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《广州医药》编辑部
目的 探讨预后营养指数(PNI)对脓毒症合并心力衰竭患者发生谵妄的预测价值,并评估其在指导护理风险分层中的作用。方法 采用回顾性队列研究,纳入2022年2月—2024年9月广东省第二中医院收治的162例脓毒症合并心力衰竭患者。通过ROC曲线确定PNI预测谵妄的最佳截断值,并以此将患者分为高低PNI组。比较两组基线特征,采用Kaplan-Meier曲线分析谵妄累积发生率和28天院内死亡率,通过Cox比例风险模型评估PNI与谵妄及预后的独立关联,并利用ROC曲线评价其预测性能。最后利用亚组分析技术进一步评估PNI预测价值的普适性。结果 低PNI(≤35.72)是谵妄发生的独立危险因素。竞争风险模型显示,低PNI组10 d谵妄累积发生率达37.8%,高于高PNI组的10.0%。多因素分析表明,PNI每降低一个单位,谵妄风险增加约17.2%。限制性立方样条分析提示PNI与谵妄风险呈线性负相关。ROC曲线分析显示PNI预测谵妄的AUC为0.721,其预测效能优于白蛋白和SOFA评分。亚组分析进一步证实PNI的保护效应在不同临床特征患者中具有一致性。结论 PNI是脓毒症合并心力衰竭患者谵妄风险的独立预测指标,其预测效能优于传统单一指标。基于PNI的风险分层有助于早期识别谵妄高危患者,为实现精准护理干预提供重要依据。
Objective To explore the predictive value of the prognostic nutritional index(PNI)for delirium in patients with sepsis complicated by heart failure,and to evaluate its role in guiding nursing risk stratification.Methods A retrospective cohort study was conducted,including 162 patients with sepsis and heart failure admitted to Guangdong Provincial Second Hospital of Traditional Chinese Medicine between February 2022 and September 2024.The optimal PNI cut-off value for predicting delirium was determined using ROC curve analysis,and patients were divided into high and low PNI groups accordingly.Baseline characteristics of the two groups were compared.Kaplan-Meier curves were used to analyze the cumulative incidence of delirium and 28-day in-hospital mortality.Cox proportional hazards models were employed to assess the independent association between PNI and delirium as well as prognosis,and ROC curves were used to evaluate its predictive performance.Subgroup analysis was further utilized to assess the generalizability of PNI’s predictive value.Results A low PNI(≤35.72)is an independent risk factor for delirium.The competing risk model showed that the cumulative incidence of delirium in the low PNI group was 37.8% at 10 days,significantly higher than the 10.0% in the high PNI group.Multivariate analysis indicated that for each unit decrease in PNI,the risk of delirium increased by 17.2% approximately.Restricted cubic spline analysis suggested a linear negative correlation between PNI and delirium risk.ROC curve analysis demonstrated that the AUC of PNI for predicting delirium was 0.721,with its predictive performance surpassing that of albumin and SOFA score.Subgroup analysis further confirmed that the protective effect of PNI was consistent across patients with different clinical characteristics.Conclusions PNI is an independent predictor of delirium risk in patients with sepsis and heart failure,with superior predictive performance compared to traditional single indicators.Risk stratification based on PNI aids in the early identification of patients at high risk for delirium,providing an important basis for precise nursing interventions.
