综述

IMB模型应用于日间腹腔镜胆囊切除术患者术后早期康复质量的研究进展

Research progress on the application of IMB model in the early postoperative rehabilitation quality of patients undergoing ambulatory laparoscopic cholecystectomy

:419-424
 
       本文概述了传统日间腹腔镜胆囊切除术患者术后早期康复质量存在的问题,IMB模型通过向患者提供科学的疾病知识,改变其疾病认知与态度,最终促使其采纳并维持健康行为。本文还介绍了IMB模型在日间腹腔镜胆囊切除术后患者早期康复质量中应用涉及的相关概念、研究背景和国内外的研究现状以及未来发展趋势与挑战。研究结果显示,IMB模型可显著降低患者术后疼痛发生率,并提高患者参与治疗决策的程度,为后期关于IMB模型在日间腹腔镜胆囊切除术患者术后早期康复质量的相关研究提供借鉴与参考,以便后期实施相关个性化干预措施,并提供相关理论依据。
       This paper summarizes the problems existing in the early postoperative rehabilitation quality of patients undergoing traditional ambulatory laparoscopic cholecystectomy.The IMB model changes patients’ disease cognition and attitude by providing them with scientific disease knowledge,and ultimately promotes their adoption and maintenance of healthy behaviors.It also introduces the relevant concepts involved in the application of the IMB model in the early postoperative rehabilitation quality of patients undergoing ambulatory laparoscopic cholecystectomy,the research background of this study,the current research status at home and abroad,as well as the future development trends and challenges.The research results show that the IMB model can significantly reduce the incidence of postoperative severe pain in patients and the degree of patient participation in treatment decision-making.This provides reference and guidance for subsequent studies on the early rehabilitation quality of patients undergoing ambulatory laparoscopic cholecystectomy using the IMB model,so as to implement relevant personalized intervention measures in the future and provide relevant theoretical basis.
论著

PENG阻滞使用低浓度罗哌卡因对衰弱患者在髋关节手术的应用

The application of PENG block using low concentration ropivacaine in hip joint surgery for frail patients

:425-432
 
       目的 探讨低浓度罗哌卡因行超声引导下髋关节囊周围神经(PENG)阻滞联合椎管内麻醉对衰弱患者髋关节手术的应用优势。方法 选择行髋关节手术的衰弱患者76例,随机分为两组,A 组(38例)行PENG阻滞联合椎管内麻醉,C 组(38例)行椎管内麻醉。比较两组入室(T0)、摆放体位时(T1)、术后6 h(T2)、术后12 h(T3)、术后24 h(T4)静息和活动状态的数字等级评定量表(NRS)疼痛评分;术后非甾体抗炎药及阿片类药物补救次数;术后 6 h、24 h患侧股四头肌徒手肌力分级(MMT);首次下床活动时间、住院时间。结果 A组T1~T4时刻静息状态NRS疼痛评分分别为2(1,3)分、1(1,2)分、2(1,2)分、3(2,4)分均低于C组的5(4,7)分、4(3,5)分、5(3,6)分、4(2,6)分,比较差异有统计学意义(均P<0.001);A组T1~T4时刻活动状态NRS疼痛评分分别为5(4,7)分、3(2,4)分、4(3,5)分、6(4,7)分均低于C组的10(9,10)分、8(6,9)分、8(7,9)分、9(8,10)分,比较差异有统计学意义(均P<0.001)。A组在T1~T4时的静息状态NRS疼痛评分低于T0时的(均P<0.01);C组在T1~T4时的静息状态NRS疼痛评分低于T0时的(均P<0.05);A组在T1~T4时的活动状态NRS疼痛评分均低于T0时的(均P<0.001);C组在T1、T2时的活动状态NRS疼痛评分均低于T0时的(均P<0.01)。A组术后非甾体抗炎药及额外阿片类药物补救次数为4(0,8)、2(0,3)次,均低于C组的15(7,19)、5(3,7)次,比较差异有统计学意义(均P<0.001)。两组术后 6 h和24 h患侧股四头肌MMT分级、首次下床活动时间和住院时间比较差异无统计学意义(P>0.05)。结论 低浓度罗哌卡因PENG阻滞可以有效减轻衰弱患者髋关节手术术后疼痛,不影响其术后下肢肌力。

