目的 比较锝[???Tc]甲氧基异丁基异腈单光子发射计算机断层扫描/计算机断层扫描(???Tc-MIBI SPECT/CT)双时相显像与颈部超声在继发性甲状旁腺功能亢进症(SHPT)患者术前定位中的诊断价值。方法 回顾性纳入2025年5月至2026年4月于黔东南苗族侗族自治州人民医院行两种影像学检查的疑似SHPT患者54例。以手术病理结果为金标准,计算超声与SPECT/CT在区域层面(共216个区域)的敏感性、特异性、准确性,并比较不同解剖区域的病灶检出率。结果 54例中确诊SHPT 45例(83.33%)。超声诊断敏感性、特异性、准确性分别为70.89%(112/158)、86.21%(50/58)、75.00%(162/216);SPECT/CT分别为92.41%(146/158)、94.83%(55/58)、93.06%(201/216)。SPECT/CT的敏感性和准确性均高于超声(P均<0.001)。SPECT/CT在左上、左下、右上三个区域的检出率均高于超声(P<0.05)。结论 99mTc-MIBI SPECT/CT双时相显像在SHPT术前定位中的敏感性和准确性优于颈部超声,尤其对左上、左下、右上区域病灶检出优势明显,可作为SHPT患者术前定位的重要补充或首选影像学方法。
目的:分析尿毒症维持性血液透析(MHD)患者红细胞相关指标、铁代谢指标水平及其同肾性贫血的关系。方法:选取我院2024年10月-2025年10月期间尿毒症MHD患者70例为研究对象,依照其是否发生肾性贫血分为贫血组(49例)、无贫血组(21例),对比两组患者红细胞相关指标以及等铁代谢指标,同时对比不同贫血严重程度患者各项指标水平差异,并分析尿毒症MHD患者肾性贫血的相关影响因素。结果:贫血组、无贫血组患者红细胞血红蛋白浓度(MCHC)、总铁结合力(TIBC)水平无较大差异(P>0.05),贫血组患者网织红细胞计数(Ret)、血清铁蛋白(SF)、转铁蛋白(TRSF)水平低于无贫血组、平均红细胞体积(MCV)水平高于无贫血组(P<0.05);轻度组、中度组、重度组患者Ret、MCV、SF、TRSF差异显著(P>0.05);不同贫血严重程度患者MCHC、TIBC水平比较,差异无统计学意义(P>0.05);多因素Logistic回归结果显示,Ret(OR=0.2063)、MCV(OR=4.152)、SF(OR=0.341)、TRSF(OR=0.281)是尿毒症MHD患者发生肾性贫血的重要影响因素(P<0.05)。结论:尿毒症MHD患者存在较高的肾性贫血风险,且不同贫血程度患者的Ret、MCV及SF、TRSF等指标水平存在差异性,亦是患者发生肾性贫血的重要影响因素。
To analyze the levels of red blood cell related indicators, iron metabolism indicators and their relationship with renal anemia in uremic patients with maintenance hemodialysis (MHD). Methods: 70 cases of uremic MHD patients in our hospital from October 2024 to October 2025 were selected as the research object, and were divided into anemia group (49 cases) and non anemia group (21 cases) according to whether renal anemia occurred. The red blood cell related indexes and iron metabolism indexes of the two groups were compared, and the differences of various indexes in patients with different anemia severity were compared, and the related influencing factors of renal anemia in uremic MHD patients were analyzed. Results: there was no significant difference in the levels of erythrocyte hemoglobin concentration (MCHC) and total iron binding capacity (TIBC) between anemia group and non anemia group (P>0.05). The levels of reticulocyte count (RET), serum ferritin (SF), transferrin (trsf) in anemia group were lower than those in non anemia group, and the level of mean corpuscular volume (MCV) was higher than that in non anemia group (P<0.05); There were significant differences in RET, MCV, SF and trsf among mild group, moderate group and severe group (P>0.05); There was no significant difference in MCHC and TIBC levels among patients with different anemia severity (P>0.05); Multivariate logistic regression results showed that RET (or=0.2063), MCV (or=4.152), SF (or=0.341), trsf (or=0.281) were important influencing factors of renal anemia in uremic MHD patients (P<0.05).Conclusion: Uremic MHD patients have a higher risk of renal anemia, and there are differences in the levels of Ret, MCV, SF, TRSF and other indicators among patients with different degrees of anemia, which are also important influencing factors for the occurrence of renal anemia in patients.
