您的位置: 首页 > 2021年9月 第52卷 第5期 > 文字全文
2023年7月 第38卷 第7期11
目录

肝硬化患者临床凝血功能检验中全自动血凝仪测定的应用及临床价值研究

Study on the application and clinical value of automatic blood coagulation apparatus in clinical coagulation function test of patients with cirrhosis

来源期刊: 广州医药 | 69-72 发布时间:2021-11-24 收稿时间:2025/11/13 18:03:27 阅读量:21
作者:
关键词:
肝硬化凝血功能全自动血凝仪临床价值
cirrhosiscoagulation functionautomatic blood coagulation instrumentclinical value
DOI:
10.3969/j.issn.1000-8535.2021.05.014
收稿时间:
2021-03-01 
修订日期:
 
接收日期:
 
引用总数:
0  
目的 探讨肝硬化患者临床凝血功能检验中全自动血凝仪测定的应用及临床价值。方法 选取2018年1月—2020年1月我院收治的64例肝硬化患者(肝硬化组),并纳入同期来我院接受健康体检者64例(对照组),应用全自动血凝仪对肝硬化患者临床凝血指标检测。再将肝硬化组患者分为出血组与无出血组,比较对照组与肝硬化组、出血与无出血组、不同肝功能分级患者血小板参数与PT检测结果。结果 与对照组比较,肝硬化组PDW、PT、MPV、INR水平更高,PCT、PLT水平更低(P<0.05);与肝硬化无出血组比较,肝硬化出血组PDW、PT、MPV、INR水平更高,PCT、PLT水平更低(P<0.05);与Child-Pugh A级患者比较,肝硬化Child-Pugh B级与C级患者PDW、PT、MPV、INR水平更高,PCT、PLT水平更低(P<0.05)。结论 在肝硬化患者病情评价中凝血功能检验发挥重要作用,可为患者临床治疗提供有效理论依据,诊断准确率较高,有利于临床治疗措施制定。因此,凝血功能检验应在肝硬化疾病诊断中广泛应用。
Objective To explore the application and clinical value of automatic blood coagulation apparatus in clinical coagulation function test of patients with cirrhosis. Methods A total of 64 patients with cirrhosis admitted to our hospital from January 2018 to January 2020 (cirrhosis group) were selected, and 64 healthy subjects admitted to our hospital during the same period (control group) were included. The clinical coagulation indexes of patients with cirrhosis were detected by automatic blood coagulation apparatus. Patients in cirrhosis group were divided into bleeding group and non-bleeding group; platelet parameters and PT test results were compared between control group and cirrhosis group, bleeding group and non-bleeding group, and patients with different liver function grades. Results Compared with the control group, the levels of PDW, PT, MPV and INR in cirrhosis group were higher, and the levels of PCT and PLT were lower (P<0.05). Compared with liver cirrhosis non-bleeding group, the levels of PDW, PT, MPV and INR were higher in liver cirrhosis with bleeding group, and the levels of PCT and PLT were lower (P<0.05). Compared with Child-Pugh A patients, the levels of PDW, PT, MPV and INR in Child-Pugh B and C patients with cirrhosis were higher, and the levels of PCT and PLT were lower (P<0.05). Conclusion The test of coagulation function plays an important role in the evaluation of patients with cirrhosis, and can provide effective theoretical basis for the clinical treatment of patients with high diagnostic accuracy, which is conducive to the formulation of clinical treatment measures. Therefore, the test of coagulation function should be widely used in the diagnosis of cirrhosis.
1、 邹珍珍,王坤,何璐,等.异常凝血酶原和甲胎蛋白联合检测在原发性肝癌中的临床价值[J].检验医学与临床,2019,16(12):1771-1773. 邹珍珍,王坤,何璐,等.异常凝血酶原和甲胎蛋白联合检测在原发性肝癌中的临床价值[J].检验医学与临床,2019,16(12):1771-1773.
