目的 分析抗中性粒细胞胞浆抗体(ANCA)阳性类风湿关节炎(RA)患者的临床及血清学特征。方法 回顾性比较分析2019—2020年本院住院113例核周型抗中性粒细胞胞浆抗体(P-ANCA)阳性及120例P-ANCA阴性RA患者的临床及实验室资料。结果 P-ANCA阳性组的抗环瓜氨酸肽(CCP)抗体为(171.47±130.48)U/mL,阴性组为(130.10±132.7)U/mL,t=2.250,P=0.026。阳性组的抗CCP抗体的阳性率为82/98(83.67%),阴性组为71/110(64.55%),χ²=9.749,P=0.003。阳性组CCP抗体高滴度率63/98(64.29%),阴性组为53/110(48.18%),χ²=5.449,P=0.025。阳性组的RF浓度:(205.14±276.08)U/mL,阴性组RF浓度:(136.94±201.51)U/mL,t=2.159,P=0.032;阳性组的RF阳性率为98/112(87.5%),阴性组的78/120(65.89%),χ²=16.016, P<0.001;阳性组的类风湿因子高浓度率73/112(64.60%),阴性组56/120(46.67%),χ²=8.042, P=0.005。结论 P-ANCA阳性的RA患者的抗体水平相对更高。

Objective To analyze the clinical and serological characteristics of rheumatoid arthritis (RA) patients with positive anti-neutrophil cytoplasmic antibodies (ANCA). Methods The clinical and laboratory data of 113 perinuclear-ANCA (P-ANCA) positive and 120 P-ANCA negative RA patients in our hospital from 2019 to 2020 were retrospectively analyzed. Results The anti-cyclic citrullinated peptide (CCP) antibody of P-ANCA positive group was (171.47±130.48) U/mL, and which in the negative group was (130.10±132.7) U/mL, t=2.250, P=0.026. The positive rate of anti-CCP antibodies in positive group was 83.67% (82/98), and that in the negative group was 64.55% (71/110), χ²=9.749, P=0.003. The high titre rate of CCP antibody in positive group was 64.29% (63/98), and that in the negative group was 53/110 (48.18%),χ²=5.449, P=0.025. The RF concentration of positive group was (205.14±276.08) U/mL, the negative group concentration was (136.94±201.51) U/mL, t=2.159, P=0.032; the RF-positive rate of positive group was 87.5% (98/112), 65.89% (78/120) in the negative group, χ²=16.016, P<0.001; the high concentration rate of rheumatoid factor in positive group was 73/112(64.60%), the negative group 56/120(46.67%), χ²=8.042, P=0.005. Conclusions RA patients with positive P-ANCA had relatively higher antibody levels.