目的 探讨临床常用非侵袭性检查指标诊断膀胱出口梗阻(BOO)的准确性及可靠性。方法 回顾性研究2003年11月—2015年11月在广州市第一人民医院就诊并接受压力—流率测定(PFS)的男性LUTS/BPH患者,以侵袭性的PFS为诊断BOO的“金标准”,以前列腺体积(PV)、移行带体积(TZV)、移行带指数(TZI)、前列腺特异性抗原(PSA)、最大尿流率(Qmax)、剩余尿量(PVR)、剩余分数(RF)等非侵袭性检查指标为诊断指标进行诊断试验评价。结果 筛选1319例患者纳入统计分析。以ICS列线图为诊断标准,PV、TZV、TZI、PSA、Qmax、RF、PVR诊断BOO的ROC曲线下面积(AUC)分别为0.803、0.807、0.698、0.775、0.740、0.679、0.641;以Schaefer列线图为诊断标准,PV、TZV、TZI、PSA、Qmax、RF、PVR诊断BOO的AUC分别为0.806、0.814、0.713、0.773、0.721、0.684、0.642。结论 PV、TZV、TZI、PSA、Qmax、RF、PVR等非侵袭性指标对筛查及诊断中老年男性BOO有一定的参考价值及临床意义,其中TZV、PV、PSA、Qmax的诊断准确性较高。
Objective To evaluate and assess the efficacy and validity of the most common and noninvasive parameters in daily clinical practice for detecting bladder outlet obstruction (BOO) in elderly male compared with the golden standard pressure-flow study (PFS). Methods Retrospectively analyze the outpatients and inpatients of male LUTS/BPH from November 2003 to November 2015 in Guangzhou First People's Hospital. Collect the PFS parameters and other noninvasive parameters including PV, TZV, TZI, PSA, Qmax, RF, and PVR. Receiver operating characteristic (ROC) curve was used to evaluate the efficiency of each parameter for detecting BOO. Statistic analyses were performed using SPSS (Version 21). Results The data from 1319 patients were analyzed. According to the ICS-nomogram. The areas under the ROC curve (AUCs) of PV, TZV, TZI, PSA, Qmax, RF, and PVR for detecting BOO were 0.803, 0.807, 0.698, 0.775, 0.740, 0.679, and 0.641, respectively. According to the Schaefer's nomogram, the AUCs of PV, TZV, TZI, PSA, Qmax, RF, and PVR for detecting BOO were 0.806, 0.814, 0.713, 0.773, 0.721, 0.684, and 0.642, respectively. Conclusion PV, TZV, TZI, PSA, Qmax, RF, and PVR would help predicting BOO in elderly male noninvasively, and providing valuable reference and guidance in clinical decision. TZV, PV, PSA and Qmax supply preferable accuracy for detecting BOO, with better sensitivity and specificity.
目的 探讨经阴道三维彩色能量多普勒成像在诊断子宫瘢痕妊娠(CSP)中的应用价值。方法 回顾性分析245例临床怀疑瘢痕妊娠(CSP)患者的二维彩色超声(2D-CDFI)及经阴道三维彩色能量多普勒成像的表现,与病理结果进行对比,总结分析它们对子宫瘢痕妊娠(CSP)的灵敏度、特异度及阳性检出率。结果 2D-CDFI 诊断CSP的灵敏度、特异度及阳性检出率分别为73.7%、68.75%及74.44%;经阴道三维彩色能量多普勒成像诊断CSP的灵敏度、特异度及阳性检出率分别为87.06%、73.33%及88.10%;两者在诊断CSP的准确率差异有统计学意义(P=0.0026,P<0.05)。结论 经阴道三维彩色能量多普勒成像检查能清晰显示包块与子宫的空间立体结构,也能够多角度多方面显示瘢痕妊娠与子宫肌层间的异常血管,是早期诊断CSP的首选方法之一,具有重要的临床价值。
