目的 分析2016—2018年度广州市单采血小板报废的主要原因,并探讨如何降低单采血小板报废率。方法 统计2016—2018年度广州市单采血小板的采集量、报废数量和报废率等相关数据,分析报废原因,提出相应改进措施。结果 2016—2018年广州血液中心单采血小板总报废率为1.13%,三年的报废率逐年下降。报废的最主要原因为血液感染因子筛查不合格或ALT异常,占总报废率64.44%;其次分别为血量不足(占比14.4%)、采血耗材/血袋/热合口漏(占比11.01%)等。结论 我中心单采血小板报废率虽逐年下降,但仍需加强献血前宣传,动员更多的健康适龄公民参加无偿献血,同时重视采前血液感染因子的筛查工作、采血前及采血过程的护理干预、设备维护保养和产品处理能力的培训,进一步有效降低血液报废率。

Objective To analyze the main causes of apheresis platelets discarding in Guangzhou from 2016 to 2018, and discuss how to reduce the discarding rate. Methods Collected the data of apheresis platelets collection, the discarding number and the discarding rate in Guangzhou from 2016 to 2018,to analysis the reasons of apheresis platelets discarding and introducing improvement measures. Results From 2016 to 2018, the total discarding rate of apheresis platelets collected from Guangzhou Blood Center was 1.13%. In the three years,the discarding rate declined year by year.The main reasons for apheresis platelets discarding were the result of blood infection factor test or ALT was not qualified, accounting for 64.44% of the total scrapping rate. Then followed by insufficient blood volume (14.4%) and Blood consumables/blood bags/heat closure leakage (11.01%). Conclusion Although the rate of apheresis platelet discarding in Guangzhou Blood Center is decreasing year by year, we still need to enhance blood donation propaganda, mobilize more healthy citizens to participate in blood donation, and pay attention to the screening of blood infection factors before blood collection, nursing blood donor before and during blood collection, and training of ability in equipment maintenance and product handling, so as to further effectively reduce the rate of blood discarding.

目的 探讨导致口服华法林患者国际标准化比值异常增高(INR>4.5)的原因。方法 选择148例做过心瓣膜置换术,出院后口服华法林抗凝,复查时国际标准化比值(INR>4.5)异常增高的患者。通过对其用药量以及服用其它药物(包括西药和中药)、营养品、食物等情况进行调查,分析导致口服华法林患者INR异常增高的有关因素,同时对PT检测过程中检验前、检验中的质量控制进行调查,排除检测过程中的影响因素,最后综合分析导致心瓣膜置换术后口服华法林患者INR异常增高的原因。结果 导致口服华法林患者INR异常增高的原因主要是药量过多,占全部调查的47.29%,其中医嘱剂量过多的为39.18%,遗忘重复服药或不理解医嘱的比例为8.10%;其次是受药物相互影响的比例为43.25%,其中受西药影响的比例为33.11%,受中药物影响的占10.14%;药物外影响的因素比例为9.47%,其中受饮食影响的比例为4.06%;受物理治疗影响的比例为5.41%。结论 导致口服华法林患者INR异常增高最主要的原因是用药量过多以及受其他药物的相互影响,同时受饮食及物理治疗的影响。

Objective To investigate the cause of abnormality increase of international normalized ratio (INR) (INR>4.5) in the patients who oral application Warfarin. Methods 148 patients were taken who had cardiac valve replacement operation and oral application warfarin post-discharge as subjects. Their INR abnormality increased when taking reexamination. Through the research of the drugs, the dose (including both Chinese crude drug and western medicine), the nourishments and the foods that the patients took, we find out factors that resulted in INR abnormality increase, while to investigate the quality control of laboratory department and analyze the process before and after PT test, to find out factors that affect the test. Finally, to analyze the causes of INR abnormality increase in patients took warfarin after cardiac valve replacement operation. Results The main reason for the abnormal increase in INR in patients with oral warfarin was the excessive dose, accounting for 47.29% of all surveys, of which 39.18% were excessively prescribed, and the proportion of patients who forgot to repeat or did not understand the doctor's order was 8.10%; The proportion of drug interaction was 43.25%, of which 33.11% were affected by western medicine, 10.14% were affected by Chinese medicine, 9.47% were affected by external medicine, and 4.06% were affected by diet; The proportion of treatment effects was 5.41%. Conclusion The main reason for the abnormal increase in INR in patients with oral warfarin is the excessive use of drugs and the interaction of other drugs, as well as the effects of diet and physical therapy.

