目的 评价现有关于干预组仅涉及不同针具针刺或联合常规针刺治疗腰椎间盘突出症系统评价的方法学质量,以比较不同针具针刺治疗腰椎间盘突出症的治疗效果。方法 通过CNKI(中国知网)、万方数据库、VIP(维普)、PubMed、Web of Science等数据库以及其他相关电子资源,对诊断、治疗腰椎间盘突出症的多种针灸技术进行全面的研究。使用AMSTAR2软件,对所有参与的系统性评估结果进行地分析,并根据不同的检测结果,确定文献筛选标准。通过Revman5.4和Cochrance风险偏倚工具,以及Stata16.0的网格Meta分析,挑选了3 381个满足纳入排除要求的随机对照试验。结果 以Stata 16.0统计软件制作排序图可知,杵针+电针的临床有效率SUCRA=81.6%排名第一;目测类比评分显示,银质针SUCRA(用于评估疗效的指标)=95%,排名第一。结论 根据现有的研究证据,杵针+电针以及银质针优于其他9种干预措施,但确切的结果仍需要大量的随机对照试验来证明。
Objective To evaluate the methodological quality of the existing systematic evaluation of the intervention group involving only different needle sets of acupuncture or combined with conventional acupuncture in the treatment of lumbar disc herniation,in order to compare the therapeutic effect of different needle sets of acupuncture in the treatment of lumbar disc herniation.Methods Through CNKI,Wanfang database,VIP,PubMed,web of science and other databases as well as other relevant resources,a variety of acupuncture techniques for the diagnosis and treatment of lumbar disc herniation were comprehensively studied.Through the use of AMSTAR2 software,all participating systematic evaluation results were effectively analyzed,and according to different test results,which literature meets the requirements were determined.Through revman5.4,Cochrane risk bias tool,and grid meta-analysis of stata16.0,3 381 RCTs meeting the inclusion and exclusion requirements were selected.Results According to the ranking chart made by stata16.0 statistical software,the clinical effective rate of pestle needle + electroacupuncture ranked first with sucra=81.6%.According to the visual analogy score,the silver needle sucra=95%,ranking first.Conclusions According to the existing research evidence,pestle needle + electroacupuncture and silver needle are better than the other nine interventions,but the exact results still need a large number of randomized controlled trials to prove.
目的 探讨术中未恢复窦性心律需要行电复律的心房颤动(房颤)患者在清醒和镇静两种状态下的安全性及有效性。方法 选择2022年1月—2023年12月100例接受射频消融术中行同步直流电复律的持续性房颤患者进行研究,采用随机数字表法将患者分为观察组(清醒状态)和对照组(镇静状态),其中观察组和对照组各为50例。观察两组患者接受电复律的成功率、复发率和不良事件发生率(呼吸抑制、低血压、谵妄、肺水肿、心律失常)等指标。结果 观察组和对照组首次电复律成功分别有48、49例,成功率分别为96%、98%,组间比较差异无统计学意义(P=0.558)。观察组术后30 min内有2例复发,对照组术后30 min内无复发,组间比较差异无统计学意义(P=0.153)。在不良反应方面,观察组共发生1例心律失常事件,1例低血压事件,不良反应的总发生率为4%。对照组共发生3例呼吸抑制事件、2例谵妄事件、1例心律失常事件、2例低血压事件,不良反应的总发生率为16%,组间比较差异有统计学意义(P=0.046)。结论 对持续性房颤患者在射频消融术中,处于清醒状态下行电复律也具有良好的临床疗效,可以减少不良事件的发生,安全性更高。
Objective To compare the safety and efficacy of awake state and sedation state in patients with atrial fibrillation(AF)who did not recover sinus rhythm and needed electrical cardioversion during operation.Methods A total of 100 patients with persistent atrial fibrillation who underwent synchronous direct current cardioversion during radiofrequency ablation from January 2022 to December 2023 were selected and divided into the observation group(awake state)and the control group(sedation state)according to the random number table method,with 50 cases in each group.The success rate of electrical cardioversion,recurrence rate and incidence of adverse events(respiratory depression,hypotension,delirium,pulmonary edema,arrhythmia)were observed.Results The first electrical cardioversion was successful in 48 and 49 patients in the observation group and the control group,and the success rates were 96% and 98%,respectively.There was no significant difference between the two groups(P=0.558).There were 2 cases of recurrence in the observation group and no recurrence in the control group within 30 minutes after operation,and there was no significant difference between the two groups(P=0.153).In terms of adverse reactions,there were 1 case of arrhythmia event and 1 case of hypotension event in the observation group,and the total incidence of adverse reactions was 4%.There were 3 cases of respiratory depression events,2 cases of delirium events,1 case of arrhythmia events,and 2 cases of hypotension events in the control group.The total incidence of adverse reactions was 16%,and the difference between the two groups was statistically significant(P=0.046).Conclusions Electrical cardioversion in awake state during radiofrequency ablation of persistent atrial fibrillation has a good clinical efficacy and safety,which can reduce the occurrence of adverse events.
目的 分析谷草转氨酶(AST)、胆碱酯酶(CHE)、糖类抗原125(CA125)以及甲胎蛋白(AFP)对肝硬化患者的诊断效能。方法 选择70例肝硬化患者为观察组研究对象,另取70例同期健康体检者为对照组。两组研究对象均接受生化检验、肿瘤标志物检验。对比两组研究对象的AST、CHE、CA125、AFP检测结果,分析上述指标对肝硬化患者的诊断效能。结果 观察组肝硬化患者的CHE低于对照组,AST、CA125与AFP高于对照组(P<0.05);AST与CHE在肝硬化诊断中具有良好的灵敏度、特异度;CA125联合AFP的灵敏度、特异度、符合率均高于CA125或AFP单独检验(P<0.05)。结论 AST、CHE、CA125、AFP在肝硬化患者临床诊断中具有良好的应用表现,是反映患者肝硬化病情进展的重要参考指标。
Objective To analyze the diagnostic efficacy of aspartate aminotransferase(AST),cholinesterase(CHE),carbohydrate antigen 125(CA125),and alpha fetoprotein(AFP)in patients with liver cirrhosis.Methods A total of 70 patients with liver cirrhosis were included in the observation group as the study subjects,and 70 healthy individuals who underwent physical examinations during the same period were selected as the control group.Both groups of research subjects underwent biochemical testing and tumor marker testing.The AST,CHE,CA125,and AFP detection results of two groups of research subjects were compared,and the diagnostic effect of the above indicators on patients with liver cirrhosis were analyzed.Results The CHE test results of patients with liver cirrhosis in the observation group were significantly lower than those of healthy individuals undergoing physical examination,and the AST,CA125,and AFP test results were higher(P<0.05).AST and CHE had good sensitivity and specificity in the diagnosis of liver cirrhosis.The sensitivity,specificity and coincidence rate of CA125 combined with AFP were higher than those of CA125 or AFP alone.Conclusions AST,CHE,CA125,and AFP have good clinical application performance in the diagnosis of liver cirrhosis patients,and are important reference indicators reflecting the progression of liver cirrhosis in patients.