11例慢性淋巴细胞白血病合并第二肿瘤的临床分析

来源期刊：广州医药 | 23-27 发布时间：2023-07-27 收稿时间：2025/11/13 18:33:18 阅读量：26

作者：: 杨方方,

邓婷芬,

向琪,

李昕芯,

张玉玲,

王顺清,

关键词：: 慢性淋巴细胞白血病第二肿瘤基因缺失; chronic lymphocytic leukemia second cancers gene deletion

DOI：: 10.3969/j.issn.1000-8535.2023.06.004

收稿时间：: 2022-09-07
修订日期：
接收日期：
引用总数：: 0

目的探讨慢性淋巴细胞白血病（CLL）合并第二肿瘤临床特征和预后。方法回顾性分析2015年8月—2021年10月我院收治的58例CLL患者,其中有11例合并第二肿瘤,47例无合并第二肿瘤,分析两组病例的临床特征及其对预后的影响。结果 CLL合并第二肿瘤和无合并第二肿瘤患者在年龄、性别、白细胞计数、血红蛋白水平、淋巴细胞计数、血小板计数、乳酸脱氢酶（LDH）、β₂-微球蛋白（β₂-MG）水平、分期、单个基因缺失类型之间比较差异无统计学意义,但CLL合并第二肿瘤患者基因缺失个数较无合并第二肿瘤CLL患者组高（χ²=11.17,P=0.03）,且总生存期较短。结论 CLL合并第二肿瘤患者常伴有多个基因缺失,且预后差,当CLL患者伴有多个基因缺失时,在诊治过程中需警惕有无合并第二肿瘤。

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