老年髋部骨折术后患者跌倒恐惧影响因素分析及列线图预测模型的构建

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目的 探讨老年髋部骨折术后患者跌倒恐惧的影响因素,构建个体化风险预测列线图模型并进行临床效能验。方法 采用便利抽样法,选取2025年4月-2025年10月在我院骨科住院并接受手术治疗的老年髋部骨折患者227例作为研究对象。采用一般资料调查表、国际版跌倒效能量表、医院综合焦虑抑郁量表、社会支持评定量表、简易体能状况量表、康复自我效能量表、临床衰弱量表及肌少症筛查问卷等进行横断面调查。采用卡方检验筛选预测变量,多因素Logistic回归分析确定跌倒恐惧的独立影响因素,并基于R语言构建列线图预测模型。通过Bootstrap法进行内部验证,采用校准曲线和受试者工作特征曲线评估模型的区分度与校准度。结果 227例患者中,150例存在跌倒恐惧。多因素Logistic回归分析显示:年龄≥75岁(OR=3.28)、视力不良(OR=6.017)、焦虑抑郁(OR=3.738),衰弱(OR=3.821),肌少症(OR=2.704),康复自我效能低(OR=0.275),为患者发生跌倒恐惧的风险因素。基于上述6个预测因子构建的列线图模型,其ROC曲线下面积为0.839(95%CI:0.832-0.916),。校准曲线显示预测概率与实际发生率一致性良好(Bootstrap验证,P=0.028),DCA结果显示,当阈值概率在0.1-0.9时,该模型净收益优于假设所有患者均接受或均不接受治疗的策略。结论 本研究构建的列线图模型能有效预测老年髋部骨折术后患者发生跌倒恐惧的风险,有助于临床医护人员早期识别高危人群并进行多维度靶向干预。

急性中毒导致缺血缺氧性脑病患者预后的影响因素及预测模型研究

Study on the influencing factors and prediction model of prognosis in patients with hypoxic-ischemic encephalopathy caused by acute poisoning

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目的:分析急性有机磷农药中毒(AOPP)引发缺血缺氧性脑病预后相关因素,建立相关的预后预测模型。方法:回顾性分析90例(33例预后不良、57例预后良好)AOPP致HIE患者(2022年3月~2025年8月)的临床资料、中毒指标和血清学指标,独立危险因素用Logistic回顾分析筛选,并构建预后不良预测模型,采用ROC工具对模型效能进行验证。结果:Logistic 回归分析显示,年龄≥60岁、重度中毒、中毒至就诊时间、LAC水平、CHE水平、CRP水平及NSE水平均为患者预后不良的独立危险因素(P<0.05);AUC、灵敏度、特异度为0.943、90.91%、87.72%。结论:高龄、中毒程度高及中毒至就诊时间长等因素可导致AOPP致HIE患者出现不良结局,据此构建风险预测模型可有效预测预后不良的发生风险。
To determine the key impacting factors for hypoxic ischemic encephalopathy (HIE) caused by acute organophosphorus pesticide poisoning (AOPP) and build a prediction model. Methods: The clinical data, poisoning indicators and serological indicators of 90 patients (33 cases with poor prognosis and 57 cases with good prognosis) with HIE caused by AOPP (from March 2022 to Aug 2025) were analyzed. Independent risk factors were screened using logistic retrospective analysis, and a poor prognosis prediction model was constructed. The model efficiency was verified by the receiver operating curve (ROC). Results: Logistic regression analysis showed that age ≥ 60 years, severe poisoning, time from poisoning to treatment, LAC level, CHE level, CRP level, and NSE level were all risk factors for the prognosis in patients (P < 0.05). The AUC, sensitivity, and specificity were 0.943, 90.91%, and 87.72%.Conclusion: Factors such as advanced age, high degree of poisoning, and long time from poisoning to treatment can lead to adverse outcomes in patients with HIE caused by AOPP. Based on this, building a risk prediction model can effectively predict the risk of poor prognosis.

