒（HPV）联合筛查随访,随访6~12个月, 任一结果异常者转诊阴道镜检查, 必要时行病理活组织检查（活检）观察鳞状上皮内病变情况。结果 92例CIN2患者中, 年龄25~45岁、有人工流产史、性伴侣人数3个及以上、因发现宫颈病变就诊者占比较多,患者均未生育。所有患者就诊时均发现HPV阳性, 20.65%患者报告HPV16阳性, HPV18阳性者占比1.09%, HPV其他12种阳性占60.87%, HPV16阳性伴其他12种阳性占17.39%。79例患者随访6个月后总HPV+LCT均阴率为74.68%（59/79）,LCT和HPV阴转率分别为92.41%（73/79）和74.68%（59/79）。所有患者术后12个月LCT均转阴。29例患者在术后12个月均无病变持续或病变发展。25岁以下患者术后6个月及12个月HPV持续率最低, 45~55岁患者术后HPV持续率最高,且多发生HPV16阳性及合并其他HPV亚型阳性的情况。结论 CO₂激光治疗可提高患者术后HPV与LCT阴转率, 所有患者术后6个月及12个月随访均无病变加重,且可明显改善年轻患者HPV感染情况。对于有生育要求且具备适应证的CIN2患者, 应积极采取CO₂激光治疗以获得更高健康收益。

Objective To evaluate the therapeutic efficacy of CO₂ laser treatment in cervical intraepithelial neoplasia grade 2（CIN2）patients. Methods We retrospectively analyzed data from 92 CIN2 patients who underwent CO₂ laser therapy at the institution from November 2021 to October 2023. Postoperative followed-up for 6-12 months, screening with liquid-based cytopathology test（LCT）and high-risk human papilloma virus（HPV）testing. Patients with abnormal results in either test were referred for colposcopy, with biopsy performed to evaluate residual or recurrent squamous intraepithelial lesions. Results Among total of 92 patients, most patients aged 25-45 years old, with a history of induced abortion, had three or more sexual partners, and visited hospital due to cervical lesions, and none of the patients gave birth. All patients were found to be HPV positive at hospital visits, with 20. 65% of HPV16 positive, 1. 09% of HPV18 positive, 60. 87% of other 12 kinds HPV positive, while HPV16 positive with other 12 kinds accounted for 17. 39%. Among the 79 patients after 6-month follow-up, the dual-negative conversion rate（HPV+LCT）was 74. 68%（59/79）, with LCT and HPV negative rates reaching 92. 41%（73/79）and 74. 68%（59/79）, respectively. After 12-month follow-up, all patients achieved LCT negativity, 29 patients with no documented lesion persistence or disease progression. Notably, patients aged <25 years exhibited the lowest postoperative HPV persistence rates between 6- to 12-month follow-up, whereas those aged 45-55 years demonstrated the highest persistence rates, frequently associated with HPV16 positivity or co-infection with other HPV subtypes. Conclusions CO₂ laser therapy significantly increases postoperative negative conversion rates for HPV and LCT. No lesion progression was observed in patients between 6- to 12-month follow-ups. The therapy also notably improves HPV clearance in younger patients. For patients with CIN2 who have fertility requirements and meet the indications, CO2 laser therapy should be actively adopted to achieve greater health benefits.

