MDSCs调控新生儿免疫应答机制及其临床意义

doi:10.3969/j.issn.1000-8535.2024.05.002

广州医药 ›› 2024, Vol. 55 ›› Issue (5): 457-462.DOI: 10.3969/j.issn.1000-8535.2024.05.002

MDSCs调控新生儿免疫应答机制及其临床意义

徐凝¹, 王丽娜², 刘国成¹, 刘雨丰³

1 广东省妇幼保健院产科（广东广州 511442）
2 广州市第一人民医院儿科（广东广州 510180）
3 广州市第一人民医院医学研究与创新转化中心（广东广州 510320）

收稿日期:2024-03-15 出版日期:2024-05-20 发布日期:2024-06-28
通讯作者: 刘雨丰,E-mail：eyyufengliu@scut.edu.cn
作者简介:刘雨丰博士,研究员,广州市第一人民医院医学研究与创新转化中心PI,华南理工大学研究生导师,博士后合作导师。广州市高层次人才、广州市医学骨干人才。以第一或通讯作者在J Clin Invest,Stem Cell Rep,Stem Cells,Nature Medicine等杂志发表高水平SCI论文20余篇。主持国家自然科学基金3项、省部级课题8项以及广州市高层次人才启动经费。国家自然科学基金函审专家、省市级科研基金评审专家、《广州医药》杂志编委。获授权国家发明专利8项、PCT国家专利1项、已完成项目临床转化应用百万元。其主持的相关研究首次证明了髓系抑制性细胞在新生儿时期具有重要的免疫保护功能,其对于预防感染、维持新生个体的免疫稳态至关重要,为研究新生儿重大疾病的防治开辟新途径。
基金资助:
国家自然科学基金面上项目（8217060280）; 广州市校（院）企联合资助项目（SL2024A03J01319）; 广东省基础与应用基础研究专题（优秀博士“续航”项目）（SL2024A04J00240）

Mechanism and clinical significance of MDSCs regulation of neonatal immune response

XU Ning¹, WANG Lina², LIU Guocheng¹, LIU Yufeng³

1 Department of Obstetrics,Guangdong Maternal and Child Health Hospital,Guangzhou 511442,China
2 Department of Pediatrics,Guangzhou First People’s Hospital,Guangzhou 510180,China
3 Center for Medical Research on Innovation and Translation,Guangzhou First People’s Hospital,Guangzhou 510320,China

Received:2024-03-15 Online:2024-05-20 Published:2024-06-28

摘要/Abstract

摘要： 新生儿期的免疫系统发育阶段对维持新生儿健康至关重要,具有独特的免疫调节机制。近年来,人们越来越关注髓源性抑制细胞（MDSCs）在新生儿免疫调节中的作用。MDSCs是一类免疫抑制功能强大的异质性细胞群体,它们能够通过多种机制调节免疫应答。MDSCs在新生儿中的调节作用对防止过度免疫反应和促进免疫耐受至关重要,有助于预防新生儿期炎症性疾病,并对其后续健康产生积极影响。近期研究文献分析展示了MDSCs在新生儿免疫调节中的多种作用机制,包括在特定病理条件下的保护作用、与新生儿期炎症反应的相互作用,以及对长期免疫发展的潜在影响。因此,深入理解MDSCs在新生儿免疫中的角色,不仅有助于揭示其复杂的调节机制,也为制定新的预防和治疗新生儿炎症性疾病的策略提供了新的思路。

关键词: 新生儿, 髓源性抑制细胞, 免疫调节

Abstract: The developmental stage of the immune system during the neonatal period is crucial for maintaining neonatal health,characterized by unique immunoregulatory mechanisms．In recent years,increasing attention has been drawn to the role of myeloid-derived suppressor cells（MDSCs）in neonatal immune regulation．MDSCs represents a heterogeneous population of cells with potent immunosuppressive functions,capable of modulating immune responses through various mechanisms．The regulatory role of MDSCs in neonates is vital for preventing excessive immune reactions and promoting immune tolerance,thereby aiding in the prevention of neonatal inflammatory diseases and positively influencing subsequent health outcomes．Analysis of recent research literature reveals multiple mechanisms through which MDSCs contribute to neonatal immune regulation,including protective effects under specific pathological conditions,interactions with neonatal inflammatory responses,and potential impacts on long-term immune development．Therefore,a comprehensive understanding of the role of MDSCs in neonatal immunity not only helps elucidate their intricate regulatory mechanisms but also provides novel insights for developing strategies for the prevention and treatment of neonatal inflammatory diseases．

Key words: newborn, myeloid-derived suppressor cells（MDSCs）, immune regulation

徐凝, 王丽娜, 刘国成, 刘雨丰. MDSCs调控新生儿免疫应答机制及其临床意义[J]. 广州医药, 2024, 55(5): 457-462.

XU Ning, WANG Lina, LIU Guocheng, LIU Yufeng. Mechanism and clinical significance of MDSCs regulation of neonatal immune response[J]. Guangzhou Medical Journal, 2024, 55(5): 457-462.

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MDSCs调控新生儿免疫应答机制及其临床意义

Mechanism and clinical significance of MDSCs regulation of neonatal immune response

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