Objective To investigate the clinical efficacy of treating kidney deficiency-cold syndrome enuresis children with thunder-fire moxibustion. Methods 60 cases were randomly divided into a control group of 30 cases and a treatment group of 30 cases. Patients in the control group were treated with basic treatment (including adjusting diet, bladder function exercise, reflex training and so on); while patients in the treatment group were treated with thunder-fire moxibustion,three weeks for treatment. The research was aimed at assessing the clinical effect of the two groups,observing the number of enuresis days per week, the number of enuresis times per day,the sleep depth per day and the change of TCM symptom score, and recording the recurrence rate after 6 months of treatment. Results The clinical efficacy of treatment group was better than that of the control group,and the efficiency was 96.67%,which was higher than that of the control group 76.67%,and the TCM symptom score of the treatment group decreased than that of the control group, both of the differences were statistically significant (P< 0.05). The recurrence rates at 6 months after treatment was 10.34% respectively,which were lower than those in the control group(P＜0.05). Conclusion The therapy has good effect,it can reduce the number of enuresis times and has low recurrence.