摘要 目的 分析固定(FB)和活动平台(MB)单髁置换术(UKA)在膝关节内侧间室骨关节炎早期阶段的临床效果与影像学差异,以指导临床假体选择。 方法 本研究回顾性纳入41例确诊为单侧膝关节内侧间室骨关节炎的患者,按照假体类型分为两组:FB组(20例,使用春立XG假体)和MB组(21例,使用春立XK假体)。分别在术前、术后及随访终点统计膝关节屈伸活动范围(ROM)、VAS 疼痛评分、美国特种外科医院膝关节评分(HSS );测量并比较股胫角(FTA)、胫骨假体内外翻角(TCVA)、胫骨假体后倾角(TCPSA);记录围手术期指标及并发症情况。 结果 两组患者术后ROM、VAS、HSS 评分均较术前显著改善(P均<0.0001);末次随访时固定平台组 VAS 评分显著低于活动平台组(P<0.05),而两组间的ROM、HSS 评分无统计学差异(均 P>0.05)。两组术后 FTA、TCVA、TCPSA 均恢复至理想范围,组间均无统计学差异(均 P>0.05)。固定平台组手术时间更短(P<0.05),两组均无严重并发症,假体生存率均为 100%。 结论 活动平台与固定平台单髁置换术均可显著改善膝关节内侧间室骨关节炎患者疼痛、活动度及功能,下肢力线恢复效果相当;固定平台假体在疼痛控制与手术便捷性方面更具优势,临床可根据患者情况与术者经验个体化选择。 关键词 单髁置换术;活动平台假体;固定平台假体;骨关节炎;并发症
Abstract Objective To investigate the early clinical outcomes and radiological differences between fixed-bearing (FB) and mobile-bearing (MB) unicompartmental knee arthroplasty (UKA) in the treatment of medial compartment knee osteoarthritis (OA), and to provide evidence for clinical prosthesis selection. Methods Clinical data of 41 patients with unilateral medial compartment knee OA were retrospectively analyzed. The FB group comprised 20 patients (using Chunli XG prosthesis), and the MB group comprised 21 patients (using Chunli XK prosthesis). Knee range of motion (ROM), Visual Analogue Scale (VAS) pain score, and Hospital for Special Surgery (HSS) knee score were compared between the two groups preoperatively, postoperatively, and at the final follow-up. Femorotibial angle (FTA), tibial component valgus angle (TCVA), and tibial component posterior slope angle (TCPSA) were measured and compared. Perioperative indicators and complications were recorded. Results Postoperative ROM, VAS, and HSS scores significantly improved compared with preoperative values in both groups (all P < 0.0001). At the final follow-up, the VAS score in the FB group was significantly lower than that in the MB group (P < 0.05), while no significant differences were observed in ROM or HSS scores between the two groups (all P > 0.05). Postoperative FTA, TCVA, and TCPSA values returned to the ideal range in both groups, with no significant intergroup differences (all P > 0.05). The FB group had a significantly shorter operative time (P < 0.05). No severe complications occurred in either group, and the prosthesis survival rate was 100% in both groups. Conclusion Both FB-UKA and MB-UKA significantly improve pain, range of motion, and function in patients with medial compartment knee OA, with comparable efficacy in restoring lower limb alignment. The FB prosthesis offers advantages in pain control and surgical convenience. Clinical selection may be individualized based on patient characteristics and surgeon experience. Keywords Unicompartmental knee arthroplasty; Mobile-bearing prosthesis; Fixed-bearing prosthesis; Osteoarthritis; Complications