目的 分析在中耳胆脂瘤患者中耳内窥镜的价值。方法 回顾性分析61例单侧中耳胆脂瘤患者的临床资料,均接受手术治疗,其中有31例实施耳内窥镜下手术,记为A组;有30例实施常规鼓室成形术,记为B组。对比2组术前和术后1个月气骨导差和气道听阈变化,临床效果和术后并发症。结果 术后1个月A组气骨导差和气道听阈分别为(8.5±1.5)dB、(21.2±2.4)dB,均较术前下降(t=38.195,P<0.001;t=27.739,P<0.001),B组分别为(13.4±2.3)dB、(25.6±2.7)dB,均较术前下降(t=23.510,P<0.001;t=21.575,P<0.001),且术后1个月A组气骨导差和气道听阈均低于B组(t=9.888,P<0.001;t=6.732,P<0.001);A组与B组临床效果分布对比差异有统计学意义(Z=6.102,P=0.014),且A组总有效率为100.00%,高于B组的83.33%(χ²=5.628,P=0.018);A组总并发症发生率为3.23%,低于B组的20.00%(χ²=4.223,P=0.040)。结论 在中耳胆脂瘤患者手术中应用耳内窥镜治疗能够显著改善气骨导差和气道听阈,较常规鼓室成形术效果更佳,安全性更高。

Objective To analyze the value of middle ear endoscopy in patients with middle ear cholesteatoma. Methods The clinical data of 61 patients with unilateral middle ear cholesteatoma were retrospectively analyzed. All of them underwent surgery. Among them, 31 underwent otoendoscopic surgery, which was recorded as group A; 30 underwent conventional tympanoplasty, which was recorded as group B. The changes of air-bone conduction, airway auditory threshold, clinical effect and complications were compared between the two groups before and 1 month after operation. Results One month after operation, the difference of air-bone conduction and airway auditory threshold in group A were (8.5±1.5) dB and (21.2 ±2.4) dB, were lower than those before operation (t=38.195, P<0.001;t= 27.739,P<0.001), group B were (13.4±2.3) dB and (25.6±2.7) dB, respectively, lower than those before operation (t= 23.510,P<0.001;t=21.575,P<0.001), one month later, the air-bone conduction and airway hearing threshold in group A were lower than those in group B (t=9.888,P=0.000;t=6.732,P<0.001); The difference was statistically significant in clinical effect distribution between group A and group B (Z=6.102,P= 0.014), and the total effective rate of group A was 100.00%, which was higher than that of group B 83.33% (χ²= 5.628,P=0.018); the total incidence of complications in group A was 3.23%, lower than that in group B 20.00% (χ²= 4.223,P=0.040). Conclusion Endoscopic ear surgery may improve the air-bone conduction and airway auditory threshold in patients with middle ear cholesteatoma, which is more effective and safe than conventional tympanoplasty.