目的 探讨颅脑超声在高危新生儿颅内疾病的诊断应用。方法 2010年7月—2014年6月间在我院新生儿重症监护室(NICU)813例新生儿应用百胜Mylab Five型彩色多普勒超声诊断仪,探头频率5~7.5 MHz,进行常规颅脑超声检查。患儿取仰卧位,经前囱作矢状切面及冠状切面按顺序扫查,重点扫查几个标志性切面。头皮留置针遮盖前囟者先予拔除,以保证检查顺利进行。结果 超声异常者85.73%(697/813)。其中颅内出血45.62%(318/697)。早期脑室周围—脑室内出血(PIVH)88.05%(280/318),以I级和II级为多;大脑出血4.40%(14/318);丘脑出血2.22%(7/318);小脑出血1.89%(6/318);蛛网膜下腔出血1.89%(6/318);硬膜下出血1.57%(5/318)。缺氧缺血性脑损伤(HIHB) 36.01%(251/697)。足月儿缺氧缺血性脑病(HIE)67.33%(169/251),轻度HIE52.59%(132/251),中重度HIE14.74%(37/251)。早产儿缺氧缺血性脑病(PVL)33.67%(82/251),化脓性脑膜炎3.30%(23/697)。脑积水15.06%(105/697),以外围性脑积水多见。出院前复查: I度及II度PIVH大部分吸收,III级及IV级PIVH可见侧脑室扩大、脑实质液化性囊腔。大脑出血、丘脑出血、小脑出血均有不同程度吸收,严重者遗留液化性囊腔,蛛网膜下腔出血及硬膜下出血亦有不同程度地吸收。轻度HIE大部分恢复正常,中重度HIE 均有脑室扩大、脑萎缩、液化性囊腔。PVL后期见囊泡性改变。化脓性脑膜炎后期可见硬膜下积液及梗阻性脑积水。结论 颅脑超声便携,可床边,价廉,可重复,具有较实用临床应用价值。适用于新生儿颅内疾病的筛查及诊断。对脑中线部位脑室周围—脑室内出血,对脑积水的程度、预后具有特异性诊断价值。它可提示颅内病变类型、程度、部位及动态监测病情进展情况。对某些颅内病变如蛛网膜下腔出血,硬膜下腔出血,小脑出血则需要结合CT、MRI等其它影像技术,为临床诊断提供依据。
目的 探讨CT、MRI影像学表现对原发性肝细胞癌(HCC)微血管侵犯(MVI)的诊断价值。方法 选取2018年1月—2024年7月江门市第二人民医院(江门市中心医院蓬江分院)和江门市中心医院120例(共158个病灶)HCC患者,均行上腹部CT、MRI平扫+增强及弥散加权成像(DWI)检查;以术后病理结果为金标准。比较CT、MRI平扫+增强及DWI对HCC MVI诊断效能;分析HCC MVI诊断中CT、MRI平扫+增强及DWI检查与术后病理确诊结果之间的一致性;比较HCC MVI与无HCC MVI患者影像学表现及表观扩散系数(ADC)值。结果 DWI检查对HCC MVI的诊断效能(灵敏度、特异度、准确度、阳性预测值、阴性预测值)均显著性高于CT、MRI平扫+增强(P<0.05);CT、MRI、DWI对原发性肝细胞癌患者微血管侵犯的诊断效能比较,差异均无统计学意义(P>0.05)。在HCC MVI诊断效能中,CT、MRI影像学表现与术后病理确诊结果之间为中度一致性;DWI与术后病理确诊结果之间为高度一致性。HCC MVI患者的强化方式在非边缘动脉期强化、强化包膜、晕状强化、结中结、门脉分支癌栓占比均显著性高于无HCC MVI患者(P<0.05)。在不同b值(400、800、1 000、1 500 s/mm2 )下,HCC MVI患者的ADC值均显著性高于无HCC MVI患者(P<0.05)。结论 CT、MRI平扫+增强及DWI对HCC MVI均具有较好的诊断效能,而MRI诊断结果与病理诊断一致性更佳,尤其DWI图中ADC值可更加精准地判断HCC的患者是否发生微血管侵犯,有助于指导临床医生建立“个体化”精准诊疗策略。
Objective To explore the diagnostic value of CT and MRI imaging manifestations for microvascular invasion(MVI)in primary hepatocellular carcinoma(HCC).Methods A total of 120 patients(158 lesions in total)with HCC in the Second People’s Hospital of Jiangmen(Pengjiang Branch of Jiangmen Central Hospital)and Jiangmen Central Hospital were selected from January 2018 to July 2024,all underwent CT and MRI plain + enhanced and diffusion-weighted imaging(DWI)of the upper abdomen;postoperative pathology results was used as the diagnostic gold standard.The diagnostic efficacy of CT,MRI plain + enhanced and DWI for HCC MVI was compared.The concordance among CT,MRI plain + enhanced and DWI examinations with postoperative pathological diagnostic findings in the diagnosis of HCC MVI.Imaging manifestations and apparent diffusion coefficient(ADC)values in patients with and without HCC MVI were compared.Results Diagnostic effectiveness of DWI examination for HCC MVI(sensitivity,specificity,accuracy,positive predictive value,negative predictive value)were all significantly higher than those of CT and MRI plain + enhanced(P<0.05);none of the differences were statistically