登革热是由登革病毒引起、经伊蚊叮咬传播的急性传染病，近年来已在全球热带和亚热带地区广泛流行，严重威胁公共卫生安全。目前临床上尚缺乏特异性抗病毒药物和高效的疫苗，临床治疗主要以中西医结合为主要模式，且两者在发病机制阐释、诊疗策略制定等方面各有侧重且互为补充。本文系统梳理登革热西医领域的流行病学特征、病理基础与发病机制及现代医学治疗现状，同时深入阐述中医对该病的病因病机与病位认知、辨证论治体系及中医药治疗进展，旨在为临床诊疗优化与科研方向拓展提供参考。

Dengue fever is an acute infectious disease caused by the dengue virus. In recent years, it has prevailed widely in tropical and subtropical regions, posing a severe threat to public health security. Given the lack of specific antiviral drugs and high-efficiency vaccines for dengue fever, its clinical treatment is predominantly based on integrated traditional Chinese and Western medicine. The two medical systems exhibit distinct focuses and complementary advantages in the interpretation of pathogenesis and the formulation of diagnosis and treatment strategies. This paper systematically reviews the epidemiological characteristics, pathological basis, pathogenesis and current Western medical treatment status of dengue fever, and further elaborates the etiology, pathogenesis, lesion location, syndrome differentiation and treatment system, as well as research progress of traditional Chinese medicine for this disease. It aims to provide references for the optimization of clinical diagnosis and treatment and the expansion of scientific research directions on dengue fever.

【摘要】 目的 系统分析音乐干预对眼科手术患者围手术期焦虑与生理反应的影响，为其临床应用提供参考。方法 系统检索国内外相关文献，从患者焦虑特征、理论基础、实施方法、干预效果及影响因素等方面进行综合分析。结果 眼科手术患者围术期焦虑发生率较高，焦虑可降低术中配合度、增加麻醉用药等风险。音乐干预通过调节边缘系统及自主神经系统发挥作用，术前、术中持续应用可显著降低焦虑评分，稳定心率、降低血压。听觉敏感性、基线焦虑水平、年龄及干预方案特征是影响干预效果的关键因素。结论 音乐干预能有效缓解眼科手术患者围手术期焦虑，具有良好应用潜力。未来需开展大样本随机对照试验，结合人工智能等技术开发个性化方案，并建立标准化实施方法。

【Abstract】Objective To systematically evaluate the effects of music intervention on perioperative anxiety and physiological responses in ophthalmic surgery patients, and to provide evidence for clinical practice. Methods Domestic and international literature on anxiety characteristics, mechanisms, implementation, efficacy, and influencing factors was systematically searched and reviewed. Results Perioperative anxiety is common in ophthalmic surgery patients and may reduce intraoperative cooperation and increase anesthetic consumption. Music intervention acts on the limbic system and the autonomic nervous system, and can effectively reduce anxiety scores, stabilize heart rate, and lower blood pressure when applied preoperatively and intraoperatively. Key influencing factors include auditory sensitivity, baseline anxiety, age, and intervention features. Conclusions Music intervention safely and effectively relieves perioperative anxiety in ophthalmic surgery patients. Further large-sample randomized controlled trials, AI-based personalized programs, and standardized protocols are needed.

      目的  探讨通过优化病案首页质控体系提高误入DRG低权重组病例转出率的效果。方法  采用PDCA循环法，通过实施分层级编码培训、基于AI赋能的专项质控模式及智能化反馈机制构建等系统性地改进措施优化质控体系。通过对比分析质控系统优化前后（2022年1—7月和2023年1—7月）DRG低权重组病例的病案首页质控过程、“经质控低权重病例入组率”和“误入低权重组病例转出率”等指标，评估质控体系优化的实施效果。结果  质控体系优化后，低权重组病例转出率由3.27%提升至4.15%（P=0.018），经质控低权重病例入组率由16.98%降至14.96%（P＜0.001）。结论  AI赋能的专项质控、分层级编码培训与智能化反馈机制三项措施并举可以系统优化质控体系，进而提升DRG低权重组病例转出率。