目的 探讨固定平台(FB)与活动平台(MB)单髁置换术(UKA)治疗膝关节内侧间室骨关节炎(OA)的早期临床疗效及影像学差异,为临床假体选择提供依据。 方法 回顾性分析41 例单侧膝关节内侧间室骨关节炎患者临床资料,其中 FB 组 20例(采用春立XG假体),MB 组 21 例(采用春立XK假体)。比较两组患者术前、术后和末次随访的膝关节活动度(ROM)、疼痛视觉模拟评分(VAS)、美国特种外科医院膝关节评分(HSS);测量并比较股胫角(FTA)、胫骨假体内外翻角(TCVA)、胫骨假体后倾角(TCPSA);记录围手术期指标及并发症情况。 结果 两组患者术后ROM、VAS、HSS 评分均较术前显著改善(P均<0.0001);末次随访时固定平台组 VAS 评分显著低于活动平台组(P<0.05),ROM、HSS 评分两组差异无统计学意义(均 P>0.05)。两组术后 FTA、TCVA、TCPSA 均恢复至理想范围,组间差异均无统计学意义(均 P>0.05)。固定平台组手术时间更短(P<0.05),两组均无严重并发症,假体生存率均为 100%。 结论 固定平台与活动平台单髁置换术均可显著改善膝关节内侧间室骨关节炎患者疼痛、活动度及功能,下肢力线恢复效果相当;固定平台假体在疼痛控制与手术便捷性方面更具优势,临床可根据患者情况与术者经验个体化选择。 关键词 单髁置换术;活动平台假体;固定平台假体;骨关节炎;并发症
Abstract Objective To investigate the early clinical outcomes and radiological differences between fixed-bearing (FB) and mobile-bearing (MB) unicompartmental knee arthroplasty (UKA) in the treatment of medial compartment knee osteoarthritis (OA), and to provide evidence for clinical prosthesis selection. Methods Clinical data of 41 patients with unilateral medial compartment knee OA were retrospectively analyzed. The FB group comprised 20 patients (using Chunli XG prosthesis), and the MB group comprised 21 patients (using Chunli XK prosthesis). Knee range of motion (ROM), Visual Analogue Scale (VAS) pain score, and Hospital for Special Surgery (HSS) knee score were compared between the two groups preoperatively, postoperatively, and at the final follow-up. Femorotibial angle (FTA), tibial component valgus angle (TCVA), and tibial component posterior slope angle (TCPSA) were measured and compared. Perioperative indicators and complications were recorded. Results Postoperative ROM, VAS, and HSS scores significantly improved compared with preoperative values in both groups (all P < 0.0001). At the final follow-up, the VAS score in the FB group was significantly lower than that in the MB group (P < 0.05), while no significant differences were observed in ROM or HSS scores between the two groups (all P > 0.05). Postoperative FTA, TCVA, and TCPSA values returned to the ideal range in both groups, with no significant intergroup differences (all P > 0.05). The FB group had a significantly shorter operative time (P < 0.05). No severe complications occurred in either group, and the prosthesis survival rate was 100% in both groups. Conclusion Both FB-UKA and MB-UKA significantly improve pain, range of motion, and function in patients with medial compartment knee OA, with comparable efficacy in restoring lower limb alignment. The FB prosthesis offers advantages in pain control and surgical convenience. Clinical selection may be individualized based on patient characteristics and surgeon experience. Keywords Unicompartmental knee arthroplasty; Mobile-bearing prosthesis; Fixed-bearing prosthesis; Osteoarthritis; Complications