2022-2024年深圳市福田区危重症孕产妇流行病学特征及相关因素分析

Analysis of Epidemiological Characteristics and Related Factors of Critically Ill Pregnant Women in Futian District, Shenzhen (2022–2024)

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摘要:目的 分析2022—2024年深圳市福田区危重症孕产妇不同亚组(不同并发症/合并症)的流行病学特征、病因构成及相关因素,为优化区域孕产妇健康管理提供依据。方法 基于福田区危重症孕产妇监测网络,对2022年1月1日至2024年12月31日期间107921例孕产妇个案资料进行回顾性描述性分析,采用描述性流行病学方法及卡方检验分析不同因素与危重症主要并发症的关联。结果 深圳市福田区3年间危重症孕产妇共729例,总体发生率为6.75‰。各年度发生率分别为2022年6.67‰、2023年7.38‰和2024年6.33‰。危重症孕产妇中,≥35岁者占33.7%,本科及以上学历者占53.8%。初检妊娠风险评级为黄色者占比最高(41.98%),高危者占21.9%。最常见并发症为产后出血(43.89%),其次为宫缩乏力(17.28%)、前置胎盘(16.59%)、子痫/子痫前期(14.67%)和胎盘植入(13.99%)。血液系统疾病为最常见合并症(57.75%),内分泌系统疾病次之(24.42%)。单因素分析显示,产后出血的发生与高龄、产检次数不足5次、经产妇身份存在统计学关联(均P<0.05);前置胎盘的发生与高龄、低学历、非汉族、初检高危评级、产检不足5次、经产存在统计学关联(均P<0.05)。结论 深圳市福田区危重症孕产妇发生率约为6.75‰,产后出血和前置胎盘为主要并发症。单因素分析显示,高龄、产检不足、初检高危分级及经产与上述主要并发症的发生相关。应加强动态妊娠风险管理和多学科协作,完善产科早期预警体系,以降低危重症孕产妇发生率,提高母婴安全水平。
Abstract: Objective To analyze the epidemiological characteristics, etiology composition, and related factors of critically ill pregnant women in Futian District, Shenzhen, from 2022 to 2024. Methods Based on the surveillance network, a retrospective descriptive analysis was conducted on 107,921 pregnant women. Chi-square tests were used to analyze the association between different factors and major complications. Results A total of 729 critically ill pregnant women were identified (overall incidence 6.75‰).??The most common complication was postpartum hemorrhage (43.89%), followed by uterine atony (17.28%), placenta previa (16.59%), eclampsia/preeclampsia (14.67%), and placenta accreta (13.99%). Univariate analysis showed that postpartum hemorrhage was statistically associated with advanced age, <5 antenatal visits, and multiparity (all P<0.05). Placenta previa was statistically associated with advanced age, low education level, non-Han ethnicity, high-risk initial assessment, <5 antenatal visits, and multiparity (all P<0.05). Conclusion The incidence of critically ill pregnant women in Futian District is approximately 6.75‰. Univariate analysis suggested that advanced age, insufficient antenatal visits, high-risk classification, and multiparity were associated with the main complications. Dynamic risk management and multidisciplinary collaboration should be strengthened.

乙型肝炎病毒感染患者并发2型糖尿病风险因素分析

Analysis of Risk Factors for Type 2 Diabetes in Patients with Hepatitis B Virus Infection

