目的 探讨宣清导浊汤加减方联合血液透析治疗对老年慢性肾衰竭（CRF）患者肾功能、微炎症状态和毒素清除率的影响。方法 回顾性选取2019年10月—2022年10月我院收治的82例老年CRF患者,将其根据治疗方法分为联合组与单一组,每组41例。单一组仅采取血液透析治疗,联合组联合宣清导浊汤加减方治疗,对比两组患者治疗前后中医证候积分、毒素清除率、炎症因子变化。结果 治疗后,两组患者口淡不渴、肢体麻木、腰膝酸软、倦怠乏力、食少纳呆以及面色晦暗相关中医证候积分均降低,且联合组低于单一组（P<0.05）;治疗后两组患者血肌酐、尿素氮、血β₂-微球蛋白均降低,联合组低于单一组（P<0.05）;治疗后两组患者白细胞介素-6、C-反应蛋白、肿瘤坏死因子-α炎性因子水平明显降低,且联合组更低（P<0.05）。两组在治疗期间均无不良反应。结论 宣清导浊汤加减方联合血液透析治疗老年CRF患者效果较佳,可通过降低机体炎症因子表达水平、提高毒素清除率来改善患者临床症状,且不会增加不良反应。

Objective To explore the effect of Xuanqing Daozhuo Decoction modified formula combined with hemodialysis treatment on renal function,micro inflammatory status,and toxin clearance rate in elderly patients with chronic renal failure（CRF）．Methods Retrospectively,82 elderly CRF patients admitted to our hospital from October 2019 to October 2022 were selected and divided into a combination group and a single group according to the treatment methods,with 41 cases in each group． The single group was treated with hemodialysis only,and the combined group was treated with Xuanqing Daozhuo Decoction modified formula additionally．The changes of TCM syndrome scores,toxin clearance rate and inflammatory factors before and after treatment were compared between the two groups．Results After treatment,the scores of TCM syndroms including tasteless mouth and no thirst,numbness of limbs,soreness and weakness of waist and knee,fatigue,poor appetite and sluggish stomach were all decreased in 2 groups,and those in combined group were lower（P<0.05）．After treatment,serum creatinine,blood urea nitrogen and β₂-microglobulin were decreased in 2 groups,and those in combined group were lower（P<0.05）．After treatment,the levels of interleukin-6,C-reactive protein and tumor necrosis factor-α inflammatory factors were significantly decreased in 2 groups,which were lower in combination group（P<0.05）．The two groups had no adverse effects during the treatment period．Conclusions Xuanqing Daozhuo Decoction modified formula and hemodialysis can improve the clinical symptoms of elderly patients with CRF,reduce the expression level of inflammatory factors in patients,and increase the clearance rate of toxins in patients,and does not increase the adverse effects．

李俊,广东省名中医,从事中医临床工作30年,尤擅长经方“峻剂轻投”治疗疑难杂症,主张根据病情需要,从小剂量用起;根据脾胃功能,以小剂量取效;根据慢性病的特点,以小剂量调治;根据个体差异,以小剂量获效;并注重杂合以治疗。

目的 分析补阳还五汤加减治疗肾病综合征(NS)的临床疗效。方法 选择本院2019年1月—2021年1月住院治疗的120例NS患者,通过随机数字表法分组,参照组60例患者采纳常规西医治疗,试验组60例患者在参照组基础上予以补阳还五汤治疗,对比2组临床疗效、中医症候积分、肾功能指标、不良反应总发生率。结果 试验组临床总有效率(96.67%)高于参照组(80.00%),试验组治疗后浮肿少尿、腰膝酸软、腹部胀满、头晕乏力积分均低于参照组,差异均有统计学意义(P＜0.05)。治疗后试验组24 h尿蛋白、尿素氮均比参照组低,差异有统计学意义P＜0.05,血肌酐治疗前后差异无统计学意义P>0.05。试验组不良反应总发生率(5.00%)与参照组(6.67%)比较,差异无统计学意义(P>0.05)。结论 补阳还五汤可有效改善NS患者临床症状、肾功能,降低蛋白尿,且不良反应较少,安全性较高,疗效确切。

Objective To analyze the clinical effect of addition or reduction of Buyang Huanwu decoction in the treatment of nephrotic syndrome (NS). Methods A total of 120 NS patients in our hospital from January 2019 to January 2021 were divided into two groups by random digital table method. Sixty patients in the control group were treated by conventional western medicine, 60 patients in the experimental group were treated with Buyang Huanwu decoction on the basis of control group.The clinical efficacy, traditional Chinese medicine syndrome score, renal function index and total incidence of adverse reactions were compared. Results The total clinical effective rate of the experimental group (96.67%) was higher than that of the control group (80.00%). The scores of edema and oliguria, lumbar and knee pain and limpness, abdominal distention and dizziness after treatment in the experimental group were all lower than those in the control group, with statistical significance (P<0.05). After treatment, 24 h urinary protein volume and blood urea nitrogen level in the experimental group were lower than those in the control group, the differences were statistically significant (P<0.05), while there was no statistically significant difference in serum creatinine before and after treatment (P>0.05). There was no significant difference in the total incidence of adverse reactions between the experimental group (5.00%) and the control group (6.67%,P>0.05). Conclusion Buyang Huanwu decoction could effectively improve the clinical symptoms and renal function, reduce proteinuria, and had less adverse reactions, high safety level and accurate curative effect.

目的 分析远红外穴位敷贴辅助蒙脱石口服液治疗小儿腹泻的疗效。方法 选择2014年9月—2016年9月我院门诊收治的腹泻患儿190例,按照随机数字表法分为对照组(n=95)和观察组(n=95),对照组患儿给予蒙脱石散口服液,观察组患儿在对照组治疗基础上给予远红外穴位敷贴治疗,比较2组患儿治疗效果、大便次数恢复正常时间、大便性状恢复正常时间、平均治愈时间及不良反应。结果 观察组患儿治疗有效率94.74%高于对照组85.26%(P<0.05);观察组患儿大便次数恢复正常时间、大便性状恢复正常时间、平均治愈时间均较对照组少(P<0.05);观察组与对照组患儿均无明显不良反应发生。结论 远红外穴位敷贴辅助蒙脱石口服液治疗小儿腹泻疗效显著,安全性较高。

Objective To analyze the efficacy of far infrared acupoint application assisted montmorillonite oral liquid on infantile diarrhea. Methods 190 cases of children with diarrhea treated in outpatient clinic of our hospital from September 2014 to September 2016 were selected for the study and divided into control group (n=95) and observation group (n=95) according to the random number table method. The control group was given the montmorillonite powder oral liquid, and the observation group was treated with far infrared acupoint application on the basis of treatment in the control group. The treatment effect, the recovery normal time of defecation frequency, the recovery normal time of stool property, the average cure time and adverse reactions were compared between the two groups. Results The effective rate of the observation group was higher than that of the control group (94.74% vs. 85.26%) (P<0.05). The recovery normal time of defecation frequency, the recovery normal time of stool property, the average cure time in the observation group were less than those of the control group (P<0.05). There were no significant adverse reactions between the observation group and the control group. Conclusion Far infrared acupoint application assisted montmorillonite oral liquid may have a significant efficacy and high safety in the treatment of infantile diarrhea.