       Objective  To investigate the effect of optimizing the medical  record front  page  quality control  system on improving the transfer-out rate of cases mistakenly assigned to low-weight DRG groups．Methods  The Plan-Do-Check-Act（PDCA）cycle methodology was employed．Systemic improvements were implemented to  optimize the medical  record front page quality control system，including hierarchical coding training，innovation of a  specialized quality control model based on AI empowerment，and establishment of an intelligent feedback mechanism．The implementation effectiveness was evaluated by comparative analysis of the following indicators before（January-July 2022）and after（January-July 2023）optimization：the medical record quality control process for low-weight DRG cases，the  rate of low-weight cases assigned to groups after quality control，and the transfer-out rate of cases mistakenly entering low-weight groups．Results  After optimizing the medical record front page quality control system，the transfer-out rate of cases from low-weight groups increased from 3.27% to 4.15%（P=0.018），while the rate of low-weight cases assigned to groups after quality control decreased from 16.98% to 14.96%（P＜0.001）．Conclusions  Implementing a three-pronged approach—AI-powered specialized quality control，hierarchical coding training，and an intelligent feedback mechanism—can systematically optimize the medical record front page quality control system，thereby improving the transfer-out rate of cases mistakenly assigned to low-weight DRG groups．

      目的   基于决策树构建老年患者吞咽障碍预警模型。方法  采用便利取样法对宁夏银川市宁夏回族自治区人民医院老年科住院的200例老年患者进行调查。结果  200例老年患者中，吞咽障碍发生率为40.5%。依据是否发生吞咽障碍将其患者分为两组，两组患者在性别、年龄、文化程度、职业、医保类型、家庭年收入、日常生活能力、衰弱、抑郁、营养、体质指数（BMI）比较（χ ² 值分别为13.321、4.064、31.944、36.695、18.230、19.681、52.509、10.253、20.456、9.070、9.483），差异均有统计学意义（均P＜0.05）。决策树模型筛选出老年患者吞咽障碍的影响因素主要有自理能力、职业、文化程度和抑郁，决策树模型受试者工作特征曲线下面积为0.862，灵敏度为79.8%，特异度为79.0%，P＜0.001。结论  基于自理能力、职业、文化程度和抑郁构建的决策树模型，能有效预测老年患者吞咽障碍风险。

       Objective  To construct a swallowing disorder warning model for elderly patients based on decision tree．Methods  Convenience  sampling was  used to  study  200  elderly  patients  admitted to the  geriatric  department  of  a tertiary comprehensive hospital in Yinchuan，Ningxia．Results  Among 200 elderly patients，the incidence of swallowing disorders was 40.5%．The two groups of patients were compared in terms of gender，age，education level，occupation，medical insurance type，annual family income，daily living ability，frailty，depression，nutrition，and BMI（χ ²  values were 13.321，4.064，31.944，36.695，18.230，19.681，52.509，10.253，20.456，9.070，9.483，respectively），and the  differences were  statistically significant（all P＜0.05）．The decision tree model identified the main influencing factors of swallowing disorders in elderly patients as self-care ability，occupation，education level，and depression．The Receiver Operating Characteristic curve of the decision tree model had an area under the curve of 0.862，sensitivity of 79.8%，and specificity of 79.0%，P＜0.001．Conclusions  A decision tree model based on self-care ability，occupation，education level，and depression can effectively predict the  risk of swallowing disorders in elderly patients．

       脑卒中后认知障碍（PSCI）是脑卒中患者常见的并发症，严重影响患者的生活质量和社会功能。近年来，随着认知储备理论的发展和早期干预理念的普及，PSCI的早期干预模式逐渐成为研究热点。文章综述了PSCI早期干预模式的研究现状与进展，包括干预的理论基础、具体措施及未来发展方向，以期为临床实践和科研提供参考。

       Post-stroke cognitive impairment（PSCI）is a common complication among stroke patients．It seriously affects the patients’ quality of life and social functions．In recent years，with the development of the cognitive  reserve theory and the popularization of the concept of early intervention，the early intervention model for PSCI has gradually become a research hotspot．This article reviews the current research status and progress of the early intervention model for PSCI，including the theoretical basis of the intervention，specific measures，and future development directions，aiming to provide  references for clinical practice and scientific research．

