目的 分析2024年2月至2026年2月郑州人民医院收治的急性下呼吸道感染（ALRTI）患儿的病原体分布情况及其流行病学特征。方法 选取2024年2月—2026年2月于郑州人民医院就诊的193例ALRTI患儿为研究对象，采集患儿咽拭子样本，统计患儿病原体检测结果，比较不同性别、不同年龄段、不同发病季节患儿病原体分布情况。结果 193例患儿中，经病原体检测出阳性患儿165例，总阳性检出率85.49%，检出率最高的前三位为RSV（20.73%）、MP（19.69%）、HRV（15.54%）；婴儿期患儿RSV感染占比（44.83%）最高，其次为HRV感染（20.69%），幼儿期患儿RSV、HRV、MP感染占比（17.31%、17.31%、19.23%）均较高，学龄前、学龄期患儿MP感染占比（33.33%、26.32%）最高，婴儿期患儿混合感染占比（6.90%）较低，学龄前患儿混合感染占比（20.00%）较高；春季时，各病原体分布较均衡，HRV、MP、SP感染占比（14.58%、12.50%、14.58%）均较高，夏季、秋季时，MP感染率（31.82%、28.85%）较高，冬季时，RSV感染率（55.10%）较高，四个季节中混合感染患儿占比较接近，其中秋季感染率（17.31%）相对较高。结论 2024年至2026年郑州人民医院收治的急性下呼吸道感染患儿病原体中，RSV、MP为主要病原体，各呼吸道病原体随患儿年龄段、季节变化存在不同发病高峰，临床应结合实际情况早期鉴别病原体，以指导临床制定针对性治疗方案，改善患儿预后。
Objective To analyze the distribution of pathogens and the epidemiological characteristics of children with acute lower respiratory tract infections (ALRTI) admitted to Zhengzhou People’s Hospital from February 2024 to February 2026. Methods: A total of 193 pediatric patients with ALRTI who visited Zhengzhou People’s Hospital between February 2024 and February 2026 were selected as study subjects. Throat swab samples were collected from the patients, and pathogen testing results were compiled to compare the distribution of pathogens across different genders, age groups, and seasons of onset. Results: Among the 193 children, 165 tested positive for pathogens, resulting in an overall positive detection rate of 85.49%. The top three most frequently detected pathogens were RSV (20.73%), MP (19.69%), and HRV (15.54%); RSV infection had the highest prevalence (44.83%) among infants, followed by HRV infection (20.69%). Among preschoolers, the prevalence of RSV, HRV, and MP infections (17.31%, 17.31%, and 19.23%, respectively) was relatively high. MP infections were most common among preschool and school-age children (33.33% and 26.32%, respectively); the proportion of mixed infections was lower among infants (6.90%) but higher among preschoolers (20.00%); In spring, the distribution of pathogens was relatively balanced, with high proportions of HRV, MP, and SP infections (14.58%, 12.50%, and 14.58%, respectively). In summer and fall, the MP infection rate was high (31.82% and 28.85%, respectively). In winter, the RSV infection rate (55.10%) was high. The proportion of children with mixed infections was relatively similar across the four seasons, with a relatively higher infection rate (17.31%) in autumn. Conclusion: Among the pathogens identified in children with acute lower respiratory tract infections admitted to Zhengzhou People’s Hospital from 2024 to 2026, RSV and MP were the primary pathogens. The incidence peaks of various respiratory pathogens varied according to the children’s age groups and seasons. Clinicians should conduct early pathogen identification based on actual conditions to guide the development of targeted treatment plans and improve patient outcomes.
