NLR、PLR、MLR与冠状动脉疾病严重程度的相关性分析

来源期刊：广州医药 | 30-35 发布时间：2023-12-12 收稿时间：2025/11/13 18:29:10 阅读量：27

作者：: 罗寒玉,

冯俊,

曹瑞,

王本龙,

关键词：: 急性冠脉综合征中性粒细胞-淋巴细胞比值（NLR）血小板-淋巴细胞比值（PLR）单核细胞-淋巴细胞比值（MLR）Gensini评分; acute coronary syndrome NLR PLR MLR Gensini score

DOI：: 10.3969/j.issn.1000-8535.2023.11.005

收稿时间：: 2023-04-24
修订日期：
接收日期：
引用总数：: 3

目的探讨接受冠状动脉造影患者的中性粒细胞-淋巴细胞比值（NLR）、血小板-淋巴细胞比值（PLR）和单核细胞-淋巴细胞比值（MLR）与冠状动脉疾病（CAD）严重程度的关系。方法收集2021年1月—2021年12月在六安市人民医院接受冠状动脉造影的150例急性冠脉综合征（ACS）患者。CAD的严重程度通过Gensini评分进行评估,150例ACS患者根据评分被分为轻度病变组（≤14分,41例）、中度病变组（15~47分,69例）和重度病变组（≥48分,40例）。比较3组的临床指标,采用相关统计学分析NLR、PLR、MLR与CAD严重性（Gensini评分）的相关性。结果纳入研究的150例患者的平均年龄为（66.49±11.43）岁,男性占67.3%。在重度病变组,NLR和PLR值高于其他两组。在Pearson相关性检验中,Gensini评分与NLR呈正相关（r=0.319,P<0.001）,然而,Gensini评分与MLR、PLR之间无相关性（P>0.05）。在Logistic回归分析中,NLR（OR：1.306,95%CI：0.107~0.427）是CAD的独立危险因素。在ROC曲线分析中,发现NLR的曲线下面积最高,为0.723（95%CI：0.629~0.817,P<0.001）,NLR≥0.25为识别CAD存在的最佳临界值,灵敏度为78.49%,特异度为60.26%。结论根据Gensini评分,NLR与CAD的严重程度呈正相关,而研究中未观察到MLR、PLR与CAD严重程度之间的关联。

1、 LI X T,FANG H,LI D,et al.Association of platelet to lymphocyte ratio with in-hospital major adverse cardiovascular events and the severity of coronary artery disease assessed by the Gensini score in patients with acute myocardial infarction[J].China Med J(Engl),2020,133(4):415-423.

2、 JI H,LI Y,FAN Z,et al.Monocyte/lymphocyte ratio predicts the severity of coronary artery disease:A syntax score assessment[J].BMC Cardiovasc Disord,2017,17(1):90.

3、 BIKASH N,JEET P G,BIPLAVE K,et al.Relation of neutrophil-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography[J].Nepalese Heart Journal,2022,19(1):1-6.

4、 LIAO J,WEI D,SUN C,et al.Prognostic value of the combination of neutrophil to lymphocyte ratio,monocyte-to-lymphocyte ratio and platelet-to-lymphocyte ratio on mortality in patients on maintenance hemodialysis[J].BMC Nephrol,2022,23(1):393.

5、 CHEN H,LI M,LIU L,et al.Monocyte/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients with non-ST-elevation myocardial infarction[J].Medicine(Baltimore),2019,98(26):e16267.

6、 HATMI Z N,SAEID A K,BROUMAND M A,et al.Multiple inflammatory prognostic factors in acute coronary syndromes:A prospective inception cohort study[J].Acta Med Iran,2010,48(1):51-57.

7、 FREITAS I A,LIMA N A,SILVA G B D J R,et al.Novel biomarkers in the prognosis of patients with atherosclerotic coronary artery disease[J].Rev Port Cardiol(Engl Ed),2020,39(11):667-672.

8、 GILANI S T A,KHAN D A,RAUF A,et al.Early diagnosis of coronary artery disease by inflammatory biomarkers of atherosclerosis in patients with angina[J].J Interferon Cytokine Res,2022,42(9):493-500.

9、 OKEKE C,AMILO G,IFEANYICHUKWU M,et al.Longitudinal assessment of the impact of tuberculosis infection and treatment on monocyte-lymphocyte ratio,neutrophil-lymphocyte ratio,and other white blood cell parameters[J].Egypt J Haematol,2020,45(2):97.

10、 LIU Z,LI Y,WANG Y,et al.The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with the severity of autoimmune encephalitis[J].Front Immunol,2022(13):911779.

11、 NISHIJIMA T F,MUSS H B,SHACHAR S S,et al.Prognostic value of lymphocyte to monocyte ratio in patients with solid tumors:a systematic review and meta-analysis[J].Cancer Treat Rev,2015,41(10):971-978.

12、 NEOFYTOU K,SMYTH E C,GIAKOUSTIDIS A,et al.The preoperative lymphocyte-to-monocyte ratio is prognostic of clinical outcomes for patients with liver-only colorectal metastases in the neoadjuvant setting[J].Ann Surg Oncol,2015,22(13):4353-4362.

13、 KOUNIS N G,SOUFRAS G D,TSIGKAS G,et al.White blood cell counts,leukocyte ratios,and eosinophils as inflammatory markers in patients with coronary artery disease[J].Clin Appl Thromb Hemost,2015,21(2):139-143.

14、 KRE?AK I,LUCIJANI? M.Platelet-to-lymphocyte ratio and accelerated atherosclerosis in essential thrombocythemia and polycythemia vera[J].Nutr Metab Cardiovasc Dis,2022,32(8):2010-2011.

15、 BALAJI S,ROBINSON C,YALAMURU S,et al.Role of neutrophil-lymphocyte ratio and mean platelet volume in the outcome of atherosclerotic peripheral vascular disease interventions[J].Indian J Vas Endo Surg,2022,9(3):236.

16、 ALIE N,ELDIB M,FAYAD Z A,et al.Inflammation,atherosclerosis,and coronary artery disease:PET/CT for the evaluation of atherosclerosis and inflammation[J].Clin Med Insights Cardiol,2015,8(Suppl 3):13-21.

17、 CHEN H,LI M,LIU L,et al.Monocyte/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients with non-ST-elevation myocardial infarction[J].Medicine(Baltimore),2019,98(26):e16267.

18、 ZHOU D,WANG G,FAN Y,et al.Platelet to lymphocyte ratio is associated with the severity of coronary artery disease and clinical outcomes of percutaneous coronary intervention in the Chinese Han population[J].Experimental and therapeutic medicine,2017,13(2):731-738.

19、 LI X,JI Y,KANG J,et al.Association between blood neutrophil-to-lymphocyte ratio and severity of coronary artery disease:Evidence from 17 observational studies involving 7017 cases[J].Medicine(Baltimore),2018,97(39):e12432.

20、 BAHRAMI H,BUDOFF M,HABERLEN S A,et al.Inflammatory markers associated with subclinical coronary artery disease:The multicenter AIDS cohort study[J].J Am Heart Assoc,2016,5(6):e003371.

21、 HAMMAMI,ZRIBI S,KOUBAA N,et al.Relationship between inflammatory markers with the presence and severity of coronary artery disease[J].Arch Card Dis Suppl,2018,10(1):117.

22、 FURLONGMILLONES M R,MOSTACEROBECERRA K,AGUIRREMILACHAY E,et al.Quality of life,anxiety,and depression in peruvian patients with acute coronary syndrome[J].Sustainability,2022,14(22):14970.

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