目的 探讨CAl99在T2DM患者与健康人群中的差异及CAl99与糖化血红蛋白(HBAlc)的相关性。方法 收集2013年1月—9月T2DM患者382例,选择同期健康体检者90例作为对照组,分别检测血清CA199与HbA1c水平,根据HbA1c水平将T2DM患者分为血糖控制组(HbA1c<7.5%),控制不佳组(HbA1C≧7.5%),T2DM患者CA199水平与对照组比较,以体重指数、空腹血糖、HbA1c等为自变量,比较各变量对CA199的影响程度。结果 T2DM患者中CA199水平高于对照组,两者比较差异有统计学意义(t=3.45,P=0.005),血糖控制不佳组CA199阳性率(21.4%)高于血糖控制组(4%),差异有统计学意义(χ²=43.33,P=0.006),HBAlc控制组(4%)与健康体检者(0.9%)无显著差异(t=0.347,P=0.254,),CA199水平与HbA1c的相关系数最高(r=0.573,P=0.004)。结论 T2DM患者CA199水平和HbA1c存在相关性, 2型糖尿病患者CAl99升高与长期血糖控制不佳有关。

Objective To explore the differences in patients with T2DM and healthy people and to explore the correlation between CA199 and HbA1c in patients with T2DM. Methods 382 patients with T2DM and 90 healthy subjects for control group were collected from January to September in 2013.The level of CA199 and HbA1c were measured by chemiluminescence method and high performance liquid chromatography assay respectively. Accordingto the level of HbA1c,patients were divided in to blood glucose controlled group(HbA1c<7.5%) and blood glucose uncontrolled group (HbA1c≧7.5%).The level of CA199 were compared with control group. Sex, age, course of disease, body mass index, fasting blood glucose and HbA1c were included as independent variables for multiple stepwise regression analysis, to compare of influences of the variables on the CA199. Results The level of CA199 in T2DM patients was significantly higher than those of healthy subjects(t=3.45, P=0.005) and the positive rate of CA199 in blood glucose uncontrolled group(21.4%) was significantly higher than those of controlled group(4.0%)(χ²=43.33,P=0.006),there is no significant difference between in blood glucose controlled group(4.0%) and healthy people group(0.9%)(t=0.347,P=0.254).Among the many variables, the level of CA199 and HbA1c correlation coefficient was the highest (r=0.573, P=0.004. Conclusion There was a close correlation between CA199 level and HbA1c.There was a correlation between the positive level of CA199 and uncontrolled blood glucose.

目的 对2010—2014年广州市越秀区食物中毒事件的流行病学特征进行分析,探讨引起食物中毒的危险因素并对其进行分析,为制定预防措施提供依据。方法 收集广州市越秀区五年内发生的13起食物中毒事件的资料,使用构成比、频数等对事件进行分析,按发生时间、致病因素、就餐场所等因素进行分析。结果 2010—2014年广州市越秀区共发生食物中毒13起,发病65例,住院7例,平均每起发病5例,罹患率8.17%,没有死亡病例。第四季为食物中毒高发季节,共5起(占38.46%)。微生物污染是主要致病因素,共11起(占84.62%),以副溶血性弧菌和金黄葡萄球菌为主。餐饮服务单位是食物中毒发生的主要场所,7起(占53.85%)。结论 针对广州市越秀区食物中毒高发季节、主要致病因素和发生场所等特点,应加强对餐饮业加工环节监督管理,加强餐饮从业人员的卫生知识培训,以减少食物中毒的发生。

目的 研究探讨适合基层医院开展白内障复明手术的手术方式。方法 随机抽取我院2010年4月—2014年4月收治的白内障患者1560例为研究对象。所有患者的患眼有2460只。并将其随机分成观察组和对照组,每组患者患眼分别有1230只。对照组采用大切口(巩膜隧道)有缝线白内障(囊外)摘除并人工晶状体植入手术,观察组患者采用小切口(巩膜隧道) 无缝线白内障(囊外)摘除并人工晶状体植入手术治疗的方法,并对两组的疗效进行分析。观察患者手术后的视力、术中以及术后并发症、住院费用等。结果 治疗结果显示,观察组患者的视力术后7天在0.4以上的患者占有89.7%,对照组患者视力在0.4以上的患者占有87.3%。差异无统计学意义(P＞0.05)。手术时间对照组长于观察组,手术费用对照组略高于观察组,差异有统计学意义(P<0.05)。两组在术中后囊膜破裂的发生率、前房型人工晶体植入的比例、上袢缝合固定后房型人工晶体植入比例比较,差异有统计学意义(P<0.05),观察组上述情况少于对照组。结论 在基层医院进行白内障复明活动,采用小切口(巩膜隧道) 无缝线白内障(囊外)摘除并人工晶状体植入手术治疗的方法疗效可靠,并发症少,手术时间短,住院总费用较低,有利于我们在资金、设备有限的情况下在限定的时间内完成较多的白内障复明手术。因此,在基层医院开展的白内障扶贫复明活动中小切口白内障(囊外)摘除并人工晶状体植入手术方法值得推广。

