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阿尔茨海默病患者APOE4等位基因与多项神经心理学量表的相关性研究

The correlations of APOE4 alleles and multiple psychological tests in people with Alzheimer's disease

来源期刊: 广州医药 | 9-13 发布时间:2021-11-28 收稿时间:2025/11/13 17:46:48 阅读量:27
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关键词:
阿尔茨海默病神经心理学量表载脂蛋白E4等位基因
Alzheimer's diseasePsychological testsApolipoprotein E4 alleles
DOI:
10.3969/j.issn.1000-8535.2020.03.003
收稿时间:
2020-03-06 
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引用总数:
0  
目的 探讨具有不同载脂蛋白E4等位基因(Apolipoprotein E4 alleles,APOE4)阿尔茨海默病患者的神经心理学量表差异。方法 纳入2014年1月—2017年12月广州市第一人民医院收治阿尔茨海默病患者28人,分别予简易精神状态检查量表、阿尔茨海默病评定量表-认知部分、临床医师通过面谈对变化的印象、日常生活活动能力量表、神经精神问卷,并检测量表间相关关系。之后随访18个月,观察量表评测的各功能变化及互相间相关性。检测不同载脂蛋白E4等位基因等阿尔茨海默病相关基因分布及与量表间相关关系。结果 认知评定量表间、认知评定量表与整体评价量表间、以及认知评定量表与日常活动能力评定量表间具有相关性。精神与行为症状量表分数与其他评定量表无明显相关性。随访中各量表分数变化间均无相关性。各基因组间功能变化无显著性差异,载脂蛋白E4等位基因变异主要影响患者的认知功能。等位基因分布与患病年龄,日常活动能力及精神与行为症状无相关性。结论 阿尔茨海默病量表评测的各认知领域间相关性不同,功能变化间无相关关系。载脂蛋白E4等位基因变异主要影响患者的认知功能。
Objective The present study aimed to elucidate the performance of multiple psychological tests among different Apolipoprotein E4 alleles (APOE4) in people with Alzheimer's disease (AD). Methods 28 patients were enrolled from January 2014 to December 2017 in Guangzhou First People'S Hospital. All patients were tested by using Mini-mental State Examination (MMSE), Alzheimer's disease Assessment Scale (ADAS-cog), Clinician's Interview-Based Impression of Change (CIBIC-Plus), Activities of Daily Living (ADL) and the NeuroPsychiatric Inventory (NPI). After 18 months follow-up visit, the change of the tests points were recorded. AD pathogenic genes, including Apolipoprotein E4 allele's variations, were detected in all patients. Then the correlations of APOE4 alleles and multiple psychological tests were analyzed. Results The correlations were confirmed between MMSE and ADAS-cog, MMSE and CIBIC-plus, MMSE and ADL, ADAS-cog and CIBIC-plus, ADAS-cog and ADL. NPI showed no correlation with the others. No correlation was found between changes of multiple psychological tests after 18 months follow-up. APOE4 alleles' variation affected cognitive function mainly. The effects of APOE4 on ADL and NPI showed no statistical significance in AD patients. No correlation was found among patients groups with different APOE4 alleles in all psychological tests and age of onset. Conclusion The correlations were existed among multiple cognitive domains while levels were different. The changes between psychological tests showed no correlations. APOE4 alleles' variation affected cognitive function mainly.
1、 翁映虹, 黄坚红. 阿尔茨海默病评定量表-认知部分中文版与日常生活能力量表评价血管性痴呆的信度与效度[J]. 中国老年学杂志, 2014,34(7):1751-1753. 翁映虹, 黄坚红. 阿尔茨海默病评定量表-认知部分中文版与日常生活能力量表评价血管性痴呆的信度与效度[J]. 中国老年学杂志, 2014,34(7):1751-1753.
2、 张玉莲, 李强, 林翠茹, 等. 轻度阿尔茨海默病患者认知功能与日常生活能力临床特点及相关性[J]. 中国老年学杂志, 2017,37(20):5149-5151. 张玉莲, 李强, 林翠茹, 等. 轻度阿尔茨海默病患者认知功能与日常生活能力临床特点及相关性[J]. 中国老年学杂志, 2017,37(20):5149-5151.
3、 王华丽, 舒良, 司天梅, 等. 阿尔茨海默病评定量表中文译本的效度和信度[J]. 中国临床心理学杂志, 2000(2):89-93. 王华丽, 舒良, 司天梅, 等. 阿尔茨海默病评定量表中文译本的效度和信度[J]. 中国临床心理学杂志, 2000(2):89-93.