目的 探讨骨质疏松椎体压缩性骨折(OVCF)患者经皮椎体成形术(PVP)术后1年内发生邻近椎体再骨折(AVCF)的影响因素,并构建Logistic风险预测模型,分析其对AVCF发生的预测效能。方法 前瞻性选取我院2022年1月~2024年1月收治的188例OVCF患者,入院后均行PVP术治疗,根据术后1年内是否发生AVCF分为发生组、未发生组。单因素分析两组临床资料,Logistic多因素回归分析OVCF患者PVP术后1年内发生AVCF的影响因素,构建Logistic风险预测模型;ROC曲线分析风险预测模型对AVCF发生的预测效能。结果 两组年龄、术前骨密度、骨折病史、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标比较差异显著(P<0.05);Logistic多因素回归方程分析结果显示,年龄、术前骨密度、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标均为OVCF患者PVP术后1年内发生AVCF的独立影响因素(P<0.05)。构建Logistic回归模型,Logit(p)=-5.234+0.445×年龄-0.124×术前骨密度+1.521×骨水泥渗漏+1.375×术前椎体内裂隙征-0.151×术后椎体高度恢复达标。Logistic风险预测模型预测预AVCF发生的AUC值为0.863(95% CI:0.812~0.913),敏感度、特异度分别为80.31%、81.64%。结论 年龄、术前骨密度、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标均为OVCF患者PVP术后1年内发生AVCF的独立影响因素,在此基础上构建的Logistic风险预测模型可为临床早期分辨PVP术后发生AVCF的高危患者提供依据,临床可据此早期制定针对性干预方案,以降低PVP术后AVCF发生风险。
摘要:目的:探讨在被确诊的甲状腺乳头状微小癌(PTMC)患者中清扫颈部VI区淋巴结时,术中使用纳米炭混悬注射液示踪技术在其治疗过程中的应用价值及临床获益情况。方法:选取肇庆市第一人民医院普外科各亚专科中在2025年1月至2026年1月间收治的90例甲状腺乳头状微小癌(PTMC)患者,采用随机数字表法进行分组,分为观察组、对照组,各45例。90例患者中术前常规行FNA,并确诊为甲状腺乳头状癌,对术前确诊的单侧甲状腺乳头状癌患者,手术方式选择行单侧甲状腺全切加峡部切除和单侧颈部VI区淋巴结清扫,对术前确诊的双侧甲状腺乳头状癌患者,手术方式选择行甲状腺双侧叶全切加峡部切除及双侧颈部VI区淋巴结清扫。对观察组患者,在手术中解剖后看到甲状腺腺体后即在甲状腺腺体背侧面注射纳米炭混悬注射液混悬注射液,约0.3ml,等待显影20min后再行淋巴结清扫,对照组患者则术中不注射纳米炭混悬注射液混悬注射液。对比观察组和对照组患者所用手术时间及术中出血量,术后第1天及术后满1个月血钙(Ca)水平及甲状旁腺激素(PTH)测定情况两组的对比情况,术手术并发症中喉返神经损伤,术后声嘶,术后血肿及低钙血症甲状旁腺暂时功能低下观察组和对照组情况对比,观察组及对照组淋巴结平均检出数,淋巴阳性检出数的对比情况。结果:观察组中手术的时间长度为98.75±7.52和对照组101.52±6.54(P>0.05),统计学无差异;观察组中术中出血量为32.57±2.78和对照组的29.55±4.21(P>0.05),统计学无差异;观察组术后第1天血钙(CA)水平为2.27±0.12和甲状旁腺激素(PTH)水平为40.21±0.06均较对照组术后第1天血钙(Ca)水平为2.20±0.05和甲状旁腺激素(PTH)水平为35.42±0.03高,术后第1天观察组显著高于对照组,差异有统计学意义(P<0.05);观察组术后第满1月血钙(Ca)水平为2.26±0.05和甲状旁腺激素(PTH)水平为43.1±4.29与对照组术后满1月血钙(Ca)水平为2.25±0.09和甲状旁腺激素(PTH)水平为42.8±3.87对比(P>0.05),统计学无差异;术后合并症观察组术后喉返神经损伤,声音嘶哑和颈部血肿分别为0,1和1与对照组的0,1和0(P>0.05),统计学无差异;术后合并症观察组术后低钙血症及甲状旁腺暂时功能低下分别为1和0与对照组术后低钙血症及甲状旁腺暂时功能低下4和3比较(P<0.05),统计学有意义;术中观察组淋巴结显影明显好于对照组淋巴结显影;观察组淋巴结平均检出数,淋巴阳性检出数为7.654±1.65、2.71±0.65均多余对照组的6.77±1.85、2.34±0.73(p<0.05),差异比较,有统计学意义。结论:对于甲状腺乳头状微小癌(PTMC)的患者,在手术中使用纳米炭混悬注射液进行标记示踪,有助于提高医生在行甲状腺乳头状癌清扫颈部VI区时的淋巴结显影效果及患者颈部VI区的淋巴结清扫效率;有助于提高患者淋巴结清扫彻底性,有助于降低术后复发风险,提高手术安全性;对术后并发低钙血症及永久性的甲状旁腺功能减退等有显著效果,增加患者术中甲状旁腺保护效率,可有助于提高患者远期的生存质量等,具有显著的临床应用价值。