        目的   比较鲁拉西酮与奥氮平用于治疗女性急性期精神分裂症患者的疗效，以及其对体质量、糖脂代谢风险的影响。以期为女性急性期的精神分裂症患者抗精神病药物的选择提供参考。方法   连续选取于2022年4月—2024年4月内江门市第三人民医院收治的女性急性期精神分裂症患者80例，采用计算机随机分组法将患者分为治疗组与阳性药物对照组进行对照。治疗组40例口服鲁拉西酮40~80 mg/d，阳性药物对照40例组口服奥氮平5~20 mg/d。分别测量两组治疗前（基线）以及连续用药治疗2、4、6周后的PANSS量表评分，以及治疗后的代谢指标［体质量指数（BMI）、血清空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载脂蛋白A（ApoA）、载脂蛋白B（ApoB）、载脂蛋白E（ApoE），并将治疗组与对照组前后疗效及各项代谢指标进行比较分析。结果   两组的总有效率比较差异无统计学意义（χ ² =1.569，P＞0.05）；两组治疗前后PANSS量表评分的时间-组别效应与组别效应均无统计学意义（χ ² =0.466、3.640，P=0.926、0.056），时间主效应显著（χ ² =363.24，P＜0.001）。两组TG、TC、HDL、ApoA、ApoB存在组别-时间交互效应（χ ² =7.562、5.991、6.163、6.958、4.397，P=0.006、0.014、0.013、0.008、0.036），两组TG、ApoA时间主效应显著（χ ² =33.473、8.846，P＜0.001、0.003），两组ApoA组别效应显著（χ ² =4.889，P=0.027）。结论   与奥氮平相比，鲁拉西酮治疗女性急性期精神分裂症的疗效相当，且对代谢指标影响更小。

        Objective  To compare the efficacy of lurasidone and olanzapine in the treatment of female patients with acute schizophrenia，as well as their effects on body mass，glucose and lipid metabolism risk．To provide  reference for the selection of antipsychotic drugs for female patients with acute schizophrenia．Methods  From April 2022 to April 2024，80 female patients with acute phase schizophrenia admitted to the Third People’s Hospital of Jiangmen City were selected as samples and included in the study．The patients were randomly divided into a treatment group and a positive drug control group using a computer randomization method for comparison．The treatment group took oral lorazepine tablets（40 cases；40-80 mg/d），while the positive drug control group took oral olanzapine tablets（40 cases；5-20 mg/d）．The Positive and Negative Symptom Scale（PANSS）scores of two groups before treatment（baseline）and after 2，4，and 6 weeks of continuous medication treatment were measured，as well as metabolic indicators after treatment （body mass index［BMI］，serum fasting blood glucose［FPG］，total cholesterol［TC］，triglycerides［TG］，high-density lipoprotein［HDL］，low-density lipoprotein［LDL］，apolipoprotein A［ApoA］，apolipoprotein B［ApoB］，apolipoprotein E［ApoE］），and the efficacy and various metabolic indicators between the treatment group and the control group before and after treatment were compared and analyzed．Results  The total effective  rate of the two groups was not statistically significant（χ ² =1.569，P＞0.05）．The time-group effect and group effect of PANSS scores before and after treatment in both groups were not statistically significant（χ ² =0.466，3.640，P=0.926，0.056），while the time main effect was significant（χ ² =363.24，P＜0.001）．There was a group-time interaction effect between two groups of TG，TC，HDL，ApoA，and ApoB（χ ² =7.562，5.991，6.163，6.958，4.397，P=0.006，0.014，0.013，0.008，0.036）．The time main effect of TG and ApoA was significant in both groups（χ ² =33.473，8.846，P＜0.001，0.003），and the group effect of ApoA was significant in both groups（χ ² =4.889，P=0.027）．Conclusions  Compared with olanzapine，the efficacy of lurasidone in the treatment of acute phase schizophrenia in women is comparable，and it has a smaller impact on metabolic indicators．