目的 探讨脑动静脉畸形(AVM)破裂出血发生的危险因素。方法 回顾性研究2014年—2018年我院收治的AVM病例42例,根据有无破裂出血,分为出血组和非出血组,对AVM破裂出血发生的相关因素进行统计学分析。结果 通过相关性及逐步回归分析,表明AVM破裂出血的独立危险因素为: 深部静脉引流和低龄患者。结论 对于引流静脉为深部静脉引流类型和低龄的AVM患者,应积极尽早治疗。

Objective To analyze the risk factors related to cerebral arteriovenous malformation(AVM)with hemorrhage. Methods The clinical data of 42 patients with AVM between 2014 and 2018 were respectively studied. According to the presence of rupture, the cases were divided into bleeding group and non-bleeding group. The factors associated with the occurence of AVM rupture were statistically analyzed. Results The correlation and logistic regression analysis suggested that the deep venous drainage and young patients were the independent risk factors for AVM rupture. Conclusion The young patients and the patients with deep venous drainage should be operated as soon as possible to avoid hemorrhage.

目的 分析儿童危重症乙型流感患者的临床特点,提高临床医师对此危重症的认识水平。方法 对2017年12月—2018年2月广州市妇女儿童医疗中心收治的7例儿童危重症乙型流感患者的临床资料进行回顾性分析。结果 危重患儿好发年龄以幼儿及学龄前期为主。5例表现为呼吸衰竭,1例表现为心源性休克,1例表现为急性坏死性脑病。起病初(3 d内)均未见白细胞减少,白细胞数最高28.1×10⁹/L。白细胞分类以中性粒细胞为主。痰培养出流感嗜血杆菌、肺炎链球菌各1例。3例存在塑型性支气管炎改变。经积极治疗,体温恢复正常最短2 d,最长7 d,平均(4.20±1.79) d。住院时间最短12 d,最长23 d,平均(16.71±3.90)d。结论 乙型流感危重患儿临床表现多样,可累及多个系统器官;呼吸道合并症最多见,可出现塑型性支气管炎改变;及早识别及积极治疗,预后良好。

Objective To analyze the clinical characteristics of the children with severe influenza B and to provide reference for identifying severe cases. Methods Clinical data of 7 children with severe influenza B were retrospectively analyzed. Results The age ranged from 11 months to 7 years old, with an average was (4.13±2.06) years old. Five cases were characterized by respiratory failure, one by cardiogenic shock and one by acute necrotizing encephalopathy. No leukopenia was observed at the beginning of the disease(in 3 days), and the number of white blood cells was as high as 28.1×10⁹/L, White blood cell classification is dominated by neutrophils. haemophilus influenzae and streptococcus pneumoniae were produced by sputum culture in 1 case for each. Three patients had plastic bronchitis changes. After active treatment, the body temperature returned to normal with minimum 2 days, longest 7 days and average (4.20+1.79)days. The length of stay was the shortest 12 days, the longest 23 days, and the average (16.71+3.90) days. Conclusion The clinical manifestations of severe influenza B are diverse and may involve multiple system organs. Respiratory complications were the most common, with plastic bronchitis changes. Early recognition and active treatment had a good prognosis.

目的 了解长沙市雨花区环卫工人的健康状况,为有针对性地制定健康教育措施提供依据。方法 为环卫工人进行体格检查,对其体检资料进行统计分析。结果 1 672名受检环卫工人中仅有57人所检项目完全正常,异常检出率达96.60%,其中男性职工的总体检出率要高于女性职工(P<0.05);男性职工慢性咽炎、高血压、血脂异常、高尿酸血症、肾囊肿的检出率较女性职工高(P<0.05);而女性职工肾结石、甲状腺结节、痔疮的检出率要高于男性职工(P<0.05)。体检结果尚具有一定的年龄段分布规律,膝关节退变、超重和肥胖、慢性咽炎、脂肪肝、高尿酸血症、甲状腺结节等检出率差异有统计学意义(P<0.05);其中膝关节退变、高血压、前列腺增生等检出率随着年龄的增长而增加。结论 环卫工人的卫生保健意识薄弱,进一步促进改善他们的工作条件,并对其进行健康教育非常必要。

