论著

新型穿戴式气压治疗仪预防深静脉血栓的非劣效性临床研究

Evaluation of new type of wearable pneumatic compression pump in prevention of deep vein thrombosis:A non-inferiority study

:1663-1668
 
       目的   评价新型穿戴式气压治疗仪预防深静脉血栓的临床疗效及安全性。方法   将156例脑梗死患者随机分为对照组和试验组,各78例。试验组使用新型穿戴式气压治疗仪(邦普医疗/VW100)进行气压治疗。对照组使用韩国元金压力治疗仪进行气压治疗。两组疗程均为10 d,观察临床疗效及安全性,比较两组深静脉血栓形成率、医护人员和患者的使用满意度。结果   治疗10 d后,试验组与对照组深静脉血栓未发生率差值为1.2%,相应的95%置信区间为–5.3%~7.9%,下限高于–10%,医护人员和患者对试验组的评价优于对照组(P<0.001)。结论   新型穿戴式气压治疗仪预防深静脉血栓形成的临床疗效不劣于市面上已有的气压治疗仪,治疗过程中未见明显不良反应,临床使用安全有效。
        Objective  To  evaluate the  effectiveness  and  safety  of  new wearable  pneumatic  compression  pump in preventing deep vein thrombosis.Methods  One hundred and fifty-six patients with cerebral infarction were randomly divided into control and study group with 78 cases in each group.Study group was treated with the new wearable pneumatic compression pump(Bangpu Medical / VW100).Control group was treated with pneumatic compression pump(Wonjin-POWER).The course of both groups was 10 days,comparing the deep vein thrombosis  rate and useage satisfaction of patients and staffs between the two groups.Results  After 10 days of treatment,the difference between the incidence of deep venous thrombosis in the study and control group was 1.2%.The corresponding 95% confidence interval was(-5.3%,7.9%),and the lower limit was greater than -10%.The appraisal from medical staffs and the patients of study group was better than that of the control group(P<0.001).Conclusions  The clinical effect of the new wearable pneumatic compression pump to prevent deep vein thrombosis is not inferior to the existing pneumatic compression pump,which clinical practice experience is better.There is no obvious adverse reactions in the treatment process,and the clinical practice is also safe and effective.
论著

血红蛋白水平对上肢骨折患者深静脉血栓形成的影响

Influence of hemoglobin level on deep vein thrombosis in patients with upper extremity fracture

:64-69
 
目的 分析血红蛋白水平对上肢骨折患者深静脉血栓形成(DVT)的影响。方法 采用回顾性分析法,对2018年1月—2021年6月期间来我院进行治疗的386例上肢骨折患者展开研究,依据患者是否发生DVT分为DVT组(n=114)和对照组(n=272)。对2组患者的各项一般资料和临床资料进行比较,对有统计学意义的因素进一步行Logistic多因素回归分析,探究上肢骨折患者发生DVT的危险因素,并Pearson分析血红蛋白水平与各危险因素的相关性。结果 与对照组相比,DVT组患者为女性、年龄>60岁、体质量指数(BMI)>25 kg/m2、冠状动脉粥样硬化性心脏病、糖尿病、合并其他骨折、受伤至超声检查时间≥3 d、受伤至手术时间>5 d、纤维蛋白降解产物(FDP)≥35 mg/L、凝血酶时间(TT)≥17 s、血红蛋白≤120 g/L、血小板计数/血红蛋白比值≥2.5、血糖≥8 mmol/L、全身麻醉、术后住院时间<7 d的发生率升高,差异有统计学意义(P<0.05)。Logistic多因素回归分析显示,年龄>60岁、BMI>25 kg/m2、受伤至手术时间>5 d、血红蛋白≤120 g/L、血小板计数/血红蛋白比值≥2.5、血糖≥8 mmol/L是上肢骨折患者发生DVT的危险因素(P<0.05)。上肢骨折患者的血红蛋白水平与年龄、BMI、受伤至手术时间、血小板计数/血红蛋白比值、血糖水平呈现负相关(P<0.05)。结论 血红蛋白≤120 g/L是上肢骨折患者发生DVT的危险因素,与DVT的发生存在相关性。
Objective To analyze the influence of hemoglobin level on deep vein thrombosis (DVT) in patients with upper extremity fractures. Methods A retrospective study of 386 upper extremity fracture patients who came to our hospital for treatment from January 2018 to June 2021 was carried out.According to whether the patients had DVT or not, they were divided into DVT group (n=114) and control group (n=272).The general data and clinical data of the two groups were compared, and the statistically significant factors were further analyzed by Logistic multivariate regression analysis to explore the risk factors of DVT in patients with upper limb fractures, and analyzed the hemoglobin level and the risk factors correlation by Pearson. Results Compared with the control group, the DVT group had increased incidence in female, age >60 years old, body mass index (BMI) >25 kg/m2, coronary heart disease, diabetes mellitus, other fractures, injury to ultrasonic time ≥3 days, injury to operation time >5 days, fibrin degradation products (FDP) ≥35 mg/L, thrombin time (TT) ≥ 17 s, hemoglobin ≤120 g / L, platelet count / hemoglobin ratio ≥2.5, blood glucose ≥8 mmol/L, general anesthesia and postoperative hospital stay <7 days, and the difference was significant (P<0.05).Logistic multivariate regression analysis showed that age>60, BMI>25 kg/m2, time from injury to operation>5 days, hemoglobin≤120 g/L, platelet count/hemoglobin ratio ≥2.5, blood glucose ≥8 mmol/L were the risk factors of DVT in patients with upper extremity fractures (P<0.05).The hemoglobin level of those patients was negatively correlated with age, BMI, time from injury to operation, platelet count/hemoglobin ratio and blood glucose level (P<0.05). Conclusions Hemoglobin ≤120 g/L was a risk factor for DVT in patients with upper extremity fractures, and it was related to the occurrence of DVT.
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