目的 探讨多组分运动干预联合多学科指导下营养干预应用于老年慢性心力衰竭(CHF)并发衰弱患者的效果。方法 选择郑州市第七人民医院收治的CHF并衰弱患者102例, 纳入时间为2023年11月—2024年10月, 按照随机数表法分为对照组51例给予常规运动干预+多学科指导下营养干预,观察组51例给予多组分运动干预+多学科指导下营养干预,观察两组衰弱状态、心功能指标、营养状况、生活质量、不良事件发生率。结果 与对照组相比,观察组干预后身体、心理、社会及总分明显更低(P<0.05)。与对照组相比,观察组干预后左室射血分数(LVEF)水平明显更高,超敏心肌肌钙蛋白T(hs-cTnT)、N末端B型利钠肽前体(NT-proBNP)、左室舒张末期内径(LVEDD)水平更低(P<0.05)。与对照组相比, 观察组干预后主观整体营养状况评价表(PG-SGA)评分明显更低,血红蛋白(Hb)、前白蛋白(PA)、白蛋白(ALB)水平更高(P<0.05)。与对照组相比,观察组干预后症状、身体、情感及总分更低(P<0.05)。观察组不良事件发生率(1.96%)低于对照组(15.69%)(P<0.05)。结论 对CHF并发衰弱患者应用多组分运动干预联合多学科指导下营养干预,能够减轻衰弱状态, 改善心功能及营养状况,促进生活质量的提升, 并降低不良事件发生率。
Objective To explore the effect of multi-component exercise intervention combined with nutritional intervention under multidisciplinary guidance in elderly patients with chronic heart failure(CHF)and frailty.Methods From November 2023 to October 2024, 102 CHF patients with frailty admitted to Zhengzhou Seventh People's Hospital were selected and included. According to the computer grouping method, they were divided into a control group with 51 patients, received routine exercise intervention and multidisciplinary nutrition intervention,and an observation group with 51 patients, received multi-component exercise intervention and multidisciplinary nutrition intervention.The frailty status, cardiac function indicators, nutritional status, quality of life and incidence of adverse events were observed in both groups.Results Compared with the control group,the observation group showed significantly lower physical, psychological, social, and total scores after intervention(P<0.05).Compared with the control group, the observation group showed significantly higher levels of left ventricular ejection fraction and lower levels of high-sensitivity cardiac troponin N-terminal pro-B-type natriuretic peptide, and left ventricular end-diastolic dimension after intervention(P<0.05).Compared with the control group,the observation group had significantly lower Patient-Generated Subjective Global Assessment scores and higher levels of hemoglobin, prealbumin, and albumin after intervention(P<0.05).Compared with the control group, the observation group had significantly lower symptoms, physical, emotional, and total scores after intervention(P<0.05).The incidence of adverse events in the observation group(1.96%)was lower than that in the control group(15.69%)(P<0.05).Conclusions Multi-component exercise intervention combined with multidisciplinary nutritional intervention in patients with CHF and frailty can alleviate frailty, improve cardiac function and nutritional status,quality of life, and reduce the incidence of adverse events.
目的 残余胆固醇(RC)是反映动脉粥样硬化性血脂异常的重要指标,其在糖尿病合并冠心病患者中的临床意义尚不明确。本研究旨在探讨RC水平对糖尿病合并冠心病患者心力衰竭风险的预测价值,并分析其相关性。方法 本研究为回顾性横断面研究,纳入2021年1月—2024年1月期间在鹤壁市人民医院接受诊治的292例糖尿病合并冠心病患者。根据是否存在心力衰竭分为心力衰竭组(128例)和无心力衰竭组(164例)。对基线特征进行比较,采用单因素和多因素Logistic回归分析RC与心力衰竭的相关性。同时,通过限制性立方样条(RCS)分析探讨RC与心力衰竭风险的线性关系,并通过受试者操作特征(ROC)曲线和曲线下面积(AUC)评估RC的预测价值。结果 心力衰竭组患者的男性比例、高血压患病率、RC水平等高于无心力衰竭组,而估算肾小球滤过率水平显著降低(P<0.05)。单因素分析显示,RC>0.7 mmol/L显著增加心力衰竭风险(OR=1.854,95%CI:1.161~2.960,P=0.010)。多因素Logistic回归分析中,全调整模型结果显示,RC作为分类变量时,RC>0.7 mmol/L的患者心力衰竭风险显著增加1.891倍(OR=1.891,95%CI:1.047~3.415,P=0.035);作为连续变量时,RC每增加1单位,心力衰竭风险增加2.464倍(OR=2.464,95%CI:1.495~4.064,P<0.001);Log10RC的风险比为6.411(95%CI:2.246~18.302,P=0.001);标化RC的风险比为1.687(95%CI:1.262~2.255,P<0.001)。限制性立方样条分析表明RC与心力衰竭风险呈线性正相关,ROC分析显示RC预测心力衰竭的AUC为0.621(95%CI:0.555~0.687,P<0.001)。结论 RC水平与糖尿病合并冠心病患者心力衰竭风险显著相关,且呈线性正相关。RC具有一定的预测价值,可作为该人群心力衰竭风险评估的潜在指标。