   Objective To explore the application advantages of low-concentration ropivacaine for ultrasound-guided pericapsular nerve group(PENG)block combined with spinal-epidural anesthesia in hip joint surgery for frail patients.Methods Seventy-six frail patients undergoing hip surgery were randomly divided into two groups:Group A(38 cases)received PENG block combined with intraspinal anesthesia,while Group C(38 cases)received only intraspinal anesthesia.The numerical rating scale(NRS)pain scores of resting and active states were compared between the two groups at the time of entering the room(T0),placing the position(T1),6 hours after surgery(T2),12 hours after surgery(T3),and 24 hours after surgery(T4).Postoperative non-steroidal drugs and opioids remedy times,muscle strength grading(MMT)of quadriceps femoris at 6 hours and 24 hours after operation,and the first time out of bed activity time,hospitalization time were also compared.Results The resting NRS pain scores at T1-T4 in Group A were 2(1,3),1(1,2),2(1,2)and 3(2,4),respectively,which were lower than 5(4,7),4(3,5),5(3,6)and 4(2,6)in Group C,and the difference was statistically significant(all P<0.001).The NRS pain scores at T1-T4 in Group A were 5(4,7),3(2,4),4(3,5)and 6(4,7),respectively,which were lower than 10(9,10),8(6,9),8(7,9)and 9(8,10)in Group C,and the difference was statistically significant(all P<0.001).The resting NRS pain score of Group A at T1-T4 was lower than that at T0(all P<0.01);the resting NRS pain score of Group C at T1-T4 was lower than that at T0(all P<0.05).The NRS pain scores at T1-T4 in Group A were lower than those at T0(all P<0.001);the NRS pain scores at T1 and T2 in Group C were lower than those at T0(all P<0.01).The number of postoperative non-steroidal drugs and additional opioids in group A(4[0,8],2[0,3])was lower than that in Group C(15[7,19],5[3,7]),and the difference was statistically significant(all P>0.001).There was no significant difference in the MMT grade of the affected quadriceps femoris at 6 h and 24 h after operation,the first time of getting out of bed and the number of days of hospitalization between the two groups(P>0.05).Conclusions Low concentration ropivacaine PENG block can effectively reduce the postoperative pain of hip joint surgery in frail patients without affecting the postoperative lower extremity muscle strength.
论著

磁共振成像CUBE序列在眼眶肿瘤及肿瘤样病变中的诊断价值

The diagnostic value of magnetic resonance imaging CUBE sequence for orbital tumors and tumor like lesions

