因气候与生活习惯影响,广东地区老年性肩周炎临床特点及康复需求具有独特性,亟待制定规范、具有当地特色的康复方案。为制订适合地区差异化的康复方案,广东省中西医结合学会康复专业委员会联合广东省康复医学发展研究会疼痛康复发展研究分会牵头发起,省内多家机构专家学者共同制订《老年性肩周炎中医全周期康复广东专家共识(2026年版)》。该共识以ICF框架为基础,立足肩周炎康复循证医学证据,结合多学科专家产教研实践经验,对肩周炎 ICF评定、中医适宜技术及康复治疗技术运用、阶梯式干预性措施制定和中西医全周期康复协同等方面形成共识性意见。本共识的发布,将为老年性肩周炎中医全周期康复提供规范化、本土化的“广东方案”。
Due to climatic and lifestyle influences,the clinical characteristics and rehabilitation needs of senile periarthritis of the shoulder in Guangdong region exhibit unique features,necessitating the development of standardized and locally tailored rehabilitation protocols.To formulate regionally differentiated rehabilitation plans,the Rehabilitation Professional Committee of Guangdong Association of Integrative Medicine and the Pain Rehabilitation Development Research Branch of Guangdong Rehabilitation Medicine Development Research Association jointly initiated the development of the “Guangdong Expert Consensus on TCM Full-Cycle Rehabilitation for Senile Periarthritis of the Shoulder(2026 Edition)” through collaboration with multiple provincial institutions and experts.Based on the International Classification of Functioning,Disability and Health(ICF)framework and evidence-based rehabilitation medicine for periarthritis of the shoulder,this consensus integrates multidisciplinary expertise from industry,academia,and research to establish unified guidelines on ICF assessment,application of appropriate TCM techniques and rehabilitation therapies,implementation of stepwise intervention measures,and integrated TCM-Western medicine full-cycle rehabilitation approaches.The publication of this consensus will provide a standardized and localized “Guangdong Solution” for TCM-based full-cycle rehabilitation of senile periarthritis of the shoulder.
目的 调查住院老年患者因经外周静脉置入中心静脉导管(PICC)而引发的血栓情况,并分析其影响因素,为老年患者置入PICC产生的相关性血栓(PICC-CRT)和症状性血栓的评估与干预提供借鉴。方法 在2023年1月—2023年12月期间,选取广州市第一人民医院接受PICC置管的317例住院老年患者。采用包括患者一般情况调查表、运动功能评定、肌力检测、 Barthel指数评定、Padua评分等多种工具进行综合评估。采用多因素 Logistic 回归构建 PICC-CRT 及症状性血栓的预测模型,并应用逐步回归法优化变量筛选过程。模型性能通过 ROC 曲线进行评估。结果 去除临床资料不完整的患者40例,最终纳入277例患者的完整资料,其中123例患者出现了PICC-CRT,发生率为44.40%(123/277)。血栓分级中,I级78例,Ⅱ级37例,Ⅲ级8例。无症状血栓83例,占67.48%,发生率29.96%(83/277);症状性血栓40例,占32.52 %,发生率14.44%(40/277)。单因素分析联合多因素Logistic回归显示,卒中史、凝血酶原时间(PT)、导管留置时间是住院老年患者PICC-CRT的关键因素(P<0.05),预测模型ROC曲线下面积为0.719;置管史、恶性肿瘤史、导管留置时间、置管后并发症数量是住院老年患者PICC症状性血栓的独立影响因素(P<0.05),预测模型ROC曲线下面积为0.812。结论 文章总结了PICC-CRT和症状性血栓独特的影响因素,基于关键因素构建了预测模型预测其发生,为护理人员预防PICC-CRT和症状性血栓的发生提供了参考。