       克罗恩病肛瘘在解剖结构、诊治措施及疾病预后上具有与普通肛瘘不同的特点, 它是克罗恩病患者常见且严重的并发症及预后不良的征兆,严重影响患者生活质量。文章概述了克罗恩病肛瘘的概念及诊治现状、患者生活质量、相关评估工具及护理措施, 旨在为此类患者的临床管理及相关研究的开展提供参考依据,以提高其生活质量。

       Perianal fistula of Crohn's Disease has different characteristics from common anal fistula in anatomical structure, diagnosis and treatment and prognosis．It is a common and serious complication and a sign of poor prognosis in patients with Crohn's disease, which seriously affects the quality of life of patients．This article summarizes the concept, current status of diagnosis and treatment of perianal fistula in Crohn's Disease, its impact on the quality of life in patients, related assessment tools and nursing measures, so as to provide a reference for the management of such patients and improve their quality of life．

       泛血管疾病（PVD）是一类以动脉粥样硬化为共同病理基础、累及心、脑、肾及外周血管系统的临床综合征, 具有多血管床共病特征, 发病率高、致残致死率大。非编码RNA（ncRNA）作为基因表达的重要调控因子, 在PVD的发生发展中发挥关键作用。微小RNA（miRNA）、长链非编码RNA（lncRNA）、环状RNA（circRNA）等ncRNA通过调节炎症反应、内皮功能、血管重塑、代谢稳态等多路径参与PVD的病理过程, 并展现出时空特异性和双向调控特征。最新研究揭示ncRNA在临床中的诊断预测及靶向干预潜力, 包括外泌体载体及circRNA递送系统等新策略。此外, 中医药通过调控ncRNA网络, 干预血瘀、痰浊等证型相关通路, 体现中西医结合治疗的系统优势。本文系统综述了ncRNA在PVD中的作用机制与研究进展, 强调其在精准诊疗与转化研究中的应用前景, 并指出未来需加强基础与临床协同、推进个体化干预策略的落地实施。

       Panvascular diseases（PVD）are a group of clinical syndromes characterized by atherosclerosis as a common pathological foundation, involving heart,brain,kidneys,and peripheral vascular systems．These diseases often exhibit multi-vascular bed comorbidities and are associated with high incidence,disability, and mortality rates．Non-coding RNAs（ncRNAs）, as key regulators of gene expression, play a crucial role in the onset and progression of PVD．Various types of ncRNAs—including microRNAs（miRNAs）, long non-coding RNAs（lncRNAs）, and circular RNAs（circRNAs）—are involved in the pathological processes of PVD through multiple pathways, such as modulation of inflammatory responses, endothelial function, vascular remodeling, and metabolic homeostasis, exhibiting spatiotemporal specificity and bidirectional regulatory effects．Recent studies have highlighted the potential of ncRNAs in clinical diagnosis, prognosis, and targeted therapy,with novel strategies including exosome-based delivery and circRNA-targeting systems．In addition, traditional Chinese medicine（TCM）exerts regulatory effects on ncRNA networks to intervene in syndrome-specific pathways, such as those related to blood stasis and phlegm-dampness, reflecting the systemic advantages of integrating TCM with Western medicine．This review systematically summarizes the regulatory mechanisms and research progress of ncRNAs in PVD,emphasizes their potential in precision medicine and translational research, and proposes the need to strengthen collaboration between basic and clinical studies to facilitate the implementation of personalized therapeutic strategies．

