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2023年7月 第38卷 第7期11
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SII、NLR和PLR 水平对急性缺血性卒中伴发卵圆孔未闭的诊断价值

Diagnostic value of SII,NLR and PLR levels in acute ischemic stroke with patent foramen ovale

来源期刊: 广州医药 | 28-33 发布时间:2023-10-12 收稿时间:2025/11/13 18:30:48 阅读量:36
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关键词:
缺血性脑卒中卵圆孔未闭全身免疫炎症指数中性粒细胞/淋巴细胞比值血小板/淋巴细胞比值
AISPFOSIINLRPLR
DOI:
10.3969/j.issn.1000-8535.2023.09.005
收稿时间:
2023-03-09 
修订日期:
 
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引用总数:
0  
目的 评估全身免疫炎症指数(SII)、中性粒细胞/淋巴细胞比值(NLR)和血小板/淋巴细胞比值(PLR)在区分急性缺血性卒中(AIS)伴发卵圆孔未闭(PFO)与非伴发PFO患者的价值。方法 回顾性分析100例AIS患者的血液和血清指标,计算SII、NLR和PLR,使用Logistic回归及受试者操作特征(ROC)曲线分析3项指标在鉴别AIS伴发PFO与非伴发PFO中的价值。结果 伴发PFO的AIS患者SII、NLR、PLR高于非伴发PFO的AIS患者,其中以SII最为明显(P均<0.05)。单因素Logistic回归显示,中性粒细胞计数、淋巴细胞计数、PLR、NLR、SII与AIS伴发PFO有关(P<0.05)。ROC曲线分析结果,SII、NLR、PLR鉴别AIS伴PFO与非伴PFO患者,最佳阈值分别为476.4、1.99、115.3,曲线下面积分别为0.777、0.767、0.708。结论 SII、NLR和PLR可作为鉴别AIS患者是否伴发PFO的生物标志物,具有潜在临床应用价值。
Objective To evaluate the value of systemic immune-inflammatory index(SII),neutrophil/lymphocyte ratio(NLR)and platelet/lymphocyte ratio(PLR)in distinguishing acute ischemic stroke(AIS)patients with patent foramen ovale(PFO)and without PFO.Methods A retrospective analysis of blood and serum indicators in 100 AIS patients was conducted,and SII,NLR and PLR indices were calculated.Logistic regression and ROC curve analyses were performed.Results SII,NLR and PLR were significantly higher in PFO patients than in non-PFO patients,with SII being the most significant.Univariate logistic regression showed that Neu,Lym,PLR,NLR,and SII variables were significantly associated with AIS combined with PFO(P<0.05).ROC curve analysis revealed that the optimal cut-off values for SII,NLR and PLR in distinguishing AIS patients with PFO from those without PFO were 476.4,1.99 and 115.3,respectively,with area under the curve of 0.777,0.767 and 0.708.Conclusions SII,NLR and PLR can serve as biomarkers for identifying AIS patients with PFO,offering potential clinical application value.
1、 TOPCUOGLU M A,PEKTEZEL M Y,YILMAZ E,et al.Systemic inflammation indices in patients with acute ischemic stroke treated with intravenous tissue plasminogen activator:clinical yield and utility[J].Angiology, 2021,72(3):279-284. TOPCUOGLU M A,PEKTEZEL M Y,YILMAZ E,et al.Systemic inflammation indices in patients with acute ischemic stroke treated with intravenous tissue plasminogen activator:clinical yield and utility[J].Angiology, 2021,72(3):279-284.
2、 ZARBOCK A,POLANOWSKA-GRABOWSKA RK,LEY K.Platelet-neutrophil-interactions:linking hemostasis and inflammation[J].Blood reviews, 2007,21(2):99-111. ZARBOCK A,POLANOWSKA-GRABOWSKA RK,LEY K.Platelet-neutrophil-interactions:linking hemostasis and inflammation[J].Blood reviews, 2007,21(2):99-111.
3、 CHEN L,WANG X,SHU J,et al.Diagnostic value of serum D-dimer,CA125,and neutrophil-to-lymphocyte ratio in differentiating ovarian cancer and endometriosis[J].Int J Gynaecol Obstet, 2019,147(2):212-218. CHEN L,WANG X,SHU J,et al.Diagnostic value of serum D-dimer,CA125,and neutrophil-to-lymphocyte ratio in differentiating ovarian cancer and endometriosis[J].Int J Gynaecol Obstet, 2019,147(2):212-218.
4、 HERZ J,SABELLEK P,LANE T E,et al.Role of neutrophils in exacerbation of brain injury after focal cerebral ischemia in Hyperlipidemic mice[J].Stroke, 2015,46(10):2916-2925. HERZ J,SABELLEK P,LANE T E,et al.Role of neutrophils in exacerbation of brain injury after focal cerebral ischemia in Hyperlipidemic mice[J].Stroke, 2015,46(10):2916-2925.
5、 CAGLAR F N T,ALP M E,KARABULUT N,et al.Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are associated with cryptogenic stroke in patients with patent foramen ovale[J].Arch Med Sci Atheroscler Dis, 2020(5):e112-e117. CAGLAR F N T,ALP M E,KARABULUT N,et al.Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are associated with cryptogenic stroke in patients with patent foramen ovale[J].Arch Med Sci Atheroscler Dis, 2020(5):e112-e117.