:453-458
 
      目的 探究磁共振成像三维快速自旋回波序列(CUBE)序列在眼眶肿瘤及肿瘤样病变中的诊断价值。方法 选取2023年5月—2025年6月郑州市第二人民医院收治的眼眶肿瘤及肿瘤样病变患者89例为研究对象,依据病理诊断结果分为眼眶肿瘤组(43例)及肿瘤样病变组(46例)。分别采用病理检查及磁共振成像CUBE序列对研究对象进行检测。比较眼眶肿瘤组与肿瘤样病变组的资料。采用Kappa检验比较病理金标准与磁共振成像CUBE序列鉴别诊断的一致性。采用2×2列联表分析磁共振成像CUBE鉴别眼眶肿瘤及肿瘤样病变的诊断效能。结果 病理鉴别诊断结果与磁共振成像CUBE序列结果比较,差异无统计学意义(P>0.05)。眼眶肿瘤组与肿瘤样病变组的资料比较,差异无统计学意义(P>0.05)。Kappa检验发现,磁共振成像CUBE序列鉴别眼眶肿瘤与肿瘤样病变与病理金标准比较的Kappa值为0.820,一致性较高(P<0.05)。磁共振成像CUBE序列鉴别眼眶肿瘤及肿瘤样病变的灵敏度为88.37%,特异度为93.48%,准确度为91.01%,误诊率为6.52%,漏诊率为11.63%,约登指数为81.85%,阳性预测概率为92.68%,阴性预测概率为89.58%。结论 磁共振成像CUBE序列鉴别诊断成人眼眶肿瘤及肿瘤样病变与病理诊断结果的一致性较高。
     Objective To investigate the diagnostic value of the three-dimensional fast spin echo sequence(CUBE)in magnetic resonance imaging for orbital tumors and tumor-like lesions.Methods From May 2023 to June 2025,89 patients with orbital tumors and tumor like lesions were included as the study subjects.Based on pathological diagnosis results,they were separated into orbital tumor group(43 cases)and tumor like lesion group(46 cases).The pathological examination and magnetic resonance imaging CUBE sequence were used to scan the study subjects.The data were compared between the orbital tumor group and the tumor like lesion group.Kappa test was used to compare the consistency of differential diagnosis between pathological gold standard and magnetic resonance imaging CUBE sequence.A 2×2 contingency table was uesd to analyze the diagnostic performance of magnetic resonance imaging CUBE in differentiating orbital tumors and tumor-like lesions.Results The difference between the pathological differential diagnosis results and the magnetic resonance imaging CUBE sequence was not statistically significant(P>0.05).The data comparison between the orbital tumor group and the tumor like lesion group showed no statistical difference(P>0.05).The Kappa test found that the Kappa value of 0.820 for differentiating orbital tumors from tumor like lesions using the magnetic resonance imaging CUBE sequence compared to the pathological gold standard was highly consistent(P<0.05).The sensitivity,specificity,accuracy,misdiagnosis rate,missed diagnosis rate,Youden index,positive predictive probability,and negative predictive probability of magnetic resonance imaging CUBE sequence in differentiating orbital tumors and tumor like lesions were 88.37%,93.48%,91.01%,6.52%,11.63%,81.85%,92.68% and 89.58%,respectively.Conclusions The magnetic resonance imaging CUBE sequence has a high consistency with pathological diagnosis results in the differential diagnosis of orbital tumors and tumor like lesions.
论著

肺泡灌洗液靶向高通量测序在鹦鹉热衣原体肺炎中的应用价值

Application of bronchoalveolar lavage fluid targeted next-generation sequencing in Chlamydia psittaci pneumonia

:459-465
 
       目的 探究肺泡灌洗液靶向高通量测序(tNGS)在鹦鹉热衣原体肺炎中应用效果。方法 选取2021年5月—2025年3月我院收治的35例鹦鹉热衣原体肺炎患者进行研究,患者均接受肺泡灌洗液tNGS检测、肺泡灌洗液常规病原检测,以病原学为金标准,分析肺泡灌洗液tNGS对鹦鹉热衣原体肺炎的诊断效能。结果 金标准对鹦鹉热衣原体阳性检出35例,检出率100.00%,肺泡灌洗液tNGS阳性检出率高于传统病原检测,检测结果回报耗时短于肺泡灌洗液传统病原检测(P<0.05)。结论 鹦鹉热衣原体肺炎临床症状缺乏特异性,容易转为重症肺炎,肺泡灌洗液tNGS可提高鹦鹉热衣原体肺炎检出率且结果回报较快,采用四环素类、喹诺酮类抗生素有助于改善患者预后。
     Objective To investigate the application effect of targeted next-generation sequencing(tNGS)of bronchoalveolar lavage fluid(BALF)in Chlamydia psittaci pneumonia.Methods Thirty-five patients with Chlamydia psittaci pneumonia admitted to our hospital from May 2021 to March 2025 were selected for the study.All patients underwent BALF tNGS and conventional BALF pathogen detection.With etiology as the gold standard,the diagnostic efficacy of BALF tNGS for Chlamydia psittaci pneumonia was analyzed.Results The gold standard detected 35 cases of Chlamydia psittaci positive,with a detection rate of 100.00%.The positive detection rate of tNGS in alveolar lavage fluid was higher than that of traditional pathogen detection,and the results report time of tNGS was shorter than that of traditional pathogen detection(P<0.05).Conclusions Chlamydia psittaci pneumonia lacks specificity in clinical symptoms and is easy to turn into severe pneumonia,bronchoalveolar lavage fluid tNGS can improve the detection rate of Chlamydia psittaci pneumonia and the results return quickly,and the use of tetracyclines and quinolones antibiotics can help improve the prognosis of patients.