Objective Residual cholesterol(RC)is an important marker reflecting dyslipidemia associated with atherosclerosis.Its clinical significance in patients with diabetes and coronary heart disease(CHD)remains unclear.To explore the predictive value of RC level for the risk of heart failure(HF)in patients with diabetes and CHD and analyze their association.Methods This retrospective cross-sectional study included 292 patients with diabetes and CHD who were treated at Hebi People’s Hospital between January 2021 and January 2024.Patients were divided into the HF group(128 cases)and the non-HF group(164 cases)based on the presence of HF.Baseline characteristics were compared,and univariate and multivariate Logistic regression analyses were performed to assess the association between RC and HF.Additionally,restricted cubic spline(RCS)analysis was used to explore the linear relationship between RC and HF risk,and the predictive value of RC was evaluated using receiveroperating characteristic(ROC)curves and the area under the curve(AUC).Results The HF group had significantly higher proportions of males,hypertension prevalence and RC levels,while estimated glomerular filtration rate were significantly lower compared to the non-HF group(P<0.05).Univariate analysis showed that RC>0.7 mmol/L significantly increased the risk of HF(OR=1.854,95%CI:1.161–2.960,P=0.010).In the fully adjusted multivariate Logistic regression model,RC(RC>0.7 mmol/L)was associated with a 1.891-fold increased risk of HF as a categorical variable(OR=1.891,95%CI:1.047–3.415,P=0.035).As a continuous variable,each increased unit in RC was associated with a 2.464-fold increased risk of HF(OR=2.464,95%CI:1.495–4.064,P<0.001).The odds ratios for Log10RC and standardized RC were 6.411(95%CI:2.246–18.302,P=0.001)and 1.687(95%CI:1.262–2.255,P<0.001),respectively.ROC analysis indicated a linear positive association between RC and HF risk(P=0.002).ROC analysis showed that RC had predictive value for HF,with an AUC of 0.621(95%CI:0.555–0.687,P<0.001).Conclusions RC levels are significantly associated with the risk of HF in patients with diabetes and CHD,demonstrating a linear positive correlation.RC has potential predictive value and may serve as a useful indicator for assessing HFrisk in this population.
目的 观察利伐沙班对心力衰竭(HF)合并心房颤动(AF)患者凝血因子及预后情况的影响。方法 采用前瞻性研究,纳入平顶山市第二人民医院2021年1月—2022年4月期间收治的123例HF合并AF患者,以数字随机表法将入组患者分为常规组(61例)和试验组(62)例,两组均行起搏器植入术(CRTD)治疗,常规组予以常规抗凝治疗辅助CRTD,试验组予以利伐沙班辅助CRTD,所有患者术后均开展一年随访,比较两组患者治疗前后的抗Xa凝血因子、心肌损伤标志物、心功能指标变化情况,以及术后血栓栓塞、心血管死亡事件发生情况。结果 治疗前,两组患者的Xa凝血因子,心肌损伤标志物,心功能指标比较差异无统计学意义(P>0.05);在不同抗凝方案下,观察组治疗1 d后的抗Xa凝血因子为(130.44±20.18)IU/mg,治疗3 d后的抗Xa凝血因子为(115.36±20.77)IU/mg,治疗7 d的抗Xa凝血因子为(90.25±20.44)IU/mg,均低于常规组[(145.33±20.19)IU/mg、(128.45±20.16)IU/mg、(103.34±20.17)IU/mg],差异有统计学意义(P<0.05)。治疗后,试验组的肌酸激酶同工酶为(7.52±2.16)U/L,心肌肌钙蛋白Ⅰ为(0.52±0.12)ng/mL,乳酸脱氢酶为(126.41±20.45)U/L,均低于常规组[(8.44±2.28)U/L、(0.94±0.31)ng/mL、(140.33±20.25)U/L],差异有统计学意义(P<0.05)。治疗后,观察组的左室射血分数为(56.12±10.41)%,高于常规组(50.24±10.33)%,左室舒张末期内径为(47.11±10.25)mm,左室舒张末期容积为(36.72±10.43)mL,均低于常规组(53.28±10.14)mm、(42.77±10.36)mL,差异有统计学意义(P<0.05)。随访期间,试验组的血栓栓塞事件发生率为4.84%(3/62),心血管死亡事件发生率为3.23%(2/62),均低于常规组[19.67%(12/61)、14.75%(9/61)],差异有统计学意义(P<0.05)。结论 利伐沙班辅助CRTD能有效增强HF合并AF患者的抗Xa凝血因子活性,对减轻心肌损伤、改善心功能并降低血栓栓塞或心血管死亡风险均有积极意义。
