P-ANCA抗体阳性的类风湿关节炎血清学特点分析

来源期刊：广州医药 | 39-43 发布时间：2023-02-07 收稿时间：2025/11/13 18:40:40 阅读量：18

作者：: 马杰桃,

李珉珉,

关键词：: 类风湿关节炎抗中性粒细胞胞浆抗体; rheumatoid arthritis anti-neutrophilic cytoplasmic antibody

DOI：: 10.3969/j.issn.1000-8535.2023.01.007

收稿时间：: 2022-01-05
修订日期：
接收日期：
引用总数：: 3

目的分析抗中性粒细胞胞浆抗体(ANCA)阳性类风湿关节炎(RA)患者的临床及血清学特征。方法回顾性比较分析2019—2020年本院住院113例核周型抗中性粒细胞胞浆抗体(P-ANCA)阳性及120例P-ANCA阴性RA患者的临床及实验室资料。结果 P-ANCA阳性组的抗环瓜氨酸肽(CCP)抗体为(171.47±130.48)U/mL,阴性组为(130.10±132.7)U/mL,t=2.250,P=0.026。阳性组的抗CCP抗体的阳性率为82/98(83.67%),阴性组为71/110(64.55%),χ²=9.749,P=0.003。阳性组CCP抗体高滴度率63/98(64.29%),阴性组为53/110(48.18%),χ²=5.449,P=0.025。阳性组的RF浓度:(205.14±276.08)U/mL,阴性组RF浓度:(136.94±201.51)U/mL,t=2.159,P=0.032;阳性组的RF阳性率为98/112(87.5%),阴性组的78/120(65.89%),χ²=16.016, P<0.001;阳性组的类风湿因子高浓度率73/112(64.60%),阴性组56/120(46.67%),χ²=8.042, P=0.005。结论 P-ANCA阳性的RA患者的抗体水平相对更高。

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