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目的 分析乙型肝炎病毒(HBV)感染患者并发2型糖尿病(T2DM)相关风险因素。方法 研究收集2024年1月~2025年5月期间,于周口市传染病医院(周口市结核病防治所、周口市第五人民医院)接受治疗的HBV感染患者临床资料,共纳入患者95例,根据HBV感染后是否并发T2DM分组,合并T2DM患者纳入并发组(n=21),非合并T2DM患者纳入对照组(n=74),比较两组患者基线资料及实验室检查数据,逻辑回归分析HBV感染患者并发T2DM风险因素。结果 并发组年龄、体重指数(BMI)、甘油三酯(TG)高于对照组(P<0.05),年龄≥45岁、BMI肥胖、HBV感染时间≥6个月、TG≥1.7mmol/L、吸烟、乙型肝炎表面抗原(HBsAg)阳性及纤维化-4(FIB-4)指数≥2.67例数占比高于对照组(P<0.05)。年龄≥45岁[OR=21.599(95%CI:2.875-162.262)]、BMI(肥胖)[OR=16.729(95%CI:1.443-193.981)]、HBV感染时间≥6个月[OR=6.199(95%CI:1.101-34.904)]、吸烟[OR=9.429(95%CI:1.344-66.141)]、TG≥1.7mmol/L[OR=71.834(95%CI:7.060-730.897)]是HBV感染患者并发T2DM危险因素(P<0.05)。结论 HBV感染患者并发T2DM受人口学特征年龄、BMI、临床病程HBV感染时间、共病血脂异常及生活方式吸烟的共同影响。
Abstract: Objective To analyze risk factors associated with the development of type 2 diabetes mellitus (T2DM) in patients with hepatitis B virus (HBV) infection. Methods Clinical data were collected from HBV-infected patients treated at the Zhoukou City Infectious Disease Hospital (Zhoukou City Tuberculosis Prevention and Control Institute)between January 2024 and May 2025. A total of 95 patients were included in the study, Patients were grouped based on the presence or absence of T2DM following HBV infection. Patients with T2DM were included in the T2DM group (n=21), while those without T2DM were included in the control group (n=74). Baseline characteristics and laboratory test data were compared between the two groups, and logistic regression analysis was performed to identify factors associated with the development of T2DM in HBV-infected patients. Results The age, body mass index (BMI), and triglycerides (TG) in the intervention group were higher than those in the control group (P < 0.05); The proportion of cases with age ≥45 years, obese BMI, HBV infection duration ≥6 months, TG ≥1.7 mmol/L, smoking, hepatitis B surface antigen (HBsAg) positivity, and a FIB-4 score ≥2.67 was higher than that in the control group (P < 0.05). Age ≥ 45 years [OR = 21.599 (95% CI: 2.875–162.262)], BMI (obesity) [OR = 16.729 (95% CI: 1.443–193.981)], duration of HBV infection ≥ 6 months [OR = 6.199 (95% CI: 1.101–34.904)], smoking [OR=9.429 (95% CI: 1.344–66.141)], and TG ≥ 1.7 mmol/L [OR=71.834 (95% CI: 7.060–730.897)] were risk factors for T2DM in patients with HBV infection (P < 0.05). Conclusion The development of T2DM in patients with HBV infection is influenced by a combination of demographic factors (age and BMI), clinical course (duration of HBV infection), comorbid dyslipidemia, and lifestyle factors (smoking).

心力衰竭患者住院期间容量管理成效及影响因素分析

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摘要:目的 探讨心力衰竭患者住院期间容量管理成效及影响因素。方法 选取2024年1月—2025年12月我院收治的666例心力衰竭患者为调查对象,根据其成效将其分为有效组(n=612)和无效组(n=54)。统计两组患者临床资料及监测指标,采用单/多因素Logistic分析心力衰竭患者住院期间容量管理成效的影响因素。结果 本研究中,心力衰竭患者住院期间容量管理的有效率为91.89%(612/666)。两组年龄、病程、心功能分级及下肢水肿发生率比较(P<0.05);性别、体重指数、文化程度、吸烟史、饮酒史、基础疾病比较无明显差异(P>0.05)。干预前及干预后,两组左室射血时间、左心室做功指数、左心室做功、每搏输出量、心脏指数、心输出量及脑钠肽比较(P<0.05)。自变量设置为一般资料中对比有差异的指标包括年龄、病程、心功能分级及下肢水肿发生率、左室射血时间、左心室做功指数、左心室做功、每搏输出量、心脏指数、心输出量及脑钠肽,因变量为心力衰竭患者住院期间容量管理成效,进行单因素Logistic回归分析,结果显示,心力衰竭患者住院期间容量管理成效的影响因素是年龄、心功能分级及下肢水肿发生率、左室射血时间、左心室做功指数、左心室做功、每搏输出量、心脏指数、心输出量及脑钠肽。校正年龄、性别等混杂因子,将单因素方差中对比有差异的数据纳入多因素Logistic回归分析,结果显示,心力衰竭患者住院期间容量管理成效的影响因素是年龄、心功能分级及下肢水肿发生率、左室射血时间、左心室做功指数、左心室做功、心输出量及脑钠肽。结论 心力衰竭患者住院期间容量管理成效较好,心力衰竭患者住院期间容量管理成效的影响因素为年龄、心功能分级及下肢水肿发生率、左室射血时间、左心室做功指数、左心室做功、心输出量及脑钠肽。

基于生物—心理—社会模式的住院患者负荷现状及多因素关联分析

Current Status and Multifactorial Association Analysis of Patient Burden in Inpatients Based on the Biopsychosocial Model