论著

消化系统恶性肿瘤患者营养风险及营养知信行分析

Research on nutritional risk and nutritional knowledge - attitude - behavior among patients with digestive system malignant tumors

:491-499
 
      目的 调查消化系统恶性肿瘤患者营养风险、营养知识-态度-行为(知信行)水平的现状,探究各因素是否对患者的营养风险、营养知信行水平具有影响,并分析两者之间的相关性。方法 选取中山大学附属第八医院(深圳福田)2024年2月—10月的244例消化系统恶性肿瘤患者为研究对象,采用一般资料调查表、营养风险筛查NRS2002量表以及消化系统肿瘤患者营养知信行问卷进行调查,数据收集后进行统计分析,从而研究消化系统恶性肿瘤患者营养筛查风险与营养知信行水平的现状、影响因素及两者间的相关性。结果 69.3%的消化系统恶性肿瘤患者存在营养风险,营养风险评分为(2.72±1.42)分。消化系统恶性肿瘤患者营养知识水平得分为(12.30±5.26)分、营养态度水平得分为(14.80±2.68)分、营养行为水平得分为(22.82±4.55)分、营养知信行水平总分为(49.96±9.50)分。家庭经济收入是患者营养风险水平的核心影响因素(P<0.05),学历水平是患者营养知信行水平的核心影响因素(P<0.05)。消化系统恶性肿瘤患者营养风险水平与营养知信行的总体水平呈负相关(r=-0.143,P<0.05)。结论 消化系统恶性肿瘤患者的营养知信行水平总体处于中等水平,但普遍存在营养风险较高的情况。在患者治疗期间实施个性化营养健康宣教至关重要,这将有助于提升患者的营养知识水平,从而整体性改善其营养知信行素养并降低其营养风险,但在进行营养宣教和制定个性化营养方案时应充分考虑患者的家庭经济收入及学历水平。
    Objective To explore the nutritional risk and nutritional knowledge-attitude-behavior status of patients with digestive system malignant tumors,to analyze the influencing factors of nutritional risk,nutritional knowledge-attitude-behavior,and explore the correlation between them.Methods From February 2024 to October 2024,244 patients with digestive system malignant tumors at the Eighth Affiliated Hospital of Sun Yat-sen University were selected as the research subjects.A general information questionnaire,Nutritional Risk Screening 2002,and digestive system tumor patient nutrition knowledge-attitude-behavior questionnaire were used to study the influencing factors and correlations between the nutritional screening risk and nutritional knowledge-attitude-behavior in patients with digestive system malignant tumors.Results There were 69.3% of the patients with digestive system malignant tumors had nutritional risk score ≥3,and the overall score was(2.72±1.42).The scores of nutritional knowledge,attitude,behavior and total score of digestive system malignant tumors patients were(12.30±5.26),(14.80±2.68),(22.82±4.55)and(49.96±9.50),respectively.Family economic income was the core influencing factors of nutritional risk in patients with digestive system malignant tumors,while educational level was the core influencing factor of nutritional knowledge-attitude-behavior in patients with digestive system malignant tumors.The nutritional risk level of patients with malignant tumors of the digestive system was significantly negatively correlated with the overall level of nutritional knowledge-attitude-behavior.Conclusions The nutritional knowledge-attitude-behavior level of patients with malignant tumors of the digestive system is generally at a medium level,but there is a widespread situation of relatively high nutritional risk.It is extremely important and necessary to conduct personalized nutrition knowledge education for patients during their treatment period,which will help enhance patients’ nutritional knowledge level,thereby comprehensively improving their nutritional knowledge-attitude-behavior literacy and reducing their nutritional risks.However,when conducting nutrition education and formulating personalized nutrition plans,the patient’s family economic income,medical payment methods and educational level should be fully considered.

