目的 调查广州市在校大学生AIDS相关知识及对HIV感染者态度现状,为学校更有效地开展大学生AIDS健康教育提供依据。方法 采用目的抽样方法,对广州市某高校 1200名在校大学生进行关于AIDS相关知识、态度的问卷调查。结果 不同年级、生源地,AIDS相关知识差异均有统计学意义(P值均＜0.01);多数学生对HIV感染者持积极态度,但仅5.73%的学生愿意与HIV感染者共餐;2.70%愿意与感染HIV的同学同住一个寝室。网络是大学生获取AIDS相关知识的最主要途径。结论 大学生AIDS相关知识知晓率水平较高,但缺乏系统性和全面性;多数学生对HIV感染者持积极态度,但是一旦与自我卷入较深,即表现出对HIV感染者的回避甚至歧视。高校应加强对大学生AIDS健康教育的系统性、全面性和深刻性,以消除对AIDS的心理恐惧,达到对HIV感染者的零歧视。

Objective To investigate the AIDS related knowledge of the Guangzhou undergraduates and the attitudes on HIV infection status, for the school to provide basis for AIDS health education and to carry out AIDS health education during college students more effectively. Methods 1200 college students in a university in Guangzhou were surveyed by a questionnaire on HIV/AIDS related knowledge and attitudes, using the way of purposive of sampling. Results There was statistical significant difference on the AIDS-related knowledge in the different grades and origin of students (P<0.01). The majority of students has a positive attitude to the HIV-infected, but only 5.73% of them wer willing to share a meal with HIV-infected persons, and 2.70% of them were willing to live with HIV-infected. The network is the most important way to access to HIV/AIDS related knowledge for college students. Conclusion The level awareness during college student on AIDS-related knowledge is high, but lack of systematic and comprehensive. The majority of students had a positive attitude towards the HIV-infetected, however once self-involved, they may avoid even discriminate the HIV-infected individuals. Therefore, the universities should strengthen AIDS health education of college students comprehensively and profoundly, in order to eliminate fear of AIDS, and reached zero discrimination HIV-infected persons in the future.

目的 本研究通过检测吸入布地奈德治疗支气管哮喘患儿前、后气道重塑、肺功能及外周血TGF-β浓度的变化,探讨布地奈德在哮喘患儿气道重塑早期干预的作用。方法 将2013年1月—2014年10月在我院确诊为支气管哮喘患儿18例,给予规律吸入布地奈德治疗6个月,分别于治疗前、后检测肺功能、外周血TGF-β浓度以及通过高分辨CT(HRCT)测量支气管管壁厚度(T)并计算管壁面积(WA)、支气管管壁厚度与气管外径之比(WT%)、气道壁横截面面积占气道总截面积的的百分比(WA%)。结果 吸入布地奈德治疗治疗6个月后,哮喘患儿WT%、WA%、肺功能以及TGF-β浓度均明显改善,与治疗前比较差异有统计学意义(P<0.05)。结论 规律吸入布地奈德治疗能减轻支气管哮喘患儿早期气道重塑,改善肺功能,可能通过下调细胞因子TGF-β的表达有关。

Objective We detected the changes of Airway remodeling,lung function and peripheral blood concentrations of TGF-β in asthmatic children before and after inhaled budesonide, and explored the role of budesonide in airway remodeling before early intervention in asthmatic children. Methods 32 cases of children were diagnosed asthma in our hospital,and given treatment of inhaled budesonide for 6 months, and to detect lung function,pheral blood TGF-β concentration as well as measuring the bronchial wall thickness (T) and calculate the wall area (WA), the outer diameter of the trachea and bronchial wall thickness ratio (WT%), the cross-sectional area of the airway wall accounted for airway percentage (WA%) of the total cross-sectional area by high-resolution CT (HRCT) before and after treatment. Results After treatment with inhaled budesonide in six months, the asthma WT%, WA%, lung function, and TGF-β concentrations were significantly improved, the differences compared with that before treatment were statistically significant(P<0.05). Conclusion The treatment of inhaled budesonide can alleviate asthmatic airway remodeling in early, improve lung function,possibly related to down the expression TGF-β.