Objective To understand the health status of sanitation workers in Yuhua District of Changsha city, and to provide evidence for the establishment of health education measures. Methods The sanitation workers were examined by medical examination and their physical examination data were statistically analyzed. Results In the 1 672 subjects of sanitation workers there were only 57 people seized items completely nor -mal. Abnormal rate was 96.60%. The total examination rate of male workers was higher than that of female workers (P<0.05); morbidity of male workers in chronic pharyngitis, hypertension, dyslipidemia, hyperuricemia and renal cysts were higher than female workers (P<0.05); morbidity of the female workers in kidney stones, thyroid nodules, hemorrhoids, was higher than that of the male workers (P<0.05). The examination results had age distribution. There was statistically significant in knee joint degeneration, overweight and obesity, chronic pharyngitis, hyperuricemia, fatty liver, thyroid nodule (P<0.05); the knee joint degeneration, hyperten -sion, prostatic hyperplasia detection rate increased with age. Conclusion The sanitation workers' awareness of health care is weak. It is necessary to further improve their working conditions and to carry out health education for them.

目的 评价血清异常凝血酶原(PIVKA-Ⅱ)检测在原发性肝癌中的诊断价值。方法 收集在我院收治的住院病人及健康体检人群血清标本共968份,其中原发性肝癌组202例,慢性乙型肝炎组385例,肝硬化组62例,脂肪肝组117例,其它消化系统疾病组93例,健康对照组109例。化学发光法分别检测标本中AFP和PIVKA-Ⅱ水平。分别以健康对照组和慢性肝病组为对照,计算AFP和PIVKA-Ⅱ单独检测和联合检测对原发性肝癌的诊断性能(敏感度、特异度、Kappa值以及ROC曲线等)。结果 原发性肝癌组血清AFP和PIVKA-Ⅱ水平均高于其他各组(P<0.05)。AFP和PIVKA-Ⅱ单独检测和联合检测诊断原发性肝癌的敏感度分别为64.36%、95.05%、97.52%;以健康组为对照,AFP和PIVKA-Ⅱ单独检测和联合检测对原发性肝癌的诊断特异度分别为97.25%、98.17%、96.33%, Kappa值分别0.910、0.917、0.937,ROC曲线下面积分别为0.908、0.987、0.992;以慢性肝病组为对照,AFP和PIVKA-Ⅱ单独检测和联合检测对原发性肝癌的诊断特异度分别为80.67%、92.38%、76.95%, Kappa值分别0.654、0.831、0.621,ROC曲线下面积分别为0.801、0.976、0.963。结论 血清PIVKA-Ⅱ在原发性肝癌的中诊断价值优于AFP,其与AFP的联合检测可提高原发性肝癌的诊断敏感度。

目的 了解我院肺炎链球菌的临床分布及耐药情况,为临床合理应用抗菌药物提供依据。方法 采用WHONET 5.6软件对我院2012年—2016年培养、分离和鉴定出的肺炎链球菌的临床分布及药敏试验结果进行分析。结果 2012年—2016年共检出肺炎链球菌519株(不含重复菌株),每年秋冬和初春季节检出率最高。五年检出的肺炎链球菌对各类抗生素的耐药率变化不大。从8个科室和病区分离出此菌,以呼吸科为主,分离出313株,占60.3%。痰液中共分离出488株,占94.03%,其次从血液中分离出32株,占4.24%。对抗生素耐药率大于60%的有:复方新诺明、四环素、克林霉素和红霉素;未出现耐药的抗生素有厄他培南、莫西沙星、利奈唑胺和万古霉素;其余抗生素的耐药率均小于30%,其中肺炎链球菌对青霉素的耐药率为2%、中介率为20%。结论 青霉素仍可以作为治疗肺炎链球菌感染的首先药物;三代头孢菌素可用于青霉素非敏感的肺炎链球菌(PNSSP)治疗;未发现万古霉素非敏感菌株;红霉素、克林霉素的耐药率极高,不适合肺炎链球菌的治疗。临床应当根据培养药敏结果合理使用抗菌药物,减少细菌耐药率的发生。