肺癌患者联合药物治疗间歇期症状评估问卷的修订及信效度评价

Revision of the Symptom Assessment Questionnaire for Lung Cancer Patients During Combined Drug Therapy Intervals and Testing of Its Reliability and Validity

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目的 修订肺癌患者联合药物治疗间歇期症状评估问卷,并评价其信效度。方法 以中文版安德森症状评估量表及肺癌特异性模块为基础,经文献分析、专家会议和认知性访谈形成测试版问卷。于2023年10-12月便利选取福州、莆田2所三级甲等医院278例肺癌患者进行调查,评价其信效度及偏倚风险。结果 修订后问卷含7个症状系统、60个条目,跳转式作答后实际作答21个条目。总问卷Cronbach's α系数为0.856,各维度为0.639~0.747;内容效度指数为0.81。验证性因子分析显示模型拟合尚可(χ2/df=2.366,RMSEA=0.070,CFI=0.858),各维度因子载荷、组合信度及平均方差提取量均达到可接受标准,区分效度良好。COSMIN-RoB评价结果为良好。结论 该问卷信效度良好,可用于评估肺癌患者联合药物治疗间歇期症状严重程度。
Objective To revise the Symptom Assessment Questionnaire for Lung Cancer Patients During Combined Drug Therapy Intervals and evaluate its reliability and validity. Methods Based on the Chinese version of the M. D. Anderson Symptom Inventory and its lung cancer-specific module, a preliminary questionnaire was developed through literature review, expert panel discussions, and cognitive interviews. From October to December 2023, a convenience sample of 278 lung cancer patients was recruited from two tertiary hospitals in Fuzhou and Putian, China. Reliability, validity, and risk of bias were evaluated. Results The revised questionnaire comprised seven symptom-system domains and 60 items, with 21 items completed through a skip-logic design. The overall Cronbach's α coefficient was 0.856, and the coefficients for each domain ranged from 0.639 to 0.747. The content validity index of the questionnaire was 0.81. Confirmatory factor analysis demonstrated an acceptable model fit (χ2/df = 2.366, RMSEA = 0.070, CFI = 0.858). Factor loadings, composite reliability, and average variance extracted of all domains met acceptable standards, indicating good discriminant validity. The overall risk of bias was rated as good according to the COSMIN Risk of Bias checklist. Conclusion The revised questionnaire demonstrated satisfactory reliability and validity and can be used to assess symptom severity in lung cancer patients during combined drug therapy intervals.

基于E-Coach健康管理模式的营养管理联合主动循环呼吸训练应用于非小细胞肺癌化疗患者的效果分析

Effect Analysis of Nutrition Management Based on E-Coach Health Management Model Combined with Active Cycle of Breathing Technique in Patients Undergoing Chemotherapy for Non-Small Cell Lung Cancer