目的 探讨骨质疏松椎体压缩性骨折(OVCF)患者经皮椎体成形术(PVP)术后1年内发生邻近椎体再骨折(AVCF)的影响因素,并构建Logistic风险预测模型,分析其对AVCF发生的预测效能。方法 前瞻性选取我院2022年1月~2024年1月收治的188例OVCF患者,入院后均行PVP术治疗,根据术后1年内是否发生AVCF分为发生组、未发生组。单因素分析两组临床资料,Logistic多因素回归分析OVCF患者PVP术后1年内发生AVCF的影响因素,构建Logistic风险预测模型;ROC曲线分析风险预测模型对AVCF发生的预测效能。结果 两组年龄、术前骨密度、骨折病史、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标比较差异显著(P<0.05);Logistic多因素回归方程分析结果显示,年龄、术前骨密度、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标均为OVCF患者PVP术后1年内发生AVCF的独立影响因素(P<0.05)。构建Logistic回归模型,Logit(p)=-5.234+0.445×年龄-0.124×术前骨密度+1.521×骨水泥渗漏+1.375×术前椎体内裂隙征-0.151×术后椎体高度恢复达标。Logistic风险预测模型预测预AVCF发生的AUC值为0.863(95% CI:0.812~0.913),敏感度、特异度分别为80.31%、81.64%。结论 年龄、术前骨密度、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标均为OVCF患者PVP术后1年内发生AVCF的独立影响因素,在此基础上构建的Logistic风险预测模型可为临床早期分辨PVP术后发生AVCF的高危患者提供依据,临床可据此早期制定针对性干预方案,以降低PVP术后AVCF发生风险。
目的 分析2021-2025年某社区卫生服务中心失眠患者用药趋势,为社区失眠规范化管理提供参考。方法 回顾性收集某社区卫生服务中心2021年1月至2025年12月失眠相关药物处方数据,共纳入处方18,042张,涉及患者3,805人。统计处方量、药物种类、患者年龄、性别、伴随疾病等信息。根据处方次数及平均处方间隔天数将患者分为三类:偶发就诊型(1次)、短期治疗型(2~10次且平均间隔≥60天)和长期用药型(>10次或平均间隔<60天),分析各类患者的用药特征及伴随疾病分布。结果 处方量从2021年2,688张增至2025年5,734张,增长2.1倍,就诊人数增长1.6倍。艾司唑仑占比从66.22%降至41.75%,右佐匹克隆从13.28%升至54.99%,2024年为关键转折点;各年龄组右佐匹克隆使用均呈上升趋势,2025年组间差异趋于消失(48%~61%)。患者平均年龄从73.2岁降至69.5岁(Tukey HSD,P<0.05),≥80岁组占比从29.36%降至14.28%。偶发就诊型占42.6%,短期治疗型占25.9%,长期用药型占31.6%。长期用药型消耗全部处方的68.2%,平均处方间隔37.3 d(中位34 d),右佐匹克隆占比43.2%。高血压是最常见伴随疾病,患病率随年龄升高(28.17%~68.17%);高血脂和焦虑呈倒U型分布。结论 社区失眠就诊需求快速增长,药物结构向新型非苯二氮?类药物明显转变。失眠患者呈年轻化趋势。长期用药型患者消耗了大部分处方资源,其用药管理模式需结合处方间隔特征进行精准分层,并重视老年患者心血管代谢共病的综合管理。
To analyze the medication trends and characteristics of insomnia patients in a community health service center from 2021 to 2025, and to provide evidence for standardized community-based insomnia management. METHODS A retrospective analysis was conducted on insomnia-related prescription data from a community health service center between January 2021 and December 2025. A total of 18,042 prescriptions involving 3,805 patients were included. Prescription volume, drug types, patient age, sex, and comorbidities were analyzed. Patients were classified into three types based on prescription count and average prescription interval: episodic consultation type (1 prescription), short-term treatment type (2–10 prescriptions with interval ≥60 days), and long-term medication type (>10 prescriptions or interval <60 days). RESULTS Prescriptions increased from 2,688 in 2021 to 5,734 in 2025 (2.1-fold), with a 1.6-fold increase in patient visits. Estazolam decreased from 66.22% to 41.75%, while eszopiclone increased from 13.28% to 54.99%, with 2024 as the turning point. Eszopiclone usage increased across all age groups, converging to 48%–61% by 2025. Mean age decreased from 73.2 to 69.5 years (Tukey HSD, P<0.05), and the proportion of patients aged ≥80 years dropped from 29.36% to 14.28%. Episodic consultation type accounted for 42.6%, short-term treatment type 25.9%, and long-term medication type 31.6%. The long-term type consumed 68.2% of all