随着医院后勤管理企业化和社会化进程的加快,医院后勤系统逐渐面对着自主经营、自我约束、自立发展的新格局。本文分析了目前医院后勤管理方面存在的问题,介绍了依托医院信息平台建设的医院后勤综合运营管理信息系统。通过质量管理、二级库房管理,被服管理等模块,理顺医院后勤业务流程,提高医院后勤业务工作的质量和效率,达到提升医院后勤业务综合管理水平之目的,并对医院后勤管理信息系统的发展方向和实施办法进行了探讨。
With the acceleration of hospital logistics management enterprise and socialization process, hospital logistics system gradually facing self-management, self-restraint, self-development of a new pattern. This paper analyzes the current hospital logistics management problems introduced relying on hospital information platform of integrated logistics operation and management of hospital information systems. Through quality management, two warehouse management, clothing management module, streamline hospital logistics business processes, improve the quality and efficiency of the hospital's logistics operations, to enhance the purpose of the hospital management level of integrated logistics services, logistics management and hospital information system direction and implementation methods were discussed.
KOA是临床上最常见,发病起源于关节软骨的慢性退行性关节疾病。近年来,应用黄芪治疗KOA的报道不断增多,并且开展了大量的机制研究。本文综述了黄芪在KOA治疗中的应用现状及研究进展,同时指出从PPAR-γ信号通路探索黄芪干预KOA的具体分子机制具有积极的理论和实践意义。
目的 研究乳管镜在乳头溢液的诊断中的应用价值。方法 回顾性分析2010年2月－2014年3月采用乳管镜检查的123例乳头溢液患者的临床资料。结果 乳管镜检查发现乳腺导管癌8例,导管内乳头状瘤33例,乳头状瘤病32例,导管扩张及炎症35例。术后病理检查证实乳腺导管癌5例,导管内乳头状瘤35例,乳头状瘤病30例,导管扩张及炎症33例。结论 乳管镜可作为诊治乳头溢液的首选措施,其所起到的作用是超声、钼靶及乳管造影所不及的。
Objective To study the clinical application value of the fiberoptic ductoscopy(FDS) on the diagnosis of nipple discharge. Methods A retrospective analysis of 123 patients with nipple discharge undergoing FDS from February 2010 to March 2014. Results After fiberoptic ductoscopy examination,it was found there were 8 cases of breast cancer,33 cases of intra-duct papilloma,35 cases of papillomatosis,35 cases of dilatation and inflammation. However there were 5 cases of breast cancer,35 cases of intra-duct papilloma,30 cases of papillomatosis, and 33 cases of dilatation and inflammation were comfirmed through postoperative pathological examination. Conclusion Fiberoptic ductoscopy is more effective than B-ultrasonography and Mo-traget mammography, so it can be the preferred method of diagnosis and treatment for nipple discharge.
目的 探讨快速康复外科理念在手术室护理中应用效果。方法 选取2012年2月—2014年10月我院手术室普外科择期手术治疗140例患者随机分为康复组和常规组,分别采用快速康复外科理念护理和常规护理,比较两组患者胃肠功能恢复时间、下床活动时间、住院时间及并发症发生情况。结果 康复组胃肠功能恢复时间、下床活动时间及住院时间均短于常规组,两组间各值比较有统计学意义(P＜0.05);康复组并发症总发生率为4.29%,低于常规组20.00%发生率,两组比较差异有统计学差异(P＜0.05)。结论 快速康复外科理念应用于手术室护理可缩短患者康复时间,降低并发症发生,有较高应用价值,值得在临床中推广应用。
目的 探讨二维超声联合三维超声检测不同孕期胎儿肢体畸形的临床价值。方法 回顾性分析我科2013年1月—2015年1月超声筛查的1352名孕15~34周的孕妇,运用二维及三维超声,采用连续顺序追踪超声法检测胎儿四肢,将产前诊断结果与引产或引产结果对照。结果 1352名孕妇胎儿畸形46例(3.40%,46/1352),总涉及肢体73处(近端肢体畸形65处,远端肢体畸形8处),其中四肢短小9例(骨发育不全2例,单纯四肢短小畸形5例,成骨发育不全2例),漏诊2例;足畸形16例34处,漏诊1例,残肢畸形15例;手畸形6例,漏诊1例。结论 孕中期二维连续顺序追踪超声法联合三维超声胎儿肢体畸形检出率高,对及早发现胎儿肢体畸形有一定的诊断价值。
目的 探讨分析白带涂片多功能染色技术(BTR 法)在妇科疾病患者中的临床应用价值。方法 选取300 例有明显感染症状的妇科疾病患者取白带,采用BTR 法、盐水法和巴氏染色法进行检测。结果 BTR 法病原体阳性率:滴虫42%、霉菌36.7%、线索细胞17.3%、纤毛菌12%、淋球菌6.7%、球杆菌86%、核异质细胞6.3%和癌细胞2.7%,阴道清洁度95%;阳性率高于盐水法和巴氏染色法,差异有统计学意义(P<0.01);而且BTR法操作简单,耗时少,检出率高,成本低,优于盐水法和巴氏染色法,差异有统计学意义(P<0.01)。结论 BTR 法可在几分钟内检出滴虫性或霉菌性或细菌性阴道炎、宫颈炎、宫颈癌、卵巢癌等异常情况,可提高妇科疾病病原体的检出率,为诊断和治疗提供可靠依据,适用于大型妇科普查和癌症筛查,值得在基层医院推广应用。
