Objective To analyze the efficacy of far infrared acupoint application assisted montmorillonite oral liquid on infantile diarrhea. Methods 190 cases of children with diarrhea treated in outpatient clinic of our hospital from September 2014 to September 2016 were selected for the study and divided into control group (n=95) and observation group (n=95) according to the random number table method. The control group was given the montmorillonite powder oral liquid, and the observation group was treated with far infrared acupoint application on the basis of treatment in the control group. The treatment effect, the recovery normal time of defecation frequency, the recovery normal time of stool property, the average cure time and adverse reactions were compared between the two groups. Results The effective rate of the observation group was higher than that of the control group (94.74% vs. 85.26%) (P<0.05). The recovery normal time of defecation frequency, the recovery normal time of stool property, the average cure time in the observation group were less than those of the control group (P<0.05). There were no significant adverse reactions between the observation group and the control group. Conclusion Far infrared acupoint application assisted montmorillonite oral liquid may have a significant efficacy and high safety in the treatment of infantile diarrhea.