       动脉粥样硬化（AS）是一种起始于炎症介导的内皮损伤的慢性血管疾病，其本质是免疫炎症驱动的病理过程，是众多心血管疾病的病理基础。CD4⁺  T细胞亚群［包括辅助性T细胞1型（T helper 1 cell，Th1）、Th2、Th17、调节性T细胞等］通过分泌特异性细胞因子参与AS的炎症反应，其中促炎性CD4+  T细胞与抗炎性CD4⁺  T细胞的抗炎功能失衡是推动斑块进展的关键环节，在AS斑块形成与发展中起关键作用。近年来，多项研究表明某些中药单体、经典复方及其有效成分，具有多靶点、多层次机制调控CD4⁺  T细胞分化及功能，这些作用共同减轻血管内皮炎症反应、抑制巨噬细胞泡沫化及平滑肌细胞迁移等，延缓AS斑块形成与发展，为AS防治提供了新思路，展现了中医药在该领域的研究展现出独特优势与广阔前景，本文综述了中医药通过干预CD4⁺  T细胞亚群平衡防治AS的最新研究进展，及其影响相关细胞因子网络及关键信号通路的作用机制，为开发具有多靶点协同优势的创新中药与中西医结合治疗方案提供了关键理论依据与实践方向。

       Atherosclerosis（AS）is a chronic vascular disease that originates from inflammation mediated endothelial 

damage．Its essence is a pathological process driven by immune inflammation，and it is the pathological basis of many cardiovascular diseases．CD4⁺  T cell subsets（including Th1，Th2，Th17，Treg，etc.）participate in the inflammatory response of AS by secreting specific cytokines．The imbalance of anti-inflammatory function between pro-inflammatory CD4⁺  T cells and anti-inflammatory CD4⁺T cells is a key link in promoting plaque progression and playing a crucial role in the formation and development of AS plaques．In recent years，a number of studies have shown that the monomers，classic prescriptions and their effective ingredients of Chinese herbs have the effect of multi-target，multi-level mechanism to regulate the differentiation and function of CD4⁺  T cells．These effects together reduce the inflammatory reaction of vascular endothelium，inhibit the foam formation of macrophages and smooth muscle cell migration，delay the formation and development of AS plaque，provide new ideas for the prevention and treatment of AS，and make the research of Chinese medicine show unique advantages and broad prospects in this field．This article  reviews the latest  research progress of Chinese medicine in the prevention and treatment of AS by intervening in the balance of CD4⁺  T cell subsets，as well as the mechanism of its effects on related cytokine networks and key signal pathways．This provides a key theoretical basis and practical direction for the development of innovative traditional Chinese medicine and integrated traditional Chinese and Western medicine treatment plans with multi-target synergistic advantages．

       铁死亡是一种以铁依赖性脂质过氧化为特征的程序性细胞死亡形式。近年来研究表明，铁死亡与缺氧应答的关键调控因子——缺氧诱导因子（HIF）存在密切关联。HIF（包括HIF-1α、HIF-2α、HIF-3α三种亚型）调控的铁死亡在结直肠癌、胃癌、溃疡性结肠炎及其他胃肠黏膜损伤性疾病中发挥作用，影响疾病的发生发展。但目前关于HIF-铁死亡通路在不同胃肠道疾病中的差异化作用及调控机制尚未完全阐明。因此，本文对HIF各亚型调控铁死亡的分子机制及其在胃肠道疾病中的作用进行综述，以期为靶向HIF-铁死亡通路治疗相关疾病提供新的思路。

       Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation．Recent 

studies have demonstrated a close association between ferroptosis and hypoxia-inducible factor（HIF），the key  regulator of the hypoxic response．Ferroptosis regulated by HIF（comprising three isoforms：HIF-1α，HIF-2α，and HIF-3α）plays a  role in colorectal cancer，gastric cancer，ulcerative colitis，and other gastrointestinal mucosal injury diseases，impacting their initiation and progression．However，the differential roles and regulatory mechanisms of the HIF-ferroptosis pathway in various gastrointestinal diseases remain incompletely elucidated．Therefore，this  review  summarizes the molecular mechanism networks through which individual HIF isoforms regulate ferroptosis and their roles in gastrointestinal diseases，with the aim of providing new perspectives for targeting the HIF-ferroptosis pathway to treat relevant diseases．