目的 对经皮冠状动脉介入(PCI)治疗术前高敏C反应蛋白(hs-CRP)水平进行测定,探究其与患者术后发生造影剂肾病相关性。方法 选取2011年4月—2013年5月在我院进行PCI手术疗的患者120例为实验对象。根据术前hs-CRP值分为3组:A组(hs-CRP<1 mg/L,n=56),B组(hs-CRP 1～3 mg/L,n=40)和C组(hs-CRP>3 mg/L,n=24)。观察各组术后造影剂肾病的发生情况以及探究其两者之间的相关性。结果 A、B、C组患者术后CIN的发生率分别为8.93%、22.5%和50.0%,经过统计学比较,差异有统计学意义(P<0.05)。患者术前hs-CRP水平年龄在75岁以上、男性、糖尿病、贫血、水化治疗均与CIN显著独立相关。C组MACE发生率均高于A组、B组(P<0.05)。结论 接受PCI手术治疗的患者,其术前hs-CRP水平与其术后CIN的发生具有一定的相关性,患者术前hs-CRP水平越高,术后更可能发生CIN,hs-CRP的水平可作为辅助CIN诊断的指标。

包虫病即棘球蚴病是全世界范围内分布的人兽共患的寄生虫病。其成虫寄生于肉食性动物,如狐狸、家犬、狼等的小肠上段,它们是棘球蚴病的主要传播者;在中国,本病主要在以畜牧业为主的西部地区,如宁夏、新疆、青海、甘肃等地,沿海等地较少见。盆腹腔棘球蚴病较为少见,盆腔包虫约占包虫病的0.5%左右,很容易被忽视而误诊。本例患者身处疫区,有密切家犬接触史。

      目的  本文聚焦DeepSeek这一国产人工智能技术，结合护理临床实践，系统探讨其在护理场景中的应用潜力、现存问题及应对策略。方法  检索国内外相关文献，与现有通用人工智能技术对比，进行综述，并提出思考和建议。结果  预计DeepSeek在护理文书自动化、个性化护理方案生成、临床决策支持、护理质控及教育培训等提供适配应用路径，针对性的服务和解决方案等。结论  DeepSeek可通过多模态技术整合与跨平台互补策略，推动护理服务向智能化、精准化方向发展，为缓解护理人力短缺、优化资源分配提供新思路。

     Objective  This study focuses on DeepSeek，a domestic artificial intelligence technology，systematically exploring its application potential，existing issues，and targeted strategies in nursing clinical scenarios through integration with practical nursing care contexts．Methods  Relevant literatures from both domestic and international sources were collected，compared with existing Artificial General Intelligence（AGI）technologies，to conduct a review，and  propose  reflections and recommendations．Results  Through literature review and technical comparisons，the  results proposed specific application paths for DeepSeek in scenarios such as automated nursing documentation，personalized care plan generation，clinical decision support，quality control，and education．It further addressed issues including data privacy，ethical risks，and technical limitations．Conclusions  The findings suggest that DeepSeek can integrate multimodal technologies and cross-platform complementary strategies to promote intelligent and precise nursing services，offering innovative solutions to alleviate nursing shortages and optimize resource allocation．

       目的   探讨BOPPPS［（导引（B），目标（O），课前测试（P），参与式学习（P），课后测试（P），总结（S）］模式下模块化教学结合模拟演练在创伤急救培训中的应用效果。方法   选取福建省泉州市正骨医院急诊科2022年8月—2024年2月90名护士，随机分为对照组和干预组，每组45名护士。对照组采用传统授课模式进行教学培训；干预组采用BOPPPS模式下模块化教学结合模拟演练进行教学培训。培训结束对两组学员的创伤急救综合理论及单项技能、创伤急救救护综合能力、培训效果满意度进行统计分析。结果   干预组的综合理论成绩为（80.74±6.87）分、单项技能成绩为（92.13±2.26）分，相较于对照组均提高（P＜0.05）。干预组对创伤急救课程的总体满意度：非常同意23例、同意20例，比例均高于对照组（P＜0.05）。干预组的创伤急救救护综合能力如病情评估预判能力，优秀26例、良好15例；护理计划分析实施能力，优秀25例、良好13例；团队协作与资源管理能力，优秀27例、良好15例；情景感知与应变能力，优秀30例、良好11例；综合救护能力，优秀36例、良好5例。显著优于对照组（P＜0.05）。结论  BOPPPS模式下模块化教学结合模拟演练能够提高急诊科护士的综合创伤救护能力，且取得了较高的满意度，值得进一步推广应用。