4、 AREVALO-RODRIGUEZ I, SMAILAGIC N, ROQUE I F M, et al. Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive imPairment (MCI)[J]. Cochrane Database Syst Rev, 2015(3):D10783. AREVALO-RODRIGUEZ I, SMAILAGIC N, ROQUE I F M, et al. Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive imPairment (MCI)[J]. Cochrane Database Syst Rev, 2015(3):D10783.
5、 贾建平. 中国痴呆与认知障碍诊治指南[M]. 北京: 人民卫生出版社, 2016. 贾建平. 中国痴呆与认知障碍诊治指南[M]. 北京: 人民卫生出版社, 2016.
6、 李霞, 肖泽萍, 肖世富, 等. ADAS-Cog中文版信效度分析[J]. 中国临床心理学杂志, 2009,17(5):538-540. 李霞, 肖泽萍, 肖世富, 等. ADAS-Cog中文版信效度分析[J]. 中国临床心理学杂志, 2009,17(5):538-540.
7、 DORAISWAMY P M, BIEBER F, KAISER L, et al. Memory, language, and praxis in alzheimer's disease: norms for outpatient clinical trial populations[J]. Psycho Pharmacol Bull, 1997,33(1):123-128. DORAISWAMY P M, BIEBER F, KAISER L, et al. Memory, language, and praxis in alzheimer's disease: norms for outpatient clinical trial populations[J]. Psycho Pharmacol Bull, 1997,33(1):123-128.
8、 HE M, SINGH P, CHENG S, et al. GRK5 Deficiency leads to selective basal forebrain cholinergic neuronal vulnerability[J]. Sci ReP, 2016(6):26116. HE M, SINGH P, CHENG S, et al. GRK5 Deficiency leads to selective basal forebrain cholinergic neuronal vulnerability[J]. Sci ReP, 2016(6):26116.
9、 ZUO L, DYCK C H V, LUO X, et al. Variation at APOE and STH loci and Alzheimer's disease[J]. Behav Brain Funct, 2006,2(1):13. ZUO L, DYCK C H V, LUO X, et al. Variation at APOE and STH loci and Alzheimer's disease[J]. Behav Brain Funct, 2006,2(1):13.
10、 EL S S, COSTANIAN C, KASSIR R, et al. APOE genotyPes in Lebanon: distribution and association with hyPercholesterolemia and Alzheimer's disease[J]. Per Med, 2019,16(1):15-23. EL S S, COSTANIAN C, KASSIR R, et al. APOE genotyPes in Lebanon: distribution and association with hyPercholesterolemia and Alzheimer's disease[J]. Per Med, 2019,16(1):15-23.
11、 GRAFF-RADFORD N, GREEN R, GO-RODNEYC P, et al. Association between apolipoprotein E genotyPe and Alzheimer disease in African American subjects[J]. Arch Neurol, 2002,59(4):594-600. GRAFF-RADFORD N, GREEN R, GO-RODNEYC P, et al. Association between apolipoprotein E genotyPe and Alzheimer disease in African American subjects[J]. Arch Neurol, 2002,59(4):594-600.
12、 JASIECKI J, LIMON-SZTENCEL A, ZUK M, et al. Synergy between the alteration in the N-terminal region of butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease[J]. Sci ReP, 2019,9(1):5223. JASIECKI J, LIMON-SZTENCEL A, ZUK M, et al. Synergy between the alteration in the N-terminal region of butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease[J]. Sci ReP, 2019,9(1):5223.
13、 MCKHANN G M, KNOPMAN D S, CHERTKOW H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease[J]. Alzheimers Dement, 2011,7(3):263-269. MCKHANN G M, KNOPMAN D S, CHERTKOW H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease[J]. Alzheimers Dement, 2011,7(3):263-269.
14、 BARKER W W, LUIS C A, KASHUBA A, et al. Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotem poral dementia, and hippocamPal sclerosis in the State of Florida Brain Bank[J]. Alzheimer Dis Assoc Disord, 2002,16(4):203-212. BARKER W W, LUIS C A, KASHUBA A, et al. Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotem poral dementia, and hippocamPal sclerosis in the State of Florida Brain Bank[J]. Alzheimer Dis Assoc Disord, 2002,16(4):203-212.
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