目的 获得广东省保健食品违法广告所针对目标消费人群的现况,为加强保健食品广告的管理提供研究基础。方法 将2009年1月—2014年10月广东省食品药品监督管理局官方网站公布总计40期保健食品违法广告的公告汇总,以目标消费群体的年龄性别作为分析因素,建立统计表进行相关研究分析。结果 2009年1月—2014年10月广东省保健食品违法广告主要是针对中老年人消费人群,并侧重于女性消费群体。结论 针对广东省保健食品违法广告存在问题,相关职能部门应增补保健品广告法规的操作细则,加强部门间协调分工及相互监督,并利用网络媒体平台开展相关保健食品知识宣传工作。

Objective This study the characters of consumers targeted by health food advertisements in Guangdong province. The results will be helpful to enhance the standard management to the advertisements of health food in Guangdong Province. Methods Forty issues announcements of illegal health food advertisements, which published in the official website of Guangdong food and drug administration center from January 2009 to October 2014, were collected and statistically analyzed by the age and gender of the target consumer groups. Results The old people, especially female consumers, were the target consumers of illegal health food advertisements in Guangdong province from January 2009 to October 2014. Conclusion Regulations and rules for the health food advertisements should be developed. And the coordination and supervision among advertizing departments, as well as knowledge to the health food advertisements based on the internet technique, should be strengthened.

目的 评价自我管理小组干预对社区2型糖尿病患者的管理效果。方法 在2013年底选取本区社区卫生服务中心100例患者研究,运用自身对照方法,管理1年后对其自我管理效能、生化指标、空腹血糖、糖化血红蛋白进行比较。结果 管理一年后饮食控制、运动控制、药物依从性、监测依从性、足部护理等指标差异有统计学意义(P<0.05)。空腹血糖、糖化血红蛋白、总胆固醇、尿酸下降,差异有统计学意义(P<0.05)。空腹血糖达标率由12%上升到37%,糖化血红蛋白达标率由10%上升到34%,差异有统计学意义(P<0.05)。结论 自我管理小组干预提高了社区2型糖尿病患者自我管理水平,改善了主要的生化指标,值得社区推广应用。

Objective To evaluate the function of self-management group program on patients with type 2 diabetes in community. Methods Self-management was carried out for one year among 100 patients with type 2 diabetes, the effect of management was analyzed. Results There was statistically significant difference in diet control, motion control, drug compliance, monitoring compliance, and foot care after one year intervention (P<0.05). GLU, HbA1c, CHOL, UA were decreased. The difference was statistically significant (P<0.05). Conclusion Self-management of group intervention is effective in patients with type 2 diabetes, is worthy of further popularization and application.

目的 探索复发性卵巢癌放射治疗临床的效果和副作用。方法 采用回顾性分析中山大学肿瘤防治中心放射治疗中心2002年1月—2014年9月收治的复发性卵巢癌采用放射治疗的临床资料和治疗结果。结果 23例患者5年生存率为48.6%,中位生存期为54,局部无瘤生存期中位数为11.9。结论 对于局限性复发性卵巢癌放射治疗有较好的疗效和较少的副作用。

Objective To explore the clinical efficacy and side effects of radiation therapy for recurrent ovarian cancer. Methods We performed a retrospective analysis of clinical data and treatment outcomes from recurrent ovarian cancer patients who received radiation therapy from January 1999 to December 2012 at radiation treatment center of Sun Yat-sen university Cancer Center. Results Among 23 patients, the five-year survival rate was 48.6%, the median survival time was 54, and the local median disease-free survival was 11.9. Conclusion Radiation therapy has better efficacy and less side effects for non-metastatic recurrent ovarian cancer.