6、 DEMIR B,CAGLAR I M,UNGAN I,et al.Mean platelet volume is elevated in patients with patent foramen ovale[J].Arch Med Sci,2013,9(6):1055-1061. DEMIR B,CAGLAR I M,UNGAN I,et al.Mean platelet volume is elevated in patients with patent foramen ovale[J].Arch Med Sci,2013,9(6):1055-1061.
7、 DüZEL B,EREN NK,BERILGEN R,et al.Decline in mean platelet volume in patients with patent foramen ovale undergoing percutaneous closure[J].Cardiovasc J Afr, 2014,25(4):165-167. DüZEL B,EREN NK,BERILGEN R,et al.Decline in mean platelet volume in patients with patent foramen ovale undergoing percutaneous closure[J].Cardiovasc J Afr, 2014,25(4):165-167.
8、 LI L H,CHEN C T,CHANG Y C,et al.Prognostic role of neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,and systemic immune inflammation index in acute ischemic stroke:A STROBE-compliant retrospective study[J].Medicine(Baltimore), 2021,100(25):e26354. LI L H,CHEN C T,CHANG Y C,et al.Prognostic role of neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,and systemic immune inflammation index in acute ischemic stroke:A STROBE-compliant retrospective study[J].Medicine(Baltimore), 2021,100(25):e26354.
9、 FAHMI R M,RAMADAN B M,SALAH H,et al.Neutrophil-lymphocyte ratio as a marker for disability and activity in multiple sclerosis[J].Mult Scler Relat Disord,2021(51):102921. FAHMI R M,RAMADAN B M,SALAH H,et al.Neutrophil-lymphocyte ratio as a marker for disability and activity in multiple sclerosis[J].Mult Scler Relat Disord,2021(51):102921.
10、 YING Y,YU F,LUO Y,et al.Neutrophil-to-lymphocyte ratio as a predictive biomarker for stroke severity and short-term prognosis in acute ischemic stroke with intracranial atherosclerotic stenosis[J].Front Neurol,2021(12):705949. YING Y,YU F,LUO Y,et al.Neutrophil-to-lymphocyte ratio as a predictive biomarker for stroke severity and short-term prognosis in acute ischemic stroke with intracranial atherosclerotic stenosis[J].Front Neurol,2021(12):705949.
11、 YAMAMOTO T,KAWADA K,OBAMA K.Inflammation-related biomarkers for the prediction of prognosis in colorectal cancer patients[J].Int J Mol Sci,2021,22(15):8002. YAMAMOTO T,KAWADA K,OBAMA K.Inflammation-related biomarkers for the prediction of prognosis in colorectal cancer patients[J].Int J Mol Sci,2021,22(15):8002.
12、 KONG W,HE Y,BAO H,et al.Diagnostic value of neutrophil-lymphocyte ratio for predicting the severity of acute pancreatitis:A meta-analysis[J].Dis Markers,2020(2020):9731854. KONG W,HE Y,BAO H,et al.Diagnostic value of neutrophil-lymphocyte ratio for predicting the severity of acute pancreatitis:A meta-analysis[J].Dis Markers,2020(2020):9731854.
13、 YANG Y,SUN G,DIAO S,et al.Diagnostic performances of neutrophil to lymphocyte ratio and lymphocyte to monocyte ratio in acute ischemic stroke caused by cervicocranial arterial dissection[J].J Clin Lab Anal, 2020,34(12):e23515. YANG Y,SUN G,DIAO S,et al.Diagnostic performances of neutrophil to lymphocyte ratio and lymphocyte to monocyte ratio in acute ischemic stroke caused by cervicocranial arterial dissection[J].J Clin Lab Anal, 2020,34(12):e23515.
14、 NAKANISHI K,YOSHIYAMA M,HOMMA S.Patent foramen ovale and cryptogenic stroke[J].Trends Cardiovasc Med, 2017,27(8):575-581. NAKANISHI K,YOSHIYAMA M,HOMMA S.Patent foramen ovale and cryptogenic stroke[J].Trends Cardiovasc Med, 2017,27(8):575-581.
15、 IOANNIDIS S G,MITSIAS P D.Patent foramen ovale in cryptogenic ischemic stroke:Direct cause,risk factor,or incidental finding?[J].Front Neurol,2020(11):567. IOANNIDIS S G,MITSIAS P D.Patent foramen ovale in cryptogenic ischemic stroke:Direct cause,risk factor,or incidental finding?[J].Front Neurol,2020(11):567.
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