       Objective  To explore the application effect of modular teaching combined with simulation exercise in trauma 

first aid training under BOPPPS model．Methods  A total of 90 nurses in the emergency department from August 2022 to February 2024 were randomly divided into control group（n=45） and intervention group（n=45）．The control group was trained  by traditional teaching mode．The intervention group was trained by BOPPPS modular teaching combined with simulation exercise．After the training，the comprehensive theory of trauma first aid，individual skills，comprehensive ability of trauma first aid and satisfaction degree of training effect of the two groups of nurses were statistically analyzed．Results  The comprehensive theoretical scores and single skill scores of the intervention group were significantly improved compared with the control group（P＜0.05）．The satisfaction degree of trauma first aid training in the intervention group was significantly higher than that in the control group（P＜0.05）．The comprehensive ability of trauma first aid in the intervention group was significantly better than that in the control group（P＜0.05）．Conclusions  The combination of modular teaching and  simulation exercise in BOPPPS model can improve the comprehensive trauma rescue ability of nurses in emergencydepartment，and has obtained a high degree of satisfaction，which is worthy of further popularization and application．

       目的   评估多种气道湿化方法对喉癌患者术后气道湿化的效果。方法   检索PubMed、Cochrane、Embase、Web of Science、Ovid、中国知网、万方、CBM、Google Scholar等数据库和网站，检索时限为建库至2023年2月。搜集关于喉癌患者术后不同气道湿化方法的随机对照试验，采用JBI2016年随机对照试验RCT评价标准评价文献质量。使用ADDIS1.16.5软件进行网状Meta分析。结果   纳入18篇研究，共1 596例患者。结果显示，镇痛泵持续泵入与注射器间断滴入、喷雾瓶间断喷雾在痰痂形成方面比较差异有统计学意义［OR（95%CI）=537.70（4.18，124 511.88）、0（0，0.52），P＜0.05］；湿化满意度方面，注射器间断滴入与喷雾瓶间断喷雾比较差异有统计学意义［OR（95%CI）=8.55（1.40，73.35），P＜0.05］；其余比较差异无统计学意义（P＞0.05）。概率排序显示，降低肺部感染、黏膜出血和痰痂形成、痰液黏稠度、咳嗽和湿化不满意的发生，最优方法分别为湿化泵持续泵入、镇痛泵持续泵入、MR400湿化器和输液器持续泵入。结论   综合网状Meta分析及概率排序结果，考虑到喉癌患者术后早期下床活动，推荐便携式持续湿化方法。

       Objective  To access the effects of multiple airway humidification methods for postoperative patients with laryngeal cancer．Methods  PubMed，Cochrane Library，EMbase，Web of Science，Ovid，China National Knowledge Infrastructure，Wanfang database，CBM and Google Scholar were searched systematically from establishment to February 2023，respectively．Related  randomized controlled trials on airway humidification for postoperative patients with laryngeal cancer was analyzed and the quality of the literature was assessed using the JBI 2016 RCT evaluation．The network Meta analysis was performed using ADDIS 1.16.5 softwares．Results  A total of 18 articles and 1596 patients were inciuded．The results showed that the analgesia pump continued to pump into the airway compared with the syringe intermittently drip and the spray bottle intermittent spray was statistically different in the formation of sputum［OR（95%CI）=537.70（4.18，124 511.88），0（0，0.52），P＜0.05］．In terms of satisfaction of wetness，the difference between the intermittent drop of the syringe and the intermittent spray of the spray bottle was statistically different［OR（95%CI）=8.55（1.40，73.35），P＜0.05］，the others were not statistically different（P＞0.05）．Probability ranking table shows that the optimal methods were the humidification pump continues to pump into the airway，the analgesia pump continued to pump into the airway，the MR400 humidifier and the infusion set continuously pumped into the airway，which were beneficial to the reduction in pulmonary infection，tracheal mucosal hemorrhage and formation of phlegm callus，the degree of sputum viscosity，cough and unsatisfactory wetness．Conclusions  Based on the comprehensive mesh meta-analysis and probability ranking results，a portable continuous humidification method is  recommended considering the early post-operative activities of laryngeal cancer patients．