虽然高效抗逆转录病毒治疗已经把艾滋病变成了能够长期管理的慢性传染病，可是患者预后的个体差异比较明显。近些年不良环境暴露被发现是影响艾滋病生存质量、免疫重建、疾病进展的重要外源性因素。环境污染物作为广泛存在而且有可预防的外部风险因素，有着低剂量、长时程、多途径暴露的特点，能够通过免疫毒性、氧化应激、慢性炎症激活、代谢紊乱等多种通路，干扰艾滋病患者的免疫重建进程和病毒抑制效果，进而影响其疾病进展、远期生存结局。本文系统综述了大气污染物、重金属、黄曲霉素、多环芳烃等典型环境污染物与艾滋病患者发病进展及预后转归的关联，深入分析人群易感性差异和当前研究存在的局限，可为优化HIV/AIDS患者的健康管理策略、降低环境相关健康风险、改善患者远期预后给予理论参考和实践依据。
Although highly active antiretroviral therapy has turned AIDS into a chronic infectious disease that can be managed for a long time, the individual differences in the prognosis of patients are obvious. In recent years, adverse environmental exposure has been found to be an important exogenous factor affecting the quality of life, immune reconstruction and disease progression of AIDS. As an external risk factor that exists and has potential intervention, environmental pollutants have the characteristics of low-dose, long-term and multi-channel exposure. They can interfere with the immune reconstruction process and virus inhibition effect of AIDS patients through various pathways such as immunotoxicity, oxidative stress, chronic inflammation activation, and metabolic disorders, thereby affecting their disease progression and long-term survival outcomes. This article systematically reviews the association between typical environmental pollutants such as air pollutants, heavy metals, aflatoxins, and polycyclic aromatic hydrocarbons and the progression and prognosis of AIDS patients. In-depth analysis of the differences in population susceptibility and the limitations of current research can provide theoretical reference and practical basis for optimizing the health management strategies of HIV / AIDS patients, reducing environmental-related health risks, and improving the long-term prognosis of patients.
目的 通过对急性深静脉血栓形成（DVT）患者经导管接触性溶栓治疗（CDT）中，影响血管导管相关感染（VCAI）危险因素及病原菌分析，为VCAI的预防提供合理、有效的措施。方法 收集2019年1月—2022年12月徐州市肿瘤医院介入科行CDT治疗的急性DVT患者的临床资料，回顾性调查患者诊疗相关资料及血培养结果，并对发生VCAI和病原菌情况进行分析。结果 本研究共调查急性DVT行CDT治疗的患者437例，发生VCAI的患者共21例，千日感染率为0.543‰。多因素Logistic回归分析结果显示：溶栓频率＞3次/天［OR=3.49（95%CI：1.86~6.45）］、导管留置时间＞7 d［OR=3.86（95%CI：1.26~10.18）］和有导管回送［OR=8.67（95%CI：4.83~12.65）］是患者发生VCAI的危险因素（P＜0.05）。发生VCAI的21例患者，血培养共培养出24株病原菌，有3例患者出现复合病原菌感染情况。其中以革兰阳性球菌最为常见，共培养出13株，占比54.17%，革兰阴性菌9株，占比37.5 %。结论 导管留置时间＞7 d、溶栓频率＞3次/天和有导管回送是急性DVT患者CDT治疗中发生VCAI的危险因素。VCAI的病原菌以单一病原菌为主，可合并其他病原菌感染，其中以革兰阳性球菌为主。
Objective By analyzing the risk factors and pathogens of vessel catheter associated infection（VCAI）in patients with acute deep vein thrombosis（DVT）undergoing catheter directed thrombolysis（CDT），to provide reasonable and effective measures for the prevention and treatment of VCAI ．Methods Clinical data of patients undergoing CDT treatment for acute DVT in the interventional department of the hospital from January 2019 to December 2022 was collected，patient diagnosis and treatment related data and blood culture results were retrospectively investigated and organized，and the occurrence of VCAI and pathogenic bacteria was statistically analyzed．Results This study investigated 437 patients undergoing CDT treatment for acute DVT，and a total of 21 patients developed VCAI，with an infection rate of 0.543‰．The results of multiple Logistic regression analysis show that thrombolysis frequency＞3 times/day（OR=3.49［95%CI：1.86-6.45］），catheter retention days＞7 days（OR=3.86［95%CI：1.26-10.18］），and the presence of catheter return（OR=8.67［95%CI：4.83-12.65］） were risk factors for the occurrence of VCAI in patients．Among the 21 patients with VCAI，a total of 24 strains of pathogenic bacteria were discoveredin blood culture，and 3 patients developed composite pathogen infections．Among them，Gram positive cocci were the most common，with a total of 13 strains cultured，accounting for 54.17%，9 strains of Gram negative bacteria，accounting for 37.5%．Conclusions The duration of catheter retention＞7 days，thrombolysis frequency＞3 times/day，and the presence of catheter return are risk factors for VCAI in acute DVT patients undergoing CDT treatment．The pathogen of VCAI is mainly single pathogen，which can be combined with other pathogens，among which Gram positive cocci are the main pathogen．
