川崎病冠脉损伤与血清1,25(OH)2D3水平关系

来源期刊：广州医药 | 18-21 发布时间：2022-11-30 收稿时间：2025/11/13 18:14:08 阅读量：106

作者：: 陈艳丽,

关键词：: 川崎病冠脉损伤 1 25 (OH)2D3; Kawasaki disease coronary artery lesion 1 25 (OH)2D3

DOI：: 10.3969/j.issn.1000-8535.2022.06.004

收稿时间：: 2021-11-25
修订日期：
接收日期：
引用总数：: 0

目的通过测定川崎病(KD)患儿血清1,25(OH)₂D₃水平,探讨其与冠脉损伤(CAL)之间的关系。方法选取在我院儿科住院的KD患儿200例,依据是否发生CAL分成CAL组(172例)和非冠脉损伤组(NCAL,28 例),并分别检测静脉内丙种球蛋白(IVIG)注射前后血清1,25(OH)₂D₃水平。选取35例健康儿童作为对照组,检测其血清1,25(OH)₂D₃水平,并进行比较。结果 IVIG输注前:CAL组和NCAL组血清1,25(OH)₂D₃水平较对照组低下(P＜0.05),CAL组最低(P＜0.05);IVIG输注后:NCAL组血清1,25(OH)₂D₃水平与对照组相比,差异无统计学意义(P＞0.05),CAL组血清1,25(OH)₂D₃水平较NCAL组和对照组低(P＜0.05);IVIG输注前后比较:CAL组和NCAL组血清1,25(OH)₂D₃水平在IVIG输注后均较输注前升高(P<0.001)。结论 KD患儿血清1,25(OH)₂D₃水平低下,而且血清1.25(OH)₂D₃水平越低,出现CAL的几率越大。

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