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《广州医药》编辑部
目的 探讨高龄妊娠期糖尿病(GDM)产妇糖耐量的特点及其与妊娠结局的关系。方法 选择2020年1月1日—2024年12月31日在广州市第一人民医院规律产检并分娩的高龄产妇727例,包括高龄初产妇226例(GDM 78例)和高龄经产妇501例(GDM 131例),按照75 g OGTT血糖异常项数进行分组:一项血糖异常产妇为GDM I组(高龄初产妇38例,高龄经产妇68例);两项血糖异常产妇为GDM Ⅱ组(高龄初产妇26例,高龄经产妇51例);三项血糖异常产妇为GDM Ⅲ组(高龄初产妇14例,高龄经产妇12例);75 g OGTT正常高龄产妇为对照组。收集研究对象一般资料、75g OGTT血糖及相关妊娠结局进行分析比较。结果 高龄初产妇GDM发生率(34.51%)较高龄经产妇GDM发生率(26.15%)高,差异具有统计学意义(P=0.021);高龄初产妇GDM Ⅲ型宫内感染(28.57%)、产后出血(14.29%)发生率最高,差异具有统计学意义(P=0.037、0.039);高龄初产妇GDM I型早产(23.68%)发生率最高,差异具有统计学意义(P=0.013)。高龄初产妇及经产妇GDM Ⅱ型的羊水过多、甲状腺功能减退、宫内感染、早产发生率均呈上升趋势。结论 高龄妊娠糖尿病产妇随OGTT血糖异常项增多出现不良妊娠结局风险升高,其中高龄初产妇的早产、宫内感染及产后出血的发生率更高,因此,针对高龄初产妇,应更加注重孕期血糖及健康管理,以减少不良妊娠结局的发生。
Objective To analyze glucose tolerance characteristics in elderly pregnant women with gestational diabetes mellitus(GDM)and relationship with pregnancy outcomes.Methods From January 1,2020,and December 31,2024,727 elderly pregnant women who underwent routine prenatal examinations and delivered in Guangzhou First People’s Hospital were recruit.Among them,226 were elderly primiparas and 501 were elderly multiparas.GDM was diagnosed in 78 elderly primiparas and 131 elderly multiparas.Based on the results of the 75 g oral glucose tolerance test(OGTT),GDM cases were classified as follows:GDM I(one abnormal glucose value;38 elderly primiparas,68 elderly multiparas),GDM II(two abnormal values;26 elderly primiparas,51 elderly multiparas),and GDM Ⅲ(three abnormal values;14 elderly primiparas,12 elderly multiparas).Elderly pregnant women with normal OGTT results served as the control group.General clinical data and pregnancy outcomes were collected.The prevalence and characteristics of GDM in elderly primiparas and multiparas were analyzed.Results The incidence of GDM was significantly higher in elderly primiparas than in elderly multiparas(P=0.021).The incidence of intrauterine infection and postpartum hemorrhage was highest in elderly primiparas with GDM Ⅲ(P=0.037,0.039).The incidence of preterm birth was highest in elderly primiparas with GDM I(P=0.013).The incidence of polyhydramnios,hypothyroidism,intrauterine infection,and preterm birth showed an increasing trend in both elderly primiparas and multiparas with GDM II.Conclusions Elderly primiparas with more severe glucose tolerance abnormalities are at a higher risk of adverse pregnancy outcomes.Enhanced blood glucose monitoring and comprehensive health management during pregnancy are crucial for reducing the incidence of adverse outcomes in this population.
目的 比较宫腔镜病灶切除术与超声监测下吸宫术治疗剖宫产瘢痕部位妊娠(CSP)的有效性。方法 回顾性分析2021年7月—2023年10月在南宁市妇幼保健院确诊为I、Ⅱ型CSP并接受治疗的129例患者,停经时间在38~83 d,中位停经时间48 d。其中42例患者接受了宫腔镜病灶切除术治疗(A组),87例患者接受超声监测下吸宫术治疗(B组),比较两组患者术后1、3、7、14 d的人绒毛膜促性腺激素水平以及手术出血量、手术时间、住院时间、住院花费。结果 两组患者在术后1 d,血清HCG水平下降,下降幅度均超过50%,且A组患者术后1 d血清HCG的下降幅度及下降速率大于B组患者(P<0.05);术后3、7、14 d,两组血清HCG水平仍持续下降。另外,A组患者手术出血量、手术时间、住院时间、住院花费分别为(15.35±14.53)mL、(60.73±53.05)min、(4.33±1.90)d、(6 689.23±2 216.19)元;B组患者手术出血量、手术时间、住院时间、住院费用分别为(26.09±29.24)mL、(51.59±54.46)min、(4.82±1.83)d、(6 270.34±2 547.85)元。A组患者术中出血量低于B组、住院时间短于B组(P<0.05),手术时间及住院费用与B组比较差异无统计学意义(P均>0.05)。结论 宫腔镜病灶切除术与超声监测下吸宫术均能有效治疗CSP,但宫腔镜病灶切除术在术后血清HCG的下降幅度及下降速率、术中出血量、住院时间等方面优于超声监测下吸宫术,而且手术时间和住院费用并没有显著增加。
Objective To compare the efficacy between hysteroscopic resection surgery and ultrasound-guided uterine aspiration in the treatment of cesarean scar pregnancy(CSP).Methods A retrospective analysis was performed in 129 patients diagnosed with CSP(type I or Ⅱ)and treated in Nanning Maternal and Child Health Hospital from July 2021 to October 2023.Their duration of amenorrhea was between 38~83 d,with a median of 48 days.Among them,42 patients were treated with hysteroscopic resection surgery therapy(group A),87 patients were treated with ultrasound-guided uterine aspiration therapy and(group B).Then,the levels of human chorionic gonadotropin(HCG),the amount of the intraoperative bleeding volume,surgical time,hospitalization time,and hospitalization expenses were compared between the two groups at one,three,seven and 14 days postoperativey.Results After one day of surgery,the serum HCG levels of two groups significantly decreased,with a decrease of more than 50%,and the magnitude and rate of decrease in serum HCG levels of group A were significantly larger than those of group B(P<0.05);After three,seven,and 14 day of surgery,serum HCG levels continued to decrease.Furthermore,the intraoperative bleeding volume,surgical time,hospitalization time,hospitalization expenses in group A were(15.35±14.53)mL,(60.73±53.05)min,(4.33±1.90)d,(6 689.23±2 216.19)yuan,respectively.That in group B were(26.09±29.24)mL,(51.59±54.46)min,(4.82±1.83)d,(6 270.34±2 547.85)yuan,respectively.Compared to group B,the intraoperative bleeding volume of group A was significantly lower(P<0.05),and the hospitalization time is shorter,while there was no significant difference in surgical time and hospitalization expenses.Conclusions Both of hysteroscopic resection surgery and ultrasound-guided uterine aspiration can treat cesarean scar pregnancy effectively,but the former is superior to the latter in terms of the magnitude and rate of decrease in serum HCG levels after surgery,intraoperative bleeding volume,and hospitalization time,with no significant increase in surgical time and hospitalization expenses.