老年人工股骨头置换术后隐性失血是影响手术的重要因素之一,手术后机体生理、病理的变化是一个较为复杂的过程。目前中医对其病因病机尚无系统研究。临床中常存在辨证思维局限,难以客观、全面揭示该病病因病机的特点,进而导致遣方用药难以把握。该文旨在对老年人工股骨头置换术后隐性失血的病因病机进行探讨,认为该病的证候特点为气血亏虚兼瘀,病性为本虚标实,病位肝脾肾,其中气血亏虚贯穿疾病始终,而气为关键。
Hidden blood loss after artificial femoral head replacement in the elderly is one of the important factors affecting the operation,and the change of physiology and pathology after operation is a complicated process．At present,there is no systematic study on its etiology and pathogenesis in traditional Chinese medicine．In clinical practice,there are limitations of dialectical thinking,which make it difficult to Objective ly and comprehensively reveal the characteristics of the etiology and pathogenesis of the disease,and difficult to prescribe．The purpose of this paper is to explore the etiology and pathogenesis of hidden blood loss after artificial femoral head replacement in the elderly．It is considered that the syndrome of the disease is characterized by deficiency of qi and blood and blood stasis,and the disease is based on deficiency of liver,spleen and kidney,in which deficiency of qi and blood runs through the disease all the time,and qi is the key．
目的 利用靶向二代测序技术探究天津市发热呼吸道症候群病原特征,分析病原流行特征,总结规律,为发热伴呼吸道症候群患者治疗策略提供指导。方法 收集2023年1月—2023年12月天津地区某四家医院初诊为发热伴呼吸道症候群的4 039例病例,通过tNGS技术检测,分析鉴定病原微生物,研究不同标本类型病原微生物分布、年龄分布、性别分布、不同时间季节感染分布、微生物类型分布趋势等。结果 4 039例经tNGS技术检测,共检测出90种潜在病原体,总阳性率为94.80%（3 829/4 039）。包括36种细菌、29种病毒、5种非典型病原体和20种真菌。不同种类病原体检出频次排序：革兰阴性细菌（G-细菌）>RNA病毒>DNA病毒>革兰阳性细菌（G+细菌）>真菌>非典型病原体。男女性别阳性检出率比较差异无统计学意义（χ2=0.249,P=0.618）;不同年龄段人群病原体谱有异质性,且阳性患者多分布在0~10岁和>60岁,阳性也集中在该两类人群,阳性率分别为47.90%（1 834/3 829）和31.24%（1 196/3 829）。在单一感染中,肺炎支原体占比最高,为4.91%,其次为新型冠状病毒,占1.59%,再次为呼吸道合胞病毒,占1.23%。不同季节不同感染类型具有差异,整体呈现夏冬季混合感染率高的特点,即夏季新冠病毒合并细菌（鲍曼不动杆菌、肺炎链球菌）,冬季肺炎支原体合并甲型、乙型流感病毒多见。肺炎支原体对大环内酯类药物耐药率随月份呈现增加趋势。结论 tNGS 技术在天津市发热呼吸道症候群样本中获得了较高的病原体检出率,病原体覆盖面广,通过提供更多的病原体信息,可以有效辅助鉴别混合感染和耐药信息。
Objective Using targeted next-generation sequencing technology to explore the composition of the pathogenic spectrum of febrile respiratory syndrome ,analyze the epidemic characteristics of the pathogen,summarize the rules,and provide accurate guidance for the treatment strategy of patients with febrile respiratory syndrome．Methods By tNGS detection of 4039 cases with fever with respiratory diseases in four hospitals in Tianjin in 2023,pathogenic microorganisms were analyzed and identified,and the distribution of pathogenic microorganisms,age distribution,gender distribution,infection distribution in different times and seasons,and distribution trend of microbial types in different specimen types were studied．Results In 4039 cases,90 potential pathogens were detected,the total positive rate was 94.80%（3 829/4 039）,including 36 kinds of bacteria,29 kinds of viruses,5 kinds of atypical pathogen and 6 kinds of fungi．The order of detection frequency of different types of pathogens：G-bacteria > RNA virus > DNA virus > G+ bacteria > fungi > atypical pathogens．There was no significant difference in the positive rate of male and female between the two groups（χ2=0.249,P=0.618）．The pathogen spectrum of different age groups was heterogeneous． The positive patients were mostly distributed in 0-10 years old [47.90%（1 834/3 829）] and >60 years old [31.23%（1 196/3 829）]．Among the single infection,Mycoplasma pneumoniae accounted for the highest proportion,4.91%（188/3829）,followed by 2019-nCoV,1.59%（61/3 829）,and respiratory syncytial virus,1.23%（47/3 829）．There were differences in different infection types in different seasons,and the overall characteristics of mixed infection rate in summer and winter were high． In summer,the new coronavirus was combined with bacteria（Acinetobacter baumannii,Streptococcus pneumoniae）,and in winter,Mycoplasma pneumoniae was combined with influenza A and B viruses．The resistance rate of Mycoplasma pneumoniae to macrolides showed an increasing trend with the time．Conclusions The tNGS technology had obtained a high pathogen detection rate in the samples of febrile respiratory syndrome in Tianjin．By providing more pathogen information,it can be effectively applied to the etiological diagnosis of respiratory infectious diseases and assist in the identification of mixed infections and drug resistance information．