目的 检测抑郁障碍患者血清中IL-2和TNF-α水平,探讨IL-2和TNF-α水平与认知功能情况相关性。方法 采用酶联免疫吸附法(ELISA)检测100例抑郁障碍患者(观察组)和100例健康人(对照组)的血清IL-2、TNF-α的水平,并结合汉密尔顿抑郁量表(HAMD)观察患者抑郁障碍的严重程度,应用Loewenstein 认知评定量表评定患者的认知状态情况进行相关分析。结果 与对照组相比,观察组的IL-2、TNF-α的水平明显更高(P<0.05)。IL-2、TNF-α的水平与HAMD,LOTCA总分呈正相关(P<0.05)。结论 抑郁障碍患者血清中IL-2、TNF-α的水平与抑郁障碍患者的严重程度和认知状态情况呈正相关。

Objective To study the levels of serum IL-2 and TNF-α in depressed patients and theircorrelations with the cognitive function. Methods 100 depressed patients (observation group) and 100 healthy people (control group) were enrolled to this study and we compared their levels of serum IL-2 and TNF-α detected by enzyme-linked immunosorbent (ELISA) from two groups. The correlation analyses of the serum IL-2 and TNF-α levels with the severity of depression of depressed patients observed with Hamilton depression scale (HAMD), and the serum IL-2 and TNF-α levels with the cognitive function evaluated with Loewenstein were conducted. Results The levels of serum IL-2 and TNF-α in the observation group were significantly higher than control group (P<0.05).There were positive correlations between the levels of IL-2 and TNF-α and HAMD scores and between the levels of IL-2 and TNF-α and LOTCA scores (P<0.05). Conclusion The levels of serum IL-2 and TNF-α in the depressed patients were positively correlative with the severity of depression and their cognitive function.

目的 探讨心肌细胞RyR2和L型钙通道的基因变异与室性心律失常和心源性猝死的相关性。方法 回顾分析2010年1月—2012年12月在我院就诊的慢性心力衰竭患者622例的临床资料,并选取同一时期体检中心体检的健康人群516例作为对照组,门诊或者电话随访记录慢性心力衰竭患者的死亡为终点,通过候选基因分析可能具有相关功能的4个基因变异,rs41315858(G1885E)、rs3766871(G1886S)、rs790896(G>A)和rs723672(T>C),采用Logestic、Cox回归分析对4个候选基因变异进行相关性研究。结果 入选622例慢性心力衰竭患者和516例对照组,基因分析结果显示RyR2上的基因变异rs376687lA等位基因携带可以增加慢性心力衰竭患者发生室性心律失常的风险性;校正可能与该疾病相关的危险因素后,rs376687lA等位基因携带会增加心源性死亡和心源性猝死的风险,RyR2上的基因变异rs790896A等位基因携带可以降低心源性猝死风险。结论 RyR2上的基因变异rs376687lA是室性心律失常和心源性猝死的遗传学预测因子,而rs790896A等位基因是慢性心力衰竭患者的保护因子,可降低室性心律失常和心源性猝死的风险。

Objective To investigate the myocardial cells RyR2 and L-type calcium channel gene variants with ventricular arrhythmias and sudden cardiac death correlation. Methods Retrospective analysis of patients with chronic heart failure from January 2010 to December 2012 in our hospital including 622 cases of clinical data, and to select 516 cases of healthy people in medical examination center during the same period as a control group.Clinic or telephone follow-up recorded chronic patients with heart failure and sudden death acting as end. We analyzed possible candidate genes, according to four gene variants related functions, rs41315858 (G1885E), rs3766871 (G1886S), rs790896 (G> A) and rs723672 (T> C), by using Logestic, Cox regression analysis of four candidate gene variants for related research. Results 622 cases of chronic heart failure patients were enrolled and 516 patients in the control group. Genetic analysis showed that the gene variant alleles carried rs376687lA RyR2 may increase in patients with chronic heart failure ventricular arrhythmia risk; correction may be associated with the disease after risk factors, rs376687lA allele carries an increased risk of cardiogenic death and sudden cardiac death, and gene mutation alleles carried on rs790896A RyR2 can reduce the risk of sudden cardiac death. Conclusion Gene mutation rs376687lA RyR2 on genetics is predictor of ventricular arrhythmias and sudden cardiac death, and rs790896A allele is protective factor in patients with chronic heart failure which can be reduced ventricular arrhythmias and sudden cardiac death in risk.

目的 探讨2型糖尿病患者发生医院感染危险因素。方法 收集2010年1月—2015年1月我院收治890例2型糖尿病患者临床资料行回顾性分析,根据是否发生医院感染分为感染组(75例)和非感染组(815例),对两组患者相关因素进行分析。结果 2型糖尿病医院感染发生率为8.43%,好发于呼吸系统感染。年龄、病程、住院时间、血糖控制差、侵袭性操作、合并并发症、合并基础疾病为2型糖尿病患者发生感染的危险因素。结论 2型糖尿病患者发生医院感染危险因素较多,临床针对高危患者应重点进行预防,降低感染率,提高患者治疗效果。