MDSCs调控新生儿免疫应答机制及其临床意义

来源期刊：广州医药 | 457-462 发布时间：2024-06-28 收稿时间：2025/11/17 15:49:09 阅读量：62

作者：: 徐凝,

王丽娜,

刘国成,

刘雨丰,

关键词：: 新生儿髓源性抑制细胞免疫调节; newborn myeloid-derived suppressor cells（MDSCs）immune regulation

DOI：: 10.3969/j.issn.1000-8535.2024.05.002

收稿时间：: 2024-03-15
修订日期：
接收日期：
引用总数：: 0

新生儿期的免疫系统发育阶段对维持新生儿健康至关重要,具有独特的免疫调节机制。近年来,人们越来越关注髓源性抑制细胞（MDSCs）在新生儿免疫调节中的作用。MDSCs是一类免疫抑制功能强大的异质性细胞群体,它们能够通过多种机制调节免疫应答。MDSCs在新生儿中的调节作用对防止过度免疫反应和促进免疫耐受至关重要,有助于预防新生儿期炎症性疾病,并对其后续健康产生积极影响。近期研究文献分析展示了MDSCs在新生儿免疫调节中的多种作用机制,包括在特定病理条件下的保护作用、与新生儿期炎症反应的相互作用,以及对长期免疫发展的潜在影响。因此,深入理解MDSCs在新生儿免疫中的角色,不仅有助于揭示其复杂的调节机制,也为制定新的预防和治疗新生儿炎症性疾病的策略提供了新的思路。

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