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目的 基于生物—心理—社会模式分析精神专科住院患者负荷现状及其关联因素。 方法 选取某三级精神专科医院住院患者为研究对象,构建涵盖住院天数、费用、护理风险、联合用药、危机干预及出院准备难度的住院负荷综合评分,采用多元线性回归和Logistic回归分析影响因素。 结果 患者住院负荷评分为57.16±15.36分,高负荷患者约占三分之一;生物、心理、社会因素联合模型可解释68.4%的负荷变异;明显睡眠问题、既往住院次数≥3次、治疗依从性差、家庭支持低、社会功能重度受损及缺乏社区衔接资源等为高住院负荷危险因素。 结论 精神专科住院负荷具有复合性和多因素累积特征,应建立多维评估与分层干预机制,以优化资源配置和连续照护。
Objective To analyze the current status of inpatient burden and its associated factors among psychiatric inpatients based on the biopsychosocial model. Methods Inpatients from a tertiary psychiatric hospital were selected as study subjects. A comprehensive inpatient burden score was developed, incorporating length of stay, cost, nursing risk, polypharmacy, crisis intervention, and difficulty in discharge preparation. Multivariate linear regression and logistic regression analyses were used to identify influencing factors. Results The mean inpatient burden score was 57.16 ± 15.36 points, with approximately one-third of patients experiencing high burden. The combined model of biological, psychological, and social factors explained 68.4% of the variance in burden. Significant sleep problems, prior hospitalizations ≥3 times, poor treatment adherence, low family support, severe impairment in social functioning, and lack of community follow-up resources were identified as risk factors for high inpatient burden. Conclusion Psychiatric inpatient burden is complex and characterized by cumulative multifactorial influences; therefore, a multidimensional assessment and tiered intervention system should be established to optimize resource allocation and ensure continuous care.

OVCF患者PVP术后1年内发生AVCF的影响因素及构建的Logistic风险预测模型对AVCF发生的预测效能

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目的 探讨骨质疏松椎体压缩性骨折(OVCF)患者经皮椎体成形术(PVP)术后1年内发生邻近椎体再骨折(AVCF)的影响因素,并构建Logistic风险预测模型,分析其对AVCF发生的预测效能。方法 前瞻性选取我院2022年1月~2024年1月收治的188例OVCF患者,入院后均行PVP术治疗,根据术后1年内是否发生AVCF分为发生组、未发生组。单因素分析两组临床资料,Logistic多因素回归分析OVCF患者PVP术后1年内发生AVCF的影响因素,构建Logistic风险预测模型;ROC曲线分析风险预测模型对AVCF发生的预测效能。结果 两组年龄、术前骨密度、骨折病史、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标比较差异显著(P<0.05);Logistic多因素回归方程分析结果显示,年龄、术前骨密度、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标均为OVCF患者PVP术后1年内发生AVCF的独立影响因素(P<0.05)。构建Logistic回归模型,Logit(p)=-5.234+0.445×年龄-0.124×术前骨密度+1.521×骨水泥渗漏+1.375×术前椎体内裂隙征-0.151×术后椎体高度恢复达标。Logistic风险预测模型预测预AVCF发生的AUC值为0.863(95% CI:0.812~0.913),敏感度、特异度分别为80.31%、81.64%。结论 年龄、术前骨密度、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标均为OVCF患者PVP术后1年内发生AVCF的独立影响因素,在此基础上构建的Logistic风险预测模型可为临床早期分辨PVP术后发生AVCF的高危患者提供依据,临床可据此早期制定针对性干预方案,以降低PVP术后AVCF发生风险。