Objective To observe the effect of rivaroxaban on coagulation factors and prognosis in patients of heart failure(HF)with atrial fibrillation(AF).Methods This is a prospective study.The patients were included from January 2021 to April 2022 in Pingdingshan Second People’s Hospital.The study subjects were 123 patients with HF and AF.The enrolled patients were divided into the conventional group(61 cases)and the experimental group(62 cases)by the method of digital random table.Both groups were treated with cardiac resynchronization therapy with defibrillator(CRTD).The conventional group was treated with conventional anticoagulation therapy to assist CRTD,and the experimental group was treated with rivaroxaban to assist CRTD.All patients were followed up for one year after surgery,the changes in anti-Xa coagulation factors,myocardial injury markers,cardiac function indicators,as well as the incidence of postoperative thromboembolism and cardiovascular death events between the two groups of patients before and after treatment were compared.Results Before treatment,there were no statistically significant differences in Xa coagulation factor,myocardial injury markers and cardiac function indicators between the two groups of patients(P>0.05).Under different anticoagulation regimens,the anti-Xa coagulation factor levels in the observation group were(130.44±20.18)IU/mg after 1 day of treatment,(115.36±20.77)IU/mg after 3 days of treatment,and(90.25±20.44)IU/mg after 7 days of treatment,which were lower than that in the conventional group [(145.33±20.19)IU/mg,(128.45±20.16)IU/mg,(103.34±20.17)IU/mg](P<0.05).After treatment,the CK-MB level of the experimental group was(7.52±2.16)U/L,cTnI was(0.52±0.12)ng/mL,and LDH was(126.41±20.45)U/L,which were lower than that of the conventional group [(8.44±2.28)U/L,(0.94±0.31)ng/mL,(140.33±20.25)U/L](P<0.05).After treatment,the left ventricular ejection fraction of the observation group was(56.12±10.41)%,which was higher than the conventional group(50.24±10.33)%,left ventricular diameter was(47.11±10.25)mm,left ventricular end disastolic volume was(36.72±10.43)mL,which were lower than the conventional group(53.28±10.14)mm,(42.77±10.36)mL(P<0.05).During the follow-up period,the incidence of thromboembolism events in the experimental group was 4.84%(3/62),and the incidence of cardiovascular death events was 3.23%(2/62),which was lower than the conventional group [19.67%(12/61),14.75%(9/61)](P<0.05).Conclusions Rivaroxaban assisted CRTD can effectively enhance the activity of anti-Xa coagulation factors in patients with HF and AF,which has positive significance in reducing myocardial injury,improving cardiac function and reducing the risk of thromboembolism or cardiovascular death.
目的 探讨达格列净辅助治疗老年心力衰竭合并2型糖尿病(T2DM)患者的效果。方法 将我院2020年9月—2022年2月期间收治的82例老年心力衰竭合并T2DM患者按照随机数字表法分为观察组和对照组,对照组41例予以常规降糖及抗心力衰竭药物治疗,观察组41例在对照组基础上予以达格列净治疗,观察2组患者血糖水平、心肌损伤标志物、心室结构以及不良反应。结果 治疗3个月后,观察组空腹血糖、餐后2小时血糖、糖化血红蛋白水平低于对照组(P<0.05);观察组NT-proBNP、AngⅡ水平低于对照组(P<0.05);观察组LAVI、LVESd、LVEDd低于对照组,观察组LVEF高于对照组(P<0.05);观察组不良反应发生率(12.20%)与对照组(7.32%)对比差异无统计学意义(P>0.05)。结论 达格列净辅助治疗老年心力衰竭合并T2DM患者有效降低血糖,减轻心肌损伤,改善心脏结构和功能,且不增加患者不良反应发生率。
目的 分析心力衰竭伴快速心房颤动(简称:心衰伴快速房颤)患者接受胺碘酮急诊抢救治疗的效果及对24 h心室率的影响。方法 将2017年1月—2020年12月急诊接诊且行西地兰治疗的60例心衰伴快速房颤患者作为对照组,将同期急诊接诊且行胺碘酮治疗的60例心衰伴快速房颤患者作为观察组,对组间心功能指标、炎症因子水平、心室率、临床疗效、药物不良反应展开分析。结果 ①组间心功能指标、炎症因子水平在治疗前无差异,P>0.05;观察组心功能指标、炎症因子水平在治疗后优于对照组,P<0.05;②组间心室率在治疗前无差异,P>0.05;观察组治疗后4 h、12 h、24 h心室率均低于对照组,P<0.05;③观察组5例无效(8.33%),对照组14例无效(23.33%),P<0.05;④观察组药物不良反应率(3.33%)与对照组药物不良反应率(5.00%)无差异,P>0.05。结论 在急诊抢救心衰伴快速房颤患者时采用胺碘酮,可以改善患者心功能、炎症反应、心室率,加之无明显不良反应,值得推广。
