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2023年7月 第38卷 第7期11
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CAR-T细胞治疗实体瘤的现状研究

Recent advances in solid tumor CAR-T cell therapy

来源期刊: 广州医药 | 1-10 发布时间:2023-10-12 收稿时间:2025/11/13 18:30:37 阅读量:36
作者:
关键词:
嵌合抗原受体T细胞(CAR-T)肿瘤免疫治疗实体瘤
CAR-Timmunotherapysolid tumors
DOI:
10.3969/j.issn.1000-8535.2023.09.001
收稿时间:
2023-06-13 
修订日期:
 
接收日期:
 
引用总数:
2  
肿瘤免疫治疗是指利用人体的免疫机制,通过主动或被动的方法增强患者免疫功能,达到杀伤肿瘤细胞的目的。嵌合抗原受体T细胞(CAR-T)作为肿瘤免疫治疗的新型精准靶向疗法,近几年通过优化和改良已成功应用于多种血液肿瘤的治疗,是目前恶性肿瘤治疗中最有潜力的疗法之一。但由于实体瘤中存在显著的异质性和复杂的肿瘤免疫微环境,CAR-T在实体瘤中的应用仍面临诸多挑战。本文将对目前 CAR-T 细胞治疗实体瘤的研究成果、现存挑战及相应的优化策略进行综述,以期为后续 CAR-T 细胞治疗实体肿瘤研究提供参考。
Tumor immunotherapy is the process of enhancing patients’ immune system through active or passive methods to achieve the goal of eliminating tumor cells.Through optimization and modification,chimeric antigen receptor T cells(CAR-T),a novel precise targeted therapy of cancer immunotherapy,have been successfully used in the treatment of several hematological malignancies in recent years.CAR-T is considered as one of the most promising therapies for the treatment of malignant tumors at the moment.However,application of CAR-T in solid tumors still confronts several difficulties due to the high heterogeneity and intricate tumor immune microenvironment.To serve as a reference for future CAR-T cell therapy for solid tumors,the present research findings,current difficulties and associated optimization techniques are reviewed in this paper.
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