Hepatitis E virus(HEV)is an important pathogen that causes acute hepatitis.Some HEV-infected individuals
may progress to liver failure.In addition,chronic infection(including liver fibrosis and cirrhosis)and extrahepatic manifestations can also occur in HEV infection.Worldwide,there are 20 million cases of HEV infection each year,with 3.3 million cases presenting clinical symptoms related to hepatitis,and an annual death toll of approximately 44,000(data from 2015).In China,HEV mainly present as sporadic outbreaks.In recent years,there has been significant progress in the pathogenesis,epidemiology,clinical diagnosis and treatment,and prevention of HEV.This review aims to summarize and analyze the current hotspots and new developments in the prevention and treatment of HEV.