        目的   分析达格列净联合沙库巴曲缬沙坦治疗射血分数降低的心力衰竭（HFrEF）效果。方法  连续抽取2021年1月—2023年6月在广州市第一人民医院心内科住院的射血分数降低的心力衰竭（HFrEF）患者203例，随访至少6个月，按照接受的治疗进行分组。对照组予常规治疗和沙库巴曲缬沙坦治疗；观察组予常规治疗、沙库巴曲缬沙坦和达格列净治疗；对比两组疗效，观察指标包括住院时间，入院及出院后6个月的心功能状态（NYHA纽约心脏病协会心功能分级）、心脏超声指标左室射血分数（LVEF）、左室舒张末内径（LVEDD）、左室收缩末内径（LVSDD）、血液指标-端脑钠肽前体（NT-proBNP N）、糖化血红蛋白（HBA1c）、血肌酐（Cr）、6个月时的再住院率及全因死亡率。结果   观察组心脏监护病房（CCU）停留时间（2.54±1.26）d，短于对照组的（3.73±1.21）d；观察组6个月时观察组心功能NYHA改善≥2级比例为95.05%高于对照组的86.27%，差异有统计学意义（P＜0.05）；观察组6个月时的LVEDD、LVESD水平分别为（48.22±7.35）（34.61±4.32）mm，低于对照组的（51.47±8.02）（43.07±5.33）mm，LVEF为（51.49±5.40）%，高于对照组的（46.18±4.21）%，差异有统计学意义（P＜0.05）；6个月时观察组的NT-proBNP为（415.58±31.57）pg/mL，低于对照组的（520.23±385.56）pg/mL，差异有统计学意义（P＜0.05）；两组的住院时间、血清肌酐（Cr）、HBA1c、6个月时的再住院率、全因病死率对比，差异不显著（P＞0.05）。观察组HBA1c值为（6.04±0.66）mmol/L，高于对照组的（5.20±0.56）mmol/L（P＜0.05）。结论  HFrEF患者采取达格列净+沙库巴曲缬沙坦治疗，可通过协同作用，缩短CCU停留时间，改善患者6个月时的心功能状态，降低NT-proBNP值，减少心脏扩大趋势，提高LVEF水平。

       Objective  To analyze the efficacy of  dapagliflozin combined with  sacubitril/valsartan in the treatment of heart failure with reduced ejection fraction（HFrEF）．Methods  A total of 203 patients with HFrEF who were hospitalized in the cardiology department of the hospital between January 2021 and June 2023 were enrolled and followed up for at least six months．Patients were divided into groups based on their treatment regimens：the control group received conventional treatment plus sacubitril/valsartan，while the observation group received conventional treatment plus sacubitril/valsartan and dapagliflozin．The two groups were compared for clinical outcomes，including length of hospital stay，cardiac function（NYHA classification）at admission and six months after discharge，echocardiographic indicators（LVEF，LVEDD，LVESD），blood indicators（NT-proBNP，HbA1c，creatinine），six-month rehospitalization rate，and all-cause mortality．Results  The observation group had a shorter CCU stay（2.54±1.26 days）compared to the control group（3.73±1.21 days）．At sixth month，the proportion of patients in the observation group with an NYHA improvement ≥2 grades（95.05%）was significantly higher than that in the control group（86.27%）（P＜0.05）．The observation group demonstrated lower LVEDD（48.22±7.35 mm）and LVESD（34.61±4.32 mm）levels and higher LVEF（51.49±5.40%）compared to the control group（LVEDD：［51.47±8.02］ mm，LVESD：［43.07±5.33］mm，LVEF：［46.18±4.21］%）（P＜0.05）．NT-proBNP levels in the observation group（［415.58±31.57］ pg/mL）were significantly lower than those in the control group（［520.23±385.56］ pg/ml）（P＜0.05）．There were no significant differences between the two groups in length of total hospital stay，serum creatinine，HbA1c，six-month rehospitalization rate，or all-cause mortality（P＞0.05）．However，HbA1c levels in the observation group（［6.04±0.66］ mmol/L）were higher than those in the control group（［5.20±0.56］ mmol/L）（P＜0.05）．Conclusions  The combination of dapagliflozin and sacubitril/valsartan in the treatment of HFrEF patients can exert a synergistic effect，shorten CCU stay，improve cardiac function at sixth month，reduce NT-proBNP levels，mitigate cardiac dilation，and increase LVEF．

