目的 通过对急性深静脉血栓形成(DVT)患者经导管接触性溶栓治疗(CDT)中,影响血管导管相关感染(VCAI)危险因素及病原菌分析,为VCAI的预防提供合理、有效的措施。方法 收集2019年1月—2022年12月徐州市肿瘤医院介入科行CDT治疗的急性DVT患者的临床资料,回顾性调查患者诊疗相关资料及血培养结果,并对发生VCAI和病原菌情况进行分析。结果 本研究共调查急性DVT行CDT治疗的患者437例,发生VCAI的患者共21例,千日感染率为0.543‰。多因素Logistic回归分析结果显示:溶栓频率>3次/天[OR=3.49(95%CI:1.86~6.45)]、导管留置时间>7 d[OR=3.86(95%CI:1.26~10.18)]和有导管回送[OR=8.67(95%CI:4.83~12.65)]是患者发生VCAI的危险因素(P<0.05)。发生VCAI的21例患者,血培养共培养出24株病原菌,有3例患者出现复合病原菌感染情况。其中以革兰阳性球菌最为常见,共培养出13株,占比54.17%,革兰阴性菌9株,占比37.5 %。结论 导管留置时间>7 d、溶栓频率>3次/天和有导管回送是急性DVT患者CDT治疗中发生VCAI的危险因素。VCAI的病原菌以单一病原菌为主,可合并其他病原菌感染,其中以革兰阳性球菌为主。
Objective By analyzing the risk factors and pathogens of vessel catheter associated infection(VCAI)in patients with acute deep vein thrombosis(DVT)undergoing catheter directed thrombolysis(CDT),to provide reasonable and effective measures for the prevention and treatment of VCAI .Methods Clinical data of patients undergoing CDT treatment for acute DVT in the interventional department of the hospital from January 2019 to December 2022 was collected,patient diagnosis and treatment related data and blood culture results were retrospectively investigated and organized,and the occurrence of VCAI and pathogenic bacteria was statistically analyzed.Results This study investigated 437 patients undergoing CDT treatment for acute DVT,and a total of 21 patients developed VCAI,with an infection rate of 0.543‰.The results of multiple Logistic regression analysis show that thrombolysis frequency>3 times/day(OR=3.49[95%CI:1.86-6.45]),catheter retention days>7 days(OR=3.86[95%CI:1.26-10.18]),and the presence of catheter return(OR=8.67[95%CI:4.83-12.65]) were risk factors for the occurrence of VCAI in patients.Among the 21 patients with VCAI,a total of 24 strains of pathogenic bacteria were discoveredin blood culture,and 3 patients developed composite pathogen infections.Among them,Gram positive cocci were the most common,with a total of 13 strains cultured,accounting for 54.17%,9 strains of Gram negative bacteria,accounting for 37.5%.Conclusions The duration of catheter retention>7 days,thrombolysis frequency>3 times/day,and the presence of catheter return are risk factors for VCAI in acute DVT patients undergoing CDT treatment.The pathogen of VCAI is mainly single pathogen,which can be combined with other pathogens,among which Gram positive cocci are the main pathogen.
目的 对比乏白细胞富血小板血浆(LP-PRP)与富白细胞富血小板血浆(LR-PRP)联合体外冲击波疗法(ESWT)治疗慢性非止点跟腱腱病(NIAT)的临床价值。方法 选取2021年12月—2023年12月赣州市人民医院收治的80例慢性NIAT患者,以随机数表法分为两组,即对照组和观察组各40例,观察组予LP-PRP联合ESWT治疗,对照组予LR-PRP联合ESWT治疗;于治疗前、第一次治疗后1个月、3个月比较两组疼痛度[视觉模拟量表(VAS)评分]、跟腱病变程度[维多利亚体育研究所跟腱评估问卷(VISA-A)]、跟腱功能(Arner-Lindholm跟腱功能评分),并比较两组并发症的发生率。结果 两组在治疗后1个月、3个月的VAS评分下降,VISA-A评分升高,且观察组治疗后3个月的VAS评分(1.05±0.31)分低于对照组的(1.82±0.45)分,VISA-A评分(83.35±5.58)分高于对照组的(76.28±5.35)分(F组间与时点交互=338.478、106.663,均P<0.05);治疗后3个月,观察组跟腱功能(优、良、差各有24、13、3例)优于对照组(优、良、差各有14、16、10例),差异有统计学意义(Z=2.529,P=0.012)。两组治疗后1个月时VAS评分、VISA-A评分及跟腱功能比较差异无统计学意义(均P>0.05)。结论 与LR-PRP比较,LP-PRP联合ESWT治疗慢性NIAT更有利于减轻患者跟腱疼痛度及病变程度,改善患者跟腱功能。
Objective To compare the clinical value of leukocyte-poor platelet rich plasma(LP-PRP)and leukocyte-rich platelet rich plasma(LR-PRP)combined with extracorporeal shock wave therapy(ESWT)in the treatment of chronic non insertional Achilles tendinopathy(NIAT).MethodsEighty patients with chronic NIAT admitted to Ganzhou People’s Hospital from December 2021 to December 2023 were randomly divided into two groups using a random number table method:a control group and an observation group,with 40 patients in each group.The observation group received LP-PRP combined with ESWT treatment,while the control group received LR-PRP combined with ESWT