微泡增强的脉冲超声治疗脾创伤出血机制的初步探讨

doi:10.3969/j.issn.1000-8535.2015.01.002

广州医药 ›› 2015, Vol. 46 ›› Issue (1): 5-7.DOI: 10.3969/j.issn.1000-8535.2015.01.002

• 论著 • 下一篇

微泡增强的脉冲超声治疗脾创伤出血机制的初步探讨

区文财, 柳建华, 何景光, 萧淑宜, 杜洪, 邱春花

广州医科大学附属广州市第一人民医院(广州 510180)

收稿日期:2014-11-27 发布日期:2021-11-30
通讯作者: 柳建华,E-mail:jhliu666666@sina.com
基金资助:
广州市医药卫生科技项目(20121A011007)

The mechanism of haemostatic effects induced by microbubble enhanced ultrasound on splenic trauma

Ou Wencai, Liu Jianhua, He Jingguang, et al

Department of ultrasound,Guangzhou First People's Hospital Affiliated to Guangzhou Medical college,Guangzhou 510180,China

Received:2014-11-27 Published:2021-11-30

摘要/Abstract

摘要： 目的初步探讨微泡增强的脉冲式超声治疗脾创伤出血的作用机制。方法 14只健康家犬随机分为3组,超声微泡组(MEUS组)6只、单纯超声组(TUS组)4只、单纯微泡组(MB组)4只。开腹切割脾建立脾破裂出血模型,MEUS组用脉冲式超声治疗仪辐照伤口,同时静脉匀速推注微泡;TUS组超声治疗时静脉推注生理盐水;MB组超声治疗仪假照的同时静脉推注微泡。治疗完毕,进行超声造影评价,并送病理组织学检查。结果 MEUS组造影示靶区造影增强缺损或者低灌注,但较粗大血管仍为增强显影。病理组织学见脾窦、微小血管扩张充血、血管周围组织水肿,血小板聚集,微小血管血栓形成。结论微小血管血栓形成、微血管淤血扩张、周围组织水肿压迫是超声联合微泡治疗脾创伤出血的可能机理。

关键词: 微泡, 脉冲式超声, 脾脏, 机制, 止血

Abstract: Objective To investigate the mechanism of haemostatic effect induced by microbubble(MB)enhanced therapeutic ultrasound(TUS)on splenic trauma. Methods 14 healthy dogs were divided into 3 groups.Six animals were treated by microbubble-enhanced therapeutic ultrasound(MEUS),the other eight animals were treated with TUS only group(n=4)and the MB only(n=4)served as the controls.The spleens of all animals were surgically exposed and a 20 mm long,5 mm deep incision was created on the spleens using scalpel.Contrast enhanced ultrasound(CEUS)was performed to assess the blocking effects of splenic circulation.The targeted spleens were harvested for pathological examination. Results A non-enhanced or perfusion defect region was formed within the treated area.The histological results showed splenic sinus hyperemia,microvascular hyperemia,perivascular tissue edema,platelet aggregation and intravascular thrombosis. Conclusion The mechanism of haemostatic effect on splenic trauma by microbubble enhanced ultrasound maybe intravascular thrombosis,microvascular hyperemia and perivascular tissue edema oppression simultaneously.

Key words: Microbubbles, Pulsed therapeutic ultrasound, Spleen, Mechanism

区文财, 柳建华, 何景光, 萧淑宜, 杜洪, 邱春花. 微泡增强的脉冲超声治疗脾创伤出血机制的初步探讨[J]. 广州医药, 2015, 46(1): 5-7.

Ou Wencai, Liu Jianhua, He Jingguang, et al. The mechanism of haemostatic effects induced by microbubble enhanced ultrasound on splenic trauma[J]. Guangzhou Medical Journal, 2015, 46(1): 5-7.

[1]	翁沛华. 超声-微泡介导miR-128通过调节PTEN抑制乳腺癌细胞阿霉素耐药[J]. 广州医药, 2021, 52(6): 35-38.
[2]	位红芹, 马穗红, 柳建华. 诊断超声及低声压治疗超声对微泡的作用效果研究[J]. 广州医药, 2021, 52(2): 33-36.
[3]	胡志文, 萧淑宜, 格桑卓玛, 金海, 董燕, 柳建华. 微泡超声空化在增强微波消融对肝脏肿瘤的热消融效应中的价值[J]. 广州医药, 2021, 52(1): 43-48.
[4]	唐昭亮, 王康玮, 王小拍, 杜洪. 脾脏炎性假瘤样滤泡树突细胞肉瘤的临床病理分析[J]. 广州医药, 2020, 51(5): 62-65.
[5]	邱婷, 周洁, 翁廷松, 林敏诗. 骨髓间充质干细胞源性微泡修复大鼠早发性卵巢功能不全的自噬机制[J]. 广州医药, 2020, 51(4): 18-21.
[6]	金海, 胡志文, 柳建华. 压迫止血法在实时超声引导经皮肾穿刺的应用价值[J]. 广州医药, 2020, 51(4): 47-50.
[7]	梁春艳. 二氢丹参酮I在胃癌AGS细胞中作用机制的生物信息学分析[J]. 广州医药, 2020, 51(2): 85-93.
[8]	赵梦瑶, 李思源, 肖志伟, 蔺茹君, 赵晓伟, 李军. 塞来昔布对食管癌EC109细胞凋亡及机制的影响[J]. 广州医药, 2020, 51(1): 10-13.
[9]	张积慧, 黄琛厦, 张文坚. 拔岗晋级结合激励机制在护士岗位管理的实践和体会[J]. 广州医药, 2018, 49(5): 111-114.
[10]	矫元君, 尹耀新. miRNAs在肝细胞肝癌发展过程中的研究进展[J]. 广州医药, 2018, 49(2): 123-126.
[11]	陈定强, 杨羚. 基于高通量测序的多重耐药大肠埃希菌HX43耐药分子机制分析[J]. 广州医药, 2017, 48(3): 7-11.
[12]	萧淑宜, 柳建华, 邱春花, 杜洪. 微泡增强的超声空化增加兔睾丸组织伊文思蓝浓度的研究[J]. 广州医药, 2016, 47(6): 10-12.
[13]	冯聪锐, 何力敏, 徐刚. 血清IL-33水平与老年COPD患者病程分期的相关性研究[J]. 广州医药, 2016, 47(6): 26-28.
[14]	位红芹, 余美玲, 韦英丽, 肖妮娜, 柳建华. 微泡增强的超声空化对荷瘤兔乳腺癌作用效果的研究[J]. 广州医药, 2016, 47(2): 32-34.
[15]	卫荆璐, 余美玲, 韦英丽, 肖妮娜, 柳建华. 低频脉冲超声联合微泡对在体微小血管作用的实验研究[J]. 广州医药, 2016, 47(2): 85-87.

微泡增强的脉冲超声治疗脾创伤出血机制的初步探讨

The mechanism of haemostatic effects induced by microbubble enhanced ultrasound on splenic trauma

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价