Objective To explore the incidence of thrombosis associated with peripherally inserted central catheter(PICC)placement in hospitalized elderly patients and to analyze its influencing factors,in order to provide a reference for the assessment and prevention of PICC-catheter related thrombosis(PICC-CRT)and symptomatic thrombosis in this population.Methods A total of 317 elderly inpatients who underwent PICC placement at a tertiary hospital in Guangzhou between January and December 2023 were enrolled.Comprehensive assessments were conducted using general patient information forms,motor function evaluation,muscle strength testing,Barthel Index,and Padua score.Multivariate Logistic regression analysis was used to construct predictive models for PICC-CRT and symptomatic thrombosis,with variable selection optimized via stepwise regression.Model performance was evaluated using receiver operating characteristic(ROC)curve analysis.Results After excluding 40 patients with incomplete clinical data,277 cases were included in the final analysis.Among them,123 patients developed PICC-CRT,with an incidence rate of 44.40%(123/277).Thrombosis was graded as Grade I in 78 cases,Grade II in 37 cases,and Grade III in 8 cases.Asymptomatic thrombosis occurred in 83 cases(29.96%),accounting for 67.48% of PICC-CRT;symptomatic thrombosis occurred in 40 cases(14.44%),accounting for 32.52%.Univariate and multivariate Logistic regression analyses identified history of stroke,prothrombin time(PT),and catheter dwell time as key risk factors for PICC-CRT(P<0.05),with the area under the curve(AUC)of 0.719.History of catheterization,malignancy,catheter dwell time,and number of post-catheterization complications were independent predictors of symptomatic thrombosis(P<0.05),with an AUC of 0.812.Conclusions This study identified distinct risk factors for PICC-CRT and symptomatic thrombosis in elderly inpatients.Predictive models based on key variables may provide useful references for clinical staff in preventing the occurrence of PICC-related and symptomatic thrombosis.
