晚期胰腺癌超级伽玛刀治疗的临床研究

来源期刊：广州医药 | 62-65 发布时间：2021-11-28 收稿时间：2025/11/13 17:39:40 阅读量：15

作者：: 宋长龙,

汪金锋,

张军,

罗晓蓉,

李勇,

蔡永广,

黄瑞文,

陈焕伟,

李太东,

康静波,

关键词：: 胰腺癌伽马刀生存质量副作用; Pancreatic cancer Gamma knife Quality of life Side effects

DOI：: 10.3969/j.issn.1000-8535.2020.06.013

收稿时间：: 2020-04-11
修订日期：
接收日期：
引用总数：: 0

目的探讨晚期胰腺癌超级伽玛刀治疗的临床效果。方法选取2015年1月—2019年1月我院收治的晚期胰腺癌患者46例,随机分为对照组(23例)与观察组(23例),对照组接受单纯化疗治疗,观察组患者接受超级伽玛刀方案治疗。收集两组患者的治疗有效率、生存时间的临床受益反应(CBR)等指标,进行对比分析。结果接受不同治疗措施干预1个月后,对两组患者治疗总有效率进行比较。观察组患者治疗总有效率为60.87%,高于对照组患者治疗总有效率13.04%(P＜0.01)。观察组患者中疼痛程度改善阳性人数比例、KPS体力改善阳性人数比例和体质量改善阳性人数比例均高于对照组患者(P＜0.05),但两组患者镇痛药物消耗量改善阳性人数比例差异并无统计学意义(P＞0.05)。观察组患者无进展生存期中位时间为4个月(95%CI,2.124±5.274),对照组患者无进展生存期中位时间为3个月(95%CI,1.804±4.851)。观察组患者无进展生存期中位时间长于对照组患者(P=0.042＜0.05)。结论基于立体定向伽马射线全身治疗系统的超级伽玛刀采用中等剂量分割方法治疗晚期胰腺癌,其临床效果切实,副作用相对较低,对患者生存治疗有明显提升效果,值得临床推广。

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