目的 分析不同年龄、不同季节河源市源城区呼吸道感染的病原学情况,指导临床用药。方法 回顾性研究2020年3月—2022年2月2 468例呼吸道感染的住院患儿,取咽部分泌物送广州达安临床检验中心进行呼吸道核酸六项检测并分析结果。包括：肺炎链球菌（Sp）、呼吸道合胞病毒（RSV）、卡他莫拉菌（MC）、流感嗜血杆菌（Hi）、肺炎支原体（LP）、腺病毒（ADV）。结果 （1）2 468例患儿的标本中阳性率52.8%,其中RSV最高,其他依次为Sp、Hi、MC、MP、ADV。而混合感染仅次于RSV。（2）婴儿组和幼儿组以RSV感染为主,在学龄前组和学龄组儿童中,以Sp感染为主,各病原体的混合感染组合很多,一种细菌合并一种病毒多见。（3）秋冬季是河源市源城区呼吸道感染的高发季节,RSV是秋冬季呼吸道感染最主要的病原体。结论 秋冬季节为河源市源城区呼吸道感染的高发季节,RSV为该季节的主要病原体。RSV也是婴幼儿组感染的主要致病菌,随着年龄增大,细菌感染导致的呼吸道疾病逐渐占优势。混合感染在各年龄组中均占比较高,值得临床诊疗的重视。
Objective To analyze the etiology of respiratory tract infection in Yuancheng District of Heyuan City ,which was in different ages and seasons,and to provide guidance of clinical drug usage．Methods Cases of 2 468 hospitalized children with respiratory tract infection from March 2020 to February 2022 were analyzed．The secretion from pharynx was collected and sent to Guangzhou Da’an Clinical Examination Center for six respiratory nucleic acid tests and then the results were analyzed,including Streptococcus pneumoniae（Sp）,respiratory syncytial virus（RSV）,Moraxella catarrhalis（MC）,Haemophilus influenzae（Hi）,Mycoplasma pneumonia（MP）,adenovirus（ADV）．Results The positive rate of 2 468 hospitalized children with respiratory tract infection was 52.8%,of which the highest was RSV,followed by Sp,Hi,MC,MP,ADV．Meanwhile the mixed infection rate was second to RSV．RSV infection was the main infection in infant group and early-aged children group,while in preschool group and school-aged group,Sp infection was the main infection．There were many mixed infection of pathogen,and one bacteria combined with one virus was more common．Respiratory tract infection had high incidence in autumn and winter in Yuancheng District of Heyuan City,RSV was the major pathogen．Conclusions Autumn and winter were the seasons with high respiratory tract infection incidence in Yuancheng District of Heyuan City,and RSV was the main pathogen in these two seasons．RSV was also the main pathogen of infant group infection．But with the increase of children’s age,bacterial infection became the main reason of respiratory tract diseases．Mixed infection accounts for a high proportion in all age groups,which should be valued in clinical diagnosis and treatment．
代谢综合征属于中医学“肥胖”“消渴”“脾瘅”等范畴,是以多种代谢异常在同一个体集结出现,包括肥胖、高血糖、血脂异常、高血压以及高尿酸血症等为表现的临床综合征。“浊毒”是由于脏腑功能失常,导致机体产生的生理、病理产物不能及时排出,蕴积体内而化生的致病因素。浊毒致病机体多有面色晦浊、腹胀满、小便浑浊、大便黏腻不爽、黄腻苔、滑数脉等表现。浊毒与代谢综合征的发病机制,在微观和宏观上具有对应性。文章从浊毒与代谢综合征的发病机制出发,对其临床治疗的共同点进行了综述。
Metabolic syndrome falls into the categories of obesity,diabetes and spleen disease in traditional Chinese medicine,and is manifested by various metabolic abnormalities in an individual,including obesity,hyperglycemia,dyslipidemia,hypertension and hyperuricemia. The turbid toxin is a pathogenic factor caused by visceral dysfunction,which leads to the accumulation of physiological and pathological wastes that fail to be eliminated from the body in time. People with turbid toxin are manifested by dull and cloudy complexion,abdominal distension,turbid urine,sticky stool,yellow greasy coating,slippery pulse,etc. The turbid toxin corresponds to the pathogenesis of metabolic syndrome at both micro and macro levels. This paper intends to explore the correlations between the turbid toxin and the pathogenesis of metabolic syndrome and make a review with relevant clinical treatment.