目的 探讨入院时血清淀粉样蛋白A(SAA)、载脂蛋白A1(ApoA1)、C反应蛋白(CRP)水平联合检测对老年急性脑梗死(ACI)患者规范治疗后3个月内发生预后不良的早期预测效能。方法 前瞻性选取2023年1月~2025年1月于焦作市第五人民医院就诊的108例老年ACI患者作为ACI组,另选取同期健康志愿者108例作为对照组。比较两组血清SAA、ApoA1、CRP水平。老年ACI患者予以规范治疗,根据治疗后3个月内预后情况将其分为预后不良(46例)和预后良好(62例)亚组,比较不同预后ACI患者患者临床资料及入院时血清SAA、ApoA1、CRP水平;Logistic回归分析入院时血清SAA、ApoA1、CRP水平是否为老年ACI患者规范治疗后3个月内发生预后不良的独立影响因素;ROC曲线分析入院时血清SAA、ApoA1、CRP水平联合检测对ACI患者预后不良的预测效能。结果 ACI组入院时血清SAA、CRP水平高于对照组,血清ApoA1水平低于对照组(P<0.05);预后不良亚组高血压占比、入院NIHSS评分、梗死体积、入院时血清SAA、CRP水平高于预后良好亚组,血清ApoA1水平低于预后良好亚组(P<0.05);剔除存在多重共线性指标高血压、入院NIHSS评分、梗死体积后,入院时血清SAA、ApoA1、CRP水平仍是老年ACI患者规范治疗后3个月内发生预后不良的独立影响因素(P<0.05);入院时血清SAA、ApoA1、CRP水平联合预测ACI患者预后不良的AUC值为0.873,显高于各指标单独预测值0.738、0.768、0.749(P<0.05)。结论 入院时血清SAA、ApoA1、CRP水平是老年ACI患者预后不良的独立影响因素,联合检测对预后不良具有较高的预测效能,可将其作为ACI患者血清敏感指标,协助临床医师早期制定针对性干预措施,减少ACI患者预后不良的发生。
目的 研究温肾利水汤联合贝前列素钠对老年原发性肾病综合征(PNS)患者T淋巴细胞亚群及肾功能的影响。方法 回顾性收集我院106例老年PNS患者临床资料(2024年4月-2026年1月),按照不同治疗方法分为研究组(n=55,温肾利水汤联合贝前列素钠)、对照组(n=51,贝前列素钠治疗)。比较两组治疗效果、中医证候积分、治疗前后肾功能[血尿素氮(BUN)、白蛋白(ABL)、血肌酐(SCR)]、T淋巴细胞亚群[CD4+、辅助性T细胞17(Th17)、CD3+]、不良反应。结果 治疗3个月后,研究组总有效率(92.73%)高于对照组(P<0.05);治疗3个月后,研究组主证积分、次证积分均低于对照组(P<0.05);治疗3个月后,研究组血清BUN、SCR水平低于对照组,ABL水平高于对照组(P<0.05);治疗3个月后,研究组CD4+、CD3+高于对照组,Th17低于对照组(P<0.05);两组不良反应发生率(5.45% VS 9.80%)相比,差异无统计学意义(P>0.05)。结论 温肾利水汤联合贝前列素钠治疗老年PNS患者能提高治疗效果,改善T淋巴细胞亚群水平,促进肾功能恢复。
目的:探究对老年腹腔镜结直肠癌根治术中患者实施环泊酚联合瑞芬太尼后对其的苏醒质量、认知功能影响。方法:选取2025年1月-10月在我院接受腹腔镜结直肠癌根治术的50例老年患者作为研究对象,并采用随机数字表法将其分为两组。对照组25例患者,实施丙泊酚联合瑞芬太尼麻醉;观察组25例患者,采用环泊酚联合瑞芬太尼进行麻醉。对两组患者的苏醒质量(睁眼时间、拔管时间、定向力恢复、Steward评分)、术后认知功能(MMSE、MOCA.POCD发生率、MOAA/S评分)、炎症反应(IL-6, TNF-a, CRP, S100B, NSE)、疼痛控制(VAS评分、镇痛药用量)、不良反应(呼吸抑制、PONV、低血压、寒战等)与术中血流动力学(血压、心率、Sp0z、PaCO2、氧合指数)进行比较分析。结果:观察组的睁眼时间(10.55±2.11 min)、拔管时间(16.44±1.55 min)、定向力恢复时间(34.55±5.33 min)短于对照组,Steward苏醒评分(5.44±0.33 min)高于对照组(P<0.05)。观察组术后的MMSE评分(27.44±1.22 分)、MoCA评分(28.44±1.66 分)、MOAA/S评分(3.22±0.44 分)均高于对照组,POCD发生率(16.00%)低于对照组(P<0.05)。观察组术后IL-6(100.22±10.22 pg/mL)、TNF-α(30.22±4.44 pg/mL)、CRP(80.44±5.22 mg/L)、S100B(0.15±0.02 μg/L)、NSE水平(13.66±3.22 μg/L)均低于对照组(P<0.05)。两组的术后VAS评分比较,统计学无差异,P>0.05;观察组24h镇痛药物用量(80.23±20.44 mg)少于对照组(P<0.05)。观察组术中血压、心率、Sp0z、PaCO2、氧合指数比对照组更稳定(P<0.05)。观察组呼吸抑制、PONV、低血压、寒战的不良反应发生率(16.00%)低于对照组(44.00%)(P<0.05)。结论:环泊酚联合瑞芬太尼麻醉方案可提高老年腹腔镜结直肠癌根治术患者的苏醒质量方面,利于患者的术后认知功能恢复,减轻其神经炎症反应,维持患者血流动力学稳定,并降低镇痛药物用量与不良反应发生率。
目的 比较横断疝囊与完全剥离疝囊在经腹腹膜前疝修补术(TAPP)在中老年单侧腹股沟疝中的临床价值。方法 回顾性选取2021年3月至2025年3月我院95例中老年单侧腹股沟疝,均采用TAPP治疗,根据疝囊具体处理策略分为横断组(横断疝囊,n=65)和剥离组(完全剥离疝囊,n=30)。比较两组手术指标、手术前后疼痛程度[疼痛数字评价量表(NRS)评分]、生活质量[生活质量综合评定问卷-74(GQOLI-74)]、并发症及术后12个月复发情况。结果 较剥离组,横断组手术、疝囊处理、卧床及住院时间缩短,腹股沟区积液及术中失血量减少(P<0.05);术后6 h、24 h、72 h横断组NRS评分较剥离组降低(P<0.05);术后3个月横断组GQOLI-74总分高于剥离组(P<0.05);两组并发症及复发率无显著差异(P>0.05)。结论 在中老年单侧腹股沟疝TAPP中应用横断疝囊能优化手术流程,减轻疼痛程度,改善生活质量,且安全性、复发效果与完全剥离疝囊相当。