prescriptions, with an average prescription interval of 37.3 days (median 34 days) and eszopiclone accounting for 43.2%. Hypertension was the most common comorbidity, increasing with age (28.17%–68.17%). Hyperlipidemia and anxiety showed an inverted U-shaped distribution. CONCLUSION Community insomnia treatment demand is growing rapidly, with a significant shift toward newer non-benzodiazepines and a trend toward younger patient demographics. Long-term medication patients consume the majority of prescription resources and require precise stratification based on prescription interval patterns, along with integrated management of cardiometabolic comorbidities in older adults.
目的 探讨子午流注穴位按摩联合颈椎功能康复训练对神经根型颈椎病(CSR)患者的康复效果。方法 以2023年1月-2025年6月我院收治的CSR患者(154例)为研究对象进行回顾性分析,根据干预方案分为参照组(77例,采取颈椎功能康复训练)、研究组(77例,采取子午流注穴位按摩联合颈椎功能康复训练)。比较两组临床疗效、复发率及干预前、后中医证候积分、疼痛视觉模拟评分(VAS)与颈椎功能障碍指数量表评分(NDI)、颈椎功能活动度、血液流变学指标[血浆黏度(PV)、全血低切黏度(LSWBV)、纤维蛋白原(FIB)、全血高切黏度(HSWBV)]。结果 与参照组总有效率(83.12%)相比,研究组(96.10%)明显升高(P<0.05);研究组干预后各中医证候积分均较参照组低(P<0.05);干预后,研究组VAS、NDI评分均低于参照组(P<0.05);研究组干预后颈椎活动度高于参照组(P<0.05);干预后,研究组LSWBV、PV、FIB、HSWBV水平均较参照组低(P<0.05);研究组干预后3个月复发率为2.72%(2/74),低于参照组的14.06%(9/64)(χ2=4.588,P<0.05)。结论 子午流注穴位按摩联合颈椎功能康复训练可提高CSR患者康复效果,改善临床症状、颈椎功能、颈椎活动度,调节血液流变学,降低颈椎疼痛程度、复发率。
Objective To explore the rehabilitation efficacy of midnight-noon ebb-flow acupoint massage combined with cervical function rehabilitation training on patients with cervical spondylotic radiculopathy (CSR). Methods A retrospective analysis was conducted on CSR patients (154 cases) admitted to our hospital from January 2023 to June 2025, who were selected as the research subjects. According to the intervention plan, they were divided into reference group (77 cases, received cervical functional rehabilitation training) and study group (77 cases, received midnight-noon ebb-flow acupoint massage combined with cervical functional rehabilitation training). The clinical efficacy and recurrence rate were compared between the two groups, as well as the TCM syndrome scores, pain visual analogue score (VAS) and cervical dysfunction index score (NDI) scores, cervical spine function activity, hemorheology indexes [plasma viscosity (PV), whole blood low shear viscosity (LSWBV), fibrinogen (FIB), whole blood high shear viscosity (HSWBV)] before and after intervention. Results Compared with the total effective rate of the reference group (83.12%), the study group (96.10%) was significantly higher (P<0.05); after intervention, the scores of all?TCM syndromes in the study group were lower than those in the reference group (P<0.05), after intervention, the VAS and NDI scores of the study group were lower than