Objective To analyze the efficacy of emergency treatment with amiodarone and its influence on 24-hour ventricular rate in patients with heart failure and rapid atrial fibrillation. Methods From January 2017 to December 2020, 60 patients with heart failure and rapid atrial fibrillation who received emergency treatment and cedilanide treatment were selected as the control group, and 60 patients with heart failure and rapid atrial fibrillation who received emergency treatment and amiodarone treatment at the same period were selected as the observation group. Results ① There was no significant difference in cardiac function index and inflammatory factors level between the two groups before treatment, P>0.05.The cardiac function index and inflammatory factors level of the observation group were more improved than those of the control group after treatment, P<0.05. ② There was no significant difference in ventricular rate between the two groups before treatment, P>0.05.The ventricular rates of the observation group at 4 h, 12 h and 24 h after treatment were lower than those of the control group, P< 0.05. ③ Treatment for 5 cases (8.33%) in the observation group, 14 cases (23.33%) in the control group were ineffective, P<0.05. ④ There was no significant difference in the adverse drug reaction incidence between the observation group (3.33%) and the control group (5.00%), P>0.05. Conclusion Amiodarone could improve the cardiac function, inflammatory reaction and ventricular rate of patients with heart failure and rapid atrial fibrillation in emergency treatment, and there was no obvious adverse reaction, so it is worthy of promotion.
目的 分析基于微信平台步行运动训练对慢性充血性心力衰竭(CHF)患者心脏康复水平的影响。方法 本次研究对象来源于梅州市中医医院一内科2020年11月—2021年12月住院的90例CHF患者,根据随机数字表法分组(每组n=45),对比组给予常规药物治疗,观察组在对比组基础上给予基于微信平台步行运动训练治疗,对比两组临床疗效、心脏功能指标、血清NT-proBNP、D-D、6分钟步行距离、日常生活能力评分、明尼苏达心力衰竭生活质量调查表(MLHFQ)评分。结果 观察组临床总有效率(95.56%)高于对比组(66.67%),观察组治疗后左心室舒张末期内径、左心室收缩末期内径均低于对比组,观察组治疗后左室射血分数高于对比组,观察组治疗后血清NT-proBNP、D-D均低于对比组,观察组治疗后6分钟步行距离、日常生活能力评分均高于对比组,观察组治疗后MLHFQ评分低于对比组,P<0.05(差异均具有统计学意义)。结论 基于微信平台步行运动训练可有效改善CHF患者心功能,抑制NT-proBNP、D-D高表达,提高日常生活能力、生存质量。
Objective To analyze the effect of walking training through Wechat on cardiac rehabilitation of chronic congestive heart failure (CHF) patients. Methods A total of 90 patients with CHF hospitalized in the First Internal Medicine Department of Meizhou Traditional Chinese Medicine Hospital from November 2020 to December 2021 were enrolled in this study. They were divided into two groups according to the random number table method (45 patients in each group).The control group was given routine drug treatment,and the observation group was given walking training through Wechat on the basis of control group. The clinical efficacy,cardiac function indexes,serum NT-proBNP,D-D levels,6-minute walking distance,ability of daily life (ADL) score and Minnesota Living with Heart Failure Questionnaire (MLHFQ) score were compared between two groups. Results The total clinical effective rate of the observation group (95.56%) was higher than that of the control group (66.67%),the LVEDd and LVESd of the observation group were lower than those of the control group after treatment,the LVEF of the observation group was higher than that of the control group after treatment,the serum NT-proBNP and D-D levels of the observation group were lower than those of the control group after treatment,the 6-minute walking distance and ADL score of the observation group were higher than those of the control group after treatment,and the MLHFQ score of the observation group was lower than that of the control group after treatment,P<0.05 (the difference was statistically significant).Conclusions Walking training by Wechat could effectively improve the cardiac function of CHF patients,inhibit the high expression of NT proBNP and D-D,and improve the ability of daily living and quality of life.