significant(P>0.05)in the comparison of diagnostic effectiveness of CT,MRI,and DWI for the diagnosis of MVI in patients with primary HCC.In HCC MVI diagnostic effectiveness,moderate concordance was found among CT,MRI imaging phenotypes and postoperative pathology results;high concordance was found between DWI and postoperative pathology results.In HCC MVI patients,the proportion of non-marginal arterial reinforcement,enhanced envelope,halo reinforcement,nodal in nodal and portal branch cancer thrombi was significantly higher than that in patients without HCC MVI(P<0.05).At different b-values(400,800,1 000,1 500 s/mm2 ),ADC values were all significantly higher in patients with HCC MVI than in patients without HCC MVI(P<0.05).Conclusions CT,MRI plain + enhanced and DWI have good diagnostic effectiveness for HCC MVI,while MRI diagnostic results are in better concordance with pathologic diagnosis.In particular,ADC values in DWI maps can more accurately determine whether MVI occurs in patients with HCC,which helps to guide clinicians to establish“individualized”and precise diagnosis and treatment strategies.
目的 探讨分析超声引导下胸膜活检(USPB)联合胸腔积液检验对于临床确诊结核性胸膜炎的应用价值。方法 选取2021年6月—2023年6月广州市胸科医院收治的96例临床诊断为结核性胸膜炎(渗出性胸膜炎)的患者为研究对象,分别使用胸腔积液检验(包含胸腔积液腺苷脱氨酶及细菌培养)、USPB、两者联合三种方法诊断,计算其准确率、特异度及灵敏度并进行分析。结果 胸腔积液诊断准确率73.96%、灵敏度72.84%,USPB诊断准确率为85.42%、灵敏度82.71%,两者联合诊断准确率为88.54%,灵敏度90.12%,较胸腔积液检验单独诊断准确率及灵敏度明显升高(P<0.05),胸腔积液、USPB、两者联合诊断特异度差异(P>0.05)无统计学意义。结论 USPB联合胸腔积液检验对结核性胸膜炎的确诊具有较高临床价值。
Objective To investigate the value of ultrasound-guided pleural biopsy(USPB)combined with pleural effusion test in the diagnosis of tuberculous pleurisy.Methods A total of 96 patients with tuberculous pleurisy(exudative pleurisy)admitted to the Guangzhou Chest Hospital from June 2021 to June 2023 were selected.The accuracy,specificity,and sensitivity of pleural effusion test(including adenosine deaminase and bacterial culture),USPB,and their combination were calculated and analyzed.Results The diagnostic accuracy of pleural effusion was 73.96% and the sensitivity was 72.84%.The diagnostic accuracy of USPB was 85.42% and the sensitivity was 82.71%.The diagnostic accuracy 88.54% and sensitivity 90.12% of USPB combined with pleural effusion test were significantly higher than that of pleural effusion alone(P<0.05),but there was no significant difference in the diagnostic specificity of pleural effusion,USPB and combination of them(P>0.05).Conclusions USPB combined with pleural effusion test has high clinical value in the diagnosis of tuberculous pleurisy.