those in the reference group (P<0.05); the cervical spine activity of the study group was higher than that of the reference group after intervention (P<0.05); after intervention, the levels of LSWBV, PV, FIB and HSWBV in the study group were lower than those in the reference group (P<0.05); the recurrence rate of the study group at 3 months after intervention was 2.72% (2/74), which was lower than 14.06% (9/64) in the reference group (χ2=4.588, P<0.05). Conclusion Midnight-noon ebb-flow acupoint massage combined with cervical function rehabilitation training can improve the rehabilitation efficacy of CSR patients, improve clinical symptoms, cervical function, cervical mobility, regulate hemorheology, and reduce cervical pain and recurrence rate.
扩张型心肌病(DCM)以左心室或双心室扩大并伴心肌收缩功能下降为主要特征,左心室逆重构(LVRR)可反映治疗后心室结构和功能恢复,并与患者预后改善相关。近年来,中医药联合常规西医治疗DCM的研究逐渐增多,部分研究显示其可改善左心室射血分数、左心室内径或容积、BNP或NT-proBNP、6min步行距离及生活质量等LVRR相关指标。现有证据提示,中医药可能通过改善心肌细胞损伤与能量代谢、减轻心肌纤维化与细胞外基质重塑、调节神经内分泌激活与心室负荷等环节参与DCM患者左心室结构重塑改善和收缩功能恢复,从而促进LVRR。然而,现有研究对LVRR的判定标准尚未统一,相关临床证据仍需进一步规范和验证。鉴于此,本文旨在围绕DCM-LVRR的概念、评价指标、中医药临床证据及可能机制进行叙述性综述,以期为DCM的中西医结合治疗及后续临床研究设计提供参考。
Dilated cardiomyopathy (DCM) is mainly characterized by left ventricular or biventricular dilatation accompanied by impaired myocardial systolic function. Left ventricular reverse remodeling (LVRR) reflects the recovery of ventricular structure and function after treatment and is associated with improved prognosis. In recent years, studies on traditional Chinese medicine (TCM) combined with conventional Western medical therapy for DCM have gradually increased. Some studies have shown that such combined treatment may improve LVRR-related indicators, including left ventricular ejection fraction, left ventricular diameter or volume, BNP or NT-proBNP, 6-minute walking distance, and quality of life. Current evidence suggests that TCM may contribute to left ventricular structural remodeling and systolic functional recovery in patients with DCM by alleviating myocardial cell injury, improving energy metabolism, attenuating myocardial fibrosis and extracellular matrix remodeling, and modulating neuroendocrine activation and ventricular load, thereby promoting LVRR. However, the criteria for defining LVRR remain inconsistent across existing studies, and the relevant clinical evidence requires further standardization and validation. Therefore, this narrative review aims to summarize the concept, evaluation indicators, clinical evidence of TCM, and potential mechanisms related to DCM-LVRR, with the aim of providing a reference for integrated Chinese and Western medical treatment of DCM and the design of future clinical studies.