目的 探讨生脉注射液联合环磷腺苷治疗慢性心力衰竭的临床疗效及对其心功能的影响。方法 选择本院2016年3月—2017年4月收治的90例慢性心力衰竭患者,随机将其分为2组,各45例。对照组采用环磷腺苷静脉滴注治疗,在此基础上观察组加用生脉注射液治疗,比较两组临床疗效、心功能及药物不良反应。结果 2个疗程后,观察组总有效率、LVEF、CI及CO水平均较对照组高,差异有统计学意义(P<0.05);两组治疗期间药物不良反应率相比,差异无统计学意义(P>0.05)。结论 生脉注射液联合环磷腺苷可提高慢性心力衰竭临床疗效,改善心功能,且用药安全性较高。
目的 探究曲美他嗪对慢性心力衰竭患者血清炎症因子水平及心功能的影响。方法 选择2015年4月—2016年3月我院收治的慢性心力衰竭患者94例,根据随机数表法分为两组,每组47例。对照组实施阿托伐他汀治疗,观察组在此基础上予以曲美他嗪治疗。比较两组患者治疗6个月后血清炎症因子和脑利钠肽(BNP)、心功能以及临床疗效。结果 观察组血清C-反应蛋白(CRP)、BNP、肿瘤坏死因子-α(TNF-α)水平均低于对照组,差异有统计学意义(P<0.05);观察组左收缩末期内径(LVESD)、左室舒张末期内径(LVEDd)水平较对照组明显降低,而左室射血分数(LVEF)高于对照组,差异有统计学意义(P<0.05);观察组患者治疗有效率与对照组相比明显提高,差异有统计学意义(P<0.05)。结论 对慢性心力衰竭患者实施曲美他嗪治疗,能有效提高患者临床疗效,降低患者血清炎症因子,改善心功能,值得临床推广与应用。
Objective To investigate the effect of Trimetazidine on serum inflammatory factors levels and cardiac function in patients with chronic heart failure (CHF). Methods 94 CHF patients admitted into our hospital from April 2015 to March 2016 were divided into two groups randomly, 47 cases in each. Control group took Atorvastatin, and on this basis observation group was given Trimetazidine. The serum inflammatory factors levels, brain natriuretic peptide (BNP), cardiac function and clinical efficacy of two groups after treatment for 6 months were compared. Results The serum C-reactive protein (CRP), BNP, Tumor necrosis factor-α (TNF-α) levels of observation group were lower than control group (P<0.05); The left ventricular end-systolic diameter (LVESD), Left ventricular end-diastolic diameter (LVEDd) levels of observation group significantly decreased compared with control group, but left ventricular ejection fraction (LVEF) was higher than control group (P<0.05); The curative effective rate of observation group significantly increased compared with control group (P<0.05). Conclusion Trimetazidine for treating CHF patients may effectively increase clinical efficacy, decrease serum inflammatory factors and improve cardiac function, which is worthy of clinical promotion and application.
目的 对比双腔耐高压PICC和股静脉置管在IV级心力衰竭患者中的应用效果。方法 选取我院 2016年1月—12月收治的端坐位IV级心力衰竭患者61例,按照便利抽样的方法将其随机分成研究组31例和对照组30例。研究组患者行耐高压PICC置管,对照组患者行双腔中心股静脉置管,观察2组患者的一次性置管成功率、导管头端位置、并发症发生率、留置导管天数和患者满意度等相关临床指标。结果 研究组患者的一次插管成功率为 93.55%(29例),高于对照组的83.33%(25例)(P<0.05);研究组患者的并发症发生率低于对照组(P<0.05)。结论 对IV级心力衰竭患者在端坐位下予以耐高压PICC 插管进行治疗,能提高一次置管成功率,降低并发症发生率,提高患者满意度,可作为患者抢救时的首选静脉通道。
Objective To compare the effect of dual chamber high pressure PICC (peripherally inserted central catheter) and femoral vein CVC(central venous catheter)catheterization in patients with IV class heart failure. Methods From January to December 2016, 61 patients with congestive heart failure in the sitting position were selected from our hospital. According to the convenient sampling method, they were randomly divided into the study group (31 cases) and the control group(n=30). The study group were treated with high pressure PICC tube, the control group underwent femoral vein catheterization. Two groups of patients with the success rate of catheterization, catheter tip location, complications, indwelling catheter days and related clinical indicators of patient satisfaction were observed. Results The successful rate of intubation in the study group was 93.55% (29 cases), higher than that of the control group (25 cases)(P<0.05), and the incidence of complications in the study group was lower than that of the control group(P<0.05)(83.33%). Conclusion Treatment for patients with heart failure IV be in sitting position under high pressure PICC intubation, may improve the success rate of catheterization, reduce the incidence of complications, improve patient satisfaction, and be the first choice when the rescue of patients with venous channel.