口服铁剂对改善男性机采血小板固定献血者铁缺乏的效果

doi:10.20223/j.cnki.1000-8535.2025.06.014

摘要/Abstract

摘要： 目的探讨口服铁剂方法用于改善铁缺乏的男性机采血小板固定献血者铁营养状况效果,为采供血机构完善无偿献血者关爱策略提供数据支持。方法选择2022年9月—2023年8月珠海市中心血站男性血小板固定献血者进行铁蛋白（FER）检测。以FER<30 ng/mL为铁缺乏的判定标准。将49名铁缺乏的男性机采血小板固定献血者随机分成干预组、对照组,分别进行口服铁剂干预,比较两组干预前后血红蛋白（Hb）、血清铁（SI）、FER的浓度变化情况。结果共检测205名男性机采固定献血者,其中49名FER<30 ng/mL（铁缺乏组）,占23.90%,其Hb、SI、FER均值低于FER≥30 ng/mL男性机采固定献血者（正常组）。49名铁缺乏的机采固定献血者口服铁剂干预后：干预组SI、FER浓度分别为（15.97±5.14）μmol/L、（30.55±14.42）ng/mL,高于对照组[（11.49±4.02）μmol/L、（12.77±5.86）ng/mL）],其差异有统计学意义（t=3.466,P<0.001;t=5.493,P<0.001）。干预组Hb为（143.42±10.85）g/L,高于对照组的（140.88±12.97）g/L,但差异无统计学意义（t=-0.726,P=0.471）。结论针对铁蛋白低值的机采男性固定献血者,采取口服铁剂方法可以有效改善其铁缺乏状况。

关键词: 机采血小板, 固定献血者, 铁蛋白, 口服铁剂

Abstract: Objective To explore the effect of oral iron supplements on improving iron deficiency in male regular plateletpheresis donors. Methods Male regular plateletpheresis donors from Zhuhai Blood Central Station were selected for ferritin（FER）detection．Using FER<30 ng/mL as the criterion for determining iron deficiency,49 donors were selected as the study subjects and divided into intervention group and control group,and the changes in hemoglobin（Hb）,serum iron（SI）,and FER concentrations were compared．Results A total of 205 male regular plateletpheresis donors underwent FER detection,of which 49 donors had FER under 30 ng/mL（iron deficiency group）,accounting for 23.90%．The mean Hb,SI,and FER levels in the iron deficiency group were significantly lower than those with FER≥30 ng/mL．After oral iron intervention,the SI and FER levels in the intervention group（[15.97±5.14] μmol/L,[30.55±14.42] ng/mL）were significantly higher than those in the control group（[11.49±4.02] μmol/L,[12.77±5.86] ng/mL）,and the difference were statistically significant（t=3.466,P<0.001;t=5.493,P=0.000）．The Hb values of the intervention group and the control group were（143.42±10.85）g/L and（140.88±12.97）g/L,respectively,with no statistically significant difference between the groups（t=-0.726,P=0.471）． Conclusions Oral iron supplementation can effectively improve iron deficiency in male regular plateletpheresis donors．

Key words: plateletpheresis donors, regular blood donors, ferritin, oral iron supplements

吴蓉, 陈永超, 邓思海, 胡小倩, 卢清怡. 口服铁剂对改善男性机采血小板固定献血者铁缺乏的效果[J]. 广州医药, 2025, 56(6): 815-818.

WU Rong, CHEN Yongchao, DENG Sihai, HU Xiaoqian, LU Qingyi. The effect of oral iron supplements on improving iron deficiency in male regular plateletpheresis donors[J]. Guangzhou Medical Journal, 2025, 56(6): 815-818.

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