目的 分析高龄呼吸道感染患者病原菌检测结果及耐药性情况,总结高龄呼吸道感染患者抗菌药物的合理用药经验。方法 对我院2018年1月—2020年12月收治的784例高龄呼吸道感染患者痰液标本进行病原菌培养及药敏试验,统计分析检测结果。结果 701株病原菌中,革兰阴性(G-)菌、革兰阳性(G+)菌和真菌分别检出497株、136株和68株,分别占70.90%、19.40%和9.70%。G-菌以肺炎克雷伯菌、铜绿假单胞菌、大肠埃希菌和奇异变形杆菌为主,分别占21.97%(154株)、18.97%(133株)、14.98%(105株)和7.13%(50株),G+菌以金黄色葡萄球菌为主,占11.27%(79株)。G-菌耐药性前五位依次为氨苄西林、哌拉西林、复方磺胺甲噁唑、头孢唑啉和头孢他啶,耐药率依次为95.96%、85.11%、79.88%、77.06%和52.92%。G+菌耐药性前五位依次为青霉素、氨苄西林、红霉素、环丙沙星和复方磺胺甲噁唑,耐药率依次为95.59%、89.71%、84.56%、80.15%和75.00%。结论 高龄呼吸道感染患者病原菌构成以肺炎克雷伯菌、铜绿假单胞菌、大肠埃希菌、奇异变形杆菌和金黄色葡萄球菌为主,G-菌对氨苄西林、哌拉西林、复方磺胺甲噁唑、头孢唑啉和头孢他啶耐药最强,G+菌对青霉素、氨苄西林、红霉素、环丙沙星和复方磺胺甲噁唑最强,且呈多重耐药特征,加强临床耐药性监测有助于指导合理用药。
Objective To analyze the test results and drug resistance of pathogenic bacteria in elderly patients with respiratory tract infections, and summarize the rational use of antibiotics in elderly patients with respiratory tract infections. Methods The sputum samples of 784 elderly patients with respiratory tract infections admitted to our hospital from January 2018 to December 2020 were collected for pathogen culture and drug sensitivity test, and the test results were statistically analyzed. Results Among 701 strains of pathogenic bacteria, 497 strains were Gram-negative (G-) bacteria (70.90%), 136 strains were Gram-positive (G+) bacteria (19.40%) and 68 strains were fungi (9.70%). G-bacteria were mainly Klebsiellapneumoniae, Pseudomonas aeruginosa, Escherichia coli and Proteus mirabilis, accounting for 21.97% (154 strains), 18.97% (133 strains), 14.98% (105 strains) and 7.13% (50 strains). G+bacteria were mainly Staphylococcus aureus, accounting for 11.27% (79 strains). The top five antibiotics which G-bacteria resisted were ampicillin, piperacillin, compound sulfamethoxazole, cefazolin and ceftazidime.The resistance rates were 95.96%, 85.11%, 79.88%, 77.06% and 52.92%,respectively. The top five antibiotics which G+bacteria resisted were penicillin, ampicillin, erythromycin, ciprofloxacin and compound sulfamethoxazole, and the drug resistance rates were 95.59%, 89.71%, 84.56%, 80.15% and 75.00%, respectively. Conclusions The pathogenic bacteria in elderly patients with respiratory tract infections were mainly Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis and Staphylococcus aureus. G-bacteria resisted ampicillin, piperacillin,compound sulfamethoxazole, cefazolin and ceftazidime the most. G+bacteria were most resistant to penicillin, ampicillin, erythromycin, ciprofloxacin and compound sulfamethoxazole, and were characterized by multi-drug resistance.Enhancing bacterial resistance monitoring helps guiding the rational use of drugs.