Objective To explore and analysis the application of leucorrhea smear multi-function BTR staining techniques(method) in gynecological disease. Methods Leucorrhea were taken in 300 gynecological disease patients with obvious infection symptoms, BTR, saline smear, pap staining were performed at the same sample. Results Pathogene positive rate ofBTR method of trichomonad, mould, clue cell, leptotrichia, gonococci, coccobacillus, dyskaryotic cell, cancer cell and vaginal cleanliness detection rate is 42%,36.7%,17.3%,12%,6.7%,86%,6.3%,2.7% and 95% respectively. The pathogens detection rate of BTR was higher than saline smear, pap staining. It showed statistical difference(P<0.01). BTR method operated simply, timely, low cost, positively than saline smear, pap staining,it showed statistical difference(P<0.01). Conclusion BTR method can detect bacterial vaginitis, colpitis mycotica, cervicitis, cervical carcinoma and ovarian cancer. It can provide reliable evidence for gynecological disease diagnosis and treatment. It can be applied in big gynecological and cancer screening. BTR method is deserved to popularize and apply in primary hospital.
目的 探讨综合康复训练对脑卒中后轻度认知障碍患者的应用效果及认知功能影响。方法 选取2022年2月—2023年2月暨南大学附属广州红十字会医院收治的80例脑卒中后轻度认知障碍患者展开前瞻性研究，应用抽签法将其分为综合康复组与常规组，各40例。常规组实施常规干预，综合康复组在常规组基础上增加综合康复训练，对比其认知功能，简易智能精神状态检查量表（MMSE）、美国国立卫生院卒中量表（NIHSS）评分变化，运动功能与平衡功能，日常生活能力与生活质量。结果 干预后综合康复组患者洛文斯顿作业疗法认知量表评分注意力为（3.36±0.42）分、思维运动为（17.34±2.31）分、定向力为（13.19±1.24）分，均高于常规组，且两组干预后高于干预前（P＜0.05）；干预后综合康复组患者MMSE评分为（25.58±4.12）分高于常规组，且两组干预后高于干预前，NIHSS评分为（14.53±2.62）分，低于常规组，且两组干预后低于干预前（P＜0.05）；干预后综合康复组患者Fugl-Meyer运动功能评定量表评分为（14.51±3.23）分、手臂动作调查测试表评分为（26.86±5.25）分、平衡量表评分为（43.06±5.13）分，高于常规组，且两组干预后高于干预前（P＜0.05）；干预后综合康复组患者日常生活活动能力量表评分为（53.02±4.43）分、脑卒中专用生活质量量表评分为（97.11±12.23）分，高于常规组，且两组干预后高于干预前（P＜0.05）。结论 针对脑卒中后轻度认知障碍患者采取综合康复训练可促进患者认知功能恢复，提升患者运动功能及机体平衡功能，改善患者智力水平与神经功能，进一步提升患者日常生活能力与生活质量。
Objective To explore the effect of comprehensive rehabilitation training on cognitive function in patients with mild cognitive impairment after stroke．Methods A prospective study was conducted on 80 patients with mild cognitive impairment after stroke，who admitted to the hospital from February 2022 to February 2023．They were divided into a comprehensive rehabilitation group and a control group using a lottery method，with 40 patients in each group．The control group received routine intervention，while the comprehensive rehabilitation group received additional comprehensive rehabilitation training on the basis of the control group．Their cognitive function，Mini Mental State Examination Scale（MMSE），National Institutes of Health Stroke Scale in the United States（NIHSS）score changes，motor function and balance function，daily living ability and quality of life were compared．Results After intervention，the Lowenstein Occupational Therapy Cognitive Scale scores of attention（3.36±0.42），thinking and motor（17.34±2.31），and orientation（13.19±1.24）in the comprehensive rehabilitation group were higher than those in the control group，and both groups had higher scores after intervention than before（P＜0.05）．After intervention，the MMSE score（25.58±4.12）of patients in the comprehensive rehabilitation group was higher than that of the control group，and both groups had higher scores after intervention compared to those before intervention．The NIHSS score（14.53±2.62）was lower than that of the control group，and both groups had lower scores after intervention compared to those before intervention（P＜0.05）．