2、 RASHVAND S, MOBASSERI M, TARIGHAT-ESFANJANI A. Effects of choline and magnesium concurrent supplementation on coagulation and lipid profile in patients with type 2 diabetes mellitus: a pilot clinical trial[J]. Biol Trace Elem Res, 2020, 194(2):328-335. RASHVAND S, MOBASSERI M, TARIGHAT-ESFANJANI A. Effects of choline and magnesium concurrent supplementation on coagulation and lipid profile in patients with type 2 diabetes mellitus: a pilot clinical trial[J]. Biol Trace Elem Res, 2020, 194(2):328-335.
3、 林艺芬.肝功能生化指标应用在肝炎肝硬化患者中的临床研究[J/OL].临床检验杂志(电子版),2019,8(4):67-68. doi: CNKI: SUN: LNJI.O.2019-04-045. 林艺芬.肝功能生化指标应用在肝炎肝硬化患者中的临床研究[J/OL].临床检验杂志(电子版),2019,8(4):67-68. doi: CNKI: SUN: LNJI.O.2019-04-045.
4、 李秀玉,刘畅,宿占军.原发性肝癌疾病中血清AFP,NGAL与Fbg联合检测的诊断意义研究[J].现代医学,2019,47(2):165-170. 李秀玉,刘畅,宿占军.原发性肝癌疾病中血清AFP,NGAL与Fbg联合检测的诊断意义研究[J].现代医学,2019,47(2):165-170.
5、 BERTSCH T, BEHRINGER W, BLASCHKE S, et al. Diagnostic accuracy of the tina-quant d-dimer gen.2 assay with age-adjusted cut-off ranges for evaluation of patients with suspected deep vein thrombosis or pulmonary embolism[J]. Blood, 2020, 136(1):14-15. BERTSCH T, BEHRINGER W, BLASCHKE S, et al. Diagnostic accuracy of the tina-quant d-dimer gen.2 assay with age-adjusted cut-off ranges for evaluation of patients with suspected deep vein thrombosis or pulmonary embolism[J]. Blood, 2020, 136(1):14-15.
6、 汪道伟,黄辉红,李冰,等.血清PCT、CRP、IL-8和IL-10联合检测在诊断肝硬化合并腹水感染中的临床应用[J].陕西医学杂志,2019,48(3):397-400. 汪道伟,黄辉红,李冰,等.血清PCT、CRP、IL-8和IL-10联合检测在诊断肝硬化合并腹水感染中的临床应用[J].陕西医学杂志,2019,48(3):397-400.
7、 王天昊,高永俊一,侯润宇,等.PCT和CRP及外周血WBC水平对预测肝硬化并发感染性休克的临床价值[J].贵阳医学院学报,2019,44(12):1443-1447. 王天昊,高永俊一,侯润宇,等.PCT和CRP及外周血WBC水平对预测肝硬化并发感染性休克的临床价值[J].贵阳医学院学报,2019,44(12):1443-1447.
8、 ZHENG K, YOSHIDA E M, TACKE F, et al. Risk of stroke in liver cirrhosis: a systematic review and meta-analysis[J]. J Clin Gastroenterol, 2020, 54(1):96-105. ZHENG K, YOSHIDA E M, TACKE F, et al. Risk of stroke in liver cirrhosis: a systematic review and meta-analysis[J]. J Clin Gastroenterol, 2020, 54(1):96-105.
9、 郑震,徐光武,姚濛.肝纤维化四项指标检测对肝硬化诊断及肝功能评估的价值[J].医学临床研究,2020,37(1):141-143. 郑震,徐光武,姚濛.肝纤维化四项指标检测对肝硬化诊断及肝功能评估的价值[J].医学临床研究,2020,37(1):141-143.
10、 曹曦,张莹,南月敏,等.血清N-糖组诊断模型在丙型肝炎患者肝纤维化评价中的应用[J].中华肝脏病杂志,2020,28(12):1023-1029. 曹曦,张莹,南月敏,等.血清N-糖组诊断模型在丙型肝炎患者肝纤维化评价中的应用[J].中华肝脏病杂志,2020,28(12):1023-1029.
11、 肖慧娟,叶青,张明,等.肝硬化合并肌肉减少症的危险因素及其对临床结局的影响[J].中华肝脏病杂志,2020,28(1):53-57. 肖慧娟,叶青,张明,等.肝硬化合并肌肉减少症的危险因素及其对临床结局的影响[J].中华肝脏病杂志,2020,28(1):53-57.
12、 王沛,林连珍,陈克金,等.一种全自动血凝仪在人凝血因子Ⅷ浓缩剂效价检测中的应用[J].中国输血杂志,2020,33(1):80-82. 王沛,林连珍,陈克金,等.一种全自动血凝仪在人凝血因子Ⅷ浓缩剂效价检测中的应用[J].中国输血杂志,2020,33(1):80-82.
13、 翟相威,刘树红,姚明解,等.基于血清高尔基体蛋白73的代偿期乙型肝炎肝硬化无创诊断模型的建立及初步应用[J].中华肝脏病杂志,2020,28(1):47-52. 翟相威,刘树红,姚明解,等.基于血清高尔基体蛋白73的代偿期乙型肝炎肝硬化无创诊断模型的建立及初步应用[J].中华肝脏病杂志,2020,28(1):47-52.
14、 李贝贝,张光文.脾动脉栓塞术对肝硬化脾功能亢进患者凝血功能的影响[J].中国现代医学杂志,2019,29(10):54-58. 李贝贝,张光文.脾动脉栓塞术对肝硬化脾功能亢进患者凝血功能的影响[J].中国现代医学杂志,2019,29(10):54-58.
15、 叶放,周静汶,皇金萍,等.肝硬化湿热瘀毒郁结复合病机的理论及临床应用研究[J].南京中医药大学学报,2020,36(6):12-15. 叶放,周静汶,皇金萍,等.肝硬化湿热瘀毒郁结复合病机的理论及临床应用研究[J].南京中医药大学学报,2020,36(6):12-15.
上一篇
下一篇
出版者信息








《广州医药》公众号
目录