目的 了解广东地区糖尿病足患者创面病原菌分布及耐药性变迁。方法 回顾性分析A组(2010年1月—2014年12月就诊的糖尿病足患者)和B组(2015年1月—2018年1月就诊的糖尿病足患者)研究者创面病原菌分布及耐药性变迁。结果 B组中创面G+菌及G-菌均有下降趋势且G-菌下降较快,细菌种类明显增加,真菌及混合感染明显上升,A组以金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌感染为主;B组以金黄色葡萄球菌、奇异变形杆菌、铜绿假单胞菌及真菌感染为主;B组相对于A组的细菌耐药性增加。结论 近年来糖尿病足患者病原菌种类明显增加且混合感染及真菌感染上升,且其耐药性增加,因此早期经验用药而后根据药敏选择抗菌药物治疗是糖尿病足感染治疗的关键。
Objective To investigate the distribution and drug resistance of pathogenic bacteria in diabetic foot wounds in Guangdong area. Methods Patients with diagnosis of diabetic foot between group A (from Jan 2010~Dec 2014 ) and group B (from Jan 2015 to Jan 2018) were retrospectively analyzed. We studied the bacteria distribution and drug resistance of pathogenic changes of group A and group B. Results In group B, both G+ and G- bacteria had a decreased trend while G- bacteria decreased rapidly, but the species of bacteria increased obviously just as fungi and mixed infection increased obviously. Bacteria infection in group A were mainly about Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli wihle group B were Staphylococcus aureus, Proteus mirabilis, Aeruginosa and Fungal infection; the resistance of group B to A was lower. Conclusion In recent years, kinds of pathogenic bacteria of diabetic foot were significantly increased and the mixed infection and increased fungal infection as well as its drug resistance increased, so the early experience of medication choice of antibiotics based on drug sensitivity and treatment are the key to the treatment of diabetic foot infection.
目的 探讨黏附因子E-钙粘蛋白(E-cadherin)和Toll样受体9(TLR9)在系统性红斑狼疮(SLE)发病机制中的作用。方法 随机选取SLE患者41例,健康对照组18例,采用酶联免疫吸附试验(ELISA)法检测血清中sE-cadherin的表达,采用流式细胞技术(FCM)检测外周血单核细胞上TLR9的表达。分析 sE-cadherin,TLR9与系统性红斑狼疮患者病情的活动性。结果 SLE组血清中sE-cadherin的表达水平高于正常组(P=0.00),差异有统计学意义;SLE活动组血清中sE-cadherin表达水平高于稳定组(P=0.06),但差异无统计学意义;SLE组TLR9表达高于健康组(P=0.00),活动组高于稳定期组(P=0.00),差异均有统计学意义;SLE患者TLR9表达与SLEDI呈正相关(r=0.727,P=0.00),差异有统计学意义。结论 血清中sE-cadherin和外周血单核细胞内TLR9均参与了SLE患者病情发展的过程,并且二者在SLE发病机制中可能具有协调作用。
Objective To explore the effect of adhesion molecule E-cadherin and Toll-like receptor-9(TLR9) in the pathogenesis of systemic lupus erythematosus(SLE). Methods 41 patients with SLE and 18 healthy controls were selected randomly.Expression of TLR9 in peripheral blood mononuclear cells determined by FCM. SE-cadherin levels were measured in the serum by ELISA analysis. The correlation between sE-cadherin、TLR9 and the patient's condition of SLE was analyzed. Results Compared with healthy subjects,the expression of sE-cadherin in serum was higher among SLE patients(P=0.00),there was statistically significant between two groups;activity group was higher than inactivity group and healthy controls(P=0.06),but there was no statistically significant between activity group and inactivity group. Compared with healthy subjects,the expression of TLR9 in peripherql blood mononuclear cells was higher among SLE patients(P=0.00);activity group was higher than inactivity group(P=0.00),there was all statistically significant between two groups.The positive correlation was observed between TLR9 expression levels and clinical measure of the SLEDAI(r=0.727,P=0.00),there was statistically significant between two groups. Conclusion SE-cadherin and TLR9 may play an important role in SLE,and may interact with each other which needed further study.