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摘要目的 探讨基于E-Coach健康管理模式的营养管理联合主动循环呼吸训练(ACBT)在非小细胞肺癌(NSCLC)化疗患者中的应用效果。方法 选取2023年6月至2025年8月我院收治的98例NSCLC化疗患者,采用随机数字表法将所有研究对象分为联合组和常规组,每组49例。常规组给予常规干预,联合组在常规组基础上予以E-Coach健康管理模式的营养管理联合ACBT干预。比较两组干预前后营养状况、肺功能、运动耐力、生活质量以及营养不良发生率。结果 干预12周后,两组BMI、ALB、PA、Hb均较干预前上升且联合组高于常规组(P<0.05);联合组FVC、FEV1、MVV及6MWT均显著高于常规组(P<0.05);干预前两组6MWT组间对比差异无统计学意义(P>0.05),干预4周、6周、8周、12周后,两组6MWT均较干预前增加,且联合组远于常规组(P<0.05);干预12周后,两组身体功能、社会或家庭功能、情感功能、功能性状况得分均较干预前上升,且联合组高于常规组(P<0.05)。结论基于E-Coach健康管理模式的营养管理联合ACBT能够有效改善NSCLC化疗患者的营养状况和肺功能,提高生活质量和运动耐力。
Abstract Objective To investigate the application effect of nutrition management based on the E-Coach health management model combined with active cycle of breathing technique (ACBT) in patients undergoing chemotherapy for non-small cell lung cancer (NSCLC). Methods A total of 98 NSCLC patients receiving chemotherapy in our hospital from June 2023 to August 2025 were selected and randomly divided into a combination group and a conventional group using a random number table method, with 49 cases in each group. The conventional group received routine intervention, while the combination group received nutrition management based on the E-Coach health management model combined with ACBT in addition to the routine intervention. The nutritional status, lung function, exercise endurance, quality of life, and incidence of malnutrition were compared between the two groups before and after the intervention. Results After 12 weeks of intervention, BMI, ALB, PA, and Hb in both groups increased compared with baseline, and the levels in the combination group were higher than those in the conventional group (P<0.05). The FVC, FEV1, MVV, and 6MWT in the combination group were significantly higher than those in the conventional group (P<0.05). There was no statistically significant difference in 6MWT between the two groups before intervention (P>0.05); after 4, 6, 8, and 12 weeks of intervention, the 6MWT in both groups increased compared with baseline, and the walking distance in the combination group was significantly longer than that in the conventional group (P<0.05). After 12 weeks of intervention, the scores of physical function, social/family function, emotional function, and functional well-being in both groups increased compared with baseline, and the scores in the combination group were higher than those in the conventional group (P<0.05). Conclusion Nutrition management based on the E-Coach health management model combined with ACBT can effectively improve the nutritional status and lung function of NSCLC patients undergoing chemotherapy, and enhance their quality of life and exercise endurance.

清咳平喘颗粒联合乙酰半胱氨酸治疗痰热闭肺型大叶性肺炎患儿的临床疗效研究

Clinical efficacy of Qingke Pingchuan granules combined with acetylcysteine in the treatment of children with lobar pneumonia of phlegm-heat obstructing lung type