treatment.The pain level(Visual Analog Scale[VAS]score),degree of Achilles tendon lesion(Victorian Institute of Sports Assessment-Achilles tendinopathy questionnaire[VISA-A]),and Achilles tendon function(Arner Lindholm Achilles tendon function score)between the two groups were compared before treatment,one month after the first treatment,and three months after treatment,as well as the incidence of complications between the two groups.Results The VAS scores of both groups decreased and the VISA-A scores increased at one and three months after treatment.The VAS score of the observation group(1.05±0.31)was lower than that of the control group(1.82±0.45)at three months after treatment,while the VISA-A score of the observation group(83.35±5.58)was higher than that of the control group(76.28±5.35)(interaction between group and time point F=338.478,106.663,both P<0.05).After three months of treatment,the Achilles tendon function of the observation group(24 cases of excellent,13 cases of good,and three cases of poor)was better than that of the control group(14 cases of excellent,16 cases of good,and 10 cases ofpoor),and the difference was statistically significant(Z=2.529,P=0.012).There was no statistically significant difference in VAS score,VISA-A score,and Achilles tendon function between the two groups one month after treatment(all P>0.05).Conclusions Compared with LR-PRP,LP-PRP combined with ESWT was more beneficial in reducing the degree of Achilles tendon pain and lesions in patients with chronic NIAT,and improving Achilles tendon function.
目的 探讨无管化微创PCNL(经皮肾镜取石术)治疗嵌顿性输尿管上段结石的效果。方法 将中山大学附属第一医院惠亚医院2019年12月—2021年12月收治的95例嵌顿性输尿管上段结石患者按照随机数字表法分组,给予对照组47例患者经尿道输尿管镜碎石术(TURL)治疗、观察组48例患者无管化微创PCNL治疗,观察两组手术一般状况、血清学指标、肾脏血流动力学以及并发症发生情况。结果 观察组手术时间、术后血尿以及住院时间均短于对照组,观察组术中出血量少于对照组,观察组结石清除率高于对照组(P<0.05);术后1 d观察组肾损伤分子-1(KIM-1)、中性粒细胞明胶相关脂脂质运载蛋白(NGAL)以及胱抑素C(Cys-C)水平低于对照组(P<0.05);两组肾动脉收缩期血流速度(Vs)以及舒张末期血流速度(Vd)对比差异无统计学意义(P>0.05);观察组并发症发生率(4.16%)低于对照组(19.15%)(P<0.05)。结论 无管化微创PCNL可改善嵌顿性输尿管上段结石手术一般状况,减轻患者肾脏损伤,提高结石清除率,不影响肾脏血流,且并发症更少。
Objective To explore the effect of tubeless minimally invasive(percutaneous nephrolithotomy,PCNL)in the treatment of impacted upper ureteral stones.Methods A total of 95 patients with impacted upper ureteral stones admitted to our hospital from December 2019 to December 2021 were grouped according to the random number table method.Control group of 47 cases were treated with transurethral ureteroscopy lithotripsy(TURL),48 patients in the observation group were given tubeless minimally invasive PCNL treatment.The general surgical conditions,serological indicators,renal hemodynamics and complications of the two groups were observed.Results The operation time,postoperative hematuria and hospitalization time of the observation group were shorter than those of the control group,the intraoperative bleeding volume of the observation group was less than that of the control group,and the stone free rate of the observation group was higher than that of the control group(P<0.05).One day after surgery,the levels of kidney injury molecule-1(KIM-1),lipocalin(NGAL)and cystatin C(Cys-C)in the observation groupwere lower than those in the control group(P<0.05);the renal artery systolic blood flow velocity(Vs)and end-diastolic blood flow velocity(Vd)had no statistical significance(P>0.05);the incidence of complications in the observation group(4.16%)was lower than that in the control group(19.15%)(P<0.05).Conclusions Tubeless minimally invasive PCNL can improve the general conditions of surgery,reduce kidney damage,increase stone free rate,does not affect renal blood flow,and has fewer complications.