       目的   探究腕踝针联合揿针治疗带状疱疹后遗痛的临床疗效观察。方法   选取上海市黄浦区中西医结合医院2021年10月—2024年4月收治的80例带状疱疹后遗神经痛患者为研究对象，按随机数表法分为研究组、对照组，各40例。对照组采用口服甲钴胺治疗；研究组采用腕踝针联合揿针治疗。比较两组治疗疗效；治疗前后采用视觉模拟评分（VAS）与阿森斯失眠量表评分（AIS）、皮肤病生活质量指数（DLQI）、汉密尔顿抑郁量表评分（HAMD）、汉密尔顿焦虑量表评分（HAMA）。结果   研究组治疗总有效率为92.5%，对照组治疗总有效率为75%。比较差异有统计学意义（P＜0.05）。两组患者治疗后VAS、AIS均比治疗前改善，研究组VAS评分为（1.00±0.45）、AIS评分为（7.15±0.89），优于对照组VAS（2.15±0.36）和AIS（5.65±0.70），比较差异有统计学意义（P＜0.05）。相较于治疗前，两组患者DLQI评分均有改善，研究组［休闲活动评分（1.73±0.45）、人际交往评分（1.13±0.34）、工作学习评分（0.94±0.25）、自觉症状评分（1.83±0.38）、日常活动评分（0.98±0.28）］优于对照组［休闲活动评分（2.06±0.40）、人际交往评分（1.81±0.39）、工作学习评分（1.08±0.38）、自觉症状评分（2.01±0.34）、日常活动评分（1.10±0.30）］，差异有统计学意义（P＜0.05）。两组患者HAMD评分、HAMA评分，相较于治疗前均有改善，研究组HAMD评分为（34.63±2.61）、HAMA评分为（35.75±2.48），优于对照组HAMD评分（47.68±3.21）和HAMA评分（46.90±3.31），差异有统计学意义（P＜0.05）。结论   腕踝针联合揿针治疗带状疱疹后遗神经痛的临床疗效显著，可有效改善患者生活质量、疼痛程度、焦虑及抑郁程度，提升患者睡眠质量。

       Objective  To investigate the clinical efficacy of wrist and ankle acupuncture combined with thumbtack needle in the treatment of postherpetic herpes zoster pain．Methods  Eighty patients with postherpetic neuralgia admitted to Shanghai Huangpu District Hospital of Integrative Medicine from October 2021 to April 2024 were selected for the study，and were divided into a study group and a control group of 40 cases each according to the random number table method．The control group was treated with oral mecoblamin tables；the study group was treated with wrist and ankle acupuncture combined with thumbtack needle．The efficacy of treatment between the two groups was compared；before and after treatment，the visual analogue score（VAS）and Asens Insomnia Scale（AIS），Dermatological Quality of Life Index（DLQI），Hamilton Depression Scale（HAMD），Hamilton Anxiety Scale（HAMA）were compared．Results  The treatment efficiency was 92.5% in the study group and 75% in the control group．The difference was statistically significant（P＜0.05）．VAS scores and AIS scores of patients in both groups improved after treatment，and VAS score（1.00±0.45），AIS score（7.15±0.89）of the study group were better than VAS score（2.15±0.36），AIS score（5.65±0.70）of the control group．The differences were statistically significant（P＜0.05）．The DLQI scores of both groups improved after treatment，and the score of study group（leisure activity score［1.73±0.45］，interpersonal interaction score［1.13±0.34］，work-study score［0.94±0.25］，self-perceived symptom score［1.83±0.38］，daily activities score［0.98±0.28］）were higher than those of the control group（leisure activity score［2.06±0.40］，interpersonal score［1.81±0.39］，work-study score［1.08±0.38］，conscious symptom score［2.01±0.34］，daily activity score［1.10±0.30］）．The differences were statistically significant（P＜0.05）．HAMD scores and HAMA scores of patients in both groups，showed significant improvement after treatment，and HAMD scores（34.63±2.61）and HAMA scores（35.75±2.48）of the study group were better than HAMD scores（47.68±3.21）and HAMA scores（46.90±3.31）of the control group．The difference was statistically significant（P＜0.05）．Conclusions  The clinical efficacy of wrist and ankle acupuncture combined with thumbtack needle in the treatment of postherpetic pain is remarkable，effectively improving the quality of life，pain，anxiety and depression，and enhancing the quality of sleep of patients．

