妊娠期肝内胆汁淤积症的围产结局分析

doi:10.3969/j.issn.1000-8535.2022.05.013

摘要/Abstract

摘要： 目的分析妊娠期肝内胆汁淤积症(ICP)孕妇与正常孕妇围产结局及ICP孕妇不同总胆汁酸水平对围产结局及新生儿的影响,为做好ICP孕妇的妊娠期管理及其新生儿预后评估提供参考依据。方法以2010年3月—2020年3月在我院分娩的ICP孕妇 249例为观察组,同期分娩的249例正常孕妇为对照组,比较2组围产结局相关指标。结果观察组羊水污染、新生儿黄疸、新生儿呼吸窘迫综合征发生率均高于对照组,根据总胆汁酸水平分组,重度组早产、羊水污染发生率高于轻度组,以上差异均有统计学意义(P＜0.05)。总胆汁酸水平是ICP孕妇发生早产的危险因素(P＜0.05)。结论 ICP孕妇总胆汁酸水平可用于发生早产的预测,及时干预有利于提高其围产期质量。

关键词: 妊娠期肝内胆汁淤积症, 总胆汁酸, 围产结局, 新生儿

Abstract: Objective To analyze the perinatal outcome of women with intrahepatic cholestasis of pregnancy (ICP) and normal pregnant women and the effects of different levels of total bile acid in ICP women on perinatal outcome and newborn. To provide a reference for the management of pregnancy and prognosis of ICP women. Methods From March 2010 to March 2020, 249 women with ICP delivered in our hospital were included as the observation group, 249 normal pregnant women delivered in the same period as the control group, the perinatal outcomes of the two groups were analyzed and compared. Results The incidences of amniotic fluid contamination, neonatal jaundice and neonatal respiratory distress syndrome in the observation group were higher than that in the control group. Grouping by the total bile acid level, the incidences of premature delivery and amniotic fluid contamination in the severe group were higher than that in the mild group, with statistical significance (P<0.05). Total bile acid level was a risk factor for premature delivery in women with ICP (P<0.05). Conclusions The level of total bile acid in women with ICP can be used to predict the occurrence of premature delivery, and timely intervention is beneficial to improve the perinatal quality of ICP women.

Key words: intrahepatic cholestasis of pregnancy, total bile acid, perinatal outcome, neonate

梁紫燕, 谭小华, 石碧君, 贾春宏, 黄仪, 崔其亮. 妊娠期肝内胆汁淤积症的围产结局分析[J]. 广州医药, 2022, 53(5): 66-71.

LIANG Ziyan, TAN Xiaohua, SHI Bijun, JIA Chunhong, HUANG Yi, CUI Qiliang. Perinatal outcome analysis of intrahepatic cholestasis during pregnancy[J]. Guangzhou Medical Journal, 2022, 53(5): 66-71.

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