目的 调查老年脆性骨折患者术前衰弱现况,并分析影响因素。方法 采用便利抽样法, 2024年11月—2025年3月, 选取于广州市某三甲医院骨科住院的207例老年脆性骨折患者, 使用一般资料调查表、简易衰弱评估量表、简版流调中心抑郁量表、广泛性焦虑量表和营养风险筛查量表2002开展问卷调查。采用有序分类Logistic回归, 分析老年脆性骨折患者术前衰弱的影响因素。结果 207例老年脆性骨折患者的术前衰弱前期占48.3%, 衰弱发生率为23.2%。有序分类Logistic 回归分析结果显示年龄（OR=1.131）、睡眠差（OR=2.557）、合并3种及以上慢性病（OR=3.990）、抑郁（OR=3.296）、营养不良风险（OR=4.005）为老年脆性骨折患者术前衰弱的危险因素,BMI正常（OR=0.206）是保护因素（均P<0.05）。结论 老年脆性骨折患者年龄, 睡眠情况, 多种共病,抑郁, 存在营养不良风险及BMI影响其术前衰弱水平, 重视衰弱的筛查及早期干预, 提升患者治疗效果和生活质量。

       Objective To explore the preoperative frailty status and influencing factors in elderly patients with osteoporotic fractures．Methods Using convenience sampling, 207 elderly patients with osteoporotic fractures admitted to the orthopedic department of a tertiary hospital in Guangzhou from November 2024 to March 2025 were selected．Data were collected using a general information questionnaire, the Frail Scale, the 10-item Center for Epidemiologic Studies Depression Scale（CES-D-10）, the Generalized Anxiety Disorder Scale（GAD-7）, and the Nutritional Risk Screening 2002（NRS-2002）．Logistic regression was used to analyze factors influencing preoperative frailty．Results Among 207 elderly patients with osteoporotic fractures, the incidence of early stages of frailty was 48.3%, and the incidence of frailty was 23.2%．Logistic regression analysis revealed the following risk factors for preoperative frailty：age（OR=1.131）, poor sleep quality（OR=2.557）, multiple chronic comorbidities（OR=3.990）, depression（OR=3.296）, nutritional risk（OR=4.005）．Normal body mass index（OR=0.206）was a protective factor．Conclusions Advanced age,poor sleep quality, multiple chronic comorbidities, depression, nutritional risk and body mass index are associated with frailty in elderly osteoporotic fracture patients．Health care providers should pay attention to frailty screening and early intervention, which can reverse or delay the progression of frailty and improve the treatment effect and quality of life of patients．

目的 研究富血小板血浆联合强骨胶囊对大鼠骨质疏松性骨折骨愈合的影响。方法 80只未交配、3月龄雌性健康SD大鼠作为研究对象,将以上大鼠分为空白组(K组)、PRP组(P组)、强骨胶囊组(Q组),联合组(L组),每组大鼠20例,分析四组大鼠的骨痂显微形态、组织形态学以及生物力学指标之间的差异。结果 经过两两比较,联合用药组患者的骨小梁体积、数量、厚度、连接密度高于单独用药组,分离度、表面积体积比低于对照组(P＜0.05);联合用药组患者的最大载荷、结构能量吸收、材料最大应力、材料能量吸收高于单独用药组;经过两两比较,联合用药组患者的骨架面积及软骨或骨性骨痂面积比高于单独用药组。结论 富血小板血浆联合强骨胶囊通过对骨折部位骨质密度以及骨质强度的增强,大鼠骨质疏松性骨折骨愈合情况良好。

Objective To study the effect of platelet rich plasma combined with Qianggu capsule on osteoporotic fracture healing in rats. Methods 80 unmatched and 3-month-old female healthy SD rats were divided into blank group (group K),PrP group (group P),Qianggu capsule group (group Q),combined group (group L) and 20 rats in each group. The differences of callus morphology,histomorphology and biomechanical indexes among the four groups were analyzed. Results After comparing the two groups,the volume,quantity,thickness and connection density of trabecula in the combined group were higher than those in the single drug group,and the separation and surface area volume ratio were lower than those in the control group (P< 0.05); the maximum load,structural energy absorption,material maximum stress and material energy absorption in the combined group were higher than those in the single group; after comparing the two groups,in the combined group,skeleton area and area ratio of cartilage or osteotylus in the treatment group were higher than that in single-drug group. Conclusion Platelet rich plasma combined with Qianggu capsule may enhance the bone density and bone strength of the fracture site,and the osteoporotic fracture healing in rats is good.