       目的   评价现有关于干预组仅涉及不同针具针刺或联合常规针刺治疗腰椎间盘突出症系统评价的方法学质量，以比较不同针具针刺治疗腰椎间盘突出症的治疗效果。方法   通过CNKI（中国知网）、万方数据库、VIP（维普）、PubMed、Web of Science等数据库以及其他相关电子资源，对诊断、治疗腰椎间盘突出症的多种针灸技术进行全面的研究。使用AMSTAR2软件，对所有参与的系统性评估结果进行地分析，并根据不同的检测结果，确定文献筛选标准。通过Revman5.4和Cochrance风险偏倚工具，以及Stata16.0的网格Meta分析，挑选了3 381个满足纳入排除要求的随机对照试验。结果   以Stata 16.0统计软件制作排序图可知，杵针+电针的临床有效率SUCRA=81.6%排名第一；目测类比评分显示，银质针SUCRA（用于评估疗效的指标）=95%，排名第一。结论   根据现有的研究证据，杵针+电针以及银质针优于其他9种干预措施，但确切的结果仍需要大量的随机对照试验来证明。

       Objective  To evaluate the methodological quality of the existing  systematic evaluation of the intervention group involving only different needle sets of acupuncture or combined with conventional acupuncture in the treatment of lumbar disc herniation，in order to compare the therapeutic effect of different needle sets of acupuncture in the treatment of lumbar disc herniation．Methods  Through CNKI，Wanfang database，VIP，PubMed，web of  science and other  databases as well as other  relevant resources，a variety of acupuncture techniques for the diagnosis and treatment of lumbar disc herniation were comprehensively studied．Through the use of AMSTAR2 software，all participating systematic evaluation results were effectively analyzed，and according to different test results，which literature meets the requirements were determined．Through revman5.4，Cochrane risk bias tool，and grid meta-analysis of stata16.0，3 381 RCTs meeting the inclusion and exclusion requirements were selected．Results  According to the ranking chart made by stata16.0 statistical software，the clinical effective rate of pestle needle + electroacupuncture ranked first with sucra=81.6%．According to the visual analogy score，the silver needle sucra=95%，ranking first．Conclusions  According to the existing research evidence，pestle needle + electroacupuncture and silver needle are better than the other nine interventions，but the exact results still need a large number of randomized controlled trials to prove．

       目的 探讨术中未恢复窦性心律需要行电复律的心房颤动（房颤）患者在清醒和镇静两种状态下的安全性及有效性。方法 选择2022年1月—2023年12月100例接受射频消融术中行同步直流电复律的持续性房颤患者进行研究，采用随机数字表法将患者分为观察组（清醒状态）和对照组（镇静状态），其中观察组和对照组各为50例。观察两组患者接受电复律的成功率、复发率和不良事件发生率（呼吸抑制、低血压、谵妄、肺水肿、心律失常）等指标。结果 观察组和对照组首次电复律成功分别有48、49例，成功率分别为96%、98%，组间比较差异无统计学意义（P=0.558）。观察组术后30 min内有2例复发，对照组术后30 min内无复发，组间比较差异无统计学意义（P=0.153）。在不良反应方面，观察组共发生1例心律失常事件，1例低血压事件，不良反应的总发生率为4%。对照组共发生3例呼吸抑制事件、2例谵妄事件、1例心律失常事件、2例低血压事件，不良反应的总发生率为16%，组间比较差异有统计学意义（P=0.046）。结论 对持续性房颤患者在射频消融术中，处于清醒状态下行电复律也具有良好的临床疗效，可以减少不良事件的发生，安全性更高。

