Objective To analyzes the current situation of hospital drug supply guarantee under the policy of centralized and volume-based procurement(hereinafter referred to as “central procurement”),and proposes optimization strategies and suggestions for the policy and guarantee.Methods By extracting the procurement data of drugs supplied through centralized procurement at Yubei District People’s Hospital in Chongqing from January 2023 to December 2024,descriptive statistical analysis of the drug supply situation through centralized procurement was conducted.Results Among the 416 selected drugs purchased,69 were in short supply during the contract period,with a shortage rate of 16.59%.The reasons for the shortage were related to the production capacity of the enterprise,seasonal demand fluctuations,strong seasonality,and mainly chronic diseases and anti-infective.Conclusions It is suggested to build a monitoring platform,improve the reporting system,formulate emergency plans,and evaluate the supply capacity to ensure supply.