症状性颅内动脉重度狭窄自膨式支架成形术预后不良的相关因素及预测模型研究

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目的 探讨症状性颅内动脉重度狭窄(sICAS)患者接受自膨式支架成形术后预后不良的相关因素,并构建预测模型。方法 回顾性连续纳入2023年1月至2025年6月于本院脑血管病科行自膨式支架联合经皮腔内血管成形支架置入术(PTAS)的重度sICAS患者96例。收集患者一般临床资料、影像学特征、手术相关资料及随访结局。以术后1年内发生主要终点事件(包括缺血性卒中复发、颅内出血、死亡或症状性支架内再狭窄)定义为预后不良。采用单因素及多因素Logistic回归分析筛选独立危险因素,并构建列线图预测模型。通过受试者工作特征曲线(ROC)及校准曲线评估模型效能。结果 96例患者中,术后1年共发生预后不良事件22例(22.9%),其中缺血性卒中复发12例(12.5%),症状性支架内再狭窄8例(8.3%),颅内出血2例(2.1%)。多因素Logistic回归分析显示,糖尿病(OR = 3.21,95% CI:1.28~8.05,P = 0.013)、术前狭窄长度≥10 mm(OR = 2.89,95% CI:1.15~7.28,P = 0.024)、Mori C型病变(OR = 4.12,95% CI:1.52~11.16,P = 0.005)及术后即刻残余狭窄率≥20%(OR = 2.67,95% CI:1.06~6.72,P = 0.037)是预后不良的独立危险因素。基于上述因素构建的预测模型AUC为0.84(95% CI:0.76~0.92),校准曲线显示模型一致性良好。结论 糖尿病、长病变、复杂Mori分型及术后残余狭窄率高是自膨式支架成形术后预后不良的独立预测因素,所构建的预测模型具有较好的区分度与校准度,可用于个体化风险评估。

OVCF患者PVP术后1年内发生AVCF的影响因素及构建的Logistic风险预测模型对AVCF发生的预测效能

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目的 探讨骨质疏松椎体压缩性骨折(OVCF)患者经皮椎体成形术(PVP)术后1年内发生邻近椎体再骨折(AVCF)的影响因素,并构建Logistic风险预测模型,分析其对AVCF发生的预测效能。方法 前瞻性选取我院2022年1月~2024年1月收治的188例OVCF患者,入院后均行PVP术治疗,根据术后1年内是否发生AVCF分为发生组、未发生组。单因素分析两组临床资料,Logistic多因素回归分析OVCF患者PVP术后1年内发生AVCF的影响因素,构建Logistic风险预测模型;ROC曲线分析风险预测模型对AVCF发生的预测效能。结果 两组年龄、术前骨密度、骨折病史、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标比较差异显著(P<0.05);Logistic多因素回归方程分析结果显示,年龄、术前骨密度、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标均为OVCF患者PVP术后1年内发生AVCF的独立影响因素(P<0.05)。构建Logistic回归模型,Logit(p)=-5.234+0.445×年龄-0.124×术前骨密度+1.521×骨水泥渗漏+1.375×术前椎体内裂隙征-0.151×术后椎体高度恢复达标。Logistic风险预测模型预测预AVCF发生的AUC值为0.863(95% CI:0.812~0.913),敏感度、特异度分别为80.31%、81.64%。结论 年龄、术前骨密度、骨水泥渗漏、术前椎体内裂隙征、术后椎体高度恢复达标均为OVCF患者PVP术后1年内发生AVCF的独立影响因素,在此基础上构建的Logistic风险预测模型可为临床早期分辨PVP术后发生AVCF的高危患者提供依据,临床可据此早期制定针对性干预方案,以降低PVP术后AVCF发生风险。

EP患者宫腔镜息肉切除术后发生IUA的风险因素及构建的Logistic风险预测模型对IUA发生的预测效能

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目的 探讨子宫内膜息肉(EP)患者宫腔镜息肉切除术后发生宫腔粘连(IUA)的影响因素,并构建Logistic回归模型,以筛选高危患者,并指导临床制定治疗方案。方法 前瞻性选取2023年1月~2025年1月于本院就诊的200例EP患者为研究对象,依据宫腔镜息肉切除术后6个月内是否发生IUA,将其分为发生组61例、未发生组139例。比较两组临床资料及多因素分析术后IUA发生的影响因素,构建Logistic回归模型,并验证该模型对术后IUA发生的预测价值。结果 手术时间、宫内节育器、剖宫产史、多发息肉、盆腔炎病史及术前血清血管内皮生长因子(VEGF)、 细胞趋化因子配体-5(CXCL5)、白细胞介素-22(IL-22)为术后IUA发生的独立危险因素(P<0.05);Logistic回归模型预测术后IUA发生风险的AUC值为0.927,敏感度、特异度分别为88.52%、88.49%,且该模型具有良好拟合度、校准度及临床应用性。结论 基于手术时间、宫内节育器、剖宫产史、多发息肉、盆腔炎病史及术前血清VEGF、CXCL5、IL-22构建预测模型,可有效预测EP患者宫腔镜息肉切除术后IUA发生风险,有助于指导临床制定干预方案。
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