Objective To investigate the clinical effect of comprehensive prosthodontics in the treatment of cracked teeth, and to provide reference for the treatment of cracked teeth. Methods Fifth-two patients with cracked teeth in our hospital from January 2019 to December 2020 were randomly divided into control group (n=26) and observation group (n=26). The control group was treated with conventional treatment, and the observation group was treated with oral comprehensive repair technology. The clinical efficacy, SF-36 score, masticatory function score and the time for symptoms to subside of each group were evaluated. Results The total effective rate of the observation group was 96.15%, which was lower than 76.92% of control group(P<0.05); the pain score of the observation group after the intervention was lower than that of the control group (P<0.05); the tooth surface crack regression time, hot and cold stimulation regression time, masticatory pain regression time of the observation group were shorter than those of the control group (P<0.05). Conclusion Comprehensive prosthodontics treatment for cracked teeth can obtain exact curative effect and help to relieve clinical symptoms.