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目的 探讨清咳平喘颗粒联合乙酰半胱氨酸对痰热闭肺型大叶性肺炎(LP)患儿的治疗效果。方法 回顾性选取我院收治的118例痰热闭肺型LP患儿(选例时间:2023年1月~2025年11月)为研究对象,根据治疗方案分为参照组(59例,采用乙酰半胱氨酸治疗)、联合组(59例,采用清咳平喘颗粒联合乙酰半胱氨酸治疗)。对比两组临床疗效、不良反应及治疗前、后肺功能[潮气量(VT)、达峰时间比(TPTEF/TE)、吸呼比(Ti/Te)、达峰容积比(VPEF/VE)]、中医证候、免疫功能、炎症因子[白细胞介素-8(IL-8)、趋化因子配体3(CCL3)、肿瘤坏死因子-α(TNF-α)、高迁移率族蛋白B1(HMGB1)]水平。结果 联合组总有效率为96.61%,高于参照组的83.05%(P<0.05);与参照组相比,治疗后联合组各中医证候积分均较低(P<0.05);联合组治疗后VT、TPTEF/TE、Ti/Te、VPEF/VE水平均较参照组高(P<0.05);联合组治疗后CD8+水平较参照组低,CD3+、CD4+、CD4+/CD8+水平较参照组高(P<0.05);治疗后联合组血清IL-8、CCL3、TNF-α、HMGB1水平均较参照组低(P<0.05);不良反应发生情况组间比较,无明显差异(P>0.05)。结论 清咳平喘颗粒联合乙酰半胱氨酸可提高痰热闭肺型LP患儿治疗效果,减轻临床症状,改善肺功能、免疫功能,降低机体炎症反应程度。
Objective To explore the therapeutic efficacy of Qingke Pingchuan granules combined with acetylcysteine on children with lobar pneumonia (LP) of phlegm-heat obstructing lung type. Methods A total of 118 children with LP of phlegm-heat obstructing lung type admitted to our hospital from January 2023 to November 2025 were retrospectively selected as the research subjects. According to different treatment regimens, they were divided into the control group (59 cases, treated with acetylcysteine) and the combined group (59 cases, treated with Qingke Pingchuan granules combined with acetylcysteine). The clinical efficacy, adverse reactions, as well as the levels of pulmonary function indicators [tidal volume (VT), time to peak tidal expiratory flow ratio (TPTEF/TE), inspiration-expiration ratio (Ti/Te), volume to peak tidal expiratory flow ratio (VPEF/VE)], traditional Chinese medicine (TCM) syndrome scores, immune function and inflammatory factors [interleukin-8 (IL-8), C-C motif chemokine ligand 3 (CCL3), tumor necrosis factor-α (TNF-α), high mobility group box 1 protein (HMGB1)] before and after treatment were compared between the two groups. Results The total effective rate of the combined group was 96.61%, which was higher than 83.05% of the control group (P<0.05). After treatment, the TCM syndrome scores of the combined group were lower than those of the control group (P<0.05). The levels of VT, TPTEF/TE, Ti/Te and VPEF/VE in the combined group were higher than those in the control group after treatment (P<0.05). After treatment, the level of CD8? in the combined group was lower, while the levels of CD3?, CD4? and CD4?/CD8? were higher than those in the control group (P<0.05). The serum levels of IL-8, CCL3, TNF-α and HMGB1 in the combined group were significantly lower than those in the control group after treatment (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The combination of Qingke Pingchuan granules and acetylcysteine can enhance the therapeutic efficacy on children with LP of phlegm-heat obstructing lung type, relieve clinical symptoms, improve pulmonary function and immune function, and reduce systemic inflammatory response.

利多卡因联合艾司氯胺酮对肺部手术患者苏醒质量及术后认知功能的影响

Effects of lidocaine combined with esketamine on recovery quality and postoperative cognitive function in patients undergoing lung surgery

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目的:探讨利多卡因复合艾司氯胺酮对肺部手术患者苏醒质量及认知功能的影响。方法:选取2023年7月至2025年6月本院收治的100例拟行肺部手术患者,按随机数字表法分为观察组和对照组,各50例。对照组采用常规麻醉方案维持麻醉,观察组在常规麻醉基础上复合利多卡因及艾司氯胺酮辅助麻醉。比较两组患者苏醒质量[拔管后30min Riker镇静躁动评分(SAS)、苏醒时间、拔管时间]、认知功能[术前及术后1d、3d简易精神状态检查表评分(MMSE)]、围术期血流动力学指标[麻醉药物输注前(T0)、气管插管时(T1)、拔管后5min(T2)平均动脉压(MAP)、心率(HR)]及术后72h不良反应发生率。结果:观察组拔管后30min SAS评分、术后1d、3d的MMSE评分高于对照组,苏醒时间、拔管时间低于对照组;观察组T0、T1、T2各时间点MAP、HR无显著差异(P>0.05);对照组T1、T2时MAP、HR高于T0(P<0.05);两组不良反应发生率无显著差异(P>0.05)。结论:利多卡因复合艾司氯胺酮应用于肺部手术,可提升患者苏醒质量、保护术后认知功能,维持围术期血流动力学稳定,且安全性良好。
Objective : To investigate the effect of lidocaine combined with esketamine on recovery quality and cognitive function in patients undergoing lung surgery. Methods : A total of 100 patients receiving pulmonary resection at our hospital between July 2023 and December 2025 were enrolled and randomized via a random number table into two equal arms (n=50 per group): observation and control. The control group was treated with routine anesthesia to maintain anesthesia, and the observation group was treated with lidocaine and esketamine on the basis of routine anesthesia. The recovery quality [ Riker sedation agitation score ( SAS ) at 30 min after extubation, recovery time, extubation time ], cognitive function [ simple mental state examination score ( MMSE ) before operation and 1 d, 3 d after operation ], perioperative hemodynamic indexes [ mean arterial pressure ( MAP ), heart rate ( HR ) before anesthesia drug infusion ( T0 ), tracheal intubation ( T1 ), 5 min after extubation ( T2 ) ] and the incidence of adverse reactions at 72 h after operation were compared between the two groups. Results : In the observation group, the SAS score measured 30 minutes post-extubation and the MMSE scores at 1 day and 3 days post-operation were significantly higher than those in the control group. Conversely, both recovery and extubation times were shorter in the observation group compared to the control group. No significant differences in MAP and HR were observed at T0, T1, and T2 within the observation group (P > 0.05). In contrast, within the control group, MAP and HR at T1 and T2 were notably elevated compared to T0, with the differences being statistically significant (P < 0.05). Conclusion : The application of lidocaine combined with esketamine in lung surgery can improve the quality of recovery, protect postoperative cognitive function, maintain perioperative hemodynamic stability, and has good safety.