目的 探讨老年髋部骨折术后患者跌倒恐惧的影响因素,构建个体化风险预测列线图模型并进行临床效能验。方法 采用便利抽样法,选取2025年4月-2025年10月在我院骨科住院并接受手术治疗的老年髋部骨折患者227例作为研究对象。采用一般资料调查表、国际版跌倒效能量表、医院综合焦虑抑郁量表、社会支持评定量表、简易体能状况量表、康复自我效能量表、临床衰弱量表及肌少症筛查问卷等进行横断面调查。采用卡方检验筛选预测变量,多因素Logistic回归分析确定跌倒恐惧的独立影响因素,并基于R语言构建列线图预测模型。通过Bootstrap法进行内部验证,采用校准曲线和受试者工作特征曲线评估模型的区分度与校准度。结果 227例患者中,150例存在跌倒恐惧。多因素Logistic回归分析显示:年龄≥75岁(OR=3.28)、视力不良(OR=6.017)、焦虑抑郁(OR=3.738),衰弱(OR=3.821),肌少症(OR=2.704),康复自我效能低(OR=0.275),为患者发生跌倒恐惧的风险因素。基于上述6个预测因子构建的列线图模型,其ROC曲线下面积为0.839(95%CI:0.832-0.916),。校准曲线显示预测概率与实际发生率一致性良好(Bootstrap验证,P=0.028),DCA结果显示,当阈值概率在0.1-0.9时,该模型净收益优于假设所有患者均接受或均不接受治疗的策略。结论 本研究构建的列线图模型能有效预测老年髋部骨折术后患者发生跌倒恐惧的风险,有助于临床医护人员早期识别高危人群并进行多维度靶向干预。
目的 评价不同运动干预对老年肌少性肥胖患者健康状况的干预效果。 方法 计算机检索PubMed、Web of Science、Embase、Cochrane Library、中国知网、万方数据库、维普数据库中关于运动干预老年肌少性肥胖患者的运动干预的随机对照试验,检索时限为建库至2025年8月。采用RevMan 5.4软件进行统计分析。 结果 共计纳入13篇文献,815名参与者。运动可显著改善患者身体质量指数 (P<0.0001)、体脂率 (P=0.001)、四肢骨骼肌质量(P<0.0001)、握力(P=0.007)、步速 (P=0.0003)、起立-行走计时测试用时(P<0.00001),提高患者IGF-1水平(P =0.0003);但IL-6(P =0.96)、血清总胆固醇(P=0.22)未见明显改变。 结论 运动可以有效降低肌少性肥胖患者的身体质量指数、体脂肪, 提高肌少性肥胖患者的身体机能、四肢骨骼肌质量和IGF-1水平,其中多组分运动和抗阻运动效果更加显著。
Objective To evaluate the effect of different exercise intervention on the health status of elderly patients with sarcopenia and obesity. Methods PubMed, Web of Science, Embase, Cochrane Library, CNKI, Wanfang database and VIP database were searched for randomized controlled trials on exercise intervention in elderly patients with sarcopenia and obesity until August 2025.Two researchers independently screened the literature, extracted the data, and evaluated the bias risk of the included studies, and then used RevMan 5. 3 software for statistical analysis. Results a total of 13 articles involving 815 participants were included.Exercise significantly reduced body mass index (P < 0.0001), body fat percentage (P = 0.001), and increased limb skeletal muscle mass (P < 0.0001).Exercise significantly improved the patient's grip strength (P = 0.007), pace (P = 0.0003), and decreased the time spent on the timed up-and-go test (P < 0. 00001).Exercise significantly increased serum IGF-1 levels (P = 0.0003), but did not significantly change serum IL-6 (P = 0.96) and serum total cholesterol (P = 0.22). Conclusion Exercise can effectively reduce the body mass index and body fat, and improve the body function, limb skeletal muscle mass and IGF-1 level in patients with sarcopenia obesity, and the effects of multi-component exercise and resistance exercise are more significant.