目的 评价调强放疗后颞颌关节损伤的鼻咽癌患者的生存情况。方法 2010年2月—2013年11月期间90例经调强放疗后出现颞颌关节损伤的鼻咽癌患者,鼻咽病灶放疗剂量70～74Gy/32～33f,转移淋巴结放疗剂量64～70Gy/32～33f,高危区预防性放疗剂量58～66Gy/32～33f,低危区预防性放疗剂量54～58Gy/32～33f,采用顺铂、奈达铂或多西他赛行同步化疗。回顾性分析患者的张口困难程度、近期疗效、无局部复发生存、无远处转移生存及总生存情况,同时评价放疗毒副反应。结果 ①颞颌关节损伤:97.8%的患者为Ⅰ级损伤,2.2%的患者为Ⅱ级损伤,无Ⅲ~Ⅳ级重度放射性损伤;②近期疗效:完全缓解67例(74.5%),部分缓解21例(23.3%),稳定1例(1.1%),进展1例(1.1%),总有效率(ORR)为97.8%(88/90),疾病控制率(DCR)为98.9%。③生存情况:中位随访时间57个月(5～84个月),5年无局部复发生存率、无远处转移生存率和总生存率分别为85.6%、71.1%和73.3%。④不良反应:3~4度不良反应有白细胞减少(发生率为24.4%)、中性粒细胞减少(发生率为21.1%)和血小板减少(发生率为1.1%)等血液学毒性以及口腔黏膜炎(发生率为43.3%)、呕吐(发生率为1.1%)和放射性皮炎(发生率为3.3%)等非血液学毒性。结论 鼻咽癌调强放疗后颞颌关节损伤以I度为主;调强放疗后出现颞颌关节损伤的鼻咽癌患者以T3~T4为主,但仍可获得较满意的局控率、较低的远处转移率和较高的总生存率,且安全性较高。

目的 分析远红外穴位敷贴辅助蒙脱石口服液治疗小儿腹泻的疗效。方法 选择2014年9月—2016年9月我院门诊收治的腹泻患儿190例,按照随机数字表法分为对照组(n=95)和观察组(n=95),对照组患儿给予蒙脱石散口服液,观察组患儿在对照组治疗基础上给予远红外穴位敷贴治疗,比较2组患儿治疗效果、大便次数恢复正常时间、大便性状恢复正常时间、平均治愈时间及不良反应。结果 观察组患儿治疗有效率94.74%高于对照组85.26%(P<0.05);观察组患儿大便次数恢复正常时间、大便性状恢复正常时间、平均治愈时间均较对照组少(P<0.05);观察组与对照组患儿均无明显不良反应发生。结论 远红外穴位敷贴辅助蒙脱石口服液治疗小儿腹泻疗效显著,安全性较高。

Objective To analyze the efficacy of far infrared acupoint application assisted montmorillonite oral liquid on infantile diarrhea. Methods 190 cases of children with diarrhea treated in outpatient clinic of our hospital from September 2014 to September 2016 were selected for the study and divided into control group (n=95) and observation group (n=95) according to the random number table method. The control group was given the montmorillonite powder oral liquid, and the observation group was treated with far infrared acupoint application on the basis of treatment in the control group. The treatment effect, the recovery normal time of defecation frequency, the recovery normal time of stool property, the average cure time and adverse reactions were compared between the two groups. Results The effective rate of the observation group was higher than that of the control group (94.74% vs. 85.26%) (P<0.05). The recovery normal time of defecation frequency, the recovery normal time of stool property, the average cure time in the observation group were less than those of the control group (P<0.05). There were no significant adverse reactions between the observation group and the control group. Conclusion Far infrared acupoint application assisted montmorillonite oral liquid may have a significant efficacy and high safety in the treatment of infantile diarrhea.