After intervention，the Fugl Meyer Assessment score（14.51±3.23），Arm Movement Survey Test Form score（26.86±5.25），and Balance Scale score（43.06±5.13）in the comprehensive rehabilitation group were higher than those in the control group，and both groups had higher scores after intervention than before（P＜0.05）．After intervention，the Basic Activity of Daily Living score（53.02±4.43）and stroke specific quality of life score（97.11±12.23）in the comprehensive rehabilitation group were higher than those in the control group，and both groups had higher scores after intervention than before（P＜0.05）．Conclusions Comprehensive rehabilitation training for patients with mild cognitive impairment after stroke can promote cognitive function recovery，improve motor function and balance function，enhance intelligence and neurological function，and further improve daily living ability and quality of life．
肿瘤治疗仍然是生物医学研究的一个突出领域。围绕各种化学治疗（化疗）药物和其他治疗药物的不良反应和靶向疗效的研究推动了各种药物载体的发展。这些载体聚焦于提高肿瘤部位的药物浓度，最大限度地减少全身不良反应，并改善治疗效果。在已报道的递送系统中，可注射水凝胶由于其微创的药物递送特性，已成为化疗药物体内递送的重要载体形式。文章系统地总结了可注射水凝胶的类型和特征，并进一步概括了可注射水凝胶装载药物的方式，同时深入讨论可注射水凝胶在治疗肿瘤的各种药物的递送应用。文章对原位注射水凝胶在治疗肿瘤方面存在的潜在性挑战和可能的解决方案提供了动态前瞻性的参考。可注射的水凝胶作为药物传递系统用于肿瘤治疗具有良好的发展前景。
Tumor treatment remains a prominent area of biomedical research．The researches surrounding the adversereactions and targeted efficacy of various chemotherapy drugs and other therapeutic drugs have driven the development of various drug carriers．These carriers focus on increasing drug concentration at tumor site，minimizing systemic adverse reactions，and improving treatment outcomes．In the reported delivery systems，injectable hydrogels have become an important carrier for the delivery of chemotherapeutic drugs in vivo due to their minimally invasive characteristics．This review systematically summarized the types and characteristics of injectable hydrogels，and further summarized their drug loading methods．At the same time，the application of injectable hydrogels in the delivery of various drugs for tumor treatment was discussed in depth．This review provides dynamic and prospective reference for the potential challenges and possible solutions of the in situ injectable hydrogels for tumor therapy．Injectable hydrogels as drug delivery systems are with good prospects for tumor treatment．
糖尿病肾病（DN）是指由糖尿病所致的慢性肾脏疾病，是目前我国和全球范围内慢性肾脏疾病和终末期肾脏疾病的首位病因。DN发病率逐年攀升，且预后不良，已成为我国重大的公共卫生问题之一。DN不仅明显降低了患者的生活质量，还增加了心血管疾病的风险。随着对DN发病机制的深入研究，近十余年来在DN治疗手段方面取得了显著进展，包括新型药物的研发、生活方式的干预及各种新兴疗法的探索。本文旨在系统性综述近年来DN领域的重要治疗进展，阐明这些进展在临床应用中的有效性和适用性，并展望未来的研究方向，以期为临床实践提供参考和指导。
Diabetic nephropathy（DN）is a form of chronic kidney disease（CKD）induced by diabetes．Diabetic nephropathy represents the leading cause of CKD and end-stage renal disease both in China and globally．The incidence of DN has been steadily increasing and its prognosis remains unfavorable．Diabetic nephropathy has become a major public health concern．Diabetic nephropathy not only significantly affects patients’ quality of life but also increases the risk of cardiovascular diseases．Recent advancements in our understanding of the pathogenesis of DN have facilitated significant progress in treatment options over the past decade．These developments include the introduction of novel pharmacological agents，the implementation of lifestyle modifications，and the exploration of various emerging therapeutic approaches．This review aims to systematically expound the significant therapeutic advancements in the field of DN in recent years，evaluate the efficacy and applicability of these advancements in clinical practice，and explore potential future research directions，thereby providing valuable insights andguidance for clinical practice．