【摘要】目的:探讨不同剂量右美托咪定对老年骨科手术患者术后谵妄的预防作用。方法:回顾性选取2022年11月至2025年11月本院收治的116例老年骨折手术患者为研究对象,根据右美托咪定维持剂量不同分为0.2μg/(kg·h)的小剂量组(58例)和0.4μg/(kg·h)的大剂量组(58例)。比较两组不同时间点[麻醉诱导前(T0)、麻醉诱导后30 min(T1)、术闭即刻(T2)]的血压(收缩压、舒张压)、心率、应激反应指标[皮质醇(COR)、肾上腺素(E)、去甲肾上腺素(NE)];采用简易智力状态检查量表(MMSE)评估两组患者术前、术后12 h、术后24 h、术后48 h的认知功能水平;统计两组患者术后谵妄及围术期不良反应发生情况。结果:小剂量组T1、T2时收缩压、舒张压和心率均高于大剂量组(P<0.05)。小剂量组T1、T2时COR、E和NE均低于大剂量组(P<0.05)。小剂量组术后12h、术后24h、术后48h的MMSE评分均高于大剂量组(P<0.05)。小剂量组术后谵妄发生率8.62%(5/58)显著低于大剂量组22.41%(13/58)(χ2=4.209,P=0.040)。小剂量组不良反应总发生率12.07%(7/58)与大剂量组20.69%(12/58)对比无显著差异(P>0.05)。结论:与0.4μg/(kg·h)的大剂量右美托咪定相比,0.2μg/(kg·h)的小剂量在老年骨科手术麻醉中应用效果更佳,能有效维持血流动力学稳定、减轻应激反应、保护认知功能,对术后谵妄具有更好的预防作用,且安全性良好,值得在临床推广应用。
目的 探讨多组分运动训练对老年慢性阻塞性肺疾病(COPD)稳定期病人骨骼肌功能的影响。方法 前瞻性选择2022年10月—2024年10月90例COPD稳定期患者,采用抽签法随机分为观察组与对照组,对照组45例采取常规运动干预,观察组45例在对照组基础上增加多组分运动训练。干预前、干预后3个月比较两组患者四肢骨骼肌含量,四肢肌群力量,运动耐力与肺功能,生活质量。结果 干预后,两组上肢、下肢骨骼肌含量均略增加,观察组高于对照组(P<0.05);干预后,两组膝伸肌、膝屈肌、肘伸肌、肘屈肌肌群力量均增加,观察组高于对照组(P<0.05);干预后,两组6 min步行试验、用力肺活量及第一秒用力呼气量均升高,观察组高于对照组(P<0.05);干预后,两组圣乔治呼吸问卷各维度分数及总分均降低,观察组低于对照组(P<0.05)。结论 针对老年COPD稳定期患者采取多组分运动训练可提升患者四肢骨骼肌含量与四肢肌群力量,改善患者运动耐力与肺功能,减轻COPD及骨骼肌功能障碍对患者生活质量造成的负面影响。
Objective To explore the effect of multi-component exercise training on skeletal muscle function in elderly patients with stable chronic obstructive pulmonary disease(COPD).Methods From October 2022 to October 2024,90 stable COPD patients were prospectively selected and randomly divided into an observation group and a control group using a lottery method.The control group consisted of 45 patients who received routine exercise care,while the observation group consisted of 45 patients who received multi-component exercise training in addition to the routine care.Skeletal muscle content,muscle group strength,exercise endurance,lung function,and quality of life between two groups of patients were compared before and three months after intervention.Results After intervention,the skeletal muscle content of both upper and lower extremities slightly increased in both groups,with the observation group being higher than the control group(P<0.05).After intervention,the strength of the knee extensor,knee flexor,elbow extensor,and elbow flexor muscle groups increased in both groups,with the observation group had better results than the control group(P<0.05).After intervention,both groups showed an increase in six-minute walking test,forced vital capacity,and forced expiratory volume in first second,with the observation group had better results than the control group(P<0.05).After intervention,the scores of each dimension and total score of the SGRQ in both groups decreased,and the observation group had lower scores than the control group(P<0.05).Conclusions Multi-component exercise training for stable elderly COPD patients can improve the skeletal muscle content and muscle strength of the extremities,enhance exercise endurance and lung function,and alleviate the negative impact of COPD and skeletal muscle dysfunction on patients’quality of life.