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血小板药物递送系统的研究进展

Advances in platelet as drug delivery systems

来源期刊: 广州医药 | 577-584 发布时间:2024-07-31 收稿时间:2025/11/13 18:47:53 阅读量:25
作者:
关键词:
血小板仿生纳米颗粒血小板衍生物药物递送系统
plateletbionic nano carriersplatelet extracellular vesiclesdrug delivery system
DOI:
10.3969/j.issn.1000-8535.2024.06.001
收稿时间:
2024-04-20 
修订日期:
 
接收日期:
 
引用总数:
0  
药物递送系统对于各类疾病意义非凡,但传统药物载体面临细胞毒性强、组织相容性低、半衰期短和靶向性弱等诸多挑战。血小板及其相关衍生物作为新型药物载体具有更为显著的优势。由于血小板自身的生理特点,以及在肿瘤、心血管疾病、血栓性疾病、感染等多种疾病中发挥的病理生理作用,血小板能够弥补传统药物载体的缺陷,具有极大的临床转化意义。该文总结了血小板相关药物递送系统目前的研究进展,以期为新型药物载体研究提供参考。
Drug delivery systems are important for various diseases,but conventional therapeutic drug have many shortcomings,such as high cytotoxicity,low histocompatibility,short half-life and weak targeting.Platelets and their derivatives have more significant advantages as novel drug carriers.Platelets play an important role in the pathophysiology of a wide range of diseases including oncology,cardiovascular diseases,thrombosis and infection.In this paper,we summarized the current research progress of platelet-related drug delivery systems to provide a reference for the research of novel drug delivery systems.
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