Root Cause Analysis 质量管理模式联合心理资本理论在手术核查团队沟通中断中的能力提升研究

Effect of Integrating Root Cause Analysis–Based Quality Management with Psychological Capital Theory on Reducing Communication Interruptions in Surgical Safety Check Teams

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探讨将 Root Cause Analysis(RCA)质量管理模式与心理资本理论相结合应用于手术核查团队,对改善沟通中断、提升沟通执行质量与团队协作能力的效果。方法 选取 2025年 1 月至 2025 年12 月某三级医院手术室手术团队成员 80 名,按手术间编号分为对照组与实验组,各 40 名。对照组实施常规手术核查流程;实验组在此基础上实施基于 RCA 的流程诊断与基于心理资本理论的综合沟通能力提升干预。干预结束后,比较两组沟通中断发生率、核查流程执行质量、沟通效率,以及心理资本量表(PCQ-24)和团队协作量表(T-TPQ)得分。结果 实验组沟通中断发生率显著低于对照组(P<0.05),核查流程执行质量和沟通效率均显著优于对照组(P<0.001)。实验组 PCQ-24 各维度及总分、T-TPQ 各维度及总分均显著高于对照组(均 P<0.001)。结论 将 RCA 流程分析与心理资本理论干预相结合,可通过流程规范化与心理动力增强双路径同步改善手术团队沟通质量与协作水平,具有良好的临床应用价值与推广潜力。
To evaluate the effectiveness of an intervention combining Root Cause Analysis (RCA)–based quality management and Psychological Capital (PsyCap) theory in reducing communication interruptions and improving communication quality and teamwork in surgical safety check teams. Methods: Eighty surgical team members from a tertiary hospital (January 2025 - December 2025.) were assigned to a control group or an intervention group according to operating room allocation (40 per group). The control group followed routine surgical safety check procedures, whereas the intervention group additionally received an RCA-guided workflow analysis and a PsyCap-based communication enhancement program. Post-intervention outcomes included communication interruption rate, execution quality and efficiency of safety checks, Psychological Capital Questionnaire (PCQ-24) scores, and TeamSTEPPS Teamwork Perceptions Questionnaire (T-TPQ) scores. Results: The intervention group demonstrated a significantly lower communication interruption rate compared with the control group (P<0.05). Execution quality and communication efficiency were significantly improved in the intervention group (P<0.001). PCQ-24 total and subscale scores were significantly higher in the intervention group than in the control group (P<0.001), as were T-TPQ total and subscale scores (P<0.001). Conclusion: Integrating RCA-based workflow optimization with PsyCap-oriented psychological and behavioral training can effectively enhance communication quality, reduce interruptions, and strengthen teamwork in surgical safety check teams. The combined model has strong applicability and potential for wider clinical promotion.
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