目的 分析早期结直肠癌内镜下治疗前行窄带成像结合放大内镜 （ME-NBI）和超声内镜技术的评估价值。方法 采用回顾性分析方法，以2021年1月— 2023 年 12月中山市第五人民医院收治的102例早期结直肠癌患者为观察对象，所有患者均接受内镜下黏膜切除术（EMR）或内镜黏膜下剥离术（ESD）治疗，根据内镜下治疗前是否进行ME-NBI和超声内镜检查分为研究组与对照组各51例。比较两组年龄、性别、肿瘤大小、直乙结肠占比及组织病理特征；比较两组治疗时间、ESD治疗后非治愈性切除发生率、治愈性切除率、并发症发生情况及再次ESD或外科手术治疗率。结果 两组年龄、性别、肿瘤大小、直乙结肠占比及组织病理比较差异均无统计学意义（P＞0.05）。研究组中37例行ESD治疗，治疗时间为（120.6±140.3）min，12例行EMR治疗，治疗时间为（11.6±9.3）min，有2例不符合内镜下治疗指征，转外科手术治疗。对照组有38例行ESD治疗，治疗时间为（128.8±144.5）min，13例行EMR治疗，治疗时间为（12.5±9.5）min，两者治疗时间比较差异均无统计学意义（P＞0.05）。研究组非治愈性切除率为7.84，低于对照组27.45；治愈性切除率为88.24，高于对照组72.55；研究组ESD手术并发症为8.11%，低于对照组31.58；ESD或外科手术率为6.12，低于对照组25.49（P＜0.05），结论 ME-NBI和超声内镜对早期结直肠癌患者行内镜下治疗指征评估更准确，可提高治愈性切除率。
Objective To study the application value of magnifying endoscopy combined with narrow band imaging （ME-NBI）and ultrasonic endoscopy system before endoscopic treatment in patients with early colorectal cancer．Methods A retrospective analysis was carried out on 102 patients with early-stage colorectal cancer who were admitted to Zhongshan Fifth People’s Hospital from January 2021 to December 2023．All patients were treated with endoscopic mucosal resection（EMR）or endoscopic submucosal dissection（ESO）．The patients were divided into study group（51 cases）and control group（51 cases）according to whether ME-NBI and ultrasonic endoscopy was performed before endoscopic treatment or not．The patient age，sex，volume of tumor，location of tumor and pathological result of the tumor were compared between two groups．Time for treatment，curative resection rate，non-curative resection rate and the complication incidence of ESD，incidences of second ESD or surgery were compared between the two groups．Results There were no statistical differences in age，sex，volume of tumor，location of tumor and pathological result of the tumor（P＞0.05）．In the study group，37 patients received ESD treatment，operation time was（120.6±140.3）minutes，and 12 patients received EMR treatment，operation time was（11.6±9.3）minutes，two cases were transferred to surgery due to endoscopic ultrasonography combined with magnifying endoscopy showed that they did not meet the indications for ESD treatment．In the control group，38 patients received ESD treatment，operation time was（128.8±144.5）minutes，13 patients received EMR treatment，operation time was（12.5±9.5）minutes．There was no significant difference in treatment duration between the two groups．The non-curative resection rate of the study group was 7.84%，which was significantly lower than that in the control group（27.45%），and the curative resection rate（88.24%）was significantly higher than that in the control group（72.55%）．The complications of ESD surgery in the study group were 8.11%，lower than 31.58% in the control group．The rate of second ESD or surgery was 6.12%，lower than 25.49% in the control group（P＜0.05）．Conclusions ME-NBI and endoscopic ultrasound are more accurate in the evaluation of endoscopic indications for early colorectal cancer patients，and can improve the curative resection rate．