  Objective  To compare the safety and efficacy of awake state and sedation state in patients with atrial fibrillation（AF）who did not recover sinus rhythm and needed electrical cardioversion during operation．Methods  A total of 100 patients with persistent atrial fibrillation who underwent synchronous direct current cardioversion during radiofrequency ablation from January 2022 to December 2023 were selected and divided into the observation group（awake state）and the control group（sedation state）according to the random number table method，with 50 cases in each group．The success rate of electrical cardioversion，recurrence rate and incidence of adverse events（respiratory depression，hypotension，delirium，pulmonary edema，arrhythmia）were observed．Results  The first electrical cardioversion was successful in 48 and 49 patients in the observation group and the control group，and the success rates were 96% and 98%，respectively．There was no significant difference between the two groups（P=0.558）．There were 2 cases of  recurrence in the observation group and no  recurrence in the control group within 30 minutes after operation，and there was no significant difference between the two groups（P=0.153）．In terms of adverse reactions，there were 1 case of arrhythmia event and 1 case of hypotension event in the observation group，and the total incidence of adverse reactions was 4%．There were 3 cases of respiratory depression events，2 cases of delirium events，1 case of arrhythmia events，and 2 cases of hypotension events in the control group．The total incidence of adverse reactions was 16%，and the difference between the two groups was statistically significant（P=0.046）．Conclusions  Electrical cardioversion in awake state during  radiofrequency ablation of persistent atrial fibrillation has a good clinical efficacy and safety，which can reduce the occurrence of adverse events．

     目的   分析谷草转氨酶（AST）、胆碱酯酶（CHE）、糖类抗原125（CA125）以及甲胎蛋白（AFP）对肝硬化患者的诊断效能。方法   选择70例肝硬化患者为观察组研究对象，另取70例同期健康体检者为对照组。两组研究对象均接受生化检验、肿瘤标志物检验。对比两组研究对象的AST、CHE、CA125、AFP检测结果，分析上述指标对肝硬化患者的诊断效能。结果   观察组肝硬化患者的CHE低于对照组，AST、CA125与AFP高于对照组（P＜0.05）；AST与CHE在肝硬化诊断中具有良好的灵敏度、特异度；CA125联合AFP的灵敏度、特异度、符合率均高于CA125或AFP单独检验（P＜0.05）。结论  AST、CHE、CA125、AFP在肝硬化患者临床诊断中具有良好的应用表现，是反映患者肝硬化病情进展的重要参考指标。

     Objective  To analyze the diagnostic efficacy of aspartate aminotransferase（AST），cholinesterase（CHE），carbohydrate antigen 125（CA125），and alpha fetoprotein（AFP）in patients with liver cirrhosis．Methods  A total of 70 patients with liver cirrhosis were included in the observation group as the study subjects，and 70 healthy individuals who underwent physical examinations during the same period were selected as the control group．Both groups of  research subjects underwent biochemical testing and tumor marker testing．The AST，CHE，CA125，and AFP detection  results of two groups of research subjects were compared，and the diagnostic effect of the above indicators on patients with liver cirrhosis were analyzed．Results  The CHE test  results of patients with liver cirrhosis in the observation group were significantly lower than those of healthy individuals undergoing physical examination，and the AST，CA125，and AFP test results were higher（P＜0.05）．AST and CHE had good sensitivity and specificity in the diagnosis of liver cirrhosis．The sensitivity，specificity and coincidence  rate of CA125 combined with AFP were higher than those of CA125 or AFP alone．Conclusions  AST，CHE，CA125，and AFP have good clinical application performance in the diagnosis of liver cirrhosis patients，and are important reference indicators reflecting the progression of liver cirrhosis in patients．