目的 运用数据挖掘、网络药理学和分子对接的方法,探讨中药复方治疗中枢性性早熟（CPP）的用药规律和作用机制,为其临床治疗提供更多依据。方法 在中国知网（CNKI）、万方数据（Wanfang）、维普中文期刊（VIP）等数据库中检索从建库至2022年10月发表的中药复方治疗CPP的文献,用Excel 2021 收集整理临床治疗CPP的常用中药复方,并通过Excel 2021、SPSS Modeler 18.0、SPSS Statistics 25.0等软件对其进行频次、关联规律等分析,研究CPP治疗的用药规律。在上述基础上采用网络药理学的研究方法,筛选出高频药对的活性成分、作用靶点以及疾病的相关靶点,构建蛋白互作网络,并通过基因本体和京都基因 基因组百科全书通路富集分析来阐明药物的作用机制。最后运用 Autodock Vina 软件进行分子对接对结果验证。结果 共筛选出224篇文献,包含方剂133首,中药188味。发现18味使用超过25次的高频药物;清热类、补虚类的药物应用较多;药物性味以寒及苦为主;归经之中以肝经占比最高;进一步关联分析得到高频药对14个;核心处方4个。网络药理学结果显示,共得到44个活性成分、200个药物靶点、1 287个疾病靶点、70个共有靶点、573条GO富集条目及136条KEGG通路,药物主要成分槲皮素、山奈酚、β-谷甾醇作用于雌激素受体、黄体酮受体等核心靶点,通过内分泌抵抗、雌激素等信号通路发挥治疗作用。分子对接结果显示药物主要活性成分与相应核心靶点具有较好的结合能力。结论 中药复方治疗CPP多为滋阴清热、补虚类药物,与药性寒,药味苦、甘,归肝、肾经的药物配伍使用。其中高频药对“知母-黄柏”通过多成分、多靶点调控内分泌抵抗、雌激素信号通路发挥治疗作用。

Objective To explore the prescription rules and mechanism of traditional Chinese medicine（TCM） in the treatment of central precocious puberty（CPP）by using data mining,network pharmacology and molecular docking,so as to provide more evidence for clinical treatment．Methods Using the literature on the treatment of CPP with TCM compounds,which was retrieved from the databases of CNKI,Wanfang,VIP and other databases from the establishment of the database to October 2022 as the data sources．Excel 2021 was used to collect and summarize the commonly used TCM prescriptions for CPP,and conducted frequency analysis and association rules analysis of CPP by Excel 2021,SPSS Modeler 18.0,SPSS Statistics 25.0 and other software,so as to study the composition rule of prescriptions for CPP．On the basis of these results,network pharmacology method was used to screen out the active ingredients and action targets of high-frequency drugs,and then screen out the disease related targets to construct PPI network．Mechanism of drugs was clarified through GO and KEGG pathway enrichment analysis．Finally,the molecular docking of autodock Vina（Vina）platform was used to verify the results．Results A total of 244 documents met the search criteria,including 133 prescriptions and 188 traditional Chinese medicines．It had been found that 18 high-frequency Chinese medicines were used more than 25 times．The drugs mainly focused on clearing heat and supplementing deficiency．The medicinal flavors were mainly cold and bitter,which belonged to the liver channel．Further correlation analysis yielded 14 high-frequency drug pairs and 4 core prescriptions．The results of network pharmacological analysis showed that 44 active components,200 drug targets,1 287 disease corresponding targets,70 common targets,573 GO enrichment entries and 136 KEGG pathways targets were obtained．It has been found that the main components of the drugs,such as quercetin,kaempferol and β-sitosterol,act on the core targets of ESR1,PGR and play a therapeutic role through endocrine resistance and estrogen signaling pathways．Finally,molecular docking results showed that the main active ingredients of the drug had good binding ability with the corresponding core targets．Conclusions In the treatment of CPP,traditional Chinese medicine is mainly used types of nourish Yin,clear heat and replenish deficiency,which is compatible with the drugs with cold properties,bitter and pliant taste,and the liver and spleen channels．Among them,high-frequency drug pair “ZhiMu-HuangBai” play a therapeutic role in the regulation of endocrine resistance and estrogen signaling pathways through multi-components and multi-targets．