NLR、PLR、MLR与冠状动脉疾病严重程度的相关性分析

来源期刊：广州医药 | 30-35 发布时间：2023-12-12 收稿时间：2025/11/13 18:29:10 阅读量：26

作者：: 罗寒玉,

冯俊,

曹瑞,

王本龙,

关键词：: 急性冠脉综合征中性粒细胞-淋巴细胞比值（NLR）血小板-淋巴细胞比值（PLR）单核细胞-淋巴细胞比值（MLR）Gensini评分; acute coronary syndrome NLR PLR MLR Gensini score

DOI：: 10.3969/j.issn.1000-8535.2023.11.005

收稿时间：: 2023-04-24
修订日期：
接收日期：
引用总数：: 3

目的探讨接受冠状动脉造影患者的中性粒细胞-淋巴细胞比值（NLR）、血小板-淋巴细胞比值（PLR）和单核细胞-淋巴细胞比值（MLR）与冠状动脉疾病（CAD）严重程度的关系。方法收集2021年1月—2021年12月在六安市人民医院接受冠状动脉造影的150例急性冠脉综合征（ACS）患者。CAD的严重程度通过Gensini评分进行评估,150例ACS患者根据评分被分为轻度病变组（≤14分,41例）、中度病变组（15~47分,69例）和重度病变组（≥48分,40例）。比较3组的临床指标,采用相关统计学分析NLR、PLR、MLR与CAD严重性（Gensini评分）的相关性。结果纳入研究的150例患者的平均年龄为（66.49±11.43）岁,男性占67.3%。在重度病变组,NLR和PLR值高于其他两组。在Pearson相关性检验中,Gensini评分与NLR呈正相关（r=0.319,P<0.001）,然而,Gensini评分与MLR、PLR之间无相关性（P>0.05）。在Logistic回归分析中,NLR（OR：1.306,95%CI：0.107~0.427）是CAD的独立危险因素。在ROC曲线分析中,发现NLR的曲线下面积最高,为0.723（95%CI：0.629~0.817,P<0.001）,NLR≥0.25为识别CAD存在的最佳临界值,灵敏度为78.49%,特异度为60.26%。结论根据Gensini评分,NLR与CAD的严重程度呈正相关,而研究中